{"id":"https://openalex.org/W2020112301","doi":"https://doi.org/10.1128/mcb.06374-11","title":"Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4","display_name":"Cardiac Expression of ms1/STARS, a Novel Gene Involved in Cardiac Development and Disease, Is Regulated by GATA4","publication_year":2012,"publication_date":"2012-03-20","ids":{"openalex":"https://openalex.org/W2020112301","doi":"https://doi.org/10.1128/mcb.06374-11","mag":"2020112301","pmid":"https://pubmed.ncbi.nlm.nih.gov/22431517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3347400"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.06374-11","doi":"https://doi.org/10.1128/mcb.06374-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.06374-11","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3347400","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063389736","display_name":"Samir Ounzain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802040150","display_name":"Glenfield Hospital","ror":"https://ror.org/048a96r61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802040150","https://openalex.org/I2802445252"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH","GB"],"is_corresponding":false,"raw_author_name":"Samir Ounzain","raw_affiliation_strings":["Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom","Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802040150"]},{"raw_affiliation_string":"Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoru Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoru Kobayashi","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research, University of South Dakota, Sioux Falls, South Dakota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research, University of South Dakota, Sioux Falls, South Dakota, USA","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056294730","display_name":"Richard E. Peterson","orcid":"https://orcid.org/0009-0001-3750-817X","observed_orcids":["https://orcid.org/0009-0001-3750-817X"]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard E. Peterson","raw_affiliation_strings":["Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066598516","display_name":"Aibin He","orcid":"https://orcid.org/0000-0002-3489-2305","observed_orcids":["https://orcid.org/0000-0002-3489-2305"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aibin He","raw_affiliation_strings":["Department of Cardiology, Children's Hospital Boston, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children's Hospital Boston, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074000588","display_name":"Anna Motterle","orcid":"https://orcid.org/0000-0002-9847-0574","observed_orcids":["https://orcid.org/0000-0002-9847-0574"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4210149920","display_name":"William Harvey Research Institute","ror":"https://ror.org/0574dzy90","country_code":"GB","type":"facility","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4210149920"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anna Motterle","raw_affiliation_strings":["William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4210149920"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614941","display_name":"Nilesh J. Samani","orcid":"https://orcid.org/0000-0002-3286-8133","observed_orcids":["https://orcid.org/0000-0002-3286-8133"]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802040150","display_name":"Glenfield Hospital","ror":"https://ror.org/048a96r61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802040150","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nilesh J. Samani","raw_affiliation_strings":["Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802040150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061323145","display_name":"Donald R. Menick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald R. Menick","raw_affiliation_strings":["Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gazes Cardiac Research Institute, Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA","institution_ids":["https://openalex.org/I153297377"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076662333","display_name":"William T. Pu","orcid":"https://orcid.org/0000-0002-4551-8079","observed_orcids":["https://orcid.org/0000-0002-4551-8079"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William T. Pu","raw_affiliation_strings":["Department of Cardiology, Children's Hospital Boston, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Children's Hospital Boston, and Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, Massachusetts, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065390666","display_name":"Qiangrong Liang","orcid":"https://orcid.org/0000-0002-6123-5685","observed_orcids":["https://orcid.org/0000-0002-6123-5685"]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiangrong Liang","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research, University of South Dakota, Sioux Falls, South Dakota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research, University of South Dakota, Sioux Falls, South Dakota, USA","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103338914","display_name":"Nelson W. Chong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153648349","display_name":"University of Leicester","ror":"https://ror.org/04h699437","country_code":"GB","type":"education","lineage":["https://openalex.org/I153648349"]},{"id":"https://openalex.org/I2802040150","display_name":"Glenfield Hospital","ror":"https://ror.org/048a96r61","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802040150","https://openalex.org/I2802445252"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nelson W. Chong","raw_affiliation_strings":["Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Group, Department of Cardiovascular Sciences, Glenfield Hospital, University of Leicester, Leicester, United Kingdom","institution_ids":["https://openalex.org/I153648349","https://openalex.org/I2802040150"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":11,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1559,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.75720414,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"32","issue":"10","first_page":"1830","last_page":"1843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gata4","display_name":"GATA4","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cardiac-gene-regulation","display_name":"cardiac gene regulation","score":0.8169999718666077},{"id":"https://openalex.org/keywords/cis-regulatory-modules","display_name":"cis-regulatory modules","score":0.878000020980835},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.9869999885559082},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.7419999837875366},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/heart-development","display_name":"heart development","score":0.7770000100135803},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8190330266952515},{"id":"https://openalex.org/C116186050","wikidata":"https://www.wikidata.org/wiki/Q4039110","display_name":"GATA4","level":4,"score":0.6793355941772461},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5734323263168335},{"id":"https://openalex.org/C69053785","wikidata":"https://www.wikidata.org/wiki/Q907394","display_name":"Serum response factor","level":4,"score":0.4701766073703766},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4610511362552643},{"id":"https://openalex.org/C111566952","wikidata":"https://www.wikidata.org/wiki/Q1303462","display_name":"Cardiac function curve","level":3,"score":0.4596762955188751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4264673888683319},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.359852135181427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2955920100212097},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.23603439331054688},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.12784135341644287},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06205648183822632}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006331","descriptor_name":"Heart Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008840","descriptor_name":"Microfilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026362","descriptor_name":"Serum Response Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050991","descriptor_name":"GATA4 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mcb.06374-11","doi":"https://doi.org/10.1128/mcb.06374-11","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.06374-11","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3347400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3347400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:22431517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22431517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unil.ch:iris/62529","doi":null,"is_oa":false,"landing_page_url":"https://iris.unil.ch/handle/iris/62529","pdf_url":null,"source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:lra.le.ac.uk:2381/12505","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2381/12505","pdf_url":null,"source":{"id":"https://openalex.org/S4306402365","display_name":"Leicester Research Archive (University of Leicester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I153648349","host_organization_name":"University of Leicester","host_organization_lineage":["https://openalex.org/I153648349"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":"Journal Article"},{"id":"pmh:oai:serval.unil.ch:BIB_0B25C66D40C3","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_0B25C66D40C3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and Cellular Biology, vol. 32, no. 10, pp. 1830-1843","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3347400","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3347400","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5776461974","display_name":null,"funder_award_id":"HL095712","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6212438074","display_name":"Signaling Pathways Mediating NCX1 Expression","funder_award_id":"R01HL066223","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G886981342","display_name":"Regulation of Heart Function by a Gata4-Fog2 transcriptional complex","funder_award_id":"R01HL095712","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":56,"referenced_works":["https://openalex.org/W190096672","https://openalex.org/W1520697307","https://openalex.org/W1971599917","https://openalex.org/W1978162225","https://openalex.org/W1979854824","https://openalex.org/W1981101983","https://openalex.org/W1984365126","https://openalex.org/W1997271589","https://openalex.org/W1998161518","https://openalex.org/W1999909705","https://openalex.org/W2006055979","https://openalex.org/W2007276697","https://openalex.org/W2007452508","https://openalex.org/W2015082418","https://openalex.org/W2022188551","https://openalex.org/W2029918174","https://openalex.org/W2033541880","https://openalex.org/W2034569019","https://openalex.org/W2036145288","https://openalex.org/W2040125291","https://openalex.org/W2045165615","https://openalex.org/W2051252121","https://openalex.org/W2053897822","https://openalex.org/W2057307695","https://openalex.org/W2061642708","https://openalex.org/W2063816440","https://openalex.org/W2063959543","https://openalex.org/W2075226418","https://openalex.org/W2076201047","https://openalex.org/W2084309586","https://openalex.org/W2084332810","https://openalex.org/W2085927442","https://openalex.org/W2086469250","https://openalex.org/W2088279810","https://openalex.org/W2090160722","https://openalex.org/W2094214128","https://openalex.org/W2096628719","https://openalex.org/W2099140108","https://openalex.org/W2107688352","https://openalex.org/W2124126928","https://openalex.org/W2128892651","https://openalex.org/W2130527936","https://openalex.org/W2132705463","https://openalex.org/W2143837955","https://openalex.org/W2143850042","https://openalex.org/W2150336836","https://openalex.org/W2150540788","https://openalex.org/W2152376785","https://openalex.org/W2154201149","https://openalex.org/W2154487371","https://openalex.org/W2154993940","https://openalex.org/W2162514244","https://openalex.org/W2164742389","https://openalex.org/W2169237598","https://openalex.org/W2335834326","https://openalex.org/W4245106190"],"related_works":["https://openalex.org/W199528325","https://openalex.org/W7009792663","https://openalex.org/W2763950760","https://openalex.org/W2764277154","https://openalex.org/W2972837756","https://openalex.org/W1991703781","https://openalex.org/W2021650900","https://openalex.org/W2138794351","https://openalex.org/W2164742389","https://openalex.org/W7168146899"],"abstract_inverted_index":{"Ms1/STARS":[0],"is":[1,27,52],"a":[2,84],"novel":[3],"muscle-specific":[4],"actin-binding":[5],"protein":[6],"that":[7,112,145],"specifically":[8],"modulates":[9],"the":[10,32,73,79,135,157,185],"myocardin-related":[11],"transcription":[12,138],"factor":[13,16,139],"(MRTF)-serum":[14],"response":[15],"(SRF)":[17],"regulatory":[18,25,35,132],"axis":[19,26],"within":[20,31,146],"striated":[21],"muscle.":[22],"This":[23,172],"ms1/STARS-dependent":[24],"of":[28,50,57,72,124,161,175,187],"central":[29],"importance":[30],"cardiac":[33,42,46,59,62,120,137,188],"gene":[34],"network":[36],"and":[37,44,55,64,93,110,117,128,149,190],"has":[38,178],"been":[39],"implicated":[40],"in":[41,78,87,169,184],"development":[43,189],"postnatal":[45],"function/homeostasis.":[47],"The":[48],"dysregulation":[49],"ms1/STARS":[51,76,154,170,176],"associated":[53,159],"with":[54,90,156],"causative":[56],"pathological":[58],"phenotypes,":[60],"including":[61],"hypertrophy":[63],"cardiomyopathy.":[65],"In":[66],"order":[67],"to":[68,134],"gain":[69],"an":[70],"understanding":[71],"mechanisms":[74],"governing":[75],"expression":[77,155,177],"heart,":[80],"we":[81,100],"have":[82,101],"coupled":[83],"comparative":[85],"genomic":[86],"silico":[88],"analysis":[89],"reporter,":[91],"gain-of-function,":[92],"loss-of-function":[94],"approaches.":[95],"Through":[96],"this":[97],"integrated":[98],"analysis,":[99],"identified":[102],"three":[103],"evolutionarily":[104],"conserved":[105],"regions":[106],"(ECRs),":[107],"\u03b1,":[108],"SINA,":[109],"DINA,":[111,129],"act":[113],"as":[114],"cis-regulatory":[115],"modules":[116],"confer":[118],"differential":[119],"cell-specific":[121],"activity.":[122],"Two":[123],"these":[125],"ECRs,":[126],"\u03b1":[127],"displayed":[130],"distinct":[131],"sensitivity":[133],"core":[136],"GATA4.":[140],"Overall,":[141],"our":[142],"results":[143],"demonstrate":[144],"embryonic,":[147],"neonatal,":[148],"adult":[150],"hearts,":[151],"GATA4":[152,162],"represses":[153],"pathologically":[158],"depletion":[160],"(type":[163],"1/type":[164],"2":[165],"diabetic":[166],"models),":[167],"resulting":[168],"upregulation.":[171],"GATA4-dependent":[173],"repression":[174],"major":[179],"implications":[180],"for":[181],"MRTF-SRF":[182],"signaling":[183],"context":[186],"disease.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}