{"id":"https://openalex.org/W2020063343","doi":"https://doi.org/10.1006/excr.1999.4501","title":"Caspase-8 Mediates Caspase-3 Activation and Cytochrome c Release during Singlet Oxygen-Induced Apoptosis of HL-60 Cells","display_name":"Caspase-8 Mediates Caspase-3 Activation and Cytochrome c Release during Singlet Oxygen-Induced Apoptosis of HL-60 Cells","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2020063343","doi":"https://doi.org/10.1006/excr.1999.4501","mag":"2020063343","pmid":"https://pubmed.ncbi.nlm.nih.gov/10388534"},"language":"en","primary_location":{"id":"doi:10.1006/excr.1999.4501","doi":"https://doi.org/10.1006/excr.1999.4501","is_oa":false,"landing_page_url":"https://doi.org/10.1006/excr.1999.4501","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048518436","display_name":"Shougang Zhuang","orcid":"https://orcid.org/0000-0001-9719-4187","observed_orcids":["https://orcid.org/0000-0001-9719-4187","https://orcid.org/0009-0003-7743-3971","https://orcid.org/0000-0001-5806-8209","https://orcid.org/0009-0001-1680-9272"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shougang Zhuang","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, 02114, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101164266","display_name":"Mary C. Lynch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary C. Lynch","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033699079","display_name":"Irene E. Kochevar","orcid":"https://orcid.org/0000-0002-3763-3923","observed_orcids":["https://orcid.org/0000-0002-3763-3923"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irene E. Kochevar","raw_affiliation_strings":["Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wellman Laboratories of Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, 02114","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5033699079"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":{"value":3270,"currency":"USD","value_usd":3270},"apc_paid":null,"fwci":2.5861,"has_fulltext":false,"cited_by_count":102,"citation_normalized_percentile":{"value":0.90155729,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"250","issue":"1","first_page":"203","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9879999756813049},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytochrome-c-release","display_name":"cytochrome c release","score":0.9940000176429749},{"id":"https://openalex.org/keywords/singlet-oxygen","display_name":"singlet oxygen","score":0.9950000047683716},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8970000147819519},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rose-bengal","display_name":"rose bengal","score":0.7269999980926514},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.843999981880188},{"id":"https://openalex.org/keywords/mitochondrial-apoptosis","display_name":"mitochondrial apoptosis","score":0.7089999914169312},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/z-ietd-fmk","display_name":"Z-IETD-FMK","score":0.7429999709129333},{"id":"https://openalex.org/keywords/z-devd-fmk","display_name":"Z-DEVD-FMK","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.8574827909469604},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.771955132484436},{"id":"https://openalex.org/C2777516457","wikidata":"https://www.wikidata.org/wiki/Q2413613","display_name":"Singlet oxygen","level":3,"score":0.6666979193687439},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6322959065437317},{"id":"https://openalex.org/C2775998712","wikidata":"https://www.wikidata.org/wiki/Q14907714","display_name":"Caspase-9","level":5,"score":0.6191011667251587},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.616078794002533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6144315004348755},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.5908965468406677},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.5261421203613281},{"id":"https://openalex.org/C2780898351","wikidata":"https://www.wikidata.org/wiki/Q11350933","display_name":"Rose bengal","level":2,"score":0.5179049372673035},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5148565173149109},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.43448519706726074},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38359689712524414},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.36684757471084595},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.34203648567199707},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32098111510276794},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.16906234622001648},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12266916036605835},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003574","descriptor_name":"Cytochrome c Group","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011065","descriptor_name":"Poly(ADP-ribose) Polymerases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D026082","descriptor_name":"Singlet Oxygen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/excr.1999.4501","doi":"https://doi.org/10.1006/excr.1999.4501","is_oa":false,"landing_page_url":"https://doi.org/10.1006/excr.1999.4501","pdf_url":null,"source":{"id":"https://openalex.org/S132505712","display_name":"Experimental Cell Research","issn_l":"0014-4827","issn":["0014-4827","1090-2422"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Cell Research","raw_type":"journal-article"},{"id":"pmid:10388534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10388534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental cell research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3462727401","display_name":null,"funder_award_id":"GM-30955","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W107210068","https://openalex.org/W1591414362","https://openalex.org/W1772341276","https://openalex.org/W1940300157","https://openalex.org/W1942214720","https://openalex.org/W1963717375","https://openalex.org/W1964390988","https://openalex.org/W1979995768","https://openalex.org/W1988864413","https://openalex.org/W1993269272","https://openalex.org/W2003962192","https://openalex.org/W2007689766","https://openalex.org/W2007861801","https://openalex.org/W2012173926","https://openalex.org/W2013936743","https://openalex.org/W2014757063","https://openalex.org/W2015608566","https://openalex.org/W2015899487","https://openalex.org/W2030892254","https://openalex.org/W2032063521","https://openalex.org/W2037473273","https://openalex.org/W2044857865","https://openalex.org/W2045563337","https://openalex.org/W2054260525","https://openalex.org/W2063960864","https://openalex.org/W2066096456","https://openalex.org/W2068147094","https://openalex.org/W2077504134","https://openalex.org/W2083658751","https://openalex.org/W2086415396","https://openalex.org/W2089811590","https://openalex.org/W2094305570","https://openalex.org/W2094334993","https://openalex.org/W2104713798","https://openalex.org/W2111986039","https://openalex.org/W2113034786","https://openalex.org/W2117104323","https://openalex.org/W2119683782","https://openalex.org/W2128016549","https://openalex.org/W2130477771","https://openalex.org/W2136995196","https://openalex.org/W2141243080","https://openalex.org/W2144701362","https://openalex.org/W2146027360","https://openalex.org/W2165021798","https://openalex.org/W2166710182","https://openalex.org/W2168413006","https://openalex.org/W2290622880","https://openalex.org/W2315629023","https://openalex.org/W2915403125"],"related_works":["https://openalex.org/W2028151158","https://openalex.org/W2061483806","https://openalex.org/W2316218740","https://openalex.org/W1991945233","https://openalex.org/W2063205344","https://openalex.org/W2013936111","https://openalex.org/W2102611193","https://openalex.org/W7099324514","https://openalex.org/W2271615814","https://openalex.org/W1836033269"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
