{"id":"https://openalex.org/W2020176140","doi":"https://doi.org/10.7164/antibiotics.46.1116","title":"Isolation on trehalamine, the aglycon of trehazolin, from microbial broths and characterization of trehazolin related compounds.","display_name":"Isolation on trehalamine, the aglycon of trehazolin, from microbial broths and characterization of trehazolin related compounds.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2020176140","doi":"https://doi.org/10.7164/antibiotics.46.1116","mag":"2020176140","pmid":"https://pubmed.ncbi.nlm.nih.gov/8360108"},"language":"en","primary_location":{"id":"doi:10.7164/antibiotics.46.1116","doi":"https://doi.org/10.7164/antibiotics.46.1116","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1116","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1116/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1116/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109197278","display_name":"Osamu Ando","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104626","display_name":"Daiichi-Sankyo (Japan)","ror":"https://ror.org/027y26122","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210104626"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"OSAMU ANDO","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan","Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan","institution_ids":["https://openalex.org/I4210104626"]},{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075513388","display_name":"Mutsuo Nakajima","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"MUTSUO NAKAJIMA","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109976432","display_name":"KIYOSHI HAMANO","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KIYOSHI HAMANO","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010006418","display_name":"KAZUKO ITOI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"KAZUKO ITOI","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108279753","display_name":"Shuji Takahashi","orcid":"https://orcid.org/0009-0006-1090-729X","observed_orcids":["https://orcid.org/0009-0006-1090-729X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"SHUJI TAKAHASHI","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079434258","display_name":"YASUYUKI TAKAMATSU","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"YASUYUKI TAKAMATSU","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019489630","display_name":"Akira Sato","orcid":"https://orcid.org/0000-0002-2239-6208","observed_orcids":["https://orcid.org/0000-0002-2239-6208"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"AKIRA SATO","raw_affiliation_strings":["Fermentation Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fermentation Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047684136","display_name":"Ryuzo Enokita","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"RYUZO ENOKITA","raw_affiliation_strings":["Tsukuba Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"TAKAO OKAZAKI","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TAKAO OKAZAKI","raw_affiliation_strings":["Tsukuba Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tsukuba Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083483395","display_name":"Hideyuki Haruyama","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"HIDEYUKI HARUYAMA","raw_affiliation_strings":["Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015166554","display_name":"Takeshi Kinoshita","orcid":"https://orcid.org/0000-0002-1290-0650","observed_orcids":["https://orcid.org/0000-0002-1290-0650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"TAKESHI KINOSHITA","raw_affiliation_strings":["Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":null,"fwci":2.537,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89143921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"46","issue":"7","first_page":"1116","last_page":"1125"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":0.6942999958992004,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10835","display_name":"Carbohydrate Chemistry and Synthesis","score":0.22509999573230743,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.050999999046325684,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trehalase-inhibitors","display_name":"trehalase inhibitors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/trehalase-inhibition","display_name":"trehalase inhibition","score":0.675000011920929},{"id":"https://openalex.org/keywords/trehalose","display_name":"trehalose","score":0.48500001430511475},{"id":"https://openalex.org/keywords/aminocyclitols","display_name":"aminocyclitols","score":0.6970000267028809},{"id":"https://openalex.org/keywords/acid-hydrolysis","display_name":"acid hydrolysis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/actinomycetes","display_name":"actinomycetes","score":0.8920000195503235},{"id":"https://openalex.org/keywords/micromonospora","display_name":"Micromonospora","score":0.9800000190734863},{"id":"https://openalex.org/keywords/amycolatopsis","display_name":"Amycolatopsis","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C2779315325","wikidata":"https://www.wikidata.org/wiki/Q410630","display_name":"Trehalase","level":3,"score":0.8718476295471191},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.6535260677337646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6533828973770142},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.5912579894065857},{"id":"https://openalex.org/C2781188889","wikidata":"https://www.wikidata.org/wiki/Q4746453","display_name":"Aminocyclitol","level":4,"score":0.5717089176177979},{"id":"https://openalex.org/C2780591741","wikidata":"https://www.wikidata.org/wiki/Q899405","display_name":"Hydroxymethyl","level":2,"score":0.5601086020469666},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.47357162833213806},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43842613697052},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30609017610549927},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11103573441505432},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004187","descriptor_name":"Disaccharides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006026","descriptor_name":"Glycoside Hydrolases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008847","descriptor_name":"Micromonospora","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D008847","descriptor_name":"Micromonospora","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009754","descriptor_name":"Nuts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010080","descriptor_name":"Oxazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012831","descriptor_name":"Bombyx","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039903","descriptor_name":"Actinobacteria","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D039903","descriptor_name":"Actinobacteria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7164/antibiotics.46.1116","doi":"https://doi.org/10.7164/antibiotics.46.1116","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1116","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1116/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},{"id":"pmid:8360108","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8360108","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antibiotics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.7164/antibiotics.46.1116","doi":"https://doi.org/10.7164/antibiotics.46.1116","is_oa":true,"landing_page_url":"https://doi.org/10.7164/antibiotics.46.1116","pdf_url":"https://www.jstage.jst.go.jp/article/antibiotics1968/46/7/46_7_1116/_pdf","source":{"id":"https://openalex.org/S154771817","display_name":"The Journal of Antibiotics","issn_l":"0021-8820","issn":["0021-8820","1881-1469"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Antibiotics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020176140.pdf","grobid_xml":"https://content.openalex.org/works/W2020176140.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W999151814","https://openalex.org/W1967453777","https://openalex.org/W1982516969","https://openalex.org/W1988234215","https://openalex.org/W1989954710","https://openalex.org/W1992335263","https://openalex.org/W2002802371","https://openalex.org/W2012345358","https://openalex.org/W2027180234","https://openalex.org/W2033403750","https://openalex.org/W2035147545","https://openalex.org/W2038528466","https://openalex.org/W2063358402","https://openalex.org/W2067723204","https://openalex.org/W2084484394","https://openalex.org/W2093849426","https://openalex.org/W2106618518","https://openalex.org/W2123763266","https://openalex.org/W2157350145","https://openalex.org/W2163466990","https://openalex.org/W2165127798","https://openalex.org/W2285949578","https://openalex.org/W2323392290","https://openalex.org/W2950565821","https://openalex.org/W6817724879"],"related_works":["https://openalex.org/W2084484394","https://openalex.org/W4237982844","https://openalex.org/W1983975531","https://openalex.org/W2950918194","https://openalex.org/W2031323625","https://openalex.org/W4250607602","https://openalex.org/W1985344542","https://openalex.org/W2004602522","https://openalex.org/W168932240","https://openalex.org/W2166678665"],"abstract_inverted_index":{"Trehalamine,":[0,32],"(3aR,4R,5S,6S,6aS)-2-amino-4-(hydroxymethyl)-3a,5,6,6a-":[1],"tetrahydro-4H-cyclo-pent[d]oxazole-4,5,6-triol":[2],"(1)":[3,63],"and":[4,53,64,100],"D-glucose":[5],"were":[6,66],"obtained":[7],"by":[8,18],"acid":[9],"hydrolysis":[10],"of":[11,24,35,44,69],"trehazolin":[12,25,46,59],"(3),":[13],"a":[14],"trehalase":[15,70],"inhibitor":[16],"produced":[17],"actinomycetes.":[19],"More":[20],"vigorous":[21],"hydrolytic":[22],"treatment":[23],"afforded":[26],"an":[27],"aminocyclitol,":[28],"(1R,2S,3R,4S,5R)-5-amino-1-":[29],"(hydroxymethyl)cyclopentane-1,2,3,4-tetraol":[30],"(2).":[31],"the":[33,41,84],"aglycon":[34],"trehazolin,":[36],"was":[37],"also":[38],"found":[39],"in":[40],"culture":[42],"broths":[43],"two":[45],"producing":[47],"strains,":[48],"Micromonospora":[49],"sp.":[50,55],"SANK":[51,56],"62390":[52],"Amycolatopsis":[54],"60791.":[57],"These":[58],"related":[60],"compounds":[61],"trehalamine":[62],"2":[65],"poor":[67],"inhibitors":[68],"(1;":[71,94],"IC50":[72,95,105],"1.8":[73],"x":[74,80,97,107],"10(-4)":[75,81],"M,":[76],"2;":[77],">":[78],"5.0":[79],"M).":[82],"On":[83],"other":[85],"hand":[86],"they":[87],"inhibited":[88],"more":[89],"potently":[90],"rat":[91],"intestinal":[92],"sucrase":[93],"6.8":[96],"10(-5)":[98],"M)":[99,109],"sweet":[101],"almond":[102],"beta-glucosidase":[103],"(2;":[104],"5.6":[106],"10(-6)":[108],"than":[110],"trehazolin.":[111]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}