{"id":"https://openalex.org/W2019804577","doi":"https://doi.org/10.1515/cclm.1999.007","title":"Urokinase and Plasminogen Activator-Inhibitor (PAI-1) Status in Primary Ovarian Carcinomas and Ovarian Metastases Compared to Benign Ovarian Tumors as A Function of Histopathological Parameters","display_name":"Urokinase and Plasminogen Activator-Inhibitor (PAI-1) Status in Primary Ovarian Carcinomas and Ovarian Metastases Compared to Benign Ovarian Tumors as A Function of Histopathological Parameters","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2019804577","doi":"https://doi.org/10.1515/cclm.1999.007","mag":"2019804577","pmid":"https://pubmed.ncbi.nlm.nih.gov/10094378"},"language":"en","primary_location":{"id":"doi:10.1515/cclm.1999.007","doi":"https://doi.org/10.1515/cclm.1999.007","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.1999.007","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"cclm","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110431976","display_name":"G. M. Hoffmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103230","display_name":"St. Josefs Hospital","ror":"https://ror.org/019jjbt65","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210103230"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerald Hoffmann","raw_affiliation_strings":["St. Josef's Hospital, Wiesbaden, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"St. Josef's Hospital, Wiesbaden, Germany","institution_ids":["https://openalex.org/I4210103230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046621484","display_name":"Kunhard Pollow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunhard Pollow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113773828","display_name":"W. Weikel","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Weikel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108755044","display_name":"Hans-Joachim Strittmatter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans-Joachim Strittmatter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089110052","display_name":"Joachim Bach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim Bach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033098421","display_name":"Michael Schaffrath","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Schaffrath","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017895489","display_name":"P. O. Knapstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Knapstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063993571","display_name":"Frank Melchert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Melchert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113769032","display_name":"Bettina Pollow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bettina Pollow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":0.6946,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.69451033,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"37","issue":"1","first_page":"47","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.012600000016391277,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urokinase-type-plasminogen-activator","display_name":"urokinase","score":0.9879999756813049},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.9660000205039978},{"id":"https://openalex.org/keywords/primary-ovarian-cancer","display_name":"primary ovarian cancer","score":0.9459999799728394},{"id":"https://openalex.org/keywords/ovarian-metastasis","display_name":"ovarian metastasis","score":0.9959999918937683},{"id":"https://openalex.org/keywords/benign-ovarian-tumors","display_name":"benign ovarian tumors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-dedifferentiation","display_name":"tumor dedifferentiation","score":0.8560000061988831},{"id":"https://openalex.org/keywords/tumor-stage","display_name":"tumor stage","score":0.847000002861023},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7039999961853027},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.4410000145435333}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.7739228010177612},{"id":"https://openalex.org/C2779679481","wikidata":"https://www.wikidata.org/wiki/Q13581432","display_name":"Plasminogen activator","level":2,"score":0.7352864742279053},{"id":"https://openalex.org/C3019054536","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinoma","level":4,"score":0.6192371845245361},{"id":"https://openalex.org/C2908651487","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian carcinomas","level":5,"score":0.5926969647407532},{"id":"https://openalex.org/C2780084626","wikidata":"https://www.wikidata.org/wiki/Q11793790","display_name":"Ovarian tumor","level":4,"score":0.5733879804611206},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.538176953792572},{"id":"https://openalex.org/C2776892390","wikidata":"https://www.wikidata.org/wiki/Q7119591","display_name":"Urokinase","level":2,"score":0.5233108997344971},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5001621246337891},{"id":"https://openalex.org/C2780675426","wikidata":"https://www.wikidata.org/wiki/Q410485","display_name":"Plasminogen activator inhibitor-1","level":3,"score":0.4838480055332184},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4552251100540161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4421330690383911},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3812706470489502},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3736434578895569},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3712517023086548},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3404732346534729},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32956767082214355}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014568","descriptor_name":"Urokinase-Type Plasminogen Activator","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1515/cclm.1999.007","doi":"https://doi.org/10.1515/cclm.1999.007","is_oa":false,"landing_page_url":"https://doi.org/10.1515/cclm.1999.007","pdf_url":null,"source":{"id":"https://openalex.org/S124948411","display_name":"Clinical Chemistry and Laboratory Medicine (CCLM)","issn_l":"1434-6621","issn":["1434-6621","1437-4331"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"cclm","raw_type":"journal-article"},{"id":"pmid:10094378","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10094378","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical chemistry and laboratory medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1491782018","https://openalex.org/W1558913702","https://openalex.org/W1564977527","https://openalex.org/W1724539534","https://openalex.org/W1926488772","https://openalex.org/W1966719969","https://openalex.org/W1967280348","https://openalex.org/W1977165292","https://openalex.org/W1979300931","https://openalex.org/W1984533079","https://openalex.org/W1988630899","https://openalex.org/W1991090424","https://openalex.org/W1994242851","https://openalex.org/W1995406904","https://openalex.org/W2029837224","https://openalex.org/W2034350621","https://openalex.org/W2057831694","https://openalex.org/W2062560678","https://openalex.org/W2063600750","https://openalex.org/W2078074277","https://openalex.org/W2087429238","https://openalex.org/W2094135777","https://openalex.org/W2095190689","https://openalex.org/W2102577298","https://openalex.org/W2111924468","https://openalex.org/W2135519239","https://openalex.org/W2157803226","https://openalex.org/W2396358164","https://openalex.org/W2405176591","https://openalex.org/W2409619492","https://openalex.org/W3041047318"],"related_works":["https://openalex.org/W2021547136","https://openalex.org/W1724539534","https://openalex.org/W1987163371","https://openalex.org/W2149851238","https://openalex.org/W1994242851","https://openalex.org/W2005389743","https://openalex.org/W1967280348","https://openalex.org/W1562370345","https://openalex.org/W2364698061","https://openalex.org/W2027583170"],"abstract_inverted_index":{"Ninety-eight":[0],"patients":[1],"with":[2,37,61,66,100,104,159],"histologically":[3],"confirmed":[4],"ovarian":[5,9,25,33,75,130,135,156,162,231],"tumors":[6,97],"(77":[7],"primary":[8,74,129,155,230],"carcinomas":[10],"of":[11,27,42,55,73,87,95,113,123,137,146,154,183,190,220],"stages":[12],"T1":[13],"to":[14,17,39,152],"T3":[15],"according":[16],"the":[18,40,62,84,96,111,121,128,133,142,144,160,164,171,181,218,221,228],"postoperative":[19],"histopathological":[20,67],"classification":[21],"pTNM":[22],"classification,":[23],"14":[24,134],"metastases":[26,136],"various":[28],"origins":[29,139],"and":[30,47,65,90,118,120,148,167,223],"seven":[31,184],"benign":[32,185],"tumors)":[34],"were":[35,59,150,174],"investigated":[36],"regard":[38],"concentration":[41],"urokinase-type":[43],"plasminogen":[44,48],"activator":[45,49],"(uPA)":[46],"inhibitor":[50],"(PAI-1)":[51],"in":[52,83,127,141,170,180,227],"membrane":[53,85,172],"extracts":[54],"tumors.":[56,186],"The":[57],"results":[58],"correlated":[60,98],"clinical":[63],"course":[64,202],"findings.":[68],"With":[69],"more":[70],"advanced":[71],"stage":[72],"carcinomas,":[76],"there":[77],"was":[78,107],"a":[79,195],"highly":[80],"significant":[81],"rise":[82],"concentrations":[86,169],"both":[88],"uPA":[89,124,147,166,209],"PAI-1.":[91,105],"However,":[92],"increasing":[93],"dedifferentiation":[94],"only":[99],"uPA,":[101],"but":[102,213],"not":[103,214],"There":[106],"no":[108],"correlation":[109],"between":[110],"number":[112],"steroid":[114],"receptors":[115],"for":[116,194,208,215],"estradiol":[117],"progesterone":[119],"content":[122],"or":[125,200],"PAI-1":[126,149,168,216],"carcinomas.":[131,157,232],"In":[132],"different":[138],"incluced":[140],"study,":[143],"contents":[145],"comparable":[151],"those":[153],"Compared":[158],"malignant":[161,229],"tumors,":[163],"median":[165],"fraction":[173],"2.5-6":[175],"fold":[176],"lower":[177],"(highly":[178],"significant)":[179],"group":[182],"A":[187],"cut-off":[188],"value":[189],"4.8ng/mg":[191],"pellet":[192],"protein":[193],"prognostically":[196],"favorable":[197],"(<":[198],"4.8)":[199,204],"unfavorable":[201],"(>":[203],"could":[205],"be":[206],"determined":[207],"(p":[210],"=":[211],"0.0392)":[212],"on":[217],"basis":[219],"Kaplan":[222],"Meier":[224],"survival":[225],"curves":[226]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
