{"id":"https://openalex.org/W2019884283","doi":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","title":"Detection of bovine leukocyte adhesion deficiency by nonisotopic ligase chain reaction","display_name":"Detection of bovine leukocyte adhesion deficiency by nonisotopic ligase chain reaction","publication_year":1994,"publication_date":"1994-04-01","ids":{"openalex":"https://openalex.org/W2019884283","doi":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","mag":"2019884283","pmid":"https://pubmed.ncbi.nlm.nih.gov/7912052"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2052.1994.tb00086.x","doi":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","pdf_url":null,"source":{"id":"https://openalex.org/S12146737","display_name":"Animal Genetics","issn_l":"0268-9146","issn":["0268-9146","1365-2052"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112416559","display_name":"Carl A. Batt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210092791","display_name":"New York State College of Agriculture & Life Sciences","ror":"https://ror.org/00j52pq61","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"C A Batt","raw_affiliation_strings":["Department of Food Science, Cornell University, Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007813839","display_name":"P. Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210092791","display_name":"New York State College of Agriculture & Life Sciences","ror":"https://ror.org/00j52pq61","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P Wagner","raw_affiliation_strings":["Department of Food Science, Cornell University, Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082217142","display_name":"Martin Wiedmann","orcid":"https://orcid.org/0000-0002-4168-5662","observed_orcids":["https://orcid.org/0000-0002-4168-5662"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210092791","display_name":"New York State College of Agriculture & Life Sciences","ror":"https://ror.org/00j52pq61","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M Wiedmann","raw_affiliation_strings":["Department of Food Science, Cornell University, Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Food Science, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210092791"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108433392","display_name":"J. Luo","orcid":"https://orcid.org/0009-0008-6813-6074","observed_orcids":["https://orcid.org/0009-0008-6813-6074"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianying Luo","raw_affiliation_strings":["Department of Microbiology, Cornell University Medical College, New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Cornell University Medical College, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040939595","display_name":"Robert Owen Gilbert","orcid":"https://orcid.org/0000-0002-1528-243X","observed_orcids":["https://orcid.org/0000-0002-1528-243X"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4210151139","display_name":"New York State College of Veterinary Medicine","ror":"https://ror.org/04r17kf39","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Gilbert","raw_affiliation_strings":["New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York State College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210151139"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5112416559"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4210092791"],"apc_list":{"value":3570,"currency":"USD","value_usd":3570},"apc_paid":null,"fwci":0.8424,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.72847347,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"25","issue":"2","first_page":"95","last_page":"98"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.7153000235557556,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12322","display_name":"Animal health and immunology","score":0.05849999934434891,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.04479999840259552,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bovine-leukocyte-adhesion-deficiency","display_name":"bovine leukocyte adhesion deficiency","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ligase-chain-reaction","display_name":"ligase chain reaction","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nonisotopic-detection","display_name":"nonisotopic detection","score":0.8399999737739563},{"id":"https://openalex.org/keywords/digoxigenin-labeled-probes","display_name":"digoxigenin-labeled probes","score":0.6520000100135803},{"id":"https://openalex.org/keywords/alkaline-phosphatase-detection","display_name":"alkaline phosphatase detection","score":0.843999981880188},{"id":"https://openalex.org/keywords/chemiluminescence","display_name":"chemiluminescence","score":0.8539999723434448},{"id":"https://openalex.org/keywords/cattle","display_name":"cattle","score":0.31299999356269836}],"concepts":[{"id":"https://openalex.org/C2776342803","wikidata":"https://www.wikidata.org/wiki/Q1154422","display_name":"Leukocyte adhesion deficiency","level":5,"score":0.772130012512207},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7401242852210999},{"id":"https://openalex.org/C2777563447","wikidata":"https://www.wikidata.org/wiki/Q7243397","display_name":"Primer (cosmetics)","level":2,"score":0.7251831889152527},{"id":"https://openalex.org/C47558249","wikidata":"https://www.wikidata.org/wiki/Q1422343","display_name":"Ligase chain reaction","level":5,"score":0.7200909852981567},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6426894068717957},{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.6117643713951111},{"id":"https://openalex.org/C2776552150","wikidata":"https://www.wikidata.org/wiki/Q420728","display_name":"Digoxigenin","level":5,"score":0.4706415832042694},{"id":"https://openalex.org/C145802702","wikidata":"https://www.wikidata.org/wiki/Q2931725","display_name":"Chemiluminescence","level":2,"score":0.45802435278892517},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4549417793750763},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4166313707828522},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.3986471891403198},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27707165479660034},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23888900876045227},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.2065918743610382},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.19010215997695923},{"id":"https://openalex.org/C90583042","wikidata":"https://www.wikidata.org/wiki/Q1952456","display_name":"Multiplex polymerase chain reaction","level":4,"score":0.1264704167842865},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0631878674030304},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.0},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.0},{"id":"https://openalex.org/C53122370","wikidata":"https://www.wikidata.org/wiki/Q2458503","display_name":"CD18","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002418","descriptor_name":"Cattle Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007153","descriptor_name":"Immunologic Deficiency Syndromes","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008025","descriptor_name":"Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012150","descriptor_name":"Polymorphism, Restriction Fragment Length","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D016177","descriptor_name":"Macrophage-1 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2052.1994.tb00086.x","doi":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2052.1994.tb00086.x","pdf_url":null,"source":{"id":"https://openalex.org/S12146737","display_name":"Animal Genetics","issn_l":"0268-9146","issn":["0268-9146","1365-2052"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal Genetics","raw_type":"journal-article"},{"id":"pmid:7912052","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7912052","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Animal genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1528279264","https://openalex.org/W1593380699","https://openalex.org/W1968876320","https://openalex.org/W1987061468","https://openalex.org/W1987834144","https://openalex.org/W2024187094","https://openalex.org/W2044692125","https://openalex.org/W2050948936","https://openalex.org/W2080471687","https://openalex.org/W2117686311","https://openalex.org/W2156380818","https://openalex.org/W2314225431","https://openalex.org/W2322232905","https://openalex.org/W4390363883"],"related_works":["https://openalex.org/W2510482997","https://openalex.org/W288418612","https://openalex.org/W1999790117","https://openalex.org/W2407950292","https://openalex.org/W2322232905","https://openalex.org/W2076661587","https://openalex.org/W2387771106","https://openalex.org/W1966869686","https://openalex.org/W2087470863","https://openalex.org/W2148523909"],"abstract_inverted_index":{"A":[0,73],"nonisotopic":[1],"ligase":[2],"chain":[3],"reaction":[4],"(LCR)":[5],"assay":[6,104,120],"was":[7,106],"developed":[8],"to":[9,100],"detect":[10],"the":[11,37,46,53,112,118],"mutation":[12],"(D128G;":[13],"Shuster":[14],"et":[15],"al.":[16],"(1992)":[17],"PNAS":[18],"89,":[19],"9225-9)":[20],"for":[21],"bovine":[22],"leukocyte":[23],"adhesion":[24],"deficiency":[25],"(BLAD).":[26],"Two":[27],"sets":[28],"of":[29,49,76,114],"diagonally":[30],"opposed":[31],"discriminating":[32,57,81],"LCR":[33,91],"primers":[34,58,77,82],"that":[35,45,78],"differentiate":[36],"normal":[38],"and":[39,65,86,117],"BLAD":[40],"allele":[41],"were":[42,59,83,93],"designed":[43],"so":[44],"3'":[47],"end":[48],"each":[50],"primer":[51],"overlapped":[52],"D128G":[54],"mutation.":[55],"These":[56],"synthesized":[60,85],"with":[61,88],"a":[62,107],"5'":[63],"biotin":[64],"could":[66],"be":[67,125],"captured":[68],"using":[69,96],"streptavidin-coated":[70],"microtitre":[71],"wells.":[72],"common":[74],"set":[75],"abut":[79],"these":[80],"also":[84],"3'-tailed":[87],"digoxigenin-ddUTP.":[89],"Captured":[90],"products":[92],"then":[94],"detected":[95],"antidigoxigenin":[97],"antibodies":[98],"coupled":[99],"alkaline":[101],"phosphatase.":[102],"The":[103],"readout":[105],"chemiluminescent":[108],"signal":[109],"generated":[110],"by":[111],"hydrolysis":[113],"Lumi-Phos":[115],"530":[116],"entire":[119],"including":[121],"DNA":[122],"isolation":[123],"can":[124],"completed":[126],"within":[127],"8":[128],"h.":[129]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
