{"id":"https://openalex.org/W2020117883","doi":"https://doi.org/10.1371/journal.pone.0012525","title":"Using Evolutionary Conserved Modules in Gene Networks as a Strategy to Leverage High Throughput Gene Expression Queries","display_name":"Using Evolutionary Conserved Modules in Gene Networks as a Strategy to Leverage High Throughput Gene Expression Queries","publication_year":2010,"publication_date":"2010-09-02","ids":{"openalex":"https://openalex.org/W2020117883","doi":"https://doi.org/10.1371/journal.pone.0012525","mag":"2020117883","pmid":"https://pubmed.ncbi.nlm.nih.gov/20824082","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932711"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0012525","doi":"https://doi.org/10.1371/journal.pone.0012525","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0012525","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012525&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012525&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070102704","display_name":"Jeanne M. Serb","orcid":"https://orcid.org/0000-0003-2112-470X","observed_orcids":["https://orcid.org/0000-0003-2112-470X"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeanne M. Serb","raw_affiliation_strings":["Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America. serb@iastate.edu","Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America. serb@iastate.edu","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Department of Ecology, Evolution and Organismal Biology, Iowa State University, Ames, Iowa, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075039061","display_name":"Megan Orr","orcid":"https://orcid.org/0000-0002-0375-3150","observed_orcids":["https://orcid.org/0000-0002-0375-3150"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan C. Orr","raw_affiliation_strings":["Department of Statistics, Iowa State University, Ames, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Iowa State University, Ames, Iowa, United States of America","institution_ids":["https://openalex.org/I173911158"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067636066","display_name":"M. Heather West Greenlee","orcid":"https://orcid.org/0000-0002-6622-0044","observed_orcids":["https://orcid.org/0000-0002-6622-0044"]},"institutions":[{"id":"https://openalex.org/I173911158","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78","country_code":"US","type":"education","lineage":["https://openalex.org/I173911158"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Heather West Greenlee","raw_affiliation_strings":["Bioinformatics and Computational Biology Program, Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America","Bioinformatics and Computational Biology Program, Iowa State University, Ames, Iowa, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics and Computational Biology Program, Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America","institution_ids":["https://openalex.org/I173911158"]},{"raw_affiliation_string":"Bioinformatics and Computational Biology Program, Iowa State University, Ames, Iowa, United States of America","institution_ids":["https://openalex.org/I173911158"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070102704"],"corresponding_institution_ids":["https://openalex.org/I173911158"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.2603,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.5458831,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"5","issue":"9","first_page":"e12525","last_page":"e12525"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-co-expression-network","display_name":"gene co-expression network","score":0.7699999809265137},{"id":"https://openalex.org/keywords/seed-networks","display_name":"seed networks","score":0.6710000038146973},{"id":"https://openalex.org/keywords/retinal-development","display_name":"retinal development","score":0.7979999780654907},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mouse-retina","display_name":"mouse retina","score":0.9649999737739563},{"id":"https://openalex.org/keywords/candidate-gene-identification","display_name":"candidate gene identification","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6958192586898804},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6010379791259766},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5718971490859985},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.5285051465034485},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5060407519340515},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.47921448945999146},{"id":"https://openalex.org/C184898388","wikidata":"https://www.wikidata.org/wiki/Q1435712","display_name":"Pairwise comparison","level":2,"score":0.4677821397781372},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4673509895801544},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.46393850445747375},{"id":"https://openalex.org/C168601633","wikidata":"https://www.wikidata.org/wiki/Q1044484","display_name":"Evolutionary developmental biology","level":2,"score":0.4302041530609131},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.420492947101593},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2716800570487976},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16299855709075928},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D012160","descriptor_name":"Retina","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0012525","doi":"https://doi.org/10.1371/journal.pone.0012525","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0012525","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012525&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2932711","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2932711","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:20824082","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20824082","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.352.1319","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.352.1319","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/eb/09/PLoS_One_2010_Sep_2_5(9)_e12525.tar.gz","raw_type":"text"},{"id":"pmh:oai:lib.dr.iastate.edu:eeob_ag_pubs-1015","doi":null,"is_oa":true,"landing_page_url":"https://lib.dr.iastate.edu/eeob_ag_pubs/19","pdf_url":null,"source":{"id":"https://openalex.org/S4377196104","display_name":"Iowa State University Digital Repository (Iowa State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I173911158","host_organization_name":"Iowa State University","host_organization_lineage":["https://openalex.org/I173911158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Ecology, Evolution and Organismal Biology Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:1b46a164a06e4333805e41290bfe2ffa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1b46a164a06e4333805e41290bfe2ffa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 5, Iss 9, p e12489 (2010)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/141829","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Using_Evolutionary_Conserved_Modules_in_Gene_Networks_as_a_Strategy_to_Leverage_High_Throughput_Gene_Expression_Queries/141829","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0012525","doi":"https://doi.org/10.1371/journal.pone.0012525","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0012525","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0012525&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/15","score":0.5799999833106995,"display_name":"Life on land"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311090","display_name":"Iowa State University","ror":"https://ror.org/04rswrd78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020117883.pdf","grobid_xml":"https://content.openalex.org/works/W2020117883.grobid-xml"},"referenced_works_count":109,"referenced_works":["https://openalex.org/W96623433","https://openalex.org/W1526567215","https://openalex.org/W1533487943","https://openalex.org/W1593050821","https://openalex.org/W1629994411","https://openalex.org/W1892101717","https://openalex.org/W1895998181","https://openalex.org/W1964738735","https://openalex.org/W1964761197","https://openalex.org/W1964933282","https://openalex.org/W1965625220","https://openalex.org/W1966407054","https://openalex.org/W1968465765","https://openalex.org/W1975744936","https://openalex.org/W1975953708","https://openalex.org/W1986234964","https://openalex.org/W1989040952","https://openalex.org/W1991040778","https://openalex.org/W1991631964","https://openalex.org/W1993336567","https://openalex.org/W1993376362","https://openalex.org/W1995251397","https://openalex.org/W1999591105","https://openalex.org/W1999977743","https://openalex.org/W2000010566","https://openalex.org/W2003655724","https://openalex.org/W2005481218","https://openalex.org/W2005791254","https://openalex.org/W2006101746","https://openalex.org/W2006937113","https://openalex.org/W2010040573","https://openalex.org/W2010677325","https://openalex.org/W2015183837","https://openalex.org/W2017071579","https://openalex.org/W2017587511","https://openalex.org/W2017701976","https://openalex.org/W2020385880","https://openalex.org/W2021507234","https://openalex.org/W2022690437","https://openalex.org/W2023958768","https://openalex.org/W2024935827","https://openalex.org/W2029833898","https://openalex.org/W2032251919","https://openalex.org/W2033585891","https://openalex.org/W2034784092","https://openalex.org/W2041598409","https://openalex.org/W2044331499","https://openalex.org/W2047464769","https://openalex.org/W2048190533","https://openalex.org/W2048621255","https://openalex.org/W2049265939","https://openalex.org/W2049291129","https://openalex.org/W2050544865","https://openalex.org/W2055743310","https://openalex.org/W2055898948","https://openalex.org/W2057463566","https://openalex.org/W2058712930","https://openalex.org/W2059752409","https://openalex.org/W2059800023","https://openalex.org/W2061342956","https://openalex.org/W2061361160","https://openalex.org/W2065618227","https://openalex.org/W2067550312","https://openalex.org/W2073264990","https://openalex.org/W2075118649","https://openalex.org/W2076899317","https://openalex.org/W2082250938","https://openalex.org/W2083481917","https://openalex.org/W2083752219","https://openalex.org/W2083891455","https://openalex.org/W2085060763","https://openalex.org/W2088612980","https://openalex.org/W2090687544","https://openalex.org/W2093664175","https://openalex.org/W2099805939","https://openalex.org/W2100155631","https://openalex.org/W2101351842","https://openalex.org/W2101728847","https://openalex.org/W2105647452","https://openalex.org/W2108236763","https://openalex.org/W2108331169","https://openalex.org/W2109210857","https://openalex.org/W2112440119","https://openalex.org/W2113436414","https://openalex.org/W2114892387","https://openalex.org/W2117439162","https://openalex.org/W2126104879","https://openalex.org/W2126414770","https://openalex.org/W2131674676","https://openalex.org/W2136514583","https://openalex.org/W2136629665","https://openalex.org/W2137084536","https://openalex.org/W2140526178","https://openalex.org/W2148342705","https://openalex.org/W2152482800","https://openalex.org/W2160873969","https://openalex.org/W2162331017","https://openalex.org/W2163517157","https://openalex.org/W2166908229","https://openalex.org/W2167692375","https://openalex.org/W2183259168","https://openalex.org/W2497297917","https://openalex.org/W2611370172","https://openalex.org/W4230511665","https://openalex.org/W4254853952","https://openalex.org/W4298870207","https://openalex.org/W6658033436","https://openalex.org/W6813168356","https://openalex.org/W6843219885"],"related_works":["https://openalex.org/W1629994411","https://openalex.org/W7100728967","https://openalex.org/W2162142896","https://openalex.org/W2496735270","https://openalex.org/W2123545746","https://openalex.org/W2161622353","https://openalex.org/W7095333667","https://openalex.org/W1969167134","https://openalex.org/W1964305071","https://openalex.org/W756956249"],"abstract_inverted_index":{"BACKGROUND:":[0],"Large-scale":[1],"gene":[2,53,82,130,273],"expression":[3,58,226],"studies":[4,94],"have":[5,21],"not":[6,24,271],"yielded":[7],"the":[8,36,78,86,100,137,197,207,228,266,280],"expected":[9],"insight":[10],"into":[11],"genetic":[12],"networks":[13],"that":[14,47,88,126,154,243],"control":[15],"complex":[16],"processes.":[17],"These":[18],"anticipated":[19],"discoveries":[20],"been":[22,193,203],"limited":[23],"by":[25,28,219],"technology,":[26],"but":[27],"a":[29,39,49,89,127,171,239],"lack":[30],"of":[31,52,81,95,129,158,189,211,258,268,282],"effective":[32,62,107,164,235],"strategies":[33],"to":[34,55,64,109,173,196,206,264,286],"investigate":[35],"data":[37],"in":[38,99,117,136,227],"manageable":[40],"and":[41,71,169,200,223,254,277],"meaningful":[42],"way.":[43],"Previous":[44],"work":[45],"suggests":[46],"using":[48],"pre-determined":[50],"seed-network":[51,157,185],"relationships":[54,131],"query":[56,177],"large-scale":[57],"datasets":[59,168],"is":[60,162],"an":[61,106,163,234,245],"way":[63,108],"generate":[65,174],"candidate":[66,112,213],"genes":[67,113,145,161,180,214],"for":[68,114,166,237],"further":[69,216],"study":[70],"network":[72,91,269],"expansion":[73],"or":[74],"enrichment.":[75],"Based":[76],"on":[77],"evolutionary":[79,246],"conservation":[80],"relationships,":[83],"we":[84,152],"test":[85],"hypothesis":[87],"seed":[90],"derived":[92],"from":[93,146],"retinal":[96,119,133],"cell":[97,134],"determination":[98],"fly,":[101],"Drosophila":[102],"melanogaster,":[103],"will":[104,261,278],"be":[105,262],"identify":[110],"novel":[111],"their":[115],"role":[116],"mouse":[118,148,160],"development.":[120],"METHODOLOGY/PRINCIPAL":[121],"FINDINGS:":[122],"Our":[123,176],"results":[124],"demonstrate":[125,153],"number":[128],"regulating":[132],"differentiation":[135],"fly":[138,253],"are":[139],"identifiable":[140],"as":[141],"pairwise":[142],"correlations":[143],"between":[144,249,275],"developing":[147,198,208,229],"retina.":[149,209,230],"In":[150],"addition,":[151],"our":[155,183],"extracted":[156,184],"correlated":[159,181],"tool":[165],"querying":[167],"provides":[170],"context":[172],"hypotheses.":[175,290],"identified":[178],"46":[179],"with":[182],"members.":[186],"Approximately":[187],"54%":[188],"these":[190],"candidates":[191],"had":[192,202],"previously":[194,204],"linked":[195,205],"brain":[199],"33%":[201],"Five":[210],"six":[212],"investigated":[215],"were":[217],"validated":[218],"experiments":[220],"examining":[221],"spatial":[222],"temporal":[224],"protein":[225],"CONCLUSIONS/SIGNIFICANCE:":[231],"We":[232],"present":[233],"strategy":[236,260],"pursuing":[238],"systems":[240],"biology":[241],"approach":[242],"utilizes":[244],"comparative":[247],"framework":[248],"two":[250],"model":[251],"organisms,":[252],"mouse.":[255],"Future":[256],"implementation":[257],"this":[259],"useful":[263],"determine":[265],"extent":[267],"conservation,":[270,274],"just":[272],"species":[276],"facilitate":[279],"use":[281],"prior":[283],"biological":[284],"knowledge":[285],"develop":[287],"rational":[288],"systems-based":[289]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
