{"id":"https://openalex.org/W2020154489","doi":"https://doi.org/10.1177/019262330002800406","title":"Live Tumor-Promoting Effect of \u03b2-Naphthoflavone, a Strong CYP 1A1/2 Inducer, and the Relationship between CYP 1A1/2 Induction and Cx32 Decrease in Its Hepatocarcinogenesis in the Rat","display_name":"Live Tumor-Promoting Effect of \u03b2-Naphthoflavone, a Strong CYP 1A1/2 Inducer, and the Relationship between CYP 1A1/2 Induction and Cx32 Decrease in Its Hepatocarcinogenesis in the Rat","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W2020154489","doi":"https://doi.org/10.1177/019262330002800406","mag":"2020154489","pmid":"https://pubmed.ncbi.nlm.nih.gov/10930040"},"language":"en","primary_location":{"id":"doi:10.1177/019262330002800406","doi":"https://doi.org/10.1177/019262330002800406","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262330002800406","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262330002800406","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262330002800406","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082211958","display_name":"Toshiyuki Shoda","orcid":"https://orcid.org/0000-0003-3864-0356","observed_orcids":["https://orcid.org/0000-0003-3864-0356"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Shoda","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041880211","display_name":"Kunitoshi Mitsumori","orcid":"https://orcid.org/0000-0002-0754-572X","observed_orcids":["https://orcid.org/0000-0002-0754-572X"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kunitoshi Mitsumori","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113595150","display_name":"Hiroshi Onodera","orcid":"https://orcid.org/0009-0000-7385-913X","observed_orcids":["https://orcid.org/0009-0000-7385-913X"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Onodera","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064056142","display_name":"Kazuhiro Toyoda","orcid":"https://orcid.org/0000-0002-8025-4531","observed_orcids":["https://orcid.org/0000-0002-8025-4531"]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Toyoda","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019798222","display_name":"Chikako Uneyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Chikako Uneyama","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111701162","display_name":"Koichi Takada","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Takada","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102399027","display_name":"Masao Hirose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151964","display_name":"National Institute of Health Sciences","ror":"https://ror.org/04s629c33","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210151964"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Hirose","raw_affiliation_strings":["Division of Pathology, National Institute of Health Sciences, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pathology, National Institute of Health Sciences, Tokyo, Japan","institution_ids":["https://openalex.org/I4210151964"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210151964"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.5335,"has_fulltext":true,"cited_by_count":57,"citation_normalized_percentile":{"value":0.61069225,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"28","issue":"4","first_page":"540","last_page":"547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.6610999703407288,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.16380000114440918,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.03830000013113022,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta-naphthoflavone","display_name":"beta-naphthoflavone","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hepatocarcinogenesis","display_name":"hepatocarcinogenesis","score":0.8230000138282776},{"id":"https://openalex.org/keywords/liver-tumor-promotion","display_name":"liver tumor promotion","score":0.765999972820282},{"id":"https://openalex.org/keywords/connexin-32","display_name":"connexin 32","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.8159999847412109},{"id":"https://openalex.org/keywords/diethylnitrosamine","display_name":"diethylnitrosamine","score":0.925000011920929},{"id":"https://openalex.org/keywords/hepatocellular-hypertrophy","display_name":"hepatocyte hypertrophy","score":0.6800000071525574},{"id":"https://openalex.org/keywords/placental-glutathione-s-transferase","display_name":"glutathione S-transferase placental","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cyp2b1-2","display_name":"CYP2B1/2","score":0.7149999737739563},{"id":"https://openalex.org/keywords/two-stage-carcinogenesis","display_name":"two-stage carcinogenesis","score":0.5609999895095825},{"id":"https://openalex.org/keywords/partial-hepatectomy","display_name":"partial hepatectomy","score":0.6869999766349792}],"concepts":[{"id":"https://openalex.org/C2778793413","wikidata":"https://www.wikidata.org/wiki/Q407241","display_name":"Phenobarbital","level":2,"score":0.7643347978591919},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.6232107281684875},{"id":"https://openalex.org/C2780122803","wikidata":"https://www.wikidata.org/wiki/Q7852681","display_name":"Tumor promotion","level":4,"score":0.6166225075721741},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5938360691070557},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5906194448471069},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.575545608997345},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5677748918533325},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4821869432926178},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.47545644640922546},{"id":"https://openalex.org/C2779838395","wikidata":"https://www.wikidata.org/wiki/Q4382200","display_name":"2-Acetylaminofluorene","level":4,"score":0.4644031524658203},{"id":"https://openalex.org/C2225953","wikidata":"https://www.wikidata.org/wiki/Q1661899","display_name":"Inducer","level":3,"score":0.4532809853553772},{"id":"https://openalex.org/C132154277","wikidata":"https://www.wikidata.org/wiki/Q5381545","display_name":"Enzyme inducer","level":3,"score":0.4328955113887787},{"id":"https://openalex.org/C140027455","wikidata":"https://www.wikidata.org/wiki/Q14864434","display_name":"CYP2E1","level":4,"score":0.42471396923065186},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.42306065559387207},{"id":"https://openalex.org/C2776964913","wikidata":"https://www.wikidata.org/wiki/Q1671502","display_name":"Liver tumor","level":3,"score":0.41041794419288635},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38069644570350647},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3378884792327881},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.28200075030326843},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.2061200737953186},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.17027804255485535},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16527551412582397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13973993062973022},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.13723129034042358},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10920444130897522},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000097002","descriptor_name":"Gap Junction beta-1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001835","descriptor_name":"Body Weight","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004032","descriptor_name":"Diet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005982","descriptor_name":"Glutathione Transferase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D008114","descriptor_name":"Liver Neoplasms, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009929","descriptor_name":"Organ Size","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017629","descriptor_name":"Gap Junctions","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017630","descriptor_name":"Connexins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019324","descriptor_name":"beta-Naphthoflavone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D019363","descriptor_name":"Cytochrome P-450 CYP1A1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/019262330002800406","doi":"https://doi.org/10.1177/019262330002800406","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262330002800406","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262330002800406","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},{"id":"pmid:10930040","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10930040","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic pathology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1177/019262330002800406","doi":"https://doi.org/10.1177/019262330002800406","is_oa":true,"landing_page_url":"https://doi.org/10.1177/019262330002800406","pdf_url":"https://journals.sagepub.com/doi/pdf/10.1177/019262330002800406","source":{"id":"https://openalex.org/S145558524","display_name":"Toxicologic Pathology","issn_l":"0192-6233","issn":["0192-6233","1533-1601"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicologic Pathology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320328549","display_name":"Terveyden ja hyvinvoinnin laitos","ror":"https://ror.org/03tf0c761"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020154489.pdf","grobid_xml":"https://content.openalex.org/works/W2020154489.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1582815775","https://openalex.org/W1602997016","https://openalex.org/W1706505140","https://openalex.org/W1803921312","https://openalex.org/W1884356536","https://openalex.org/W1965830185","https://openalex.org/W1979171525","https://openalex.org/W1983185789","https://openalex.org/W2048573905","https://openalex.org/W2048963964","https://openalex.org/W2054663612","https://openalex.org/W2060403220","https://openalex.org/W2073704727","https://openalex.org/W2084959410","https://openalex.org/W2085247041","https://openalex.org/W2100837269","https://openalex.org/W2108802321","https://openalex.org/W2242310113","https://openalex.org/W2292254628","https://openalex.org/W2341437467","https://openalex.org/W2418323835","https://openalex.org/W2465147979"],"related_works":["https://openalex.org/W2075859096","https://openalex.org/W1985317486","https://openalex.org/W2031852392","https://openalex.org/W2043467526","https://openalex.org/W2011227502","https://openalex.org/W2020886253","https://openalex.org/W2061969972","https://openalex.org/W2154497672","https://openalex.org/W2325572102","https://openalex.org/W2355038666"],"abstract_inverted_index":{"Interrelationships":[0],"among":[1],"induction":[2,135,237],"of":[3,34,47,50,124,136,163,172,174,193],"cytochrome":[4,137],"P-450":[5],"(CYP)":[6],"1A1/2,":[7],"decrease":[8],"in":[9,20,26,104,130,143,148,168,186,203,241],"connexin":[10],"32":[11],"(Cx32),":[12],"and":[13,90,97,140,152,191,226,238],"liver":[14,29,99,214],"tumor-promoting":[15],"activity":[16],"by":[17,122],"beta-naphthoflavone":[18],"(BNF)":[19],"the":[21,56,105,111,131,149,169,175,204],"promotion":[22],"stage":[23],"were":[24,40,54,65,80,91,101,146,178,184,201],"examined":[25],"a":[27,43,67,83,213],"2-stage":[28],"carcinogenesis":[30],"model.":[31],"A":[32],"total":[33],"20":[35],"male":[36],"Fischer":[37],"344":[38],"rats":[39,177],"initiated":[41],"with":[42,117],"single":[44],"intraperitoneal":[45],"injection":[46],"150":[48],"mg/kg":[49],"diethylnitrosamine":[51],"(DEN)":[52],"or":[53,72],"given":[55],"saline":[57],"vehicle":[58],"alone.":[59],"Starting":[60],"2":[61],"weeks":[62],"later,":[63],"they":[64],"fed":[66],"diet":[68],"containing":[69],"2%,":[70],"1%,":[71],"0%":[73],"BNF":[74,211,242],"for":[75,156,196],"6":[76],"weeks.":[77],"All":[78],"animals":[79],"subjected":[81],"to":[82,110,229],"two-thirds":[84],"partial":[85],"hepatectomy":[86],"at":[87,93],"week":[88,94],"3":[89],"sacrificed":[92],"8.":[95],"Absolute":[96],"relative":[98],"weights":[100],"significantly":[102,179],"increased":[103,202],"DEN+BNF":[106,150],"groups":[107],"as":[108],"compared":[109],"DEN-alone":[112],"group.":[113],"Diffuse":[114],"hepatocellular":[115],"hypertrophy":[116],"cytoplasmic":[118],"eosinophilia,":[119],"sometimes":[120],"accompanied":[121],"development":[123],"adenoma-like":[125],"hepatic":[126],"foci,":[127],"was":[128,158],"observed":[129,159,185],"BNF-treated":[132,176,205],"rats.":[133],"Remarkable":[134],"CYP":[138,144,223,235],"1A1/2":[139,236],"significant":[141],"increase":[142],"2E1":[145],"noted":[147],"groups,":[151],"positive":[153,195],"immunohistochemical":[154],"staining":[155],"both":[157],"diffusely.":[160],"The":[161,189],"areas":[162,171,192],"Cx32-positive":[164],"spots":[165],"per":[166],"hepatocyte":[167],"centrilobular":[170],"livers":[173],"decreased,":[180],"but":[181],"no":[182,231],"changes":[183],"periportal":[187],"areas.":[188],"numbers":[190],"foci":[194],"glutathione":[197],"S-transferase":[198],"placental":[199],"form":[200],"groups.":[206],"These":[207],"results":[208],"suggest":[209],"that":[210],"is":[212],"tumor":[215],"promoter":[216],"that,":[217],"unlike":[218],"phenobarbital,":[219],"does":[220],"not":[221],"induce":[222],"2B1/2":[224],"isozymes,":[225],"there":[227],"seems":[228],"be":[230],"direct":[232],"relationship":[233],"between":[234],"Cx32":[239],"reduction":[240],"hepatocarcinogenesis.":[243]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}