{"id":"https://openalex.org/W2019870824","doi":"https://doi.org/10.1006/bbrc.1996.1888","title":"Transcriptional Regulation of \u03b3-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells","display_name":"Transcriptional Regulation of \u03b3-Glutamylcysteine Synthetase-Heavy Subunit by Oxidants in Human Alveolar Epithelial Cells","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2019870824","doi":"https://doi.org/10.1006/bbrc.1996.1888","mag":"2019870824","pmid":"https://pubmed.ncbi.nlm.nih.gov/8954980"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.1996.1888","doi":"https://doi.org/10.1006/bbrc.1996.1888","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1996.1888","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058348723","display_name":"Irfan Rahman","orcid":"https://orcid.org/0000-0003-2274-2454","observed_orcids":["https://orcid.org/0000-0003-2274-2454"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Irfan Rahman","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, Scotland, EH8 9AG, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, Scotland, EH8 9AG, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073886243","display_name":"Agnes Bel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Agnes Bel","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017317372","display_name":"Brigitte Mulier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Brigitte Mulier","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042942054","display_name":"Mark F. Lawson","orcid":"https://orcid.org/0000-0001-5361-2842","observed_orcids":["https://orcid.org/0000-0001-5361-2842"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mark F. Lawson","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064922783","display_name":"David James Harrison","orcid":"https://orcid.org/0000-0001-9041-9988","observed_orcids":["https://orcid.org/0000-0001-9041-9988"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Harrison","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050425677","display_name":"William MacNee","orcid":"https://orcid.org/0000-0002-3692-1448","observed_orcids":["https://orcid.org/0000-0002-3692-1448"]},"institutions":[{"id":"https://openalex.org/I2802789809","display_name":"Edinburgh Royal Infirmary","ror":"https://ror.org/009bsy196","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2802789809"]},{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"William Macnee","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Medicine, Department of the Royal Infirmary, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I2802789809","https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103634474","display_name":"Christopher A.D. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher A.D. Smith","raw_affiliation_strings":["Rayne Laboratory, Respiratory Medicine Unit, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, Department of Pathology, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]},{"raw_affiliation_string":"Rayne Laboratory, Respiratory Medicine Unit, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058348723"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":4.544,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.95660877,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"229","issue":"3","first_page":"832","last_page":"837"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.5692999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12187","display_name":"Glutathione Transferases and Polymorphisms","score":0.17180000245571136,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.16990000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gamma-glutamylcysteine-synthetase","display_name":"gamma-glutamylcysteine synthetase","score":0.9200000166893005},{"id":"https://openalex.org/keywords/glutathione-synthesis","display_name":"glutathione synthesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.7120000123977661},{"id":"https://openalex.org/keywords/antioxidant-response-element","display_name":"antioxidant response element","score":0.765999972820282},{"id":"https://openalex.org/keywords/promoter-analysis","display_name":"promoter analysis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/menadione","display_name":"menadione","score":0.8220000267028809},{"id":"https://openalex.org/keywords/hydrogen-peroxide","display_name":"hydrogen peroxide","score":1.0},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.9139999747276306},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8650000095367432},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.7179999947547913}],"concepts":[{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.8226160407066345},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5277234315872192},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5071964263916016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35154932737350464},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32420802116394043},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32021379470825195},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3068024516105652}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005721","descriptor_name":"Glutamate-Cysteine Ligase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005721","descriptor_name":"Glutamate-Cysteine Ligase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006861","descriptor_name":"Hydrogen Peroxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D016877","descriptor_name":"Oxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.1996.1888","doi":"https://doi.org/10.1006/bbrc.1996.1888","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.1996.1888","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:8954980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8954980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.504800021648407,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","score":0.46000000834465027,"display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2076785040","https://openalex.org/W2151387909","https://openalex.org/W1580210576","https://openalex.org/W2184733840","https://openalex.org/W2001051081","https://openalex.org/W126979569","https://openalex.org/W1982585224","https://openalex.org/W2175898172","https://openalex.org/W2078256247","https://openalex.org/W2115646712"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}