{"id":"https://openalex.org/W2020108404","doi":"https://doi.org/10.1021/jm980441h","title":"1-Benzopyran-4-one Antioxidants as Aldose Reductase Inhibitors","display_name":"1-Benzopyran-4-one Antioxidants as Aldose Reductase Inhibitors","publication_year":1999,"publication_date":"1999-05-11","ids":{"openalex":"https://openalex.org/W2020108404","doi":"https://doi.org/10.1021/jm980441h","mag":"2020108404","pmid":"https://pubmed.ncbi.nlm.nih.gov/10354396"},"language":"en","primary_location":{"id":"doi:10.1021/jm980441h","doi":"https://doi.org/10.1021/jm980441h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm980441h","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/11380/304830","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046494707","display_name":"Luca Costantino","orcid":"https://orcid.org/0000-0001-5334-8084","observed_orcids":["https://orcid.org/0000-0001-5334-8084"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Luca Costantino","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066566738","display_name":"Giulio Rastelli","orcid":"https://orcid.org/0000-0002-2474-0607","observed_orcids":["https://orcid.org/0000-0002-2474-0607"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Giulio Rastelli","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041335841","display_name":"Maria Cristina Gamberini","orcid":"https://orcid.org/0000-0002-7591-2886","observed_orcids":["https://orcid.org/0000-0002-7591-2886"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Maria Cristina Gamberini","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059298223","display_name":"Joe Allen Vinson","orcid":"https://orcid.org/0000-0002-1850-208X","observed_orcids":["https://orcid.org/0000-0002-1850-208X"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Joe A. Vinson","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013379402","display_name":"Pratima Bose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Pratima Bose","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028640520","display_name":"Anna Iannone","orcid":"https://orcid.org/0000-0002-6151-7818","observed_orcids":["https://orcid.org/0000-0002-6151-7818"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Anna Iannone","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076721202","display_name":"Mariagrazia Staffieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Mariagrazia Staffieri","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113561596","display_name":"Luciano Antolini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Luciano Antolini","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052485604","display_name":"Antonella DEL CORSO","orcid":"https://orcid.org/0000-0003-3165-6128","observed_orcids":["https://orcid.org/0000-0003-3165-6128"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Antonella Del Corso","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075459608","display_name":"Umberto Mura","orcid":"https://orcid.org/0000-0001-8280-6275","observed_orcids":["https://orcid.org/0000-0001-8280-6275"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":false,"raw_author_name":"Umberto Mura","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016612075","display_name":"Albano Albasini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]},{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]},{"id":"https://openalex.org/I124113063","display_name":"University of Scranton","ror":"https://ror.org/05xwb6v37","country_code":"US","type":"education","lineage":["https://openalex.org/I124113063"]}],"countries":["IT","US"],"is_corresponding":true,"raw_author_name":"Albano Albasini","raw_affiliation_strings":["Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Farmaceutiche, Dipartimento di Scienze Biomediche, and Dipartimento di Chimica, Universit\u00e0 di Modena, Via Campi 183, 41100 Modena, Italy, Department of Chemistry, University of Scranton, Scranton, Pennsylvania 18510-4626, and Dipartimento di Fisiologia e Biochimica, Universit\u00e0 di Pisa,Via S. Maria 55, 56100 Pisa, Italy","institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5016612075"],"corresponding_institution_ids":["https://openalex.org/I108290504","https://openalex.org/I122346577","https://openalex.org/I124113063"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.7747,"has_fulltext":false,"cited_by_count":105,"citation_normalized_percentile":{"value":0.65189661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"42","issue":"11","first_page":"1881","last_page":"1893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13023","display_name":"Synthesis of Organic Compounds","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aldose-reductase-inhibitors","display_name":"aldose reductase inhibitors","score":0.9509999752044678},{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sorbinil","display_name":"sorbinil","score":0.9229999780654907},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9929999709129333},{"id":"https://openalex.org/keywords/diabetes-complications","display_name":"diabetes complications","score":0.8289999961853027},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.8949999809265137},{"id":"https://openalex.org/keywords/molecular-modeling","display_name":"molecular modeling","score":0.6399999856948853},{"id":"https://openalex.org/keywords/enzyme-active-site-binding","display_name":"enzyme active site binding","score":0.7739999890327454},{"id":"https://openalex.org/keywords/pka","display_name":"pKa","score":0.7770000100135803}],"concepts":[{"id":"https://openalex.org/C2776614240","wikidata":"https://www.wikidata.org/wiki/Q1259458","display_name":"Sorbinil","level":5,"score":0.9871746301651001},{"id":"https://openalex.org/C2776439734","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldose reductase","level":3,"score":0.981934130191803},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.886725127696991},{"id":"https://openalex.org/C2910800646","wikidata":"https://www.wikidata.org/wiki/Q414213","display_name":"Aldehyde Reductase","level":4,"score":0.7811423540115356},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.6263670325279236},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.618260383605957},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.5579046010971069},{"id":"https://openalex.org/C2777374081","wikidata":"https://www.wikidata.org/wiki/Q4713968","display_name":"Aldose reductase inhibitor","level":4,"score":0.5546629428863525},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5224881768226624},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.5006661415100098},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.46998703479766846},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.3838018774986267}],"mesh":[{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000449","descriptor_name":"Aldehyde Reductase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008077","descriptor_name":"Lipoproteins, LDL","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008079","descriptor_name":"Lipoproteins, VLDL","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/jm980441h","doi":"https://doi.org/10.1021/jm980441h","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm980441h","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:10354396","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10354396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/191375","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/191375","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimore.it:11380/304830","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/304830","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:iris.unimore.it:11380/304830","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/304830","pdf_url":null,"source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W88634328","https://openalex.org/W597121318","https://openalex.org/W1601924230","https://openalex.org/W1964448491","https://openalex.org/W1965039913","https://openalex.org/W1967647876","https://openalex.org/W1976161355","https://openalex.org/W1976545454","https://openalex.org/W1986604347","https://openalex.org/W1996582638","https://openalex.org/W2000190319","https://openalex.org/W2002019037","https://openalex.org/W2004014072","https://openalex.org/W2010978263","https://openalex.org/W2011343734","https://openalex.org/W2011530878","https://openalex.org/W2019293938","https://openalex.org/W2025701628","https://openalex.org/W2036468771","https://openalex.org/W2040658253","https://openalex.org/W2044363961","https://openalex.org/W2048842203","https://openalex.org/W2052875009","https://openalex.org/W2054338762","https://openalex.org/W2057335489","https://openalex.org/W2057522312","https://openalex.org/W2067455153","https://openalex.org/W2072672526","https://openalex.org/W2076116297","https://openalex.org/W2077388901","https://openalex.org/W2081398145","https://openalex.org/W2081852232","https://openalex.org/W2082040139","https://openalex.org/W2091830691","https://openalex.org/W2109927701","https://openalex.org/W2115337518","https://openalex.org/W2116000210","https://openalex.org/W2122199548","https://openalex.org/W2136121467","https://openalex.org/W2149263899","https://openalex.org/W2311078281","https://openalex.org/W2325407356","https://openalex.org/W2492101850","https://openalex.org/W2577013855","https://openalex.org/W2724228702","https://openalex.org/W3088599528"],"related_works":["https://openalex.org/W2965868817","https://openalex.org/W2072541255","https://openalex.org/W2407456491","https://openalex.org/W2594025818","https://openalex.org/W2051622931","https://openalex.org/W1163018918","https://openalex.org/W2950267363","https://openalex.org/W2982523295","https://openalex.org/W2107222529","https://openalex.org/W2007552090"],"abstract_inverted_index":{"Starting":[0],"from":[1],"the":[2,6,27,34,56,82,93,99,118],"inhibitory":[3,38],"activity":[4,39],"of":[5,11,20,29,33,43,84,95,102],"flavonoid":[7],"Quercetin,":[8],"a":[9,77],"series":[10],"4H-1-benzopyran-4-one":[12],"derivatives":[13],"was":[14],"synthesized":[15],"and":[16,51,62,120],"tested":[17],"for":[18],"inhibition":[19],"aldose":[21,103],"reductase,":[22,61],"an":[23],"enzyme":[24,119],"involved":[25],"in":[26,107],"appearance":[28],"diabetic":[30],"complications.":[31],"Some":[32],"compounds":[35,69,86],"obtained":[36],"display":[37],"similar":[40],"to":[41,55,109,117,122],"that":[42],"Sorbinil":[44,52],"but":[45],"are":[46],"more":[47],"selective":[48],"than":[49,74],"Quercetin":[50],"with":[53],"respect":[54],"closely":[57],"related":[58],"enzyme,":[59],"aldehyde":[60],"also":[63,121],"possess":[64,70],"antioxidant":[65],"activity.":[66],"Remarkably,":[67],"these":[68,85,112],"higher":[71],"pKa":[72],"values":[73],"carboxylic":[75],"acids,":[76],"characteristic":[78],"which":[79],"could":[80],"make":[81],"pharmacokinetics":[83],"very":[87],"interesting.":[88],"Molecular":[89],"modeling":[90],"investigations":[91],"on":[92],"structures":[94],"inhibitors":[96,114],"bound":[97],"at":[98],"active":[100],"site":[101],"reductase":[104],"were":[105],"performed":[106],"order":[108],"suggest":[110],"how":[111],"new":[113],"might":[115],"bind":[116],"interpret":[123],"structure-activity":[124],"relationships.":[125]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}