{"id":"https://openalex.org/W2020134005","doi":"https://doi.org/10.1021/bi00068a025","title":"Antibodies against highly conserved sites in the epidermal growth factor receptor tyrosine kinase domain as probes for structure and function","display_name":"Antibodies against highly conserved sites in the epidermal growth factor receptor tyrosine kinase domain as probes for structure and function","publication_year":1993,"publication_date":"1993-05-04","ids":{"openalex":"https://openalex.org/W2020134005","doi":"https://doi.org/10.1021/bi00068a025","mag":"2020134005","pmid":"https://pubmed.ncbi.nlm.nih.gov/7683493"},"language":"en","primary_location":{"id":"doi:10.1021/bi00068a025","doi":"https://doi.org/10.1021/bi00068a025","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00068a025","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Nancy A. Brown","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy A. Brown","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201-3098"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Oregon Health Sciences University, Portland 97201-3098","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Larry A. Compton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry A. Compton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110060543","display_name":"Gail M. Clinton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gail M. Clinton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.3115,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.62034558,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"32","issue":"17","first_page":"4659","last_page":"4664"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9833999872207642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.011699999682605267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epidermal-growth-factor-receptor","display_name":"epidermal growth factor receptor","score":1.0},{"id":"https://openalex.org/keywords/tyrosine-kinase-domain","display_name":"tyrosine kinase domain","score":0.8379999995231628},{"id":"https://openalex.org/keywords/anti-peptide-antibodies","display_name":"anti-peptide antibodies","score":0.9369999766349792},{"id":"https://openalex.org/keywords/conserved-motifs","display_name":"conserved motifs","score":0.6100000143051147},{"id":"https://openalex.org/keywords/dfg-motif","display_name":"DFG motif","score":0.9850000143051147},{"id":"https://openalex.org/keywords/autophosphorylation-sites","display_name":"autophosphorylation sites","score":0.9010000228881836},{"id":"https://openalex.org/keywords/epitope-exposure","display_name":"epitope exposure","score":0.9259999990463257},{"id":"https://openalex.org/keywords/protein-topology","display_name":"protein topology","score":0.597000002861023},{"id":"https://openalex.org/keywords/sodium-dodecyl-sulfate","display_name":"sodium dodecyl sulfate","score":0.8009999990463257},{"id":"https://openalex.org/keywords/temperature-effects","display_name":"temperature effects","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.7507469654083252},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5533403158187866},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4981684684753418},{"id":"https://openalex.org/C36503486","wikidata":"https://www.wikidata.org/wiki/Q11235244","display_name":"Domain (mathematical analysis)","level":2,"score":0.4591812789440155},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.41411495208740234},{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.35147756338119507},{"id":"https://openalex.org/C23123220","wikidata":"https://www.wikidata.org/wiki/Q816826","display_name":"Information retrieval","level":1,"score":0.3233978748321533},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22719711065292358},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22716480493545532},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13320079445838928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11099940538406372},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000939","descriptor_name":"Epitopes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001666","descriptor_name":"Binding Sites, Antibody","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002384","descriptor_name":"Catalysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004815","descriptor_name":"Epidermal Growth Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007163","descriptor_name":"Immunosorbent Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010446","descriptor_name":"Peptide Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi00068a025","doi":"https://doi.org/10.1021/bi00068a025","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi00068a025","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:7683493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7683493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2162160382","display_name":null,"funder_award_id":"CA39641","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6666262904","display_name":"SERUM TYROSYL KINASES IN HUMAN NEOPLASIA","funder_award_id":"5r01ca039641-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W115701967","https://openalex.org/W222506362","https://openalex.org/W1014698510","https://openalex.org/W1140243098","https://openalex.org/W1480410640","https://openalex.org/W1483470782","https://openalex.org/W1509816791","https://openalex.org/W1528611173","https://openalex.org/W1548292004","https://openalex.org/W1555656146","https://openalex.org/W1558300532","https://openalex.org/W1602919567","https://openalex.org/W1656231611","https://openalex.org/W1838164920","https://openalex.org/W1850881834","https://openalex.org/W1994231412","https://openalex.org/W1995337883","https://openalex.org/W1998502804","https://openalex.org/W2010820226","https://openalex.org/W2012635088","https://openalex.org/W2018843265","https://openalex.org/W2020257412","https://openalex.org/W2032359283","https://openalex.org/W2039247251","https://openalex.org/W2057631371","https://openalex.org/W2062706311","https://openalex.org/W2064550368","https://openalex.org/W2067405360","https://openalex.org/W2072731386","https://openalex.org/W2077686814","https://openalex.org/W2082743073","https://openalex.org/W2091455173","https://openalex.org/W2092009736","https://openalex.org/W2095381863","https://openalex.org/W2103174300","https://openalex.org/W2123904777","https://openalex.org/W2291586364","https://openalex.org/W2399866381","https://openalex.org/W2406562748"],"related_works":["https://openalex.org/W307860981","https://openalex.org/W1140243098","https://openalex.org/W2080304781","https://openalex.org/W1996692289","https://openalex.org/W2028127376","https://openalex.org/W1968097479","https://openalex.org/W2282358207","https://openalex.org/W2133051701","https://openalex.org/W1978026453","https://openalex.org/W2114055187"],"abstract_inverted_index":{"We":[0],"generated":[1],"anti-peptide":[2,74],"antibodies":[3,33,75],"against":[4,14],"four":[5],"highly":[6,49],"conserved":[7,50],"sequences":[8,17],"in":[9,21,41,62,91,104,134],"the":[10,22,26,48,72,82,85,94,105,114,125],"kinase":[11,78],"domain":[12,24],"and":[13,39,55,67,132],"two":[15],"nonconserved":[16],"surrounding":[18],"autophosphorylation":[19],"sites":[20,87],"carboxyl-terminal":[23],"of":[25,43,47,81,84,113,124],"epidermal":[27],"growth":[28],"factor":[29],"receptor":[30],"(EGFR).":[31],"These":[32],"were":[34],"used":[35],"to":[36,60,98,101,117,138],"examine":[37],"topology":[38,83],"function":[40],"catalysis":[42,63],"specific":[44],"sequences.":[45],"Two":[46],"sites,":[51],"HRD":[52,66,95,115],"(residues":[53,57],"811-818)":[54],"DFG":[56,69],"827-838),":[58],"appeared":[59,97],"participate":[61],"since":[64],"alpha":[65,68],"but":[70],"not":[71],"other":[73],"inhibited":[76],"EGFR":[77],"activity.":[79],"Examination":[80],"six":[86],"revealed":[88],"that":[89,109],"epitopes":[90],"all":[92],"except":[93],"site":[96,116],"be":[99],"exposed":[100],"antibody":[102,120],"binding":[103],"EGFR.":[106],"The":[107],"conditions":[108],"caused":[110],"increased":[111],"exposure":[112],"interaction":[118],"with":[119],"included":[121],"autophosphorylation,":[122],"addition":[123],"ionic":[126],"detergent":[127],"sodium":[128],"dodecyl":[129],"sulfate":[130],"(SDS),":[131],"elevation":[133],"temperature":[135],"from":[136],"4":[137],"34":[139],"degrees":[140],"C.":[141]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
