{"id":"https://openalex.org/W2020165801","doi":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","title":"Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage","display_name":"Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage","publication_year":2007,"publication_date":"2007-10-09","ids":{"openalex":"https://openalex.org/W2020165801","doi":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","mag":"2020165801","pmid":"https://pubmed.ncbi.nlm.nih.gov/17927576"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0625.2007.00616.x","doi":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065231814","display_name":"Myron K. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Myron K. Jacobson","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc.,Tucson, AZ 85724, USA. mjacobson@pharmacy.arizona.edu","Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Niadyne Development Inc.,Tucson, AZ 85724, USA. mjacobson@pharmacy.arizona.edu","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]},{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100737774","display_name":"Hyun-Tae Kim","orcid":"https://orcid.org/0000-0001-5124-7976","observed_orcids":["https://orcid.org/0000-0001-5124-7976"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hyuntae Kim","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004557093","display_name":"W. Russell Coyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"W. Russell Coyle","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088020704","display_name":"Moonsun Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moonsun Kim","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026430429","display_name":"Donna L. Coyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donna L. Coyle","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111998102","display_name":"Ronald L. Rizer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald L. Rizer","raw_affiliation_strings":["Thomas Stephens & Associates, Inc., Colorado Springs, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomas Stephens & Associates, Inc., Colorado Springs, CO, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111671740","display_name":"Elaine L. Jacobson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]},{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine L. Jacobson","raw_affiliation_strings":["Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology & Toxicology, College of Pharmacy, and Arizona Cancer Center, University of Arizona, Tucson, AZ, USA;","institution_ids":["https://openalex.org/I138006243","https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":1.0242,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75688137,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"11","first_page":"927","last_page":"935"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retinoic-acid-therapy","display_name":"retinoic acid therapy","score":0.9459999799728394},{"id":"https://openalex.org/keywords/skin-barrier-function","display_name":"skin barrier function","score":0.9210000038146973},{"id":"https://openalex.org/keywords/transepidermal-water-loss","display_name":"transepidermal water loss","score":1.0},{"id":"https://openalex.org/keywords/treatment-side-effects","display_name":"treatment side effects","score":0.7289999723434448},{"id":"https://openalex.org/keywords/epidermal-thickness","display_name":"epidermal thickness","score":0.8320000171661377},{"id":"https://openalex.org/keywords/ki-67-proliferation-index","display_name":"Ki-67 proliferation index","score":0.8109999895095825},{"id":"https://openalex.org/keywords/loricrin","display_name":"loricrin","score":0.9729999899864197}],"concepts":[{"id":"https://openalex.org/C95150158","wikidata":"https://www.wikidata.org/wiki/Q7833972","display_name":"Transepidermal water loss","level":3,"score":0.7847025394439697},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.7114618420600891},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.7035808563232422},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5797303915023804},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.5472615957260132},{"id":"https://openalex.org/C2780576536","wikidata":"https://www.wikidata.org/wiki/Q7451065","display_name":"Sensitive skin","level":2,"score":0.48118120431900024},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4588187336921692},{"id":"https://openalex.org/C2779963572","wikidata":"https://www.wikidata.org/wiki/Q29417","display_name":"Tretinoin","level":4,"score":0.4472441077232361},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.445792019367218},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42010605335235596},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.41066303849220276},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.38259392976760864},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28259527683258057},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2133365273475647},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19343379139900208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09649878740310669},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005145","descriptor_name":"Face","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007641","descriptor_name":"Keratolytic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009525","descriptor_name":"Niacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D014867","descriptor_name":"Water","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1600-0625.2007.00616.x","doi":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2007.00616.x","pdf_url":null,"source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:17927576","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17927576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5720072916","display_name":"Topical Micronutrient Delivery System","funder_award_id":"R44CA090085","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7709471183","display_name":"Chemoprevention of Skin Cancer Program Project","funder_award_id":"P01CA027502","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000909272","display_name":"University of Arizona Cancer Center - Cancer Center Support Grant","funder_award_id":"P30CA023074","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320309707","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320310160","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332222","display_name":"University of Illinois at Urbana-Champaign","ror":"https://ror.org/047426m28"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W14690785","https://openalex.org/W141758346","https://openalex.org/W1504523524","https://openalex.org/W1551998217","https://openalex.org/W1581455991","https://openalex.org/W1593783156","https://openalex.org/W1973159760","https://openalex.org/W1975127503","https://openalex.org/W1985074609","https://openalex.org/W1987707948","https://openalex.org/W1990218144","https://openalex.org/W1992635317","https://openalex.org/W1993773377","https://openalex.org/W1999438233","https://openalex.org/W2006291617","https://openalex.org/W2025185784","https://openalex.org/W2030088567","https://openalex.org/W2036560885","https://openalex.org/W2038141352","https://openalex.org/W2039364304","https://openalex.org/W2051503115","https://openalex.org/W2057000848","https://openalex.org/W2063659378","https://openalex.org/W2064879717","https://openalex.org/W2072152713","https://openalex.org/W2077292033","https://openalex.org/W2078701818","https://openalex.org/W2082846747","https://openalex.org/W2095069298","https://openalex.org/W2115361098","https://openalex.org/W2122511155","https://openalex.org/W2134159453","https://openalex.org/W2137376407","https://openalex.org/W2138430984","https://openalex.org/W2159741685","https://openalex.org/W2163792021","https://openalex.org/W2282454718","https://openalex.org/W4210304960","https://openalex.org/W4250928742","https://openalex.org/W4256094532"],"related_works":["https://openalex.org/W7057915598","https://openalex.org/W2150634509","https://openalex.org/W2134159453","https://openalex.org/W163283303","https://openalex.org/W2020920454","https://openalex.org/W2137365157","https://openalex.org/W2180600487","https://openalex.org/W3088040869","https://openalex.org/W2057937773","https://openalex.org/W4247378087"],"abstract_inverted_index":{"Based":[0],"on":[1,196],"the":[2,24,130,135,152,157,164,181,246],"hypothesis":[3],"that":[4,39,79,96,218,233],"skin":[5,41,76],"barrier":[6,42,242],"impairment":[7,243],"is":[8],"a":[9,18,34,56],"contributor":[10],"to":[11,49,65],"side-effects":[12,155],"associated":[13],"with":[14,30,47,60,134,188,226,257],"retinoic":[15,28,68,80,227,249],"acid":[16,29,69,81,228,250],"therapy,":[17],"double-blind,":[19],"placebo-controlled":[20],"pilot":[21],"study":[22,54],"examined":[23],"combined":[25],"use":[26,101,125,141,150,162,184,237],"of":[27,37,67,75,88,111,116,126,142,154,156,167,205,214,238,248],"myristyl":[31],"nicotinate":[32],"(MN),":[33],"lipophilic":[35],"derivative":[36],"niacin":[38],"enhances":[40],"function,":[43],"in":[44,84,107,132,207],"female":[45],"subjects":[46],"mild":[48],"moderate":[50],"facial":[51,253],"photodamage.":[52],"The":[53],"involved":[55],"1-month":[57],"run-in":[58],"period":[59],"placebo":[61],"or":[62,222],"MN":[63,100,127,143,149,183,219,239],"prior":[64,140,161,234],"initiation":[66],"therapy":[70,82,158,251],"for":[71,252],"3":[72],"months.":[73],"Analysis":[74,204],"biopsies":[77],"revealed":[78],"resulted":[83,106],"stratum":[85],"corneum":[86],"thinning":[87],"approximately":[89,117],"25%":[90],"(P":[91,102,119,144,175,199],"=":[92,120,145,200],"0.006":[93],"versus":[94,122,147,178,202],"baseline)":[95,123,179],"was":[97],"ameliorated":[98],"by":[99,139],"<":[103,176],"0.005).":[104],"Therapy":[105],"an":[108],"increased":[109],"rate":[110],"transepidermal":[112],"water":[113],"loss":[114],"(TEWL)":[115],"45%":[118],"0.001":[121],"and":[124,159,193,212,235,244],"protected":[128],"against":[129],"increase":[131],"TEWL":[133],"strongest":[136],"protection":[137],"provided":[138,163],"0.056":[146],"placebo).":[148,203],"reduced":[151],"incidence":[153],"again":[160],"greatest":[165],"reduction":[166],"side-effects.":[168],"Subjects":[169],"showed":[170],"statistically":[171],"significant":[172],"clinical":[173,190],"improvement":[174,191],"0.05":[177],"during":[180],"study.":[182],"did":[185,223],"not":[186,224],"interfere":[187,225],"any":[189],"parameters":[192],"improved":[194,221],"effects":[195],"temple":[197],"laxity":[198],"0.01":[201],"changes":[206],"epidermal":[208],"thickness,":[209],"Ki67-positive":[210],"cells":[211],"intensity":[213],"loricrin":[215],"staining":[216],"demonstrated":[217],"either":[220],"efficacy.":[229,258],"These":[230],"results":[231],"show":[232],"concurrent":[236],"can":[240],"mitigate":[241],"improve":[245],"tolerability":[247],"photodamage":[254],"without":[255],"interfering":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}