{"id":"https://openalex.org/W2019939591","doi":"https://doi.org/10.1016/s0165-0327(98)00221-3","title":"Mechanism of action of serotonin selective reuptake inhibitors","display_name":"Mechanism of action of serotonin selective reuptake inhibitors","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W2019939591","doi":"https://doi.org/10.1016/s0165-0327(98)00221-3","mag":"2019939591","pmid":"https://pubmed.ncbi.nlm.nih.gov/10333979"},"language":"en","primary_location":{"id":"doi:10.1016/s0165-0327(98)00221-3","doi":"https://doi.org/10.1016/s0165-0327(98)00221-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-0327(98)00221-3","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015501263","display_name":"Stephen M. Stahl","orcid":"https://orcid.org/0000-0002-6536-6973","observed_orcids":["https://orcid.org/0000-0002-6536-6973"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Stephen M. Stahl","raw_affiliation_strings":["Clinical Neuroscience Research Center, San Diego, CA 02122, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroscience Research Center, San Diego, CA 02122, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5015501263"],"corresponding_institution_ids":[],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":null,"fwci":0.2773,"has_fulltext":false,"cited_by_count":563,"citation_normalized_percentile":{"value":0.26970954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"51","issue":"3","first_page":"215","last_page":"235"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.8726000189781189,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.09260000288486481,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0284000001847744,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/selective-serotonin-reuptake-inhibitors","display_name":"selective serotonin reuptake inhibitors","score":0.9459999799728394},{"id":"https://openalex.org/keywords/serotonin-transporter","display_name":"serotonin transporter","score":0.7829999923706055},{"id":"https://openalex.org/keywords/negative-allosteric-modulation","display_name":"negative allosteric modulation","score":0.9570000171661377},{"id":"https://openalex.org/keywords/serotonin-receptor-subtypes","display_name":"serotonin receptor subtypes","score":0.6809999942779541},{"id":"https://openalex.org/keywords/5-ht1a-autoreceptors","display_name":"5-HT1A autoreceptors","score":0.8930000066757202},{"id":"https://openalex.org/keywords/receptor-desensitization","display_name":"receptor desensitization","score":0.9179999828338623},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6309999823570251},{"id":"https://openalex.org/keywords/antidepressant-mechanism-of-action","display_name":"antidepressant mechanism","score":0.7080000042915344},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.44999998807907104},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.9240000247955322},{"id":"https://openalex.org/keywords/panic-disorder","display_name":"panic disorder","score":0.8180000185966492},{"id":"https://openalex.org/keywords/bulimia-nervosa","display_name":"bulimia nervosa","score":0.890999972820282},{"id":"https://openalex.org/keywords/midbrain-raphe","display_name":"midbrain raphe","score":0.6819999814033508}],"concepts":[{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.7321890592575073},{"id":"https://openalex.org/C2778897192","wikidata":"https://www.wikidata.org/wiki/Q410142","display_name":"Serotonin transporter","level":4,"score":0.6372393369674683},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5930696725845337},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.5809822678565979},{"id":"https://openalex.org/C2908747647","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"Serotonin Plasma Membrane Transport Proteins","level":5,"score":0.500063419342041},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.48824313282966614},{"id":"https://openalex.org/C8439214","wikidata":"https://www.wikidata.org/wiki/Q417749","display_name":"Autoreceptor","level":4,"score":0.47422122955322266},{"id":"https://openalex.org/C2779779143","wikidata":"https://www.wikidata.org/wiki/Q3493547","display_name":"Desensitization (medicine)","level":3,"score":0.47384458780288696},{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.4582926034927368},{"id":"https://openalex.org/C31487548","wikidata":"https://www.wikidata.org/wiki/Q4859664","display_name":"Reuptake inhibitor","level":4,"score":0.4416746497154236},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.41595563292503357},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3695477247238159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3128765821456909},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3090249300003052},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1593591868877411},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001523","descriptor_name":"Mental Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002032","descriptor_name":"Bulimia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002032","descriptor_name":"Bulimia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008636","descriptor_name":"Mesencephalon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011903","descriptor_name":"Raphe Nuclei","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016584","descriptor_name":"Panic Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016584","descriptor_name":"Panic Disorder","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017367","descriptor_name":"Selective Serotonin Reuptake Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D017660","descriptor_name":"Autoreceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017660","descriptor_name":"Autoreceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0165-0327(98)00221-3","doi":"https://doi.org/10.1016/s0165-0327(98)00221-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0165-0327(98)00221-3","pdf_url":null,"source":{"id":"https://openalex.org/S113871862","display_name":"Journal of Affective Disorders","issn_l":"0165-0327","issn":["0165-0327","1573-2517"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Affective Disorders","raw_type":"journal-article"},{"id":"pmid:10333979","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10333979","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of affective disorders","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5627724609","display_name":null,"funder_award_id":"5 RO1 MH45787-02","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6219254170","display_name":"HUMAN 5HT RECEPTOR REGULATION BY ANTIDEPRESSANTS","funder_award_id":"R01MH045787","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G8878637015","display_name":"General Clinical Research Center","funder_award_id":"M01RR000827","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G892026892","display_name":null,"funder_award_id":"MH30914","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W28253652","https://openalex.org/W59067326","https://openalex.org/W84973167","https://openalex.org/W107719831","https://openalex.org/W113922606","https://openalex.org/W156306960","https://openalex.org/W309976811","https://openalex.org/W413659140","https://openalex.org/W414535264","https://openalex.org/W567851353","https://openalex.org/W576858572","https://openalex.org/W588751218","https://openalex.org/W1522214799","https://openalex.org/W1539382539","https://openalex.org/W1605166260","https://openalex.org/W1745413444","https://openalex.org/W1862144680","https://openalex.org/W1940108733","https://openalex.org/W1964560048","https://openalex.org/W1965174921","https://openalex.org/W1975429926","https://openalex.org/W1976034286","https://openalex.org/W1979231092","https://openalex.org/W1979274121","https://openalex.org/W1984737218","https://openalex.org/W1988834587","https://openalex.org/W1991708936","https://openalex.org/W1997491331","https://openalex.org/W1998148889","https://openalex.org/W1998531143","https://openalex.org/W2000186902","https://openalex.org/W2001233081","https://openalex.org/W2002033308","https://openalex.org/W2002224654","https://openalex.org/W2002305756","https://openalex.org/W2012838392","https://openalex.org/W2016025411","https://openalex.org/W2016325203","https://openalex.org/W2017358382","https://openalex.org/W2019521957","https://openalex.org/W2024008470","https://openalex.org/W2027571060","https://openalex.org/W2028560297","https://openalex.org/W2035632600","https://openalex.org/W2040798945","https://openalex.org/W2044436505","https://openalex.org/W2048283236","https://openalex.org/W2049640043","https://openalex.org/W2050850901","https://openalex.org/W2051531767","https://openalex.org/W2054450221","https://openalex.org/W2064611362","https://openalex.org/W2072447647","https://openalex.org/W2076112136","https://openalex.org/W2077660449","https://openalex.org/W2082119274","https://openalex.org/W2083659148","https://openalex.org/W2084240947","https://openalex.org/W2084565105","https://openalex.org/W2086193772","https://openalex.org/W2087396777","https://openalex.org/W2089417412","https://openalex.org/W2092326568","https://openalex.org/W2092880342","https://openalex.org/W2094417837","https://openalex.org/W2094615514","https://openalex.org/W2098847323","https://openalex.org/W2106918877","https://openalex.org/W2140163531","https://openalex.org/W2141778027","https://openalex.org/W2146162140","https://openalex.org/W2149328165","https://openalex.org/W2152962921","https://openalex.org/W2173228382","https://openalex.org/W2217465947","https://openalex.org/W2221127954","https://openalex.org/W2280684008","https://openalex.org/W2290621392","https://openalex.org/W2313002552","https://openalex.org/W2326068394","https://openalex.org/W2330237148","https://openalex.org/W2336274156","https://openalex.org/W2341365624","https://openalex.org/W2391176442","https://openalex.org/W2400988824","https://openalex.org/W2407115578","https://openalex.org/W2407523820","https://openalex.org/W2408477947","https://openalex.org/W2415110042","https://openalex.org/W2425952345","https://openalex.org/W2486442685","https://openalex.org/W2487294570","https://openalex.org/W2487648474","https://openalex.org/W2488542613","https://openalex.org/W2886879883","https://openalex.org/W4239438238","https://openalex.org/W6640449102","https://openalex.org/W6713845385"],"related_works":["https://openalex.org/W2424611615","https://openalex.org/W1988612597","https://openalex.org/W1976336543","https://openalex.org/W2403951278","https://openalex.org/W1998519842","https://openalex.org/W2028977103","https://openalex.org/W203710690","https://openalex.org/W2034272133","https://openalex.org/W7117537834","https://openalex.org/W1991461979"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":27},{"year":2025,"cited_by_count":35},{"year":2024,"cited_by_count":26},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":34},{"year":2018,"cited_by_count":28},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":21}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
