{"id":"https://openalex.org/W2019960565","doi":"https://doi.org/10.1038/leu.2010.268","title":"ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1","display_name":"ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1","publication_year":2010,"publication_date":"2010-11-19","ids":{"openalex":"https://openalex.org/W2019960565","doi":"https://doi.org/10.1038/leu.2010.268","mag":"2019960565","pmid":"https://pubmed.ncbi.nlm.nih.gov/21102429","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3049868"},"language":"en","primary_location":{"id":"doi:10.1038/leu.2010.268","doi":"https://doi.org/10.1038/leu.2010.268","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2010.268","pdf_url":"https://www.nature.com/articles/leu2010268.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.nature.com/articles/leu2010268.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"M Thai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Thai","raw_affiliation_strings":["Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Molecular Biology Institute, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088634670","display_name":"Pamela Y. Ting","orcid":"https://orcid.org/0009-0004-7323-7962","observed_orcids":["https://orcid.org/0009-0004-7323-7962"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Y Ting","raw_affiliation_strings":["Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111746614","display_name":"Jami McLaughlin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J McLaughlin","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102280864","display_name":"Donghui Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Cheng","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050087793","display_name":"Markus M\u00fcschen","orcid":"https://orcid.org/0000-0002-6064-8613","observed_orcids":["https://orcid.org/0000-0002-6064-8613"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]},{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M M\u00fcschen","raw_affiliation_strings":["Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA","Children's Hospital Los Angeles,University of Southern California, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]},{"raw_affiliation_string":"Children's Hospital Los Angeles,University of Southern California, Los Angeles, USA","institution_ids":["https://openalex.org/I1174212","https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087708211","display_name":"Owen N. Witte","orcid":"https://orcid.org/0000-0003-4461-4533","observed_orcids":["https://orcid.org/0000-0003-4461-4533"]},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"O N Witte","raw_affiliation_strings":["Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Microbiology, Immunology and Molecular Genetics, Howard Hughes Medical Institute, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043226629","display_name":"John Colicelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I4390039293","display_name":"UCLA Jonsson Comprehensive Cancer Center","ror":"https://ror.org/0599cs764","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799798094","https://openalex.org/I4390039293"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J Colicelli","raw_affiliation_strings":["Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]},{"raw_affiliation_string":"Department of Biological Chemistry, Molecular Biology Institute and Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, USA","institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5043226629"],"corresponding_institution_ids":["https://openalex.org/I161318765","https://openalex.org/I4390039293"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":{"value":5190,"currency":"USD","value_usd":5190},"fwci":1.6014,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.84516192,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"25","issue":"2","first_page":"290","last_page":"300"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12104","display_name":"Protein Tyrosine Phosphatases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rin1","display_name":"RIN1","score":0.8629999756813049},{"id":"https://openalex.org/keywords/bcr-abl1","display_name":"BCR-ABL1","score":0.9710000157356262},{"id":"https://openalex.org/keywords/tyrosine-kinase-regulation","display_name":"tyrosine kinase regulation","score":0.8379999995231628},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.8330000042915344},{"id":"https://openalex.org/keywords/kinase-inhibitor-sensitivity","display_name":"kinase inhibitor sensitivity","score":0.6570000052452087},{"id":"https://openalex.org/keywords/leukemogenesis","display_name":"leukemogenesis","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.5690000057220459},{"id":"https://openalex.org/keywords/t315i-mutation","display_name":"T315I mutation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/chronic-myeloid-leukemia","display_name":"chronic myeloid leukemia","score":0.7630000114440918},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.7163903117179871},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6978961229324341},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.660318911075592},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6353510022163391},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.43816789984703064},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.4344395101070404},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.43309780955314636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33319592475891113},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31615233421325684},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.31271445751190186},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1828090250492096},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1626604199409485},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05695238709449768},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.055239468812942505},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014178","descriptor_name":"Translocation, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016044","descriptor_name":"Fusion Proteins, bcr-abl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016313","descriptor_name":"Genes, abl","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018909","descriptor_name":"src Homology Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020014","descriptor_name":"K562 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1038/leu.2010.268","doi":"https://doi.org/10.1038/leu.2010.268","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2010.268","pdf_url":"https://www.nature.com/articles/leu2010268.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3049868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3049868","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Text"},{"id":"pmid:21102429","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21102429","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"Journal Article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt77t5d3q4","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/77t5d3q4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Leukemia, vol 25, iss 2","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt77t5d3q4","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/77t5d3q4","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Leukemia, vol 25, iss 2","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/leu.2010.268","doi":"https://doi.org/10.1038/leu.2010.268","is_oa":true,"landing_page_url":"https://doi.org/10.1038/leu.2010.268","pdf_url":"https://www.nature.com/articles/leu2010268.pdf","source":{"id":"https://openalex.org/S149476849","display_name":"Leukemia","issn_l":"0887-6924","issn":["0887-6924","1476-5551"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Leukemia","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8999999761581421,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.5699999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2295669384","display_name":null,"funder_award_id":"CA136699","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4632117140","display_name":"Mechanism of RIN1 Signaling in Neuronal Plasticity","funder_award_id":"R01NS046787","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G4883047212","display_name":"A Novel Screen for Compounds that Outflank BCR-ABL Drug-Resistance","funder_award_id":"R01CA136699","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"},{"id":"https://openalex.org/F4320338302","display_name":"Jonsson Cancer Center Foundation","ror":"https://ror.org/046rm7j60"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019960565.pdf","grobid_xml":"https://content.openalex.org/works/W2019960565.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W268614872","https://openalex.org/W1603690859","https://openalex.org/W1924282327","https://openalex.org/W1968572823","https://openalex.org/W1973198779","https://openalex.org/W1976990046","https://openalex.org/W1984210773","https://openalex.org/W1989429950","https://openalex.org/W1997577435","https://openalex.org/W1999614615","https://openalex.org/W2000589976","https://openalex.org/W2006518962","https://openalex.org/W2013477475","https://openalex.org/W2013864385","https://openalex.org/W2014249275","https://openalex.org/W2016656445","https://openalex.org/W2033990776","https://openalex.org/W2043018762","https://openalex.org/W2057147161","https://openalex.org/W2058840115","https://openalex.org/W2066211653","https://openalex.org/W2066998725","https://openalex.org/W2074231009","https://openalex.org/W2076101248","https://openalex.org/W2082780838","https://openalex.org/W2085307511","https://openalex.org/W2088811751","https://openalex.org/W2089834044","https://openalex.org/W2090004346","https://openalex.org/W2095229706","https://openalex.org/W2096003848","https://openalex.org/W2100669756","https://openalex.org/W2103513673","https://openalex.org/W2104039084","https://openalex.org/W2105533439","https://openalex.org/W2107503279","https://openalex.org/W2108315653","https://openalex.org/W2110471949","https://openalex.org/W2110648386","https://openalex.org/W2111025707","https://openalex.org/W2112688349","https://openalex.org/W2119847916","https://openalex.org/W2120660100","https://openalex.org/W2128175263","https://openalex.org/W2131174104","https://openalex.org/W2134748741","https://openalex.org/W2136987415","https://openalex.org/W2141753142","https://openalex.org/W2142962849","https://openalex.org/W2148889205","https://openalex.org/W2150866896","https://openalex.org/W2157369898","https://openalex.org/W2161117293","https://openalex.org/W2161835431","https://openalex.org/W2264620640","https://openalex.org/W2275486737","https://openalex.org/W4238038536"],"related_works":["https://openalex.org/W1989429950","https://openalex.org/W1865211688","https://openalex.org/W2111025707","https://openalex.org/W2556047608","https://openalex.org/W2073640953","https://openalex.org/W7097887467","https://openalex.org/W4282978297","https://openalex.org/W2580123825","https://openalex.org/W2579386761","https://openalex.org/W2565152163"],"abstract_inverted_index":{"ABL":[0,25,56,113,165,182],"gene":[1],"translocations":[2],"create":[3],"constitutively":[4],"active":[5],"tyrosine":[6,34],"kinases":[7],"that":[8,31,47,154,170],"are":[9],"causative":[10],"in":[11,185],"chronic":[12],"myeloid":[13],"leukemia,":[14],"acute":[15],"lymphocytic":[16],"leukemia":[17],"and":[18,67,145,179],"other":[19],"hematopoietic":[20],"malignancies.":[21],"Consistent":[22],"retention":[23],"of":[24,104,126,160],"SH3/SH2":[26,57],"autoinhibitory":[27],"domains,":[28],"however,":[29],"suggests":[30],"these":[32],"leukemogenic":[33],"kinase":[35,49,114,183],"fusion":[36],"proteins":[37],"remain":[38],"subject":[39],"to":[40,111,141],"regulation.":[41],"We":[42],"resolve":[43],"this":[44],"paradox,":[45],"demonstrating":[46],"BCR-ABL1":[48,60,107,129],"activity":[50,61],"is":[51],"regulated":[52],"by":[53,64,69,80,91,96,119,139,164],"RIN1,":[54],"an":[55,127],"binding":[58],"protein.":[59],"was":[62,117],"increased":[63,118],"RIN1":[65,70,98,120,124,140,171],"overexpression":[66],"decreased":[68],"silencing.":[71],"Moreover,":[72],"Rin1(-/-)":[73],"bone":[74],"marrow":[75],"cells":[76],"were":[77],"not":[78],"transformed":[79],"BCR-ABL1,":[81],"ETV6-ABL1":[82],"or":[83],"BCR-ABL1(T315I),":[84],"a":[85,100,150],"patient-derived":[86],"drug-resistant":[87],"mutant,":[88],"as":[89],"judged":[90],"growth":[92],"factor":[93],"independence.":[94],"Rescue":[95],"ectopic":[97],"verified":[99],"cell":[101,146],"autonomous":[102],"mechanism":[103],"collaboration":[105],"with":[106,123],"during":[108],"transformation.":[109],"Sensitivity":[110],"the":[112],"inhibitor":[115],"imatinib":[116],"silencing,":[121],"consistent":[122],"stabilization":[125],"activated":[128],"conformation":[130],"having":[131],"reduced":[132],"drug":[133],"affinity.":[134],"The":[135,167],"dependence":[136],"on":[137],"activation":[138],"unleash":[142],"full":[143],"catalytic":[144],"transformation":[147],"potential":[148],"reveals":[149],"previously":[151],"unknown":[152],"vulnerability":[153],"could":[155,173],"be":[156,174],"exploited":[157],"for":[158,176],"treatment":[159],"leukemic":[161],"cases":[162],"driven":[163],"translocations.":[166],"findings":[168],"suggest":[169],"targeting":[172],"efficacious":[175],"imatinib-resistant":[177],"disease":[178],"might":[180],"complement":[181],"inhibitors":[184],"first-line":[186],"therapy.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
