{"id":"https://openalex.org/W2019947482","doi":"https://doi.org/10.1128/jvi.00184-14","title":"In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease","display_name":"In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease","publication_year":2014,"publication_date":"2014-02-26","ids":{"openalex":"https://openalex.org/W2019947482","doi":"https://doi.org/10.1128/jvi.00184-14","mag":"2019947482","pmid":"https://pubmed.ncbi.nlm.nih.gov/24574394","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3993796"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00184-14","doi":"https://doi.org/10.1128/jvi.00184-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00184-14","pdf_url":"https://jvi.asm.org/content/jvi/88/9/5087.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://jvi.asm.org/content/jvi/88/9/5087.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005482776","display_name":"Nadine Althof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadine Althof","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048177811","display_name":"Stephanie Harkins","orcid":"https://orcid.org/0000-0001-7825-4025","observed_orcids":["https://orcid.org/0000-0001-7825-4025"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie Harkins","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046203211","display_name":"Christopher C. Kemball","orcid":"https://orcid.org/0009-0003-9068-8338","observed_orcids":["https://orcid.org/0009-0003-9068-8338"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher C. Kemball","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063148839","display_name":"Claudia T. Flynn","orcid":"https://orcid.org/0009-0003-3067-6781","observed_orcids":["https://orcid.org/0009-0003-3067-6781"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claudia T. Flynn","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069231772","display_name":"Mehrdad Alirezaei","orcid":"https://orcid.org/0000-0003-2154-0789","observed_orcids":["https://orcid.org/0000-0003-2154-0789"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehrdad Alirezaei","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064260007","display_name":"J. Lindsay Whitton","orcid":"https://orcid.org/0000-0001-8218-551X","observed_orcids":["https://orcid.org/0000-0001-8218-551X"]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Lindsay Whitton","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California, USA","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":null,"apc_paid":null,"fwci":2.7444,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.90949442,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"88","issue":"9","first_page":"5087","last_page":"5099"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.8734999895095825,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.12189999967813492,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.8289999961853027},{"id":"https://openalex.org/keywords/type-i-interferon-receptor","display_name":"type I interferon receptor","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8859999775886536},{"id":"https://openalex.org/keywords/coxsackievirus-b3","display_name":"coxsackievirus B3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-myocarditis","display_name":"acute myocarditis","score":0.8709999918937683},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.8299999833106995},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6579999923706055},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5490000247955322},{"id":"https://openalex.org/keywords/focal-infection","display_name":"focal infection","score":0.4399999976158142},{"id":"https://openalex.org/keywords/cardiomyopathy","display_name":"cardiomyopathy","score":0.5720000267028809},{"id":"https://openalex.org/keywords/transgenic-mice","display_name":"transgenic mice","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7948908805847168},{"id":"https://openalex.org/C2779120600","wikidata":"https://www.wikidata.org/wiki/Q1138287","display_name":"Coxsackievirus","level":4,"score":0.7074451446533203},{"id":"https://openalex.org/C2780875844","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Myocarditis","level":2,"score":0.7029294967651367},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6888059973716736},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5464982390403748},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.5174115896224976},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5151439905166626},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49759557843208313},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4912976622581482},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.4896877110004425},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.46643686294555664},{"id":"https://openalex.org/C2909190889","wikidata":"https://www.wikidata.org/wiki/Q186235","display_name":"Viral Myocarditis","level":3,"score":0.45121386647224426},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.43468767404556274},{"id":"https://openalex.org/C2777888124","wikidata":"https://www.wikidata.org/wiki/Q519796","display_name":"Enterovirus","level":3,"score":0.3247998356819153},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2605498433113098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13116711378097534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003384","descriptor_name":"Coxsackievirus Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009205","descriptor_name":"Myocarditis","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029822","descriptor_name":"Enterovirus B, Human","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D053633","descriptor_name":"Receptor, Interferon alpha-beta","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1128/jvi.00184-14","doi":"https://doi.org/10.1128/jvi.00184-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00184-14","pdf_url":"https://jvi.asm.org/content/jvi/88/9/5087.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3993796","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3993796","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Virol","raw_type":"Text"},{"id":"pmid:24574394","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24574394","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00184-14","doi":"https://doi.org/10.1128/jvi.00184-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00184-14","pdf_url":"https://jvi.asm.org/content/jvi/88/9/5087.full.pdf","source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8700000047683716}],"study_designs":[],"awards":[{"id":"https://openalex.org/G319759129","display_name":"Coxsackie Myocarditis and Viral Persistence in the Heart","funder_award_id":"R01AI042314","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3382987919","display_name":null,"funder_award_id":"AI-042314","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5039035362","display_name":null,"funder_award_id":"HL093177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6170509322","display_name":"Analyzing the effects of type I interferons in the enterovirus-infected heart","funder_award_id":"R01AI110621","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7088203755","display_name":"Training in Immunology and Molecular Pathogenesis","funder_award_id":"T32AI007610","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8743919973","display_name":"Innate and Adaptive Immune Responses in the Virus-Infected Heart","funder_award_id":"R01HL093177","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W2019947482.pdf"},"referenced_works_count":103,"referenced_works":["https://openalex.org/W3575872","https://openalex.org/W97974045","https://openalex.org/W197664057","https://openalex.org/W1525846398","https://openalex.org/W1537472448","https://openalex.org/W1565506790","https://openalex.org/W1732323254","https://openalex.org/W1798317578","https://openalex.org/W1875946043","https://openalex.org/W1968720766","https://openalex.org/W1970953541","https://openalex.org/W1972650771","https://openalex.org/W1974130697","https://openalex.org/W1978503782","https://openalex.org/W1979944315","https://openalex.org/W1988041124","https://openalex.org/W1996368356","https://openalex.org/W1998631730","https://openalex.org/W1999669258","https://openalex.org/W2001043513","https://openalex.org/W2004829503","https://openalex.org/W2010197322","https://openalex.org/W2011075614","https://openalex.org/W2011326628","https://openalex.org/W2015708271","https://openalex.org/W2016578964","https://openalex.org/W2022477315","https://openalex.org/W2022753461","https://openalex.org/W2025371580","https://openalex.org/W2026895252","https://openalex.org/W2031066016","https://openalex.org/W2032235021","https://openalex.org/W2036872855","https://openalex.org/W2037872087","https://openalex.org/W2040653543","https://openalex.org/W2041562506","https://openalex.org/W2047882003","https://openalex.org/W2048267645","https://openalex.org/W2049639045","https://openalex.org/W2054626746","https://openalex.org/W2055374064","https://openalex.org/W2059395206","https://openalex.org/W2059884663","https://openalex.org/W2068625452","https://openalex.org/W2068871282","https://openalex.org/W2070103589","https://openalex.org/W2071556127","https://openalex.org/W2072851969","https://openalex.org/W2073715156","https://openalex.org/W2076690763","https://openalex.org/W2076794877","https://openalex.org/W2081745189","https://openalex.org/W2083973655","https://openalex.org/W2086655271","https://openalex.org/W2086886993","https://openalex.org/W2087837555","https://openalex.org/W2088074892","https://openalex.org/W2089932575","https://openalex.org/W2092176663","https://openalex.org/W2095480645","https://openalex.org/W2099633666","https://openalex.org/W2102196716","https://openalex.org/W2104010513","https://openalex.org/W2113080976","https://openalex.org/W2116778443","https://openalex.org/W2116787729","https://openalex.org/W2117963002","https://openalex.org/W2120348388","https://openalex.org/W2127407420","https://openalex.org/W2128821726","https://openalex.org/W2130491986","https://openalex.org/W2132819084","https://openalex.org/W2134039588","https://openalex.org/W2134208169","https://openalex.org/W2134707116","https://openalex.org/W2137198892","https://openalex.org/W2137937248","https://openalex.org/W2145812105","https://openalex.org/W2146150145","https://openalex.org/W2146230109","https://openalex.org/W2146566162","https://openalex.org/W2147692295","https://openalex.org/W2150501736","https://openalex.org/W2150634944","https://openalex.org/W2152072371","https://openalex.org/W2153542390","https://openalex.org/W2158953832","https://openalex.org/W2159041114","https://openalex.org/W2159868031","https://openalex.org/W2160161662","https://openalex.org/W2164362872","https://openalex.org/W2167317609","https://openalex.org/W2169405818","https://openalex.org/W2412203034","https://openalex.org/W2412554379","https://openalex.org/W2412875234","https://openalex.org/W2468571675","https://openalex.org/W2468830975","https://openalex.org/W2600089808","https://openalex.org/W4211040940","https://openalex.org/W4239797347","https://openalex.org/W4240413437","https://openalex.org/W4313333733"],"related_works":["https://openalex.org/W2153542390","https://openalex.org/W2937959237","https://openalex.org/W7096425954","https://openalex.org/W2113080976","https://openalex.org/W2099633666","https://openalex.org/W1493687925","https://openalex.org/W2025371580","https://openalex.org/W2076794877","https://openalex.org/W2031066016","https://openalex.org/W1875946043"],"abstract_inverted_index":{"UNLABELLED:":[0],"Acute":[1,256],"coxsackievirus":[2,257],"B3":[3,258],"(CVB3)":[4,259],"infection":[5,36,197,226,260,323],"is":[6,20,37,261,281],"one":[7,262],"of":[8,13,27,44,91,98,132,145,224,232,246,263,268,332],"the":[9,24,35,42,55,62,96,101,109,130,140,143,179,189,195,202,220,225,228,264,286,294,325],"most":[10,265],"prevalent":[11],"causes":[12,267],"acute":[14,269],"myocarditis,":[15,270,347],"a":[16,45,88,104,165,185,241,250,271,303,329],"disease":[17],"that":[18,51,122,178,210,283,289,316,337],"frequently":[19],"identified":[21],"only":[22],"after":[23],"sudden":[25],"death":[26],"apparently":[28],"healthy":[29],"individuals.":[30],"CVB3":[31,84,322],"infects":[32],"cardiomyocytes,":[33,343],"but":[34,311],"highly":[38,81,199],"focal,":[39,200],"even":[40],"in":[41,100,107,115,118,139,142,192,253,293,306],"absence":[43,144,231],"strong":[46],"adaptive":[47],"immune":[48,64,287],"response,":[49],"suggesting":[50,177],"virus":[52,137,148,170,291,309],"spread":[53,292],"within":[54,87,324],"heart":[56,102,295],"may":[57,182,318],"be":[58,113],"tightly":[59],"constrained":[60],"by":[61,153,240,249],"innate":[63],"system.":[65],"Type":[66,299],"I":[67,300],"interferons":[68,301],"(T1IFNs)":[69],"are":[70,80,216],"an":[71],"obvious":[72],"candidate,":[73],"and":[74,135,158,244,248,273,296,348],"T1IFN":[75,123,233],"receptor":[76],"(T1IFNR)":[77],"knockout":[78],"mice":[79,194],"susceptible":[82],"to":[83,129,205,207,218],"infection,":[85],"succumbing":[86],"few":[89],"days":[90],"challenge.":[92],"Here,":[93,327],"we":[94,284,335],"investigated":[95],"role":[97,305],"T1IFNs":[99],"using":[103,328],"mouse":[105],"model":[106],"which":[108,169],"T1IFNR":[110],"gene":[111],"can":[112],"ablated":[114],"vivo,":[116],"specifically":[117],"cardiomyocytes.":[119],"We":[120],"found":[121],"signaling":[124,234],"into":[125,235,342],"cardiomyocytes":[126,181,236],"contributed":[127],"substantially":[128],"suppression":[131],"viral":[133,345],"replication":[134],"infectious":[136],"yield":[138],"heart;":[141],"such":[146],"signaling,":[147],"titers":[149],"were":[150],"markedly":[151],"elevated":[152],"day":[154,162],"3":[155],"postinfection":[156],"(p.i.)":[157],"remained":[159,198],"high":[160],"at":[161,168],"12":[163],"p.i.,":[164],"time":[166],"point":[167],"was":[171,238],"absent":[172],"from":[173],"genetically":[174],"intact":[175],"littermates,":[176],"T1IFN-unresponsive":[180],"act":[183],"as":[184,213],"safe":[186],"haven":[187],"for":[188],"virus.":[190],"Nevertheless,":[191],"these":[193,338],"myocardial":[196],"despite":[201],"cardiomyocytes'":[203],"inability":[204],"respond":[206],"T1IFN,":[208],"indicating":[209],"other":[211,297],"factors,":[212],"yet":[214],"unidentified,":[215],"sufficient":[217],"prevent":[219],"more":[221],"widespread":[222],"dissemination":[223],"throughout":[227],"heart.":[229,326],"The":[230],"also":[237],"accompanied":[239],"profound":[242],"acceleration":[243],"exacerbation":[245],"myocarditis":[247],"significant":[251],"increase":[252],"mortality.":[254],"IMPORTANCE:":[255],"common":[266],"serious":[272],"sometimes":[274],"fatal":[275],"disease.":[276],"To":[277],"optimize":[278],"treatment,":[279],"it":[280,312],"vital":[282],"identify":[285],"factors":[288],"limit":[290],"organs.":[298],"play":[302],"key":[304],"controlling":[307],"many":[308],"infections,":[310],"has":[313],"been":[314],"suggested":[315],"they":[317],"not":[319],"directly":[320,341],"impact":[321],"novel":[330],"line":[331],"transgenic":[333],"mice,":[334],"show":[336],"cytokines":[339],"signal":[340],"limiting":[344],"replication,":[346],"death.":[349]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
