{"id":"https://openalex.org/W2020028069","doi":"https://doi.org/10.1148/radiol.11110315","title":"Intrinsic Damage to the Major White Matter Tracts in Patients with Different Clinical Phenotypes of Multiple Sclerosis: A Voxelwise Diffusion-Tensor MR Study","display_name":"Intrinsic Damage to the Major White Matter Tracts in Patients with Different Clinical Phenotypes of Multiple Sclerosis: A Voxelwise Diffusion-Tensor MR Study","publication_year":2011,"publication_date":"2011-06-15","ids":{"openalex":"https://openalex.org/W2020028069","doi":"https://doi.org/10.1148/radiol.11110315","mag":"2020028069","pmid":"https://pubmed.ncbi.nlm.nih.gov/21673227"},"language":"en","primary_location":{"id":"doi:10.1148/radiol.11110315","doi":"https://doi.org/10.1148/radiol.11110315","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.11110315","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088924447","display_name":"Paolo Preziosa","orcid":"https://orcid.org/0000-0002-7826-0019","observed_orcids":["https://orcid.org/0000-0002-7826-0019"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Preziosa","raw_affiliation_strings":["Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084674707","display_name":"Maria Assunta Rocca","orcid":"https://orcid.org/0000-0003-2358-4320","observed_orcids":["https://orcid.org/0000-0003-2358-4320"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria A. Rocca","raw_affiliation_strings":["Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088263037","display_name":"\u0160arlota Mesaro\u0161","orcid":"https://orcid.org/0000-0002-1068-9142","observed_orcids":["https://orcid.org/0000-0002-1068-9142"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Sarlota Mesaros","raw_affiliation_strings":["Clinics of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinics of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066806555","display_name":"Elisabetta Pagani","orcid":"https://orcid.org/0000-0002-1850-1175","observed_orcids":["https://orcid.org/0000-0002-1850-1175"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisabetta Pagani","raw_affiliation_strings":["Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111528045","display_name":"Tatjana Sto\u0161i\u0107-Opin\u0107al","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Tatjana Stosic-Opincal","raw_affiliation_strings":["Radiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111059656","display_name":"Katarina Ka\u010dar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Katarina Kacar","raw_affiliation_strings":["Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008438428","display_name":"Martina Absinta","orcid":"https://orcid.org/0000-0003-0276-383X","observed_orcids":["https://orcid.org/0000-0003-0276-383X"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Martina Absinta","raw_affiliation_strings":["Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005439850","display_name":"Domenico Caputo","orcid":"https://orcid.org/0000-0003-0513-3251","observed_orcids":["https://orcid.org/0000-0003-0513-3251"]},"institutions":[{"id":"https://openalex.org/I4210116940","display_name":"Don Carlo Gnocchi Foundation","ror":"https://ror.org/02e3ssq97","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210116940"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Domenico Caputo","raw_affiliation_strings":["Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Scientific Institute Fondazione Don Gnocchi, Milan, Italy","institution_ids":["https://openalex.org/I4210116940"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085187558","display_name":"Jelena S. Drulovic","orcid":"https://orcid.org/0000-0002-4516-3458","observed_orcids":["https://orcid.org/0000-0002-4516-3458"]},"institutions":[{"id":"https://openalex.org/I4068193","display_name":"University of Belgrade","ror":"https://ror.org/02qsmb048","country_code":"RS","type":"education","lineage":["https://openalex.org/I4068193"]}],"countries":["RS"],"is_corresponding":false,"raw_author_name":"Jelena Drulovic","raw_affiliation_strings":["Clinics of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinics of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia","institution_ids":["https://openalex.org/I4068193"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043499649","display_name":"G\u0131ancarlo Com\u0131","orcid":"https://orcid.org/0000-0002-6989-1054","observed_orcids":["https://orcid.org/0000-0002-6989-1054"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Comi","raw_affiliation_strings":["Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003010065","display_name":"Massimo Filippi","orcid":"https://orcid.org/0000-0002-5485-0479","observed_orcids":["https://orcid.org/0000-0002-5485-0479"]},"institutions":[{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Massimo Filippi","raw_affiliation_strings":["Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]},{"raw_affiliation_string":"Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute and University Hospital, Via Olgettina 60, 20132 Milan, Italy","institution_ids":["https://openalex.org/I4210133214"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.8222,"has_fulltext":false,"cited_by_count":77,"citation_normalized_percentile":{"value":0.96752485,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"260","issue":"2","first_page":"541","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.35519999265670776,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13648","display_name":"Cerebrovascular and genetic disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/white-matter-tracts","display_name":"white matter tracts","score":0.8140000104904175},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.718999981880188},{"id":"https://openalex.org/keywords/clinically-isolated-syndrome","display_name":"clinically isolated syndrome","score":0.765999972820282},{"id":"https://openalex.org/keywords/relapsing-remitting-multiple-sclerosis","display_name":"relapsing-remitting multiple sclerosis","score":0.996999979019165},{"id":"https://openalex.org/keywords/secondary-progressive-multiple-sclerosis","display_name":"secondary progressive multiple sclerosis","score":0.9779999852180481},{"id":"https://openalex.org/keywords/primary-progressive-multiple-sclerosis","display_name":"primary progressive multiple sclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/benign-multiple-sclerosis","display_name":"benign multiple sclerosis","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mean-diffusivity","display_name":"mean diffusivity","score":0.8259999752044678},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"fractional anisotropy","score":0.9070000052452087},{"id":"https://openalex.org/keywords/axial-and-radial-diffusivity","display_name":"axial and radial diffusivity","score":0.8849999904632568},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.5720000267028809},{"id":"https://openalex.org/keywords/t2-weighted-lesions","display_name":"T2-weighted lesions","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.8605238795280457},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7909015417098999},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7653168439865112},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7462784051895142},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.7273144721984863},{"id":"https://openalex.org/C146638467","wikidata":"https://www.wikidata.org/wiki/Q10529587","display_name":"Hyperintensity","level":3,"score":0.4568506181240082},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4546199440956116},{"id":"https://openalex.org/C84787856","wikidata":"https://www.wikidata.org/wiki/Q3076659","display_name":"Tractography","level":4,"score":0.45129698514938354},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.43268224596977234},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.41581061482429504},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3845037817955017},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.22409787774085999},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.09119042754173279}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004185","descriptor_name":"Disability Evaluation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007090","descriptor_name":"Image Interpretation, Computer-Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009103","descriptor_name":"Multiple Sclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009413","descriptor_name":"Nerve Fibers, Myelinated","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038524","descriptor_name":"Diffusion Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1148/radiol.11110315","doi":"https://doi.org/10.1148/radiol.11110315","is_oa":false,"landing_page_url":"https://doi.org/10.1148/radiol.11110315","pdf_url":null,"source":{"id":"https://openalex.org/S50280174","display_name":"Radiology","issn_l":"0033-8419","issn":["0033-8419","1527-1315"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315931","host_organization_name":"Radiological Society of North America","host_organization_lineage":["https://openalex.org/P4310315931"],"host_organization_lineage_names":["Radiological Society of North America"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"journal-article"},{"id":"pmid:21673227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21673227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/47282","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/47282","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1968810687","https://openalex.org/W1994972002","https://openalex.org/W1995004187","https://openalex.org/W2005100134","https://openalex.org/W2012224032","https://openalex.org/W2029226538","https://openalex.org/W2029736756","https://openalex.org/W2035802521","https://openalex.org/W2041823936","https://openalex.org/W2046622101","https://openalex.org/W2046748764","https://openalex.org/W2047062145","https://openalex.org/W2060042291","https://openalex.org/W2072718666","https://openalex.org/W2087589796","https://openalex.org/W2097866416","https://openalex.org/W2102345898","https://openalex.org/W2103224749","https://openalex.org/W2104355947","https://openalex.org/W2112165124","https://openalex.org/W2115656804","https://openalex.org/W2122545833","https://openalex.org/W2131777156","https://openalex.org/W2135714538","https://openalex.org/W2139158372","https://openalex.org/W2142568997","https://openalex.org/W2144508667","https://openalex.org/W2160215963","https://openalex.org/W2161281218","https://openalex.org/W2164526354","https://openalex.org/W2165037359","https://openalex.org/W2171753008"],"related_works":["https://openalex.org/W2067919153","https://openalex.org/W7101120144","https://openalex.org/W4388228707","https://openalex.org/W1970044218","https://openalex.org/W1976806715","https://openalex.org/W2184938472","https://openalex.org/W7201922179","https://openalex.org/W2048918000","https://openalex.org/W2800247887","https://openalex.org/W4403207168"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"apply":[2],"voxelwise":[3],"analysis":[4,138],"of":[5,31,39,47,92,124,139,168,193,234,247,259,269,282],"diffusion-tensor":[6],"(DT)":[7],"magnetic":[8],"resonance":[9],"(MR)":[10],"tractography":[11],"and":[12,28,37,73,117,162,182,207,227],"T2-weighted":[13],"MR":[14,75,271],"lesion":[15],"measurements":[16],"to":[17,21,34,244],"characterize":[18],"intrinsic":[19],"damage":[20,33,189,243],"the":[22,29,35,43,125,144,148,166,191,205,212,216,232,245,252,260,280],"brain":[23,127],"white":[24],"matter":[25],"(WM)":[26],"tracts":[27,129,226,248,261],"relation":[30],"this":[32],"presence":[36],"location":[38],"focal":[40],"lesions":[41],"among":[42],"main":[44],"clinical":[45,283],"phenotypes":[46],"multiple":[48],"sclerosis":[49],"(MS).":[50],"MATERIALS":[51],"AND":[52],"METHODS:":[53],"The":[54,171,236],"study":[55],"was":[56,66,202],"conducted":[57],"with":[58,82,86,96,102,108,113,143,150,185,211,251],"institutional":[59],"review":[60],"board":[61],"approval.":[62],"Written":[63],"informed":[64],"consent":[65],"obtained":[67,78],"from":[68],"each":[69],"participant.":[70],"Brain":[71],"dual-echo":[72],"DT":[74,270],"images":[76],"were":[77,130,134],"in":[79,165,179,199,223,231],"172":[80],"patients":[81,149],"MS":[83,174,214,239,254,284],"(22":[84],"[13%]":[85],"clinically":[87],"isolated":[88],"syndromes":[89],"[CIS]":[90],"suggestive":[91],"MS,":[93,99,105,110],"51":[94],"[30%]":[95],"relapsing-remitting":[97],"[RR]":[98],"44":[100],"[26%]":[101],"secondary":[103,237],"progressive":[104,115,173,238],"20":[106],"[12%]":[107],"benign":[109,213,253],"35":[111],"[20%]":[112],"primary":[114,172],"MS)":[116],"46":[118],"healthy":[119,145],"control":[120,146],"subjects.":[121],"Probability":[122],"maps":[123],"major":[126],"WM":[128,169,194,225],"produced.":[131],"Between-group":[132],"comparisons":[133],"assessed":[135],"by":[136],"using":[137],"covariance.":[140],"RESULTS:":[141],"Compared":[142,210],"subjects,":[147],"CIS":[151,206],"had":[152,219,241],"significantly":[153],"increased":[154],"(P":[155],"<":[156],".001)":[157],"mean":[158],"diffusivity,":[159,161,184],"axial":[160,229],"radial":[163,183],"diffusivity":[164,200,230],"majority":[167,192,233,246],"tracts.":[170,195,235],"group":[175,218,240],"showed":[176],"diffuse":[177],"increases":[178],"mean,":[180],"axial,":[181],"fractional":[186],"anisotropy":[187],"(FA)":[188],"involving":[190],"No":[196],"relevant":[197,262],"difference":[198],"measures":[201],"found":[203],"between":[204],"RR-MS":[208,217],"groups.":[209],"group,":[215,255],"reduced":[220],"FA":[221,257],"values":[222],"all":[224],"decreased":[228],"pronounced":[242,256],"and,":[249],"compared":[250],"alteration":[258],"for":[263,278],"motor":[264],"impairment.":[265],"CONCLUSION:":[266],"Voxelwise":[267],"assessment":[268],"index":[272],"abnormalities":[273],"is":[274],"a":[275],"rewarding":[276],"strategy":[277],"understanding":[279],"heterogeneity":[281],"phenotypes.":[285]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}