{"id":"https://openalex.org/W2020124645","doi":"https://doi.org/10.1097/00004647-200202000-00001","title":"Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or Death","display_name":"Molecular Pathways of Protein Synthesis Inhibition during Brain Reperfusion: Implications for Neuronal Survival or Death","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2020124645","doi":"https://doi.org/10.1097/00004647-200202000-00001","mag":"2020124645","pmid":"https://pubmed.ncbi.nlm.nih.gov/11823711"},"language":"en","primary_location":{"id":"doi:10.1097/00004647-200202000-00001","doi":"https://doi.org/10.1097/00004647-200202000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004647-200202000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020708662","display_name":"Donald J. DeGracia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Donald J. DeGracia","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076570506","display_name":"Rita Kumar","orcid":"https://orcid.org/0000-0002-9573-7667","observed_orcids":["https://orcid.org/0000-0002-9573-7667"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rita Kumar","raw_affiliation_strings":["Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044684990","display_name":"Cheri R. Owen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheri R. Owen","raw_affiliation_strings":["Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060254766","display_name":"Gary S. Krause","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary S. Krause","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111723927","display_name":"Blaine C. White","orcid":"https://orcid.org/0000-0002-7477-9956","observed_orcids":["https://orcid.org/0000-0002-7477-9956"]},"institutions":[{"id":"https://openalex.org/I185443292","display_name":"Wayne State University","ror":"https://ror.org/01070mq45","country_code":"US","type":"education","lineage":["https://openalex.org/I185443292"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blaine C. White","raw_affiliation_strings":["Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]},{"raw_affiliation_string":"Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan, U.S.A","institution_ids":["https://openalex.org/I185443292"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5020708662"],"corresponding_institution_ids":["https://openalex.org/I185443292"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":2.0469,"has_fulltext":false,"cited_by_count":238,"citation_normalized_percentile":{"value":0.88169643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"127","last_page":"141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-synthesis-inhibition","display_name":"protein synthesis inhibition","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.8100000023841858},{"id":"https://openalex.org/keywords/eif2alpha-phosphorylation","display_name":"eIF2\u03b1 phosphorylation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/perk","display_name":"PERK","score":0.9369999766349792},{"id":"https://openalex.org/keywords/internal-ribosome-entry-site","display_name":"internal ribosome entry site","score":0.781000018119812},{"id":"https://openalex.org/keywords/unfolded-protein-response","display_name":"unfolded protein response","score":0.7839999794960022},{"id":"https://openalex.org/keywords/chop","display_name":"CHOP","score":0.6309999823570251},{"id":"https://openalex.org/keywords/atf4","display_name":"ATF4","score":0.8410000205039978},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.4180000126361847},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.8730000257492065},{"id":"https://openalex.org/keywords/serca2b","display_name":"SERCA2b","score":0.9309999942779541},{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.6480000019073486},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.8569999933242798},{"id":"https://openalex.org/keywords/translation-initiation","display_name":"translation initiation","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7748515605926514},{"id":"https://openalex.org/C2780900454","wikidata":"https://www.wikidata.org/wiki/Q21102119","display_name":"ATF4","level":4,"score":0.7393588423728943},{"id":"https://openalex.org/C139447449","wikidata":"https://www.wikidata.org/wiki/Q14633900","display_name":"Unfolded protein response","level":3,"score":0.629662275314331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6109565496444702},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5294154286384583},{"id":"https://openalex.org/C93734116","wikidata":"https://www.wikidata.org/wiki/Q1017133","display_name":"eIF2","level":5,"score":0.4868128001689911},{"id":"https://openalex.org/C2778997996","wikidata":"https://www.wikidata.org/wiki/Q18036598","display_name":"ATF6","level":4,"score":0.4794546365737915},{"id":"https://openalex.org/C77430603","wikidata":"https://www.wikidata.org/wiki/Q166992","display_name":"Internal ribosome entry site","level":5,"score":0.46809056401252747},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.42798006534576416},{"id":"https://openalex.org/C62493599","wikidata":"https://www.wikidata.org/wiki/Q424137","display_name":"Initiation factor","level":5,"score":0.4249982535839081},{"id":"https://openalex.org/C97154109","wikidata":"https://www.wikidata.org/wiki/Q906570","display_name":"Eukaryotic initiation factor","level":5,"score":0.4215785562992096},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.3180696368217468},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.30887120962142944},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2538347840309143},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23174411058425903},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015427","descriptor_name":"Reperfusion Injury","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004647-200202000-00001","doi":"https://doi.org/10.1097/00004647-200202000-00001","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004647-200202000-00001","pdf_url":null,"source":{"id":"https://openalex.org/S89339265","display_name":"Journal of Cerebral Blood Flow & Metabolism","issn_l":"0271-678X","issn":["0271-678X","1559-7016"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cerebral Blood Flow & Metabolism","raw_type":"journal-article"},{"id":"pmid:11823711","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11823711","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5433832678","display_name":null,"funder_award_id":"NS33196","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G6214239949","display_name":"SUPPRESSION OF PROTEIN SYNTHESIS IN REPERFUSED BRAIN","funder_award_id":"R01NS033196","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":140,"referenced_works":["https://openalex.org/W131687389","https://openalex.org/W138849845","https://openalex.org/W211016413","https://openalex.org/W260527689","https://openalex.org/W280130700","https://openalex.org/W287525851","https://openalex.org/W645770732","https://openalex.org/W962151231","https://openalex.org/W1488906799","https://openalex.org/W1506590264","https://openalex.org/W1509584111","https://openalex.org/W1518241176","https://openalex.org/W1536352052","https://openalex.org/W1546139069","https://openalex.org/W1547705375","https://openalex.org/W1549081254","https://openalex.org/W1559638105","https://openalex.org/W1561611893","https://openalex.org/W1566676785","https://openalex.org/W1575156763","https://openalex.org/W1580653784","https://openalex.org/W1581245087","https://openalex.org/W1605456662","https://openalex.org/W1749755354","https://openalex.org/W1860702156","https://openalex.org/W1898674034","https://openalex.org/W1905806846","https://openalex.org/W1906283391","https://openalex.org/W1964375719","https://openalex.org/W1965744968","https://openalex.org/W1965751914","https://openalex.org/W1967867017","https://openalex.org/W1969124793","https://openalex.org/W1973342484","https://openalex.org/W1979512764","https://openalex.org/W1981282746","https://openalex.org/W1986257122","https://openalex.org/W1991999080","https://openalex.org/W1997451852","https://openalex.org/W1998960746","https://openalex.org/W1999199122","https://openalex.org/W2001631877","https://openalex.org/W2004476219","https://openalex.org/W2005389122","https://openalex.org/W2006492012","https://openalex.org/W2010581370","https://openalex.org/W2013310858","https://openalex.org/W2015198580","https://openalex.org/W2015288395","https://openalex.org/W2015556894","https://openalex.org/W2016184298","https://openalex.org/W2016708780","https://openalex.org/W2017888504","https://openalex.org/W2021263359","https://openalex.org/W2024413659","https://openalex.org/W2024493787","https://openalex.org/W2024672012","https://openalex.org/W2024944868","https://openalex.org/W2029380379","https://openalex.org/W2033324724","https://openalex.org/W2036793658","https://openalex.org/W2040849685","https://openalex.org/W2041753238","https://openalex.org/W2044068299","https://openalex.org/W2046028670","https://openalex.org/W2049876394","https://openalex.org/W2050030183","https://openalex.org/W2050599965","https://openalex.org/W2055794524","https://openalex.org/W2055836716","https://openalex.org/W2056797637","https://openalex.org/W2057080108","https://openalex.org/W2057311240","https://openalex.org/W2060922355","https://openalex.org/W2065305397","https://openalex.org/W2065442591","https://openalex.org/W2066281989","https://openalex.org/W2069924169","https://openalex.org/W2070280418","https://openalex.org/W2070368192","https://openalex.org/W2073923559","https://openalex.org/W2075018537","https://openalex.org/W2078075518","https://openalex.org/W2080901528","https://openalex.org/W2081294646","https://openalex.org/W2083828722","https://openalex.org/W2087521824","https://openalex.org/W2093158584","https://openalex.org/W2093316965","https://openalex.org/W2093571366","https://openalex.org/W2094094604","https://openalex.org/W2099816146","https://openalex.org/W2100347985","https://openalex.org/W2100472948","https://openalex.org/W2103483160","https://openalex.org/W2106730818","https://openalex.org/W2107601804","https://openalex.org/W2109399660","https://openalex.org/W2111052126","https://openalex.org/W2114079476","https://openalex.org/W2115137627","https://openalex.org/W2117404153","https://openalex.org/W2118581975","https://openalex.org/W2119902047","https://openalex.org/W2120736516","https://openalex.org/W2122399381","https://openalex.org/W2123642481","https://openalex.org/W2127639686","https://openalex.org/W2127848114","https://openalex.org/W2130320075","https://openalex.org/W2131011042","https://openalex.org/W2131459517","https://openalex.org/W2132015518","https://openalex.org/W2133581899","https://openalex.org/W2133771702","https://openalex.org/W2137755719","https://openalex.org/W2140798038","https://openalex.org/W2141571283","https://openalex.org/W2144918294","https://openalex.org/W2155884826","https://openalex.org/W2157497892","https://openalex.org/W2157742504","https://openalex.org/W2159175279","https://openalex.org/W2160153212","https://openalex.org/W2161964660","https://openalex.org/W2163285372","https://openalex.org/W2163309884","https://openalex.org/W2169488737","https://openalex.org/W2170939329","https://openalex.org/W2170949754","https://openalex.org/W2216300320","https://openalex.org/W2223269882","https://openalex.org/W2333784672","https://openalex.org/W2346878152","https://openalex.org/W2407277460","https://openalex.org/W2412253612","https://openalex.org/W2419694822","https://openalex.org/W2488909940","https://openalex.org/W4238261567","https://openalex.org/W4252380315"],"related_works":["https://openalex.org/W7095648153","https://openalex.org/W2185436754","https://openalex.org/W2026736660","https://openalex.org/W1995544663","https://openalex.org/W2185594114","https://openalex.org/W1906283391","https://openalex.org/W2138913375","https://openalex.org/W1973342484","https://openalex.org/W1994044388","https://openalex.org/W7098831600"],"abstract_inverted_index":{"Protein":[0],"synthesis":[1,126,223,253],"inhibition":[2,59,254],"occurs":[3,41,75],"in":[4,16,141,207,224,229,236,270,280],"neurons":[5,225],"immediately":[6,42],"on":[7,43],"reperfusion":[8,44,160],"after":[9],"ischemia":[10,81,158,241],"and":[11,22,45,58,82,94,106,116,159,198,209,242,263,272,282],"involves":[12],"at":[13],"least":[14],"alterations":[15,206],"eukaryotic":[17],"initiation":[18,178,193],"factors":[19],"2":[20],"(eIF2)":[21],"4":[23],"(eIF4).":[24],"Phosphorylation":[25],"of":[26,30,54,60,79,101,111,127,136,167,179,234,285],"the":[27,34,61,86,125,129,153,249,256,264,286],"alpha":[28],"subunit":[29],"eIF2":[31,208],"[eIF2(alphaP)]":[32],"by":[33,123,220,240],"endoplasmic":[35,55,62,70],"reticulum":[36,56,63,71],"transmembrane":[37],"eIF2alpha":[38],"kinase":[39],"PERK":[40,49],"inhibits":[46],"translation":[47,177,192],"initiation.":[48],"activation,":[50],"along":[51],"with":[52],"depletion":[53],"Ca2+":[57,64],"-ATPase,":[65],"SERCA2b,":[66],"indicate":[67],"that":[68,259,266,275],"an":[69],"unfolded":[72,88],"protein":[73,89,222,232,252],"response":[74,90],"as":[76],"a":[77],"consequence":[78],"brain":[80,227],"reperfusion.":[83,243],"In":[84],"mammals,":[85],"upstream":[87,138,146],"components":[91],"PERK,":[92],"IRE1,":[93],"ATF6":[95],"activate":[96],"prosurvivial":[97],"mechanisms":[98,108],"(e.g.,":[99],"transcription":[100,131,238],"GRP78,":[102],"PDI,":[103],"SERCA2b":[104],")":[105],"proapoptotic":[107,122,273],"(i.e.,":[109,194],"activation":[110],"Jun":[112],"N-terminal":[113],"kinases,":[114],"caspase-12,":[115],"CHOP":[117,130],"transcription).":[118],"Sustained":[119],"eIF2(alphaP)":[120],"is":[121],"inducing":[124],"ATF4,":[128],"factor,":[132],"through":[133],"\"bypass":[134],"scanning\"":[135],"5'":[137],"open-reading":[139,147],"frames":[140,148],"ATF4":[142,154],"messenger":[143,180,216],"RNA;":[144],"these":[145,267],"normally":[149],"inhibit":[150],"access":[151],"to":[152,173,255],"coding":[155],"sequence.":[156],"Brain":[157],"also":[161,202],"induce":[162],"mu-calpain-mediated":[163],"or":[164],"caspase-3-mediated":[165],"proteolysis":[166],"eIF4G,":[168],"which":[169,215],"shifts":[170,248],"message":[171],"selection":[172],"m":[174],"7":[175],"G-cap-independent":[176],"RNAs":[181,217],"containing":[182],"internal":[183,188],"ribosome":[184,189],"entry":[185,190],"sites.":[186],"This":[187],"site-mediated":[191],"for":[195,214],"apoptosis-activating":[196],"factor-1":[197],"death-associated":[199],"protein-5)":[200],"can":[201],"promote":[203],"apoptosis.":[204],"Thus,":[205],"eIF4":[210],"have":[211],"major":[212],"implications":[213],"are":[218],"translated":[219],"residual":[221],"during":[226],"reperfusion,":[228],"turn":[230],"constraining":[231],"expression":[233],"changes":[235],"gene":[237],"induced":[239],"Therefore,":[244],"our":[245],"current":[246],"understanding":[247],"focus":[250],"from":[251],"molecular":[257],"pathways":[258,268],"underlie":[260],"this":[261],"inhibition,":[262],"role":[265],"play":[269],"prosurvival":[271],"processes":[274],"may":[276],"be":[277],"differentially":[278],"expressed":[279],"vulnerable":[281],"resistant":[283],"regions":[284],"reperfused":[287],"brain.":[288]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":12}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}