{"id":"https://openalex.org/W2019839506","doi":"https://doi.org/10.1073/pnas.89.1.162","title":"Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.","display_name":"Insulin-induced surface redistribution regulates internalization of the insulin receptor and requires its autophosphorylation.","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2019839506","doi":"https://doi.org/10.1073/pnas.89.1.162","mag":"2019839506","pmid":"https://pubmed.ncbi.nlm.nih.gov/1729685","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/48196"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.89.1.162","doi":"https://doi.org/10.1073/pnas.89.1.162","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.1.162","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC48196","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108603354","display_name":"J L Carpentier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J L Carpentier","raw_affiliation_strings":["Department of Morphology, University of Geneva Medical Center, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva Medical Center, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108418550","display_name":"J P Paccaud","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J P Paccaud","raw_affiliation_strings":["Department of Morphology, University of Geneva Medical Center, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva Medical Center, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070064147","display_name":"Phillip G\u00f6rden","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"P Gorden","raw_affiliation_strings":["Department of Morphology, University of Geneva Medical Center, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva Medical Center, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036382303","display_name":"William J. Rutter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"W J Rutter","raw_affiliation_strings":["Department of Morphology, University of Geneva Medical Center, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva Medical Center, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034171652","display_name":"Lelio Orci","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"L Orci","raw_affiliation_strings":["Department of Morphology, University of Geneva Medical Center, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Morphology, University of Geneva Medical Center, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114457229"],"apc_list":null,"apc_paid":null,"fwci":3.9666,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.93628571,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"89","issue":"1","first_page":"162","last_page":"166"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.9067000150680542,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.06069999933242798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"insulin receptor","score":0.9610000252723694},{"id":"https://openalex.org/keywords/receptor-internalization","display_name":"receptor internalization","score":0.9599999785423279},{"id":"https://openalex.org/keywords/receptor-autophosphorylation","display_name":"receptor autophosphorylation","score":0.8980000019073486},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.859000027179718},{"id":"https://openalex.org/keywords/microvilli","display_name":"microvilli","score":0.843999981880188},{"id":"https://openalex.org/keywords/cho-cells","display_name":"CHO cells","score":0.5889999866485596}],"concepts":[{"id":"https://openalex.org/C139770010","wikidata":"https://www.wikidata.org/wiki/Q1339807","display_name":"Internalization","level":3,"score":0.968790590763092},{"id":"https://openalex.org/C150109051","wikidata":"https://www.wikidata.org/wiki/Q3630494","display_name":"Autophosphorylation","level":4,"score":0.8675345182418823},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.7286278009414673},{"id":"https://openalex.org/C175656101","wikidata":"https://www.wikidata.org/wiki/Q56646","display_name":"Chinese hamster ovary cell","level":3,"score":0.6986991763114929},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6860675811767578},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.671001672744751},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5623239278793335},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.5234954953193665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5096085071563721},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4389127194881439},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28230708837509155},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23983481526374817},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.19086256623268127},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.12173253297805786},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.046551674604415894}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001345","descriptor_name":"Autoradiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011972","descriptor_name":"Receptor, Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.89.1.162","doi":"https://doi.org/10.1073/pnas.89.1.162","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.89.1.162","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:72630","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC48196","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:48196","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/48196","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:1729685","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1729685","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:72630","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC48196","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1503598995","https://openalex.org/W1505075493","https://openalex.org/W1555031898","https://openalex.org/W1577741430","https://openalex.org/W1590657000","https://openalex.org/W1596598368","https://openalex.org/W1607784649","https://openalex.org/W1964586605","https://openalex.org/W1965371391","https://openalex.org/W1975382404","https://openalex.org/W1978089805","https://openalex.org/W2008791108","https://openalex.org/W2016910304","https://openalex.org/W2018751358","https://openalex.org/W2019313055","https://openalex.org/W2025136141","https://openalex.org/W2030156849","https://openalex.org/W2031731565","https://openalex.org/W2060052605","https://openalex.org/W2085570743","https://openalex.org/W2086276378","https://openalex.org/W2094069133","https://openalex.org/W2095262331","https://openalex.org/W2103575418","https://openalex.org/W2132647577"],"related_works":["https://openalex.org/W1975382404","https://openalex.org/W2049707782","https://openalex.org/W1848295934","https://openalex.org/W2007809546","https://openalex.org/W1986381441","https://openalex.org/W1974850588","https://openalex.org/W7096973424","https://openalex.org/W2083134272","https://openalex.org/W41982943","https://openalex.org/W2090534767"],"abstract_inverted_index":{"The":[0],"role":[1],"of":[2,39,100],"insulin-induced":[3,40],"receptor":[4],"autophosphorylation":[5],"in":[6,17,48,52,88],"its":[7],"internalization":[8,16,43,70],"was":[9,44,71],"analyzed":[10],"by":[11],"comparing":[12],"125I-labeled":[13],"insulin":[14,30],"(125I-insulin)":[15],"Chinese":[18],"hamster":[19],"ovary":[20],"(CHO)":[21],"cell":[22,34,56],"lines":[23,35,57],"transfected":[24],"with":[25,36,58],"normal":[26],"(CHO.T)":[27],"or":[28,62],"mutated":[29],"receptors.":[31],"In":[32],"four":[33],"a":[37],"defect":[38],"autophosphorylation,":[41,68],"125I-insulin":[42,69],"impaired.":[45],"By":[46],"contrast,":[47],"CHO.T":[49],"cells":[50],"and":[51,95],"two":[53],"other":[54],"CHO":[55],"amino":[59],"acid":[60],"deletions":[61],"insertions":[63],"that":[64,78],"do":[65],"not":[66,72],"perturb":[67],"affected.":[73],"A":[74],"morphological":[75],"analysis":[76],"showed":[77],"the":[79,84,90,101],"inhibition":[80],"is":[81],"linked":[82],"to":[83],"ligand-specific":[85],"surface":[86],"redistribution":[87],"which":[89],"insulin-receptor":[91],"complexes":[92],"leave":[93],"microvilli":[94],"concentrate":[96],"on":[97],"nonvillous":[98],"segments":[99],"membrane":[102],"where":[103],"endocytosis":[104],"occurs.":[105]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
