{"id":"https://openalex.org/W2020166071","doi":"https://doi.org/10.1099/0022-1317-17-1-13","title":"Specific Inhibition of Poliovirus Induced Blockade of Cell Protein Synthesis by a Thiopyrimidine Derivative","display_name":"Specific Inhibition of Poliovirus Induced Blockade of Cell Protein Synthesis by a Thiopyrimidine Derivative","publication_year":1972,"publication_date":"1972-10-01","ids":{"openalex":"https://openalex.org/W2020166071","doi":"https://doi.org/10.1099/0022-1317-17-1-13","mag":"2020166071","pmid":"https://pubmed.ncbi.nlm.nih.gov/4343527"},"language":"en","primary_location":{"id":"doi:10.1099/0022-1317-17-1-13","doi":"https://doi.org/10.1099/0022-1317-17-1-13","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-17-1-13","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046830492","display_name":"P. La Colla","orcid":"https://orcid.org/0000-0001-5904-3812","observed_orcids":["https://orcid.org/0000-0001-5904-3812"]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P. La Colla","raw_affiliation_strings":["Institute of Microbiology II, University of Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology II, University of Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113544319","display_name":"Maria Antonietta Marcialis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. A. Marcialis","raw_affiliation_strings":["Institute of Microbiology II, University of Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology II, University of Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067701124","display_name":"Giampaolo Mereu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"G. P. Mereu","raw_affiliation_strings":["Institute of Microbiology II, University of Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology II, University of Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067418461","display_name":"Bernardo Loddo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I172446870","display_name":"University of Cagliari","ror":"https://ror.org/003109y17","country_code":"IT","type":"education","lineage":["https://openalex.org/I172446870"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"B. Loddo","raw_affiliation_strings":["Institute of Microbiology II, University of Cagliari, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microbiology II, University of Cagliari, Italy","institution_ids":["https://openalex.org/I172446870"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I172446870"],"apc_list":null,"apc_paid":null,"fwci":2.4404,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.88284182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"17","issue":"1","first_page":"13","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.05400000140070915,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/poliovirus","display_name":"poliovirus","score":0.9900000095367432},{"id":"https://openalex.org/keywords/s-7","display_name":"S^7","score":0.781000018119812},{"id":"https://openalex.org/keywords/antiviral-agents","display_name":"antiviral agents","score":0.5820000171661377},{"id":"https://openalex.org/keywords/viral-rna-synthesis-inhibition","display_name":"viral RNA synthesis inhibition","score":0.7699999809265137},{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8494378924369812},{"id":"https://openalex.org/C2779631682","wikidata":"https://www.wikidata.org/wiki/Q12438936","display_name":"Poliovirus","level":3,"score":0.7741281390190125},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7628734111785889},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.7459566593170166},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5995270609855652},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.47667574882507324},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31853318214416504},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15291762351989746},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10637450218200684},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003513","descriptor_name":"Cycloheximide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003609","descriptor_name":"Dactinomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006146","descriptor_name":"Guanidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013455","descriptor_name":"Sulfur","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014529","descriptor_name":"Uridine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017955","descriptor_name":"Poliovirus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1099/0022-1317-17-1-13","doi":"https://doi.org/10.1099/0022-1317-17-1-13","is_oa":false,"landing_page_url":"https://doi.org/10.1099/0022-1317-17-1-13","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmid:4343527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4343527","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.600.4254","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.600.4254","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://vir.sgmjournals.org/content/17/1/13.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.830.6731","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.830.6731","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.microbiologyresearch.org/docserver/fulltext/jgv/17/1/JV0170010013.pdf?accname%3Dguest%26checksum%3DD09AE2E1757E59F9F048EFF9FFD3F40D%26expires%3D1457230744%26id%3Did","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1982135231","https://openalex.org/W1984569700","https://openalex.org/W2017521685","https://openalex.org/W2046171723","https://openalex.org/W2085172136","https://openalex.org/W2091587355","https://openalex.org/W2108583965"],"related_works":["https://openalex.org/W7098420294","https://openalex.org/W7100066987","https://openalex.org/W1984569700","https://openalex.org/W384209653","https://openalex.org/W2003831995","https://openalex.org/W2404777553","https://openalex.org/W1522849109","https://openalex.org/W1962868002","https://openalex.org/W2436970987","https://openalex.org/W2064546731"],"abstract_inverted_index":{"SUMMARY":[0],"A":[1],"thiopyrimidine":[2],"derivative,":[3],"i.e.":[4],"ethyl-2-methylthio-4-methyl-5-pyrimidine":[5],"carboxylate":[6],"(S-7)":[7],"is":[8],"capable":[9],"of":[10,20],"preventing":[11],"both":[12],"poliovirus":[13],"RNA":[14],"synthesis":[15],"and":[16],"virus":[17],"induced":[18],"inhibition":[19],"cell":[21],"protein":[22],"synthesis.":[23]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
