{"id":"https://openalex.org/W2019979826","doi":"https://doi.org/10.1021/cc0498783","title":"Conformational Studies of Resin-Bound Vancomycin and the Complex of Vancomycin and Ac2- l -Lys- d -Ala- d -Ala","display_name":"Conformational Studies of Resin-Bound Vancomycin and the Complex of Vancomycin and Ac2- l -Lys- d -Ala- d -Ala","publication_year":2004,"publication_date":"2004-12-15","ids":{"openalex":"https://openalex.org/W2019979826","doi":"https://doi.org/10.1021/cc0498783","mag":"2019979826","pmid":"https://pubmed.ncbi.nlm.nih.gov/15638491"},"language":"en","primary_location":{"id":"doi:10.1021/cc0498783","doi":"https://doi.org/10.1021/cc0498783","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cc0498783","pdf_url":null,"source":{"id":"https://openalex.org/S4210175341","display_name":"Journal of Combinatorial Chemistry","issn_l":"1520-4766","issn":["1520-4766","1520-4774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Combinatorial Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066547423","display_name":"Nianhuan Yao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Nian-Huan Yao","raw_affiliation_strings":["Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109851150","display_name":"Wen\u2010Yi He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Wen-Yi He","raw_affiliation_strings":["Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016566536","display_name":"Kit S. Lam","orcid":"https://orcid.org/0000-0002-3076-6969","observed_orcids":["https://orcid.org/0000-0002-3076-6969"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kit S. Lam","raw_affiliation_strings":["Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100412436","display_name":"Gang Liu","orcid":"https://orcid.org/0000-0002-3431-3270","observed_orcids":["https://orcid.org/0000-0002-3431-3270"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4390039352","display_name":"UC Davis Comprehensive Cancer Center","ror":"https://ror.org/02kcc1z29","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160856","https://openalex.org/I4390039352"]},{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Gang Liu","raw_affiliation_strings":["Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chinese Academy of Medical Sciences & Peking Union Medical College, Institute of Materia Medica, 1 Xian Nong Tan Street, Beijing 100050, P. R. China, and University of California, Davis Cancer Center, 4501 X Street, Sacramento, California 95817","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4390039352","https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2367,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.50314497,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"7","issue":"1","first_page":"123","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vancomycin","display_name":"vancomycin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/d-ala-d-ala","display_name":"D-Ala-D-Ala","score":0.8339999914169312},{"id":"https://openalex.org/keywords/glycopeptide-antibiotics","display_name":"glycopeptides","score":0.6119999885559082},{"id":"https://openalex.org/keywords/drug-target-interactions","display_name":"drug-target interactions","score":0.5059999823570251},{"id":"https://openalex.org/keywords/high-resolution-magic-angle-spinning-nmr","display_name":"high-resolution magic angle spinning","score":0.8519999980926514},{"id":"https://openalex.org/keywords/molecular-conformation","display_name":"molecular conformation","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C2778980435","wikidata":"https://www.wikidata.org/wiki/Q424027","display_name":"Vancomycin","level":4,"score":0.6553875207901001},{"id":"https://openalex.org/C137610392","wikidata":"https://www.wikidata.org/wiki/Q2425020","display_name":"Glycopeptide","level":3,"score":0.46712666749954224},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4375784695148468},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3441725969314575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25659364461898804},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.22845962643623352},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.22122615575790405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.14174798130989075},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012117","descriptor_name":"Resins, Synthetic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014640","descriptor_name":"Vancomycin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020650","descriptor_name":"Combinatorial Chemistry Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/cc0498783","doi":"https://doi.org/10.1021/cc0498783","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cc0498783","pdf_url":null,"source":{"id":"https://openalex.org/S4210175341","display_name":"Journal of Combinatorial Chemistry","issn_l":"1520-4766","issn":["1520-4766","1520-4774"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Combinatorial Chemistry","raw_type":"journal-article"},{"id":"pmid:15638491","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15638491","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of combinatorial chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W216672338","https://openalex.org/W1967709842","https://openalex.org/W1968808667","https://openalex.org/W1969998422","https://openalex.org/W1977541902","https://openalex.org/W1984379350","https://openalex.org/W2002097614","https://openalex.org/W2010177672","https://openalex.org/W2019560756","https://openalex.org/W2026374982","https://openalex.org/W2031571847","https://openalex.org/W2038679943","https://openalex.org/W2054066537","https://openalex.org/W2056555157","https://openalex.org/W2065811877","https://openalex.org/W2073026029","https://openalex.org/W2086626577","https://openalex.org/W2089571021","https://openalex.org/W2104276816","https://openalex.org/W2126905278","https://openalex.org/W2402066319","https://openalex.org/W3004565440"],"related_works":["https://openalex.org/W2026374982","https://openalex.org/W2781967430","https://openalex.org/W2101979163","https://openalex.org/W2093127646","https://openalex.org/W2044337051","https://openalex.org/W2016904985","https://openalex.org/W3114185939","https://openalex.org/W2400620314","https://openalex.org/W2004808721","https://openalex.org/W1976926795"],"abstract_inverted_index":{"The":[0,20],"molecular":[1,21,128],"target":[2,132],"of":[3,23,80,88,95,127,140],"vancomycin,":[4,40],"a":[5,52],"commonly":[6],"used":[7],"glycopeptide":[8],"antibiotic,":[9],"is":[10,31,35,49,84],"the":[11,16,47,89,96,120,136,141],"D-Ala-D-Ala":[12,28,45],"dipeptide":[13],"subunit":[14],"on":[15,39],"bacterial":[17],"cell":[18],"wall.":[19],"basis":[22],"interaction":[24,43,129],"between":[25],"vancomycin":[26,58,83,104,107],"and":[27,41,93],"in":[29,102,125],"solution":[30],"well-known.":[32],"However,":[33],"there":[34],"no":[36],"structural":[37],"data":[38],"its":[42,68,131],"with":[44,110,130],"when":[46,108],"drug":[48],"tethered":[50],"to":[51,86],"solid":[53],"support.":[54],"In":[55],"this":[56],"Article,":[57],"was":[59],"directly":[60],"coupled":[61],"onto":[62],"TentaGel":[63],"or":[64,105],"PEGA":[65,81],"resin":[66],"through":[67],"C":[69],"terminus.":[70],"High-resolution":[71],"magic":[72],"angle":[73],"spinning":[74],"NMR":[75],"studies":[76],"indicated":[77],"that":[78,87,115],"conformation":[79],"bead-bound":[82,116],"identical":[85],"free":[90],"drug.":[91],"Broadening":[92],"shifts":[94],"same":[97,121],"proton":[98],"resonances":[99],"were":[100],"observed":[101],"solution-phase":[103,123],"PEGA-bound":[106],"complexed":[109],"Ac(2)-L-Lys-D-Ala-D-Ala.":[111],"This":[112],"study":[113],"demonstrates":[114],"molecules":[117,124],"can":[118],"behave":[119],"as":[122],"terms":[126],"molecule,":[133],"thus":[134],"validating":[135],"on-bead":[137],"screening":[138],"approach":[139],"\"one-bead-one-compound\"":[142],"combinatorial":[143],"library":[144],"method.":[145]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}