{"id":"https://openalex.org/W2020043868","doi":"https://doi.org/10.1371/journal.pntd.0002596","title":"Praziquantel Treatment Decreases Schistosoma mansoni Genetic Diversity in Experimental Infections","display_name":"Praziquantel Treatment Decreases Schistosoma mansoni Genetic Diversity in Experimental Infections","publication_year":2013,"publication_date":"2013-12-19","ids":{"openalex":"https://openalex.org/W2020043868","doi":"https://doi.org/10.1371/journal.pntd.0002596","mag":"2020043868","pmid":"https://pubmed.ncbi.nlm.nih.gov/24367712","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868512"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0002596","doi":"https://doi.org/10.1371/journal.pntd.0002596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002596","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002596&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002596&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012126638","display_name":"Regina Coeli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Regina Coeli","raw_affiliation_strings":["Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051593784","display_name":"Elio H. Baba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Elio H. Baba","raw_affiliation_strings":["Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103419387","display_name":"Neusa Ara\u00fajo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Neusa Araujo","raw_affiliation_strings":["Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085607583","display_name":"Paulo Marcos Zech Coelho","orcid":"https://orcid.org/0000-0002-2443-8897","observed_orcids":["https://orcid.org/0000-0002-2443-8897"]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Paulo M. Z. Coelho","raw_affiliation_strings":["Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Schistosomiasis, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048496084","display_name":"Guilherme Oliveira","orcid":"https://orcid.org/0000-0003-0054-3438","observed_orcids":["https://orcid.org/0000-0003-0054-3438"]},"institutions":[{"id":"https://openalex.org/I4405286130","display_name":"Fiocruz Minas","ror":"https://ror.org/016szx330","country_code":"BR","type":"government","lineage":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"id":"https://openalex.org/I52325","display_name":"Funda\u00e7\u00e3o Oswaldo Cruz","ror":"https://ror.org/04jhswv08","country_code":"BR","type":"facility","lineage":["https://openalex.org/I52325"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Guilherme Oliveira","raw_affiliation_strings":["Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil ; National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil ; National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]},{"raw_affiliation_string":"Genomics and Computational Biology Group, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130"]},{"raw_affiliation_string":"National Institute of Science and Technology in Tropical Diseases, Centro de Pesquisas Ren\u00e9 Rachou, Fiocruz, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048496084"],"corresponding_institution_ids":["https://openalex.org/I4405286130","https://openalex.org/I52325"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":5.6908,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.96761706,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"e2596","last_page":"e2596"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/schistosoma-mansoni","display_name":"Schistosoma mansoni","score":0.9959999918937683},{"id":"https://openalex.org/keywords/praziquantel","display_name":"praziquantel","score":0.9890000224113464},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8389999866485596},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.7160000205039978},{"id":"https://openalex.org/keywords/microsatellite-markers","display_name":"microsatellite markers","score":0.8270000219345093},{"id":"https://openalex.org/keywords/selective-pressure","display_name":"selection pressure","score":0.7639999985694885},{"id":"https://openalex.org/keywords/endogamy","display_name":"endogamy","score":0.824999988079071},{"id":"https://openalex.org/keywords/schistosomiasis-chemotherapy","display_name":"schistosomiasis chemotherapy","score":0.8870000243186951},{"id":"https://openalex.org/keywords/parasite-population-genetics","display_name":"parasite population genetics","score":0.718999981880188}],"concepts":[{"id":"https://openalex.org/C2779744950","wikidata":"https://www.wikidata.org/wiki/Q424145","display_name":"Praziquantel","level":4,"score":0.971585214138031},{"id":"https://openalex.org/C2776863245","wikidata":"https://www.wikidata.org/wiki/Q2324689","display_name":"Schistosoma mansoni","level":4,"score":0.9225208163261414},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7608686685562134},{"id":"https://openalex.org/C2776225656","wikidata":"https://www.wikidata.org/wiki/Q221159","display_name":"Schistosomiasis","level":3,"score":0.736448347568512},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.6598845720291138},{"id":"https://openalex.org/C2778491710","wikidata":"https://www.wikidata.org/wiki/Q1457418","display_name":"Schistosoma","level":5,"score":0.5464088916778564},{"id":"https://openalex.org/C2777474118","wikidata":"https://www.wikidata.org/wiki/Q1345671","display_name":"Tropical disease","level":3,"score":0.47268038988113403},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.4526141285896301},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.45110028982162476},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.43303316831588745},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4115399122238159},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35881808400154114},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.27928224205970764},{"id":"https://openalex.org/C165901193","wikidata":"https://www.wikidata.org/wiki/Q3129936","display_name":"Helminths","level":2,"score":0.2543790638446808},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.21646246314048767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16613593697547913},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16381219029426575},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.10582971572875977},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.055733174085617065}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000871","descriptor_name":"Anthelmintics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011223","descriptor_name":"Praziquantel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":true},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012550","descriptor_name":"Schistosoma mansoni","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012555","descriptor_name":"Schistosomiasis mansoni","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D012641","descriptor_name":"Selection, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018895","descriptor_name":"Microsatellite Repeats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pntd.0002596","doi":"https://doi.org/10.1371/journal.pntd.0002596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002596","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002596&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2853869","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3868512","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24367712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24367712","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3868512","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3868512/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:www.arca.fiocruz.br:icict/29982","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/29982","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.796.4752","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.796.4752","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/1f/8f/pntd.0002596.PMC3868512.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:2326647","doi":null,"is_oa":true,"landing_page_url":"https://www.arca.fiocruz.br/handle/icict/29982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"reponame:Reposit\u00f3rio Institucional da FIOCRUZ (ARCA)","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:arca.fiocruz.br:icict/29982","doi":null,"is_oa":true,"landing_page_url":"https://arca.fiocruz.br/handle/icict/29982","pdf_url":null,"source":{"id":"https://openalex.org/S7407055450","display_name":"Arca - Reposit\u00f3rio Institucional da Fiocruz","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:16d7f782ae1e4c9584b40785f554a359","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/16d7f782ae1e4c9584b40785f554a359","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 7, Iss 12, p e2596 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0002596","doi":"https://doi.org/10.1371/journal.pntd.0002596","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002596","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002596&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8560000061988831,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G138562754","display_name":null,"funder_award_id":"2009-3","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G1690248604","display_name":null,"funder_award_id":"573839/2008-5","funder_id":"https://openalex.org/F4320322025","funder_display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico"},{"id":"https://openalex.org/G3566165748","display_name":"IDENTIFICA\u00c7\u00c3O DE NOVOS ALVOS PARA O COMBATE A ESQUISTOSSOMOSE","funder_award_id":"PPM-00439-10","funder_id":"https://openalex.org/F4320322980","funder_display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais"},{"id":"https://openalex.org/G4407732016","display_name":"Schistosoma Epigenetics - Targets, Regulation, New Drugs","funder_award_id":"241865","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322980","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","ror":"https://ror.org/00nc55f03"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2020043868.pdf","grobid_xml":"https://content.openalex.org/works/W2020043868.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W126028520","https://openalex.org/W1527406256","https://openalex.org/W1538974034","https://openalex.org/W1843013032","https://openalex.org/W1952912025","https://openalex.org/W1965665735","https://openalex.org/W1965932545","https://openalex.org/W1971315193","https://openalex.org/W1972688104","https://openalex.org/W1974965021","https://openalex.org/W1975354637","https://openalex.org/W1980016106","https://openalex.org/W1981306522","https://openalex.org/W1983793443","https://openalex.org/W1989409796","https://openalex.org/W1992581726","https://openalex.org/W1993816034","https://openalex.org/W2006300406","https://openalex.org/W2008169720","https://openalex.org/W2014408406","https://openalex.org/W2015569812","https://openalex.org/W2019546376","https://openalex.org/W2023374722","https://openalex.org/W2045135702","https://openalex.org/W2046062863","https://openalex.org/W2058962103","https://openalex.org/W2067454999","https://openalex.org/W2072014244","https://openalex.org/W2074437097","https://openalex.org/W2084217431","https://openalex.org/W2091282899","https://openalex.org/W2091746068","https://openalex.org/W2102993269","https://openalex.org/W2106825249","https://openalex.org/W2107930827","https://openalex.org/W2115578623","https://openalex.org/W2117723673","https://openalex.org/W2123551520","https://openalex.org/W2124538952","https://openalex.org/W2129486290","https://openalex.org/W2132297696","https://openalex.org/W2132753699","https://openalex.org/W2136831466","https://openalex.org/W2155150012","https://openalex.org/W2160943186","https://openalex.org/W2167497811","https://openalex.org/W2169577133","https://openalex.org/W2172159150","https://openalex.org/W2177715039","https://openalex.org/W2187144093","https://openalex.org/W2408855002","https://openalex.org/W2794253813","https://openalex.org/W2984764290","https://openalex.org/W4285719527","https://openalex.org/W4294232824"],"related_works":["https://openalex.org/W7096132386","https://openalex.org/W4410921889","https://openalex.org/W4406352174","https://openalex.org/W16722359","https://openalex.org/W2001533212","https://openalex.org/W7045249250","https://openalex.org/W2772853575","https://openalex.org/W3189168014","https://openalex.org/W4210584642","https://openalex.org/W4292220074"],"abstract_inverted_index":{"BACKGROUND:":[0],"Schistosomiasis":[1],"has":[2,245],"a":[3,91,118,189,254],"considerable":[4],"impact":[5,86,110],"on":[6,95,114,154,248],"public":[7],"health":[8],"in":[9,57,76,82,227,258],"many":[10],"tropical":[11],"and":[12,36,51,79,98,166,230,251],"subtropical":[13],"areas.":[14],"In":[15,198],"the":[16,23,30,37,63,77,83,109,115,139,155,174,249],"new":[17],"world,":[18],"schistosomiasis":[19],"is":[20,29,44,49,102],"caused":[21],"by":[22,121,220],"digenetic":[24],"trematode":[25],"Schistosoma":[26],"mansoni.":[27],"Chemotherapy":[28],"main":[31],"measure":[32],"for":[33,42,81],"controlling":[34],"schistosomiasis,":[35],"current":[38],"drug":[39,243],"of":[40,65,87,111,117,125,142,151,173,235,253],"choice":[41],"treatment":[43,153],"praziquantel":[45],"(PZQ).":[46],"Although":[47],"PZQ":[48,72,112,136,152,211,221,255],"efficient":[50],"safe,":[52],"its":[53],"repetitive":[54],"large-scale":[55],"use":[56],"endemic":[58,259],"areas":[59],"may":[60],"lead":[61],"to":[62,71,182,187,196,210,223,241],"selection":[64],"resistant":[66],"strains.":[67],"Isolates":[68],"less":[69],"susceptible":[70,209],"have":[73],"been":[74],"found":[75],"field":[78],"selected":[80],"laboratory.":[84],"The":[85,149,216,233],"selecting":[88],"strains":[89],"with":[90,134,171,193],"decreased":[92,194,224],"susceptibility":[93,195],"phenotype":[94,257],"disease":[96],"dynamics":[97],"parasite":[99,156,179],"population":[100,120,157,192],"genetics":[101,116],"not":[103],"fully":[104],"understood.":[105],"This":[106],"study":[107],"addresses":[108],"pressure":[113,218,244],"laboratory":[119],"analyzing":[122],"frequency":[123],"variations":[124],"polymorphic":[126,162],"genetic":[127,167,225],"markers.":[128,164],"METHODOLOGY:":[129],"Infected":[130],"mice":[131],"were":[132,169,207],"treated":[133],"increasing":[135],"doses":[137],"until":[138],"highest":[140],"dose":[141],"3":[143],"\u00d7":[144],"300":[145],"mg/Kg":[146],"was":[147,158,185],"reached.":[148],"effect":[150],"assessed":[159],"using":[160],"five":[161],"microsatellite":[163],"Parasitological":[165],"data":[168],"compared":[170],"those":[172],"untreated":[175],"control.":[176],"After":[177],"six":[178],"generations":[180],"submitted":[181],"treatment,":[183],"it":[184],"possible":[186],"obtain":[188],"S.":[190,228,237],"mansoni":[191,229,238],"PZQ.":[197],"our":[199],"experiments":[200],"we":[201],"also":[202],"observed":[203],"that":[204],"female":[205],"worms":[206],"more":[208],"than":[212],"male":[213],"worms.":[214],"CONCLUSIONS:":[215],"selective":[217],"exerted":[219],"led":[222],"variability":[226],"increased":[231],"endogamy.":[232],"understanding":[234],"how":[236],"populations":[239],"respond":[240],"successive":[242],"important":[246],"implications":[247],"appearance":[250],"maintenance":[252],"resistance":[256],"regions.":[260]},"counts_by_year":[{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}