{"id":"https://openalex.org/W2019973807","doi":"https://doi.org/10.1016/j.cmet.2007.11.013","title":"Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis","display_name":"Hepatic Insulin Resistance Is Sufficient to Produce Dyslipidemia and Susceptibility to Atherosclerosis","publication_year":2008,"publication_date":"2008-02-01","ids":{"openalex":"https://openalex.org/W2019973807","doi":"https://doi.org/10.1016/j.cmet.2007.11.013","mag":"2019973807","pmid":"https://pubmed.ncbi.nlm.nih.gov/18249172","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4251554"},"language":"en","primary_location":{"id":"doi:10.1016/j.cmet.2007.11.013","doi":"https://doi.org/10.1016/j.cmet.2007.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2007.11.013","pdf_url":"http://www.cell.com/article/S1550413107003683/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.cell.com/article/S1550413107003683/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036574845","display_name":"Sudha B. Biddinger","orcid":"https://orcid.org/0000-0002-2352-067X","observed_orcids":["https://orcid.org/0000-0002-2352-067X"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudha B. Biddinger","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081836451","display_name":"Antonio Hern\u00e1ndez\u2010Ono","orcid":"https://orcid.org/0000-0002-8435-4505","observed_orcids":["https://orcid.org/0000-0002-8435-4505"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio Hernandez-Ono","raw_affiliation_strings":["Department of Medicine, Columbia University, New York, NY 10032, USA","Dept of Medicine, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071750698","display_name":"Christian Rask\u2010Madsen","orcid":"https://orcid.org/0000-0002-8548-466X","observed_orcids":["https://orcid.org/0000-0002-8548-466X"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christian Rask-Madsen","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047135384","display_name":"Joel T. Haas","orcid":"https://orcid.org/0000-0002-0028-5988","observed_orcids":["https://orcid.org/0000-0002-0028-5988","https://orcid.org/0000-0002-6313-1214"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel T. Haas","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053139625","display_name":"Jos\u00e9 O. Alem\u00e1n","orcid":"https://orcid.org/0000-0003-3753-6717","observed_orcids":["https://orcid.org/0000-0003-3753-6717"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 O. Alem\u00e1n","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062136115","display_name":"Ryo Suzuki","orcid":"https://orcid.org/0000-0002-2965-6906","observed_orcids":["https://orcid.org/0000-0002-2965-6906"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryo Suzuki","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109407447","display_name":"Erez F. Scapa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Erez F. Scapa","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046388816","display_name":"Chhavi Agarwal","orcid":"https://orcid.org/0000-0002-3623-8091","observed_orcids":["https://orcid.org/0000-0002-3623-8091"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chhavi Agarwal","raw_affiliation_strings":["Department of Medicine, Columbia University, New York, NY 10032, USA","Dept of Medicine, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113687963","display_name":"Martin C. Carey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin C. Carey","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009763658","display_name":"Gregory N Stephanopoulos","orcid":"https://orcid.org/0000-0001-6909-4568","observed_orcids":["https://orcid.org/0000-0001-6909-4568"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory Stephanopoulos","raw_affiliation_strings":["Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004209066","display_name":"David E. Cohen","orcid":"https://orcid.org/0000-0001-9827-6926","observed_orcids":["https://orcid.org/0000-0001-9827-6926"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David E. Cohen","raw_affiliation_strings":["Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009528569","display_name":"George Liang King","orcid":"https://orcid.org/0000-0002-0335-5881","observed_orcids":["https://orcid.org/0000-0002-0335-5881"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George L. King","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007048045","display_name":"Henry N. Ginsberg","orcid":"https://orcid.org/0000-0002-4103-3592","observed_orcids":["https://orcid.org/0000-0002-4103-3592"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Henry\u00a0N. Ginsberg","raw_affiliation_strings":["Department of Medicine, Columbia University, New York, NY 10032, USA","Dept of Medicine, Columbia University, New York, NY 10032, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Dept of Medicine, Columbia University, New York, NY 10032, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051737440","display_name":"C. Ronald Kahn","orcid":"https://orcid.org/0000-0002-7583-9228","observed_orcids":["https://orcid.org/0000-0002-7583-9228"]},"institutions":[{"id":"https://openalex.org/I1293231726","display_name":"Joslin Diabetes Center","ror":"https://ror.org/0280a3n32","country_code":"US","type":"facility","lineage":["https://openalex.org/I1293231726"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C. Ronald Kahn","raw_affiliation_strings":["Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA","institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051737440"],"corresponding_institution_ids":["https://openalex.org/I1293231726","https://openalex.org/I136199984"],"apc_list":{"value":10400,"currency":"USD","value_usd":10400},"apc_paid":null,"fwci":30.912,"has_fulltext":true,"cited_by_count":467,"citation_normalized_percentile":{"value":0.99757881,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"125","last_page":"134"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.4058000147342682,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.4058000147342682,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.28780001401901245,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.27000001072883606,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatic-insulin-resistance","display_name":"hepatic insulin resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/dyslipidemia","display_name":"dyslipidemia","score":0.875},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/metabolic-syndrome","display_name":"metabolic syndrome","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.6869999766349792},{"id":"https://openalex.org/keywords/apolipoprotein-b-containing-lipoproteins","display_name":"apolipoprotein B-containing lipoproteins","score":0.8389999866485596},{"id":"https://openalex.org/keywords/vldl-secretion","display_name":"VLDL secretion","score":0.9160000085830688},{"id":"https://openalex.org/keywords/hdl-cholesterol","display_name":"HDL cholesterol","score":0.7979999780654907},{"id":"https://openalex.org/keywords/srebp-1c","display_name":"SREBP-1c","score":0.9589999914169312},{"id":"https://openalex.org/keywords/srebp-2","display_name":"SREBP2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ldl-receptor","display_name":"LDL receptor","score":0.8500000238418579},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9020000100135803},{"id":"https://openalex.org/keywords/atherogenic-diet","display_name":"atherogenic diet","score":0.7940000295639038},{"id":"https://openalex.org/keywords/lipogenic-enzymes","display_name":"lipogenic enzymes","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8747598528862},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.8740049600601196},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.8094466924667358},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.715179443359375},{"id":"https://openalex.org/C8243546","wikidata":"https://www.wikidata.org/wiki/Q419074","display_name":"Very low-density lipoprotein","level":4,"score":0.6450832486152649},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.606743574142456},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.5984824895858765},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.4918551445007324},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.4679234027862549},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.46341413259506226},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4599413573741913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4067029654979706},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4051593542098999},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3746944069862366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3491041958332062}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004198","descriptor_name":"Disease Susceptibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008074","descriptor_name":"Lipoproteins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008107","descriptor_name":"Liver Diseases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.cmet.2007.11.013","doi":"https://doi.org/10.1016/j.cmet.2007.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2007.11.013","pdf_url":"http://www.cell.com/article/S1550413107003683/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},{"id":"pmid:18249172","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18249172","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4251554","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4251554","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Cell Metab","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.cmet.2007.11.013","doi":"https://doi.org/10.1016/j.cmet.2007.11.013","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.cmet.2007.11.013","pdf_url":"http://www.cell.com/article/S1550413107003683/pdf","source":{"id":"https://openalex.org/S177533077","display_name":"Cell Metabolism","issn_l":"1550-4131","issn":["1550-4131","1932-7420"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315673","host_organization_name":"Cell Press","host_organization_lineage":["https://openalex.org/P4310315673","https://openalex.org/P4310320990"],"host_organization_lineage_names":["Cell Press","Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1602607200","display_name":"Insulin Receptor Structure and Turnover","funder_award_id":"R37DK031036","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1925239979","display_name":"The Interaction Between Hepatic Insulin Resistance and Cholesterol Metabolism","funder_award_id":"K08DK073358","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2063905486","display_name":"Fatty Acid Regulation of Liver Lipoprotein Production","funder_award_id":"R01HL073030","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2083490969","display_name":"Insulin Receptor Structure and Turnover","funder_award_id":"R01DK031036","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2259240050","display_name":"Selective Insulin Resistance- Diabetic Cardiovascular Diseases","funder_award_id":"R01DK053105","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2758369363","display_name":null,"funder_award_id":"HL55368","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2810564815","display_name":null,"funder_award_id":"DK31036","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4099681973","display_name":"Vanderbilt Mouse Metabolic Phenotyping Center","funder_award_id":"U24DK059637","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4138677399","display_name":null,"funder_award_id":"DK59637-01","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G508144266","display_name":null,"funder_award_id":"DK-036588","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5132148558","display_name":"Molecular Pathogenesis of Cystic Fibrosis Liver Disease","funder_award_id":"R01DK073687","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G551785301","display_name":"GENE EXPRESSION IN DIABETES BY SUBTRACTIVE CLONING","funder_award_id":"R01DK045935","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5788186513","display_name":"Phospholipid-Mediated Metabolic Control in the Pathogenesis of NAFLD","funder_award_id":"R01DK056626","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G5986770304","display_name":"Career Development in Diabetes for Pediatric Endocrinolo","funder_award_id":"K12DK063696","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7521878547","display_name":"Regulation of Hepatic Lipid and Glucose Metabolism by PC-TP/StarD2","funder_award_id":"R37DK048873","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G7875077486","display_name":"Elucidating modulators of hepatic metabolism by quantitative flux analysis","funder_award_id":"R01DK075850","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000868266","display_name":"Diabetes Research Center","funder_award_id":"P30DK036836","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000914200","display_name":"Lipid-Mediated Control of Acetyl-CoA Metabolism in the Pathogenesis of NAFLD","funder_award_id":"R01DK048873","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019973807.pdf","grobid_xml":"https://content.openalex.org/works/W2019973807.grobid-xml"},"referenced_works_count":80,"referenced_works":["https://openalex.org/W1482006640","https://openalex.org/W1503419520","https://openalex.org/W1523158326","https://openalex.org/W1911007922","https://openalex.org/W1933294490","https://openalex.org/W1969623264","https://openalex.org/W1975390269","https://openalex.org/W1976844911","https://openalex.org/W1978476677","https://openalex.org/W1982489657","https://openalex.org/W1986349550","https://openalex.org/W1986519087","https://openalex.org/W1990805315","https://openalex.org/W1991735443","https://openalex.org/W2001901848","https://openalex.org/W2005430088","https://openalex.org/W2009033372","https://openalex.org/W2009306260","https://openalex.org/W2016291847","https://openalex.org/W2022543078","https://openalex.org/W2023662872","https://openalex.org/W2024851295","https://openalex.org/W2030610610","https://openalex.org/W2032731208","https://openalex.org/W2036812212","https://openalex.org/W2039250890","https://openalex.org/W2039999119","https://openalex.org/W2047046963","https://openalex.org/W2047583916","https://openalex.org/W2049878977","https://openalex.org/W2051870109","https://openalex.org/W2054239245","https://openalex.org/W2056245899","https://openalex.org/W2060968396","https://openalex.org/W2061864595","https://openalex.org/W2063086702","https://openalex.org/W2067324334","https://openalex.org/W2072036731","https://openalex.org/W2073625229","https://openalex.org/W2074371792","https://openalex.org/W2078156869","https://openalex.org/W2080528312","https://openalex.org/W2084273795","https://openalex.org/W2095500795","https://openalex.org/W2096773810","https://openalex.org/W2102785858","https://openalex.org/W2107957163","https://openalex.org/W2111895850","https://openalex.org/W2115621633","https://openalex.org/W2118688616","https://openalex.org/W2119390770","https://openalex.org/W2120852510","https://openalex.org/W2120862552","https://openalex.org/W2122687475","https://openalex.org/W2123289485","https://openalex.org/W2127629859","https://openalex.org/W2131553564","https://openalex.org/W2134292324","https://openalex.org/W2135536111","https://openalex.org/W2136629006","https://openalex.org/W2137591316","https://openalex.org/W2141823673","https://openalex.org/W2142156174","https://openalex.org/W2142263097","https://openalex.org/W2146109620","https://openalex.org/W2146544786","https://openalex.org/W2153661281","https://openalex.org/W2155391879","https://openalex.org/W2157817725","https://openalex.org/W2166961959","https://openalex.org/W2167130513","https://openalex.org/W2168724512","https://openalex.org/W2171290692","https://openalex.org/W2187391773","https://openalex.org/W2313099710","https://openalex.org/W2331274940","https://openalex.org/W2481895695","https://openalex.org/W4252021281","https://openalex.org/W4254624568","https://openalex.org/W6669959541"],"related_works":["https://openalex.org/W2014101304","https://openalex.org/W2351528721","https://openalex.org/W7097240046","https://openalex.org/W2040732264","https://openalex.org/W2618037390","https://openalex.org/W2009598229","https://openalex.org/W2066768833","https://openalex.org/W2058555764","https://openalex.org/W2271837249","https://openalex.org/W2084098964"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":16},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":26},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":27},{"year":2013,"cited_by_count":25},{"year":2012,"cited_by_count":26}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
