{"id":"https://openalex.org/W2019742973","doi":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","title":"A convenient five\u2010drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study","display_name":"A convenient five\u2010drug cocktail for the assessment of major drug metabolizing enzymes: a pilot study","publication_year":2004,"publication_date":"2004-06-21","ids":{"openalex":"https://openalex.org/W2019742973","doi":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","mag":"2019742973","pmid":"https://pubmed.ncbi.nlm.nih.gov/15327588","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884572"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.2004.02162.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02162.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02162.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070867379","display_name":"Ashish Sharma","orcid":"https://orcid.org/0000-0001-9998-9709","observed_orcids":["https://orcid.org/0000-0001-9998-9709"]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ashish Sharma","raw_affiliation_strings":["The Qu\u00e9bec Heart and Lung Institute, Laval Hospital, Qu\u00e9bec, Canada. ashish.sharma@biovail.com","The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital, Qu\u00e9bec, Canada. ashish.sharma@biovail.com","institution_ids":["https://openalex.org/I4210135357"]},{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109918430","display_name":"Sylvie Pilote","orcid":"https://orcid.org/0000-0002-1327-8429","observed_orcids":["https://orcid.org/0000-0002-1327-8429"]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sylvie Pilote","raw_affiliation_strings":["The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]},{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110594461","display_name":"P M B\u00e9langer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Pierre M. B\u00e9langer","raw_affiliation_strings":["The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]},{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000093838","display_name":"Marie Arsenault","orcid":"https://orcid.org/0009-0001-9585-5639","observed_orcids":["https://orcid.org/0009-0001-9585-5639"]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie Arsenault","raw_affiliation_strings":["The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]},{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111775601","display_name":"Bettina A. Hamelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210135357","display_name":"Institut universitaire de cardiologie et de pneumologie de Qu\u00e9bec","ror":"https://ror.org/03gf7z214","country_code":"CA","type":"education","lineage":["https://openalex.org/I2801902503","https://openalex.org/I4210135357","https://openalex.org/I4210139015","https://openalex.org/I4405279980"]},{"id":"https://openalex.org/I43406934","display_name":"Universit\u00e9 Laval","ror":"https://ror.org/04sjchr03","country_code":"CA","type":"education","lineage":["https://openalex.org/I43406934"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Bettina A. Hamelin","raw_affiliation_strings":["The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Que\u0301bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Que\u0301bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]},{"raw_affiliation_string":"The Qu\u00e9bec Heart and Lung Institute, Laval Hospital and the Faculty of Pharmacy, Laval University, Qu\u00e9bec, Canada","institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5070867379"],"corresponding_institution_ids":["https://openalex.org/I4210135357","https://openalex.org/I43406934"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":0.7075,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.66285607,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"58","issue":"3","first_page":"288","last_page":"297"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":1.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-metabolizing-enzymes","display_name":"drug-metabolizing enzymes","score":0.7940000295639038},{"id":"https://openalex.org/keywords/probe-drugs","display_name":"probe drugs","score":0.7179999947547913},{"id":"https://openalex.org/keywords/metoprolol","display_name":"metoprolol","score":0.7820000052452087},{"id":"https://openalex.org/keywords/chlorzoxazone","display_name":"chlorzoxazone","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tolbutamide","display_name":"tolbutamide","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dapsone","display_name":"dapsone","score":0.9639999866485596},{"id":"https://openalex.org/keywords/caffeine","display_name":"caffeine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cyp2d6","display_name":"CYP2D6","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cyp2e1","display_name":"CYP2E1","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":1.0},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":1.0},{"id":"https://openalex.org/keywords/n-acetyltransferase-2","display_name":"N-acetyltransferase 2","score":0.9559999704360962},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/enzyme-activity-assay","display_name":"enzyme activity assay","score":0.49799999594688416},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.5860000252723694},{"id":"https://openalex.org/keywords/urinary-metabolites","display_name":"urinary metabolites","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2776658834","wikidata":"https://www.wikidata.org/wiki/Q3294630","display_name":"Chlorzoxazone","level":5,"score":0.9557746648788452},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7642320394515991},{"id":"https://openalex.org/C2781280847","wikidata":"https://www.wikidata.org/wiki/Q409468","display_name":"Metoprolol","level":2,"score":0.7325764894485474},{"id":"https://openalex.org/C2776054734","wikidata":"https://www.wikidata.org/wiki/Q414275","display_name":"Tolbutamide","level":3,"score":0.7138710618019104},{"id":"https://openalex.org/C86745063","wikidata":"https://www.wikidata.org/wiki/Q3737406","display_name":"CYP1A2","level":4,"score":0.6716113090515137},{"id":"https://openalex.org/C33664856","wikidata":"https://www.wikidata.org/wiki/Q3271142","display_name":"CYP2D6","level":4,"score":0.6180494427680969},{"id":"https://openalex.org/C2778162141","wikidata":"https://www.wikidata.org/wiki/Q419223","display_name":"Paraxanthine","level":5,"score":0.5856212377548218},{"id":"https://openalex.org/C2778095195","wikidata":"https://www.wikidata.org/wiki/Q407308","display_name":"Theophylline","level":2,"score":0.546505331993103},{"id":"https://openalex.org/C2777600422","wikidata":"https://www.wikidata.org/wiki/Q3704421","display_name":"Debrisoquine","level":5,"score":0.5162322521209717},{"id":"https://openalex.org/C2778500429","wikidata":"https://www.wikidata.org/wiki/Q60235","display_name":"Caffeine","level":2,"score":0.513179361820221},{"id":"https://openalex.org/C2777640609","wikidata":"https://www.wikidata.org/wiki/Q422226","display_name":"Dapsone","level":2,"score":0.5115512013435364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5094226002693176},{"id":"https://openalex.org/C2781245242","wikidata":"https://www.wikidata.org/wiki/Q407781","display_name":"Dextromethorphan","level":2,"score":0.48957571387290955},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.4817512035369873},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.4803927540779114},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.4383113384246826},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4009062647819519},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.3668307065963745},{"id":"https://openalex.org/C140027455","wikidata":"https://www.wikidata.org/wiki/Q14864434","display_name":"CYP2E1","level":4,"score":0.22752732038497925},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.2162977159023285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16612163186073303},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1648963987827301},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.1505262553691864},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12285745143890381},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11805182695388794},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.08939427137374878},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000096926","descriptor_name":"Benzenesulfonamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002110","descriptor_name":"Caffeine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002753","descriptor_name":"Chlorzoxazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003622","descriptor_name":"Dapsone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008790","descriptor_name":"Metoprolol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010629","descriptor_name":"Phenformin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014044","descriptor_name":"Tolbutamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.2004.02162.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02162.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1884572","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884572","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:15327588","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15327588","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.2004.02162.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02162.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02162.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019742973.pdf","grobid_xml":"https://content.openalex.org/works/W2019742973.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W179252842","https://openalex.org/W207511860","https://openalex.org/W1522494919","https://openalex.org/W1601798900","https://openalex.org/W1774308757","https://openalex.org/W1937401809","https://openalex.org/W1949292594","https://openalex.org/W1969236135","https://openalex.org/W1969695802","https://openalex.org/W1971236082","https://openalex.org/W1971559706","https://openalex.org/W1974459071","https://openalex.org/W1975704419","https://openalex.org/W1976217151","https://openalex.org/W1979716218","https://openalex.org/W1984561836","https://openalex.org/W1998943150","https://openalex.org/W2003017820","https://openalex.org/W2010985370","https://openalex.org/W2012168568","https://openalex.org/W2015555489","https://openalex.org/W2019319769","https://openalex.org/W2022866198","https://openalex.org/W2029832414","https://openalex.org/W2035091931","https://openalex.org/W2036648741","https://openalex.org/W2045328772","https://openalex.org/W2062178042","https://openalex.org/W2070202746","https://openalex.org/W2073959427","https://openalex.org/W2075870841","https://openalex.org/W2077816489","https://openalex.org/W2081909460","https://openalex.org/W2084403972","https://openalex.org/W2087484754","https://openalex.org/W2089423429","https://openalex.org/W2092510009","https://openalex.org/W2093737687","https://openalex.org/W2094805343","https://openalex.org/W2095350251","https://openalex.org/W2100085751","https://openalex.org/W2109393924","https://openalex.org/W2114542242","https://openalex.org/W2115650781","https://openalex.org/W2122993239","https://openalex.org/W2155268095","https://openalex.org/W2155324370","https://openalex.org/W2169972394","https://openalex.org/W2170250016","https://openalex.org/W2296797125","https://openalex.org/W2337566006","https://openalex.org/W2337877567","https://openalex.org/W3146286451"],"related_works":["https://openalex.org/W2075870841","https://openalex.org/W2010985370","https://openalex.org/W1985308090","https://openalex.org/W1872908422","https://openalex.org/W2070202746","https://openalex.org/W1980580492","https://openalex.org/W1965307398","https://openalex.org/W2100213712","https://openalex.org/W4225740084","https://openalex.org/W7002191985"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"assess":[2],"the":[3,8,36,55,100,177,184,207,210],"feasibility":[4],"of":[5,13,38,60,115,121,143,180,183,195,204,209],"administering":[6,111],"at":[7,93],"same":[9],"time":[10],"low":[11],"doses":[12],"five":[14,185,196],"probe":[15,186],"drugs,":[16,199],"metoprolol":[17,86,112],"(25":[18],"mg),":[19,22,25],"chlorzoxazone":[20,73],"(250":[21,24],"tolbutamide":[23,118],"dapsone":[26,79],"(100":[27,31],"mg)":[28,32],"and":[29,45,74,80,87,95,152,162],"caffeine":[30],"to":[33],"determine":[34],"simultaneously":[35,205],"activities":[37,208],"CYP2D6,":[39,156],"CYP2E1,":[40,158],"CYP2C9,":[41,157],"CYP3A4,":[42,155],"CYP1A2,":[43,159],"N-acetyltransferase-2":[44],"xanthine":[46,163],"oxidase.":[47],"METHODS:":[48],"Ten":[49],"healthy":[50],"young":[51],"non-smoking":[52],"males":[53],"received":[54],"following":[56,101],"drugs":[57,61,90,133],"or":[58,117],"combinations":[59,182],"over":[62],"a":[63,201],"5-week":[64],"period:":[65],"week":[66],"1)":[67],"metoprolol;":[68,81],"2)":[69],"tolbutamide;":[70],"3)":[71],"caffeine,":[72,77,83],"dapsone;":[75],"4)":[76],"chlorzoxazone,":[78,84],"5)":[82],"dapsone,":[85],"tolbutamide.":[88],"The":[89,139],"were":[91,124,134,145,174],"self-administered":[92],"bedtime":[94],"urine":[96],"was":[97],"collected":[98],"for":[99,154],"8":[102],"h.":[103],"RESULTS:":[104],"Mean":[105],"molar":[106],"phenotypic":[107],"ratios":[108],"obtained":[109,130],"after":[110],"(mean":[113,119],"change":[114,120],"-11%)":[116],"-0.3%)":[122],"alone,":[123],"not":[125],"significantly":[126],"different":[127],"from":[128],"those":[129],"when":[131],"other":[132],"co-administered":[135],"(P":[136,171],">":[137,172],"0.05).":[138],"mean":[140],"within-subject":[141],"coefficients":[142],"variation":[144],"33%,":[146],"18%,":[147],"22%,":[148],"13%,":[149],"16%,":[150],"13%":[151],"5%":[153],"N-acetyltransferase":[160],"2":[161],"oxidase":[164],"metabolic":[165],"ratios,":[166],"respectively.":[167],"No":[168],"significant":[169],"interactions":[170],"0.5)":[173],"observed":[175],"during":[176],"simultaneous":[178],"administration":[179],"various":[181],"drugs.":[187],"CONCLUSIONS:":[188],"We":[189],"propose":[190],"that":[191],"this":[192],"cocktail,":[193],"composed":[194],"widely":[197],"available":[198],"constitutes":[200],"promising":[202],"means":[203],"determining":[206],"major":[211],"CYP":[212],"enzymes":[213],"in":[214],"large":[215],"populations.":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}