{"id":"https://openalex.org/W2019744799","doi":"https://doi.org/10.4161/mabs.29680","title":"A general approach to antibody thermostabilization","display_name":"A general approach to antibody thermostabilization","publication_year":2014,"publication_date":"2014-06-24","ids":{"openalex":"https://openalex.org/W2019744799","doi":"https://doi.org/10.4161/mabs.29680","mag":"2019744799","pmid":"https://pubmed.ncbi.nlm.nih.gov/25517312","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4623350"},"language":"en","primary_location":{"id":"doi:10.4161/mabs.29680","doi":"https://doi.org/10.4161/mabs.29680","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.29680","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.29680?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.29680?needAccess=true&role=button","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036463293","display_name":"Audrey D. McConnell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Audrey D McConnell","raw_affiliation_strings":["a AnaptysBio, Inc. ; San Diego , CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"a AnaptysBio, Inc. ; San Diego , CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100768662","display_name":"Xue Zhang","orcid":"https://orcid.org/0000-0002-5782-2174","observed_orcids":["https://orcid.org/0000-0002-5782-2174"]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xue Zhang","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059094439","display_name":"John L. Macomber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L Macomber","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108788797","display_name":"Betty Chau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Chau","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076617262","display_name":"Joseph C Sheffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C Sheffer","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075783685","display_name":"Sorena Rahmanian","orcid":"https://orcid.org/0000-0002-5692-163X","observed_orcids":["https://orcid.org/0000-0002-5692-163X"]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sorena Rahmanian","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027437832","display_name":"Eric Hare","orcid":"https://orcid.org/0000-0002-4277-3146","observed_orcids":["https://orcid.org/0000-0002-4277-3146"]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Hare","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071417724","display_name":"Vladimir Spasojevic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vladimir Spasojevic","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090859950","display_name":"Robert A. Horlick","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Horlick","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101541338","display_name":"David J. King","orcid":"https://orcid.org/0000-0003-3482-6049","observed_orcids":["https://orcid.org/0000-0003-3482-6049"]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J King","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076377384","display_name":"Peter M. Bowers","orcid":"https://orcid.org/0000-0002-4990-7100","observed_orcids":["https://orcid.org/0000-0002-4990-7100"]},"institutions":[{"id":"https://openalex.org/I4405267126","display_name":"AnaptysBio, Inc. (United States)","ror":"https://ror.org/01aaevk09","country_code":"US","type":"company","lineage":["https://openalex.org/I4405267126"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter M Bowers","raw_affiliation_strings":["AnaptysBio, Inc.; San Diego, CA USA","AnaptysBio, Inc","San Diego, CA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"AnaptysBio, Inc.; San Diego, CA USA","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"AnaptysBio, Inc","institution_ids":["https://openalex.org/I4405267126"]},{"raw_affiliation_string":"San Diego, CA USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076377384"],"corresponding_institution_ids":["https://openalex.org/I4405267126"],"apc_list":{"value":2915,"currency":"GBP","value_usd":3575},"apc_paid":{"value":2915,"currency":"GBP","value_usd":3575},"fwci":1.0623,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.73438307,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"6","issue":"5","first_page":"1274","last_page":"1282"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibody-engineering","display_name":"antibody engineering","score":0.7770000100135803},{"id":"https://openalex.org/keywords/cdr-grafting","display_name":"CDR grafting","score":0.8489999771118164},{"id":"https://openalex.org/keywords/mammalian-cell-display","display_name":"mammalian cell display","score":0.8650000095367432},{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"affinity maturation","score":0.8029999732971191},{"id":"https://openalex.org/keywords/adalimumab","display_name":"adalimumab","score":0.9190000295639038},{"id":"https://openalex.org/keywords/denosumab","display_name":"denosumab","score":1.0},{"id":"https://openalex.org/keywords/cetuximab","display_name":"cetuximab","score":1.0},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.972000002861023},{"id":"https://openalex.org/keywords/therapeutic-antibodies","display_name":"therapeutic antibodies","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.7695311307907104},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.762636125087738},{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.7129128575325012},{"id":"https://openalex.org/C85630698","wikidata":"https://www.wikidata.org/wiki/Q3826179","display_name":"Complementarity determining region","level":4,"score":0.5764225125312805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43989044427871704},{"id":"https://openalex.org/C2781216036","wikidata":"https://www.wikidata.org/wiki/Q902494","display_name":"Thermostability","level":3,"score":0.4300695061683655},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.41612154245376587},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37292397022247314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34509730339050293},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29205653071403503},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20541277527809143},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.18197068572044373},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1014581024646759}],"mesh":[{"descriptor_ui":"D000068818","descriptor_name":"Cetuximab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068879","descriptor_name":"Adalimumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069448","descriptor_name":"Denosumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000915","descriptor_name":"Antibody Affinity","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002152","descriptor_name":"Calorimetry, Differential Scanning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D027041","descriptor_name":"Somatic Hypermutation, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061505","descriptor_name":"Cell Surface Display Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.4161/mabs.29680","doi":"https://doi.org/10.4161/mabs.29680","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.29680","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.29680?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3614567","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4623350","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25517312","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25517312","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4623350","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4623350/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"MAbs","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.4161/mabs.29680","doi":"https://doi.org/10.4161/mabs.29680","is_oa":true,"landing_page_url":"https://doi.org/10.4161/mabs.29680","pdf_url":"https://www.tandfonline.com/doi/pdf/10.4161/mabs.29680?needAccess=true&role=button","source":{"id":"https://openalex.org/S169123381","display_name":"mAbs","issn_l":"1942-0862","issn":["1942-0862","1942-0870"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315740","host_organization_name":"Landes Bioscience","host_organization_lineage":["https://openalex.org/P4310315740"],"host_organization_lineage_names":["Landes Bioscience"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mAbs","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019744799.pdf","grobid_xml":"https://content.openalex.org/works/W2019744799.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1515330096","https://openalex.org/W1956550888","https://openalex.org/W1967693680","https://openalex.org/W2008973887","https://openalex.org/W2009138688","https://openalex.org/W2009727305","https://openalex.org/W2010533241","https://openalex.org/W2013003092","https://openalex.org/W2013128795","https://openalex.org/W2021067723","https://openalex.org/W2021547240","https://openalex.org/W2024905279","https://openalex.org/W2026370963","https://openalex.org/W2034006833","https://openalex.org/W2045725488","https://openalex.org/W2055152097","https://openalex.org/W2067608620","https://openalex.org/W2068310820","https://openalex.org/W2072678801","https://openalex.org/W2073562518","https://openalex.org/W2074620876","https://openalex.org/W2080057469","https://openalex.org/W2081787960","https://openalex.org/W2082144099","https://openalex.org/W2083636872","https://openalex.org/W2116644153","https://openalex.org/W2117131474","https://openalex.org/W2128724236","https://openalex.org/W2148043455","https://openalex.org/W2164148151","https://openalex.org/W4232439000"],"related_works":["https://openalex.org/W2116644153","https://openalex.org/W2062793526","https://openalex.org/W2073610559","https://openalex.org/W2027856172","https://openalex.org/W2738611529","https://openalex.org/W4308568614","https://openalex.org/W2474330836","https://openalex.org/W2765462232","https://openalex.org/W1952166052","https://openalex.org/W2989567843"],"abstract_inverted_index":{"Antibody":[0],"engineering":[1,33],"to":[2,39,75,115,144],"enhance":[3],"thermostability":[4],"may":[5,158],"enable":[6],"further":[7],"application":[8],"and":[9,62,73,95,143],"ease":[10],"of":[11,13,18,32,42,51,79,88,98,106,109,123,167,172],"use":[12],"antibodies":[14,41,108,130,168],"across":[15,169],"a":[16,30,49,145,170],"number":[17,171],"different":[19],"areas.":[20],"A":[21],"modified":[22],"human":[23],"IgG":[24],"framework":[25,118],"has":[26],"been":[27],"developed":[28],"through":[29,48,119],"combination":[31,50],"approaches,":[34],"which":[35],"can":[36],"be":[37,159],"used":[38],"stabilize":[40],"diverse":[43,110],"specificity.":[44],"This":[45,68,152],"is":[46],"achieved":[47],"complementarity-determining":[52],"region":[53],"(CDR)-grafting":[54],"onto":[55],"the":[56,80,86,102,116,128,164],"stable":[57,117],"framework,":[58],"mammalian":[59],"cell":[60],"display":[61],"in":[63],"vitro":[64],"somatic":[65],"hypermutation":[66],"(SHM).":[67],"approach":[69,157],"allows":[70],"both":[71],"stabilization":[72,87],"maturation":[74,97],"affinities":[76],"beyond":[77],"those":[78],"original":[81,103],"antibody,":[82],"as":[83],"shown":[84],"by":[85,92,133,137,141,150],"an":[89],"anti-HA33":[90],"antibody":[91],"approximately":[93,99],"10\u00b0C":[94],"affinity":[96],"300-fold":[100],"over":[101],"antibody.":[104],"Specificities":[105],"10":[107],"origin":[111],"were":[112],"successfully":[113,125],"transferred":[114],"CDR-grafting,":[120],"with":[121],"8":[122],"these":[124],"stabilized,":[126],"including":[127],"therapeutic":[129],"adalimumab,":[131],"stabilized":[132,136,140,149],"9.9\u00b0C,":[134],"denosumab,":[135],"7\u00b0C,":[138],"cetuximab":[139],"6.9\u00b0C":[142],"lesser":[146],"extent":[147],"trastuzumab":[148],"0.8\u00b0C.":[151],"data":[153],"suggests":[154],"that":[155],"this":[156],"broadly":[160],"useful":[161],"for":[162],"improving":[163],"biophysical":[165],"characteristics":[166],"applications.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
