{"id":"https://openalex.org/W2019995104","doi":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","title":"Identification of higenamine in Radix AconitiLateralis Preparataas a beta2-adrenergic receptor agonist1","display_name":"Identification of higenamine in Radix AconitiLateralis Preparataas a beta2-adrenergic receptor agonist1","publication_year":2008,"publication_date":"2008-10-01","ids":{"openalex":"https://openalex.org/W2019995104","doi":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","mag":"2019995104","pmid":"https://pubmed.ncbi.nlm.nih.gov/18817623"},"language":"en","primary_location":{"id":"doi:10.1111/j.1745-7254.2008.00859.x","doi":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084393924","display_name":"Gang Bai","orcid":"https://orcid.org/0000-0001-9161-2173","observed_orcids":["https://orcid.org/0000-0001-9161-2173"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Gang BAI","raw_affiliation_strings":["College of Life Sciences, Nankai University, Tianjin 300071, China. gangbai@nankai.edu.cn","College of Life Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin 300071, China. gangbai@nankai.edu.cn","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Yang YANG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang YANG","raw_affiliation_strings":["College of Life Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018376309","display_name":"Qian Shi","orcid":"https://orcid.org/0000-0003-2634-9553","observed_orcids":["https://orcid.org/0000-0003-2634-9553","https://orcid.org/0009-0006-4426-6478"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qian SHI","raw_affiliation_strings":["College of Life Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041165857","display_name":"Ze Liu","orcid":"https://orcid.org/0000-0002-1635-5573","observed_orcids":["https://orcid.org/0000-0002-1635-5573"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ze LIU","raw_affiliation_strings":["College of Life Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100360199","display_name":"Qi Zhang","orcid":"https://orcid.org/0000-0001-5803-2556","observed_orcids":["https://orcid.org/0000-0001-5803-2556","https://orcid.org/0009-0005-8552-2637"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi ZHANG","raw_affiliation_strings":["College of Pharmaceutical Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100765279","display_name":"Yuanyuan Zhu","orcid":"https://orcid.org/0000-0003-4842-5510","observed_orcids":["https://orcid.org/0000-0003-4842-5510"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan-yuan ZHU","raw_affiliation_strings":["College of Pharmaceutical Sciences, Nankai University, Tianjin, 300071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmaceutical Sciences, Nankai University, Tianjin, 300071, China","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5084393924"],"corresponding_institution_ids":["https://openalex.org/I205237279"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":0.8328,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.69825694,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"29","issue":"10","first_page":"1187","last_page":"1194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13095","display_name":"Plant-based Medicinal Research","score":0.9487000107765198,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/higenamine","display_name":"higenamine","score":0.9380000233650208},{"id":"https://openalex.org/keywords/radix-aconiti-lateralis-preparata","display_name":"Radix Aconiti Lateralis Preparata","score":0.9909999966621399},{"id":"https://openalex.org/keywords/beta-2-adrenergic-agonists","display_name":"beta2-adrenergic agonists","score":0.968999981880188},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8100000023841858},{"id":"https://openalex.org/keywords/bronchoconstriction","display_name":"bronchoconstriction","score":0.9359999895095825},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7620000243186951},{"id":"https://openalex.org/keywords/bioassay-guided-fractionation","display_name":"bioassay-guided fractionation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/tracheal-smooth-muscle-relaxation","display_name":"tracheal smooth muscle relaxation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.6589999794960022}],"concepts":[{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.7050489783287048},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.689262866973877},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.6075915098190308},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.5781118869781494},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5292054414749146},{"id":"https://openalex.org/C58732023","wikidata":"https://www.wikidata.org/wiki/Q770260","display_name":"Partial agonist","level":4,"score":0.516588568687439},{"id":"https://openalex.org/C2780769369","wikidata":"https://www.wikidata.org/wiki/Q4375","display_name":"Bronchoconstriction","level":3,"score":0.5052195191383362},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.4694240689277649},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4297712743282318},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.4271836578845978},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30125924944877625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.24674615263938904},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.202377587556839},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19421043992042542},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17197293043136597},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10709193348884583},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000318","descriptor_name":"Adrenergic beta-Agonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000470","descriptor_name":"Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D001249","descriptor_name":"Asthma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009126","descriptor_name":"Muscle Relaxation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014132","descriptor_name":"Trachea","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D031841","descriptor_name":"Aconitum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D044005","descriptor_name":"Tetrahydroisoquinolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058666","descriptor_name":"Adrenergic beta-2 Receptor Agonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1745-7254.2008.00859.x","doi":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1745-7254.2008.00859.x","pdf_url":null,"source":{"id":"https://openalex.org/S4210186974","display_name":"Acta Pharmacologica Sinica","issn_l":"0253-9756","issn":["0253-9756","1671-4083","1745-7254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Pharmacologica Sinica","raw_type":"journal-article"},{"id":"pmid:18817623","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18817623","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta pharmacologica Sinica","raw_type":"Journal Article"},{"id":"mag:3144795299","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/qk/95561A/200810/28433996.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306542255","display_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u56fd\u836f\u7406\u5b66\u62a5\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4536049353","display_name":null,"funder_award_id":"2006AA020502","funder_id":"https://openalex.org/F4320335773","funder_display_name":"National High-tech Research and Development Program"}],"funders":[{"id":"https://openalex.org/F4320323993","display_name":"Natural Science Foundation of Tianjin City","ror":null},{"id":"https://openalex.org/F4320335773","display_name":"National High-tech Research and Development Program","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W181225137","https://openalex.org/W1525713084","https://openalex.org/W1968136804","https://openalex.org/W1974539105","https://openalex.org/W2008143154","https://openalex.org/W2017046552","https://openalex.org/W2022822025","https://openalex.org/W2030536223","https://openalex.org/W2031969192","https://openalex.org/W2040428071","https://openalex.org/W2052227833","https://openalex.org/W2082908197","https://openalex.org/W2089571568","https://openalex.org/W2091168222","https://openalex.org/W2095480014","https://openalex.org/W2123091473","https://openalex.org/W2135875906","https://openalex.org/W2171082263","https://openalex.org/W2281522791","https://openalex.org/W4254769978","https://openalex.org/W4406056544"],"related_works":["https://openalex.org/W3144795299","https://openalex.org/W3213119558","https://openalex.org/W7206149735","https://openalex.org/W4308057905","https://openalex.org/W2794706004","https://openalex.org/W4391785493","https://openalex.org/W2967985075","https://openalex.org/W4283315721","https://openalex.org/W2072112810","https://openalex.org/W4310434699"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
