{"id":"https://openalex.org/W2019851271","doi":"https://doi.org/10.1021/ic2012843","title":"Analysis of the Conformational Behavior and Stability of the SAP and TSAP Isomers of Lanthanide(III) NB-DOTA-Type Chelates","display_name":"Analysis of the Conformational Behavior and Stability of the SAP and TSAP Isomers of Lanthanide(III) NB-DOTA-Type Chelates","publication_year":2011,"publication_date":"2011-08-05","ids":{"openalex":"https://openalex.org/W2019851271","doi":"https://doi.org/10.1021/ic2012843","mag":"2019851271","pmid":"https://pubmed.ncbi.nlm.nih.gov/21819053","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204396"},"language":"en","primary_location":{"id":"doi:10.1021/ic2012843","doi":"https://doi.org/10.1021/ic2012843","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic2012843","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204396","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047385121","display_name":"Gyula Tircs\u00f3","orcid":"https://orcid.org/0000-0002-7896-7890","observed_orcids":["https://orcid.org/0000-0002-7896-7890"]},"institutions":[{"id":"https://openalex.org/I132735039","display_name":"University of Debrecen","ror":"https://ror.org/02xf66n48","country_code":"HU","type":"education","lineage":["https://openalex.org/I132735039"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gyula Tircso","raw_affiliation_strings":["Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, Egyetem t\u00e9r 1, Debrecen H-4010, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Inorganic and Analytical Chemistry, University of Debrecen, P.O. Box 21, Egyetem t\u00e9r 1, Debrecen H-4010, Hungary","institution_ids":["https://openalex.org/I132735039"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078363956","display_name":"Benjamin C. Webber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin C. Webber","raw_affiliation_strings":["Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon 97201, United States","PORTLAND STATE UNIVERSITY,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I126345244"]},{"raw_affiliation_string":"PORTLAND STATE UNIVERSITY,","institution_ids":["https://openalex.org/I126345244"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020871997","display_name":"B.E. Kucera","orcid":"https://orcid.org/0000-0002-5321-5131","observed_orcids":["https://orcid.org/0000-0002-5321-5131"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin E. Kucera","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083276722","display_name":"Victor G. Young","orcid":"https://orcid.org/0000-0003-4238-0032","observed_orcids":["https://orcid.org/0000-0003-4238-0032"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor G. Young","raw_affiliation_strings":["Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455, United States","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005068927","display_name":"Mark Woods","orcid":"https://orcid.org/0000-0003-4890-7544","observed_orcids":["https://orcid.org/0000-0003-4890-7544"]},"institutions":[{"id":"https://openalex.org/I126345244","display_name":"Portland State University","ror":"https://ror.org/00yn2fy02","country_code":"US","type":"education","lineage":["https://openalex.org/I126345244"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark Woods","raw_affiliation_strings":["Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L485, Portland, Oregon 97239, United States","Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon 97201, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Imaging Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L485, Portland, Oregon 97239, United States","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Department of Chemistry, Portland State University, 1719 SW 10th Avenue, Portland, Oregon 97201, United States","institution_ids":["https://openalex.org/I126345244"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5005068927"],"corresponding_institution_ids":["https://openalex.org/I126345244","https://openalex.org/I165690674"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.8223,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.84524411,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"50","issue":"17","first_page":"7966","last_page":"7979"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11279","display_name":"Lanthanide and Transition Metal Complexes","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10578","display_name":"Supramolecular Chemistry and Complexes","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/regioisomers","display_name":"regioisomers","score":0.902999997138977},{"id":"https://openalex.org/keywords/chelate-stability","display_name":"chelate stability","score":0.6340000033378601},{"id":"https://openalex.org/keywords/ligand-conformation","display_name":"ligand conformation","score":0.7120000123977661},{"id":"https://openalex.org/keywords/water-exchange-kinetics","display_name":"water exchange kinetics","score":0.8629999756813049},{"id":"https://openalex.org/keywords/relaxivity","display_name":"relaxivity","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9342939257621765},{"id":"https://openalex.org/C2779931791","wikidata":"https://www.wikidata.org/wiki/Q161515","display_name":"DOTA","level":3,"score":0.8975890874862671},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.7897582054138184},{"id":"https://openalex.org/C197404232","wikidata":"https://www.wikidata.org/wiki/Q319827","display_name":"Chelation","level":2,"score":0.7032830715179443},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.6788076162338257},{"id":"https://openalex.org/C201770740","wikidata":"https://www.wikidata.org/wiki/Q19569","display_name":"Lanthanide","level":3,"score":0.6520564556121826},{"id":"https://openalex.org/C2779432074","wikidata":"https://www.wikidata.org/wiki/Q25323956","display_name":"Macrocyclic ligand","level":3,"score":0.5694596171379089},{"id":"https://openalex.org/C2776525051","wikidata":"https://www.wikidata.org/wiki/Q1154761","display_name":"Square antiprism","level":4,"score":0.47727006673812866},{"id":"https://openalex.org/C202235601","wikidata":"https://www.wikidata.org/wiki/Q7361732","display_name":"Structural isomer","level":2,"score":0.46967798471450806},{"id":"https://openalex.org/C68913812","wikidata":"https://www.wikidata.org/wiki/Q238156","display_name":"Coordination complex","level":3,"score":0.4460860788822174},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.4434829652309418},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4231751561164856},{"id":"https://openalex.org/C2777459166","wikidata":"https://www.wikidata.org/wiki/Q416407","display_name":"Cyclen","level":2,"score":0.4125370979309082},{"id":"https://openalex.org/C115624301","wikidata":"https://www.wikidata.org/wiki/Q895901","display_name":"Crystal structure","level":2,"score":0.22013935446739197},{"id":"https://openalex.org/C544153396","wikidata":"https://www.wikidata.org/wiki/Q11426","display_name":"Metal","level":2,"score":0.1715581715106964},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15179961919784546},{"id":"https://openalex.org/C145148216","wikidata":"https://www.wikidata.org/wiki/Q36496","display_name":"Ion","level":2,"score":0.084570974111557},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002614","descriptor_name":"Chelating Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D003287","descriptor_name":"Contrast Media","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006573","descriptor_name":"Heterocyclic Compounds, 1-Ring","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D009942","descriptor_name":"Organometallic Compounds","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013237","descriptor_name":"Stereoisomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013816","descriptor_name":"Thermodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D028581","descriptor_name":"Lanthanoid Series Elements","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1021/ic2012843","doi":"https://doi.org/10.1021/ic2012843","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ic2012843","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},{"id":"pmid:21819053","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21819053","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:real.mtak.hu:15662","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/15662/1/IC_2011_pNO2BzDOTMAs_ic2012843.pdf","pdf_url":"http://real.mtak.hu/15662/1/IC_2011_pNO2BzDOTMAs_ic2012843.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:europepmc.org:2436917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3204396","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204396","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Inorg Chem","raw_type":"Text"},{"id":"pmh:oai:pdxscholar.library.pdx.edu:chem_fac-1312","doi":null,"is_oa":false,"landing_page_url":"https://pdxscholar.library.pdx.edu/chem_fac/312","pdf_url":null,"source":{"id":"https://openalex.org/S4377196300","display_name":"PDXScholar  (Portland State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I126345244","host_organization_name":"Portland State University","host_organization_lineage":["https://openalex.org/I126345244"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry Faculty Publications and Presentations","raw_type":"text"},{"id":"pmh:oai:ganymedesd.lib.unideb.hu:2437/111239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2437/111239","pdf_url":null,"source":{"id":"https://openalex.org/S4306402089","display_name":"University of Debrecen Electronic Archive (University of Debrecen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I132735039","host_organization_name":"University of Debrecen","host_organization_lineage":["https://openalex.org/I132735039"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"foly\u00f3iratcikk"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2436917","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3204396","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8303623239","display_name":"Improving the Effectiveness of ParaCEST Agents by Controlling the Conformation","funder_award_id":"R21EB011687","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"}],"funders":[{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W1965091072","https://openalex.org/W1966487765","https://openalex.org/W1968142586","https://openalex.org/W1984577230","https://openalex.org/W1985305470","https://openalex.org/W1986532232","https://openalex.org/W1995275534","https://openalex.org/W2008681268","https://openalex.org/W2015775406","https://openalex.org/W2021137787","https://openalex.org/W2023073862","https://openalex.org/W2031330413","https://openalex.org/W2033503179","https://openalex.org/W2041168154","https://openalex.org/W2041437133","https://openalex.org/W2045942148","https://openalex.org/W2046420744","https://openalex.org/W2050158839","https://openalex.org/W2053691477","https://openalex.org/W2059969251","https://openalex.org/W2063707213","https://openalex.org/W2066393913","https://openalex.org/W2067348722","https://openalex.org/W2074066467","https://openalex.org/W2078507874","https://openalex.org/W2098294786","https://openalex.org/W2119643174","https://openalex.org/W2144332006","https://openalex.org/W2147364228","https://openalex.org/W2151012570","https://openalex.org/W2156049516","https://openalex.org/W2164870675","https://openalex.org/W2325702572","https://openalex.org/W3003680839"],"related_works":["https://openalex.org/W2328356729","https://openalex.org/W2072648621","https://openalex.org/W2060595427","https://openalex.org/W2318410322","https://openalex.org/W2031330413","https://openalex.org/W13090363","https://openalex.org/W2335097689","https://openalex.org/W2943012813","https://openalex.org/W2147364228","https://openalex.org/W2516612737"],"abstract_inverted_index":{"Controlling":[0],"the":[1,13,28,32,39,54,61,80,93,104,116,123,132,141,144,160,177,180,189,192,202,211,213,216],"water":[2,35],"exchange":[3,36],"kinetics":[4,37],"of":[5,15,31,38,53,79,108,118,143,149,159,179,191,201,210],"macrocyclic":[6,145],"Gd(3+)":[7,88],"chelates,":[8,89],"a":[9,137,157],"key":[10],"parameter":[11],"in":[12,84,162,164],"design":[14],"improved":[16],"magnetic":[17],"resonance":[18],"imaging":[19],"(MRI)":[20],"contrast":[21],"media,":[22],"may":[23],"be":[24],"facilitated":[25],"by":[26,130],"selecting":[27],"coordination":[29,82],"geometry":[30,83],"chelate.":[33],"The":[34,147,182],"mono-":[40],"capped":[41,56],"twisted":[42],"square":[43,57],"antiprism":[44,58],"(TSAP)":[45],"being":[46],"much":[47],"closer":[48],"to":[49,115,154,198],"optimal":[50],"than":[51],"those":[52],"mono":[55],"(SAP)":[59],"render":[60],"TSAP":[62,81],"isomer":[63],"more":[64],"desirable":[65],"for":[66,77],"high":[67],"relaxivity":[68],"applications.":[69],"Two":[70],"systems":[71],"have":[72],"been":[73],"developed":[74],"that":[75,169,185],"allow":[76],"selection":[78],"1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic":[85],"acid":[86],"(DOTA)-type":[87],"both":[90,173],"based":[91],"upon":[92,206],"macrocycle":[94,212],"nitrobenzyl":[95,133,203],"cyclen.":[96],"In":[97],"this":[98],"paper":[99],"we":[100],"report":[101],"investigations":[102],"into":[103],"stability":[105],"and":[106,175],"formation":[107,190],"these":[109,150],"chelates.":[110],"Particular":[111],"focus":[112],"is":[113,167],"given":[114],"production":[117],"two":[119,151],"regioisomeric":[120],"chelates":[121],"during":[122,188],"chelation":[124],"reaction.":[125],"These":[126],"regioisomers":[127,152],"are":[128],"distinguished":[129],"having":[131],"substituent":[134,204],"either":[135],"on":[136,140],"corner":[138],"or":[139],"side":[142],"ring.":[146],"origin":[148],"appears":[153],"stem":[155],"from":[156,207],"conformation":[158],"ligand":[161],"solution":[163],"which":[165,208],"it":[166],"hypothesized":[168],"pendant":[170],"arms":[171],"lie":[172],"above":[174],"below":[176],"plane":[178],"macrocycle.":[181],"conformational":[183],"changes":[184],"then":[186],"result":[187],"intermediate":[193],"H(2)GdL(+)":[194],"chelate":[195],"give":[196],"rise":[197],"differing":[199],"positions":[200],"depending":[205],"face":[209],"Ln(3+)":[214],"approaches":[215],"ligand.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}