{"id":"https://openalex.org/W2020126480","doi":"https://doi.org/10.1038/sj.onc.1205476","title":"Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation","display_name":"Tbx3 impinges on the p53 pathway to suppress apoptosis, facilitate cell transformation and block myogenic differentiation","publication_year":2002,"publication_date":"2002-05-28","ids":{"openalex":"https://openalex.org/W2020126480","doi":"https://doi.org/10.1038/sj.onc.1205476","mag":"2020126480","pmid":"https://pubmed.ncbi.nlm.nih.gov/12032820"},"language":"en","primary_location":{"id":"doi:10.1038/sj.onc.1205476","doi":"https://doi.org/10.1038/sj.onc.1205476","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1205476","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064685158","display_name":"Hanqian L. Carlson","orcid":"https://orcid.org/0009-0009-8446-0509","observed_orcids":["https://orcid.org/0009-0009-8446-0509"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanqian Carlson","raw_affiliation_strings":["Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, OR 97201, USA","Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, OR 97201, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022871464","display_name":"Sara Ota","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara Ota","raw_affiliation_strings":["Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059671296","display_name":"Youngsup Song","orcid":"https://orcid.org/0000-0002-6268-5223","observed_orcids":["https://orcid.org/0000-0002-6268-5223"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youngsup Song","raw_affiliation_strings":["Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100732042","display_name":"Yanwen Chen","orcid":"https://orcid.org/0000-0002-3467-2871","observed_orcids":["https://orcid.org/0000-0002-3467-2871","https://orcid.org/0000-0001-7959-5040"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanwen Chen","raw_affiliation_strings":["Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001559616","display_name":"Peter J. Hurlin","orcid":"https://orcid.org/0000-0002-0455-9827","observed_orcids":["https://orcid.org/0000-0002-0455-9827"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I2800078164","display_name":"Shriners Hospitals for Children - Portland","ror":"https://ror.org/00snwj435","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800078164","https://openalex.org/I4210144267"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter J Hurlin","raw_affiliation_strings":["Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Shriners Hospitals for Children, Oregon Health Sciences University, 3101 Sam Jackson Park Road, Portland, 97201, Oregon, USA","institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001559616"],"corresponding_institution_ids":["https://openalex.org/I165690674","https://openalex.org/I2800078164"],"apc_list":{"value":5990,"currency":"USD","value_usd":5990},"apc_paid":null,"fwci":3.7213,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.93096757,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"21","issue":"24","first_page":"3827","last_page":"3835"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tbx3","display_name":"TBX3","score":1.0},{"id":"https://openalex.org/keywords/p53-signaling-pathway","display_name":"p53 pathway","score":0.8889999985694885},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6610000133514404},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.6919999718666077},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oncogenic-ras","display_name":"oncogenic Ras","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p19arf","display_name":"p19ARF","score":0.9570000171661377},{"id":"https://openalex.org/keywords/ulnar-mammary-syndrome","display_name":"ulnar-mammary syndrome","score":0.871999979019165},{"id":"https://openalex.org/keywords/t-box-transcription-factor","display_name":"T-box transcription factor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/c2c12-myoblasts","display_name":"C2C12 myoblasts","score":0.871999979019165},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.8600000143051147},{"id":"https://openalex.org/keywords/oncogenic-cooperation","display_name":"oncogene cooperation","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9077014923095703},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6634564399719238},{"id":"https://openalex.org/C204241405","wikidata":"https://www.wikidata.org/wiki/Q461499","display_name":"Transformation (genetics)","level":3,"score":0.589229166507721},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4898969531059265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4895826280117035},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4644913971424103},{"id":"https://openalex.org/C2777210771","wikidata":"https://www.wikidata.org/wiki/Q4927124","display_name":"Block (permutation group theory)","level":2,"score":0.4392213523387909},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43508633971214294},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3329737186431885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23951712250709534},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016271","descriptor_name":"Proto-Oncogene Proteins c-myc","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016475","descriptor_name":"3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018631","descriptor_name":"ras Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020825","descriptor_name":"T-Box Domain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/sj.onc.1205476","doi":"https://doi.org/10.1038/sj.onc.1205476","is_oa":false,"landing_page_url":"https://doi.org/10.1038/sj.onc.1205476","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:12032820","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12032820","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1512072225","https://openalex.org/W1529528490","https://openalex.org/W1531836615","https://openalex.org/W1534009876","https://openalex.org/W1548932088","https://openalex.org/W1591091640","https://openalex.org/W1973886069","https://openalex.org/W1976220823","https://openalex.org/W1986820083","https://openalex.org/W1989009382","https://openalex.org/W1989589242","https://openalex.org/W1991595805","https://openalex.org/W1996834340","https://openalex.org/W2016840856","https://openalex.org/W2018078167","https://openalex.org/W2018892038","https://openalex.org/W2038512674","https://openalex.org/W2041820220","https://openalex.org/W2044918998","https://openalex.org/W2046958356","https://openalex.org/W2060823106","https://openalex.org/W2071246492","https://openalex.org/W2079477526","https://openalex.org/W2087404852","https://openalex.org/W2094002913","https://openalex.org/W2105298978","https://openalex.org/W2108559706","https://openalex.org/W2111463552","https://openalex.org/W2122411833","https://openalex.org/W2122679701","https://openalex.org/W2127387556","https://openalex.org/W2142480298","https://openalex.org/W2150608281","https://openalex.org/W2151504171","https://openalex.org/W2164967206","https://openalex.org/W2166063778","https://openalex.org/W7217031427"],"related_works":["https://openalex.org/W2981580264","https://openalex.org/W2621251683","https://openalex.org/W7096793682","https://openalex.org/W2109174791","https://openalex.org/W2041399250","https://openalex.org/W2160651117","https://openalex.org/W2168866981","https://openalex.org/W2026571063","https://openalex.org/W2025766502","https://openalex.org/W6980621591"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
