{"id":"https://openalex.org/W2019837285","doi":"https://doi.org/10.1248/bpb.28.2258","title":"Antiviral Activity of the Marine Alga Symphyocladia latiuscula against Herpes Simplex Virus (HSV-1) in Vitro and Its Therapeutic Efficacy against HSV-1 Infection in Mice","display_name":"Antiviral Activity of the Marine Alga Symphyocladia latiuscula against Herpes Simplex Virus (HSV-1) in Vitro and Its Therapeutic Efficacy against HSV-1 Infection in Mice","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W2019837285","doi":"https://doi.org/10.1248/bpb.28.2258","mag":"2019837285","pmid":"https://pubmed.ncbi.nlm.nih.gov/16327161"},"language":"en","primary_location":{"id":"doi:10.1248/bpb.28.2258","doi":"https://doi.org/10.1248/bpb.28.2258","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.2258","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/12/28_12_2258/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/bpb/28/12/28_12_2258/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100754745","display_name":"Hye\u2010Jin Park","orcid":"https://orcid.org/0000-0001-5682-6539","observed_orcids":["https://orcid.org/0000-0001-5682-6539"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I4405287106","display_name":"Institute of Natural Medicine, University of Toyama","ror":"https://ror.org/0449t5597","country_code":"JP","type":"facility","lineage":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hye-Jin Park","raw_affiliation_strings":["Institute of Natural Medicine, Toyama Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Medicine, Toyama Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101985321","display_name":"Masahiko Kurokawa","orcid":"https://orcid.org/0000-0002-8701-9454","observed_orcids":["https://orcid.org/0000-0002-8701-9454"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahiko Kurokawa","raw_affiliation_strings":["School of Medicine, Toyama Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Toyama Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103205037","display_name":"Kimiyasu Shiraki","orcid":"https://orcid.org/0000-0002-5218-4249","observed_orcids":["https://orcid.org/0000-0002-5218-4249"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kimiyasu Shiraki","raw_affiliation_strings":["School of Medicine, Toyama Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Medicine, Toyama Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I42766147"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101399477","display_name":"Norio Nakamura","orcid":"https://orcid.org/0000-0001-6740-5633","observed_orcids":["https://orcid.org/0000-0001-6740-5633"]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I4405287106","display_name":"Institute of Natural Medicine, University of Toyama","ror":"https://ror.org/0449t5597","country_code":"JP","type":"facility","lineage":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Nakamura","raw_affiliation_strings":["Institute of Natural Medicine, Toyama Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Medicine, Toyama Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102376980","display_name":"Jae-Sue Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I8991828","display_name":"Pukyong National University","ror":"https://ror.org/0433kqc49","country_code":"KR","type":"education","lineage":["https://openalex.org/I8991828"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae-Sue Choi","raw_affiliation_strings":["Faculty of Food Science and Biotechnology, Pukyong National University, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Food Science and Biotechnology, Pukyong National University, Korea","institution_ids":["https://openalex.org/I8991828"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103499657","display_name":"Masao Hattori","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I42766147","display_name":"University of Toyama","ror":"https://ror.org/0445phv87","country_code":"JP","type":"education","lineage":["https://openalex.org/I42766147"]},{"id":"https://openalex.org/I4405287106","display_name":"Institute of Natural Medicine, University of Toyama","ror":"https://ror.org/0449t5597","country_code":"JP","type":"facility","lineage":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masao Hattori","raw_affiliation_strings":["Institute of Natural Medicine, Toyama Medical and Pharmaceutical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Medicine, Toyama Medical and Pharmaceutical University","institution_ids":["https://openalex.org/I42766147","https://openalex.org/I4405287106"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8103,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.81369863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"28","issue":"12","first_page":"2258","last_page":"2262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9340000152587891},{"id":"https://openalex.org/keywords/marine-algae-extracts","display_name":"marine algae extracts","score":0.871999979019165},{"id":"https://openalex.org/keywords/oral-antiviral-therapy","display_name":"oral antiviral therapy","score":0.7210000157356262},{"id":"https://openalex.org/keywords/rhodomelaceae","display_name":"Rhodomelaceae","score":0.7940000295639038}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7325619459152222},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5726690888404846},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.559853196144104},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.552198052406311},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.540250301361084},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5238154530525208},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.49954700469970703},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49880480766296387},{"id":"https://openalex.org/C2776147627","wikidata":"https://www.wikidata.org/wiki/Q24783855","display_name":"Thymidine kinase","level":4,"score":0.4769112765789032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4690592288970947},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43034419417381287},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.34671086072921753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3382856845855713},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.32754456996917725},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.22526130080223083},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2221067249774933},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000212","descriptor_name":"Acyclovir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000461","descriptor_name":"Rhodophyta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004987","descriptor_name":"Ethers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006561","descriptor_name":"Herpes Simplex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1248/bpb.28.2258","doi":"https://doi.org/10.1248/bpb.28.2258","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.2258","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/12/28_12_2258/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:16327161","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16327161","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological & pharmaceutical bulletin","raw_type":"Journal Article"},{"id":"mag:639203556","doi":null,"is_oa":false,"landing_page_url":"https://ci.nii.ac.jp/naid/40015392246","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1248/bpb.28.2258","doi":"https://doi.org/10.1248/bpb.28.2258","is_oa":true,"landing_page_url":"https://doi.org/10.1248/bpb.28.2258","pdf_url":"https://www.jstage.jst.go.jp/article/bpb/28/12/28_12_2258/_pdf","source":{"id":"https://openalex.org/S165235614","display_name":"Biological and Pharmaceutical Bulletin","issn_l":"0918-6158","issn":["0918-6158","1347-5215"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biological and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019837285.pdf","grobid_xml":"https://content.openalex.org/works/W2019837285.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1607404850","https://openalex.org/W1851936098","https://openalex.org/W1967439259","https://openalex.org/W1969869332","https://openalex.org/W1970877276","https://openalex.org/W1974855481","https://openalex.org/W2005747474","https://openalex.org/W2010918171","https://openalex.org/W2015768233","https://openalex.org/W2020933095","https://openalex.org/W2021931329","https://openalex.org/W2038175841","https://openalex.org/W2044067145","https://openalex.org/W2045360603","https://openalex.org/W2048246686","https://openalex.org/W2050052073","https://openalex.org/W2059380155","https://openalex.org/W2063399192","https://openalex.org/W2081800171","https://openalex.org/W2102335382","https://openalex.org/W2148231276","https://openalex.org/W2168528017","https://openalex.org/W2225285240","https://openalex.org/W2315693002","https://openalex.org/W4252157992"],"related_works":["https://openalex.org/W639203556","https://openalex.org/W2001814176","https://openalex.org/W2019577986","https://openalex.org/W2004977763","https://openalex.org/W3086779648","https://openalex.org/W7127901078","https://openalex.org/W4398776075","https://openalex.org/W2133086279","https://openalex.org/W7096571808","https://openalex.org/W2074321074"],"abstract_inverted_index":{"The":[0,86,120],"antiviral":[1,58],"activities":[2,59],"of":[3,8,25,30,41,50,93,113,123,150,160,171],"extracts":[4],"from":[5,129],"5":[6],"species":[7],"marine":[9],"algae":[10],"collected":[11],"at":[12],"Haeundae":[13],"(Pusan,":[14],"Korea),":[15],"were":[16,139],"examined":[17,134],"using":[18],"plaque":[19],"reduction":[20],"assays.":[21],"Although":[22],"the":[23,35,124,151,158,169,193],"activity":[24],"a":[26,94,201],"methanol":[27],"(MeOH)":[28],"extract":[29,49,126,153],"Sargassum":[31],"ringoldianum":[32],"(Sargassaceae)":[33],"was":[34,44,97,132],"most":[36],"potent":[37],"against":[38,60,99],"several":[39],"types":[40],"viruses,":[42],"it":[43],"also":[45],"cytotoxic.":[46],"A":[47],"MeOH":[48,125,152],"Symphyocladia":[51],"latiuscula":[52,131],"(Rhodomelaceae)":[53],"and":[54,63,78,108,116,127,154,167,195],"its":[55],"fractions":[56],"exhibited":[57],"acyclovir":[61],"(ACV)":[62],"phosphonoacetic":[64],"acid":[65],"(PAA)-resistant":[66],"(AP(r))":[67],"herpes":[68],"simplex":[69],"type":[70,80,101],"1":[71],"(HSV-1),":[72],"thymidine":[73],"kinase":[74],"(TK(-))":[75],"deficient":[76],"HSV-1":[77,81,107,110,143],"wild":[79,100],"in":[82,135,178,192],"vitro":[83],"without":[84,181],"cytotoxicity.":[85],"major":[87],"component,":[88],"2,3,6-tribromo-4,5-dihydroxybenzyl":[89],"methyl":[90],"ether":[91],"(TDB)":[92],"CH(2)Cl(2)-soluble":[95],"fraction":[96],"active":[98],"HSV-1,":[102],"as":[103,105],"well":[104],"AP(r)":[106],"TK(-)":[109],"(IC(50)":[111],"values":[112],"5.48,":[114],"4.81":[115],"23.3":[117],"microg/ml,":[118],"respectively).":[119],"therapeutic":[121],"effectiveness":[122],"TDB":[128,155,188,198],"S.":[130],"further":[133,172],"BALB/c":[136],"mice":[137,180],"that":[138],"cutaneously":[140],"infected":[141,179],"with":[142,184],"strain":[144],"7401H.":[145],"Three":[146],"daily":[147],"oral":[148],"administrations":[149],"significantly":[156],"delayed":[157],"appearance":[159],"score":[161,173],"2":[162],"skin":[163],"lesions":[164,177],"(local":[165],"vesicles)":[166],"limited":[168],"development":[170],"6":[174],"(mild":[175],"zosteriform)":[176],"toxicity":[182],"compared":[183],"controls.":[185],"In":[186],"addition,":[187],"suppressed":[189],"virus":[190],"yields":[191],"brain":[194],"skin.":[196],"Therefore":[197],"should":[199],"be":[200],"promising":[202],"anti":[203],"HSV":[204],"agent.":[205]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}