{"id":"https://openalex.org/W2019739356","doi":"https://doi.org/10.1021/cn200013d","title":"Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists","display_name":"Discovery of 3-Substituted Aminocyclopentanes as Potent and Orally Bioavailable NR2B Subtype-Selective NMDA Antagonists","publication_year":2011,"publication_date":"2011-04-15","ids":{"openalex":"https://openalex.org/W2019739356","doi":"https://doi.org/10.1021/cn200013d","mag":"2019739356","pmid":"https://pubmed.ncbi.nlm.nih.gov/22816022","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3369735"},"language":"en","primary_location":{"id":"doi:10.1021/cn200013d","doi":"https://doi.org/10.1021/cn200013d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cn200013d","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3369735","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042273890","display_name":"Mark E. Layton","orcid":"https://orcid.org/0000-0002-2607-0379","observed_orcids":["https://orcid.org/0000-0002-2607-0379"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Mark E. Layton","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael J. Kelly","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael J. Kelly","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080914019","display_name":"Kevin J. Rodzinak","orcid":"https://orcid.org/0000-0002-2217-8163","observed_orcids":["https://orcid.org/0000-0002-2217-8163"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin J. Rodzinak","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066287008","display_name":"Philip E.J. Sanderson","orcid":"https://orcid.org/0009-0002-7006-650X","observed_orcids":["https://orcid.org/0009-0002-7006-650X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Philip E. Sanderson","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072588174","display_name":"Steven D. Young","orcid":"https://orcid.org/0009-0006-9427-891X","observed_orcids":["https://orcid.org/0009-0006-9427-891X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven D. Young","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065019511","display_name":"Rodney A. Bednar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rodney A. Bednar","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041384227","display_name":"Anthony G. DiLella","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anthony G. DiLella","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105465090","display_name":"Terrence P. McDonald","orcid":"https://orcid.org/0000-0003-4397-9557","observed_orcids":["https://orcid.org/0000-0003-4397-9557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Terrence P. Mcdonald","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446196","display_name":"Hao Wang","orcid":"https://orcid.org/0000-0003-1862-8229","observed_orcids":["https://orcid.org/0000-0003-1862-8229"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Wang","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109134982","display_name":"Scott D. Mosser","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott D. Mosser","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065447896","display_name":"John F. Fay","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John F. Fay","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003326448","display_name":"Michael E. A. Cunningham","orcid":"https://orcid.org/0000-0002-1941-0056","observed_orcids":["https://orcid.org/0000-0002-1941-0056"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael E. Cunningham","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046673026","display_name":"Duane R. Reiss","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Duane R. Reiss","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090176699","display_name":"Christine M. Fandozzi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Fandozzi","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075540393","display_name":"Nicole B. Trainor","orcid":"https://orcid.org/0000-0002-3758-9969","observed_orcids":["https://orcid.org/0000-0002-3758-9969"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Trainor","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109992495","display_name":"Annie Liang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Annie Liang","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047666701","display_name":"Edward V. Lis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edward V. Lis","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011976598","display_name":"Guy R. Seabrook","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy R. Seabrook","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110132861","display_name":"Mark O. Urban","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark O. Urban","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111882926","display_name":"James A. Yergey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Yergey","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084126298","display_name":"Kenneth S. Koblan","orcid":"https://orcid.org/0000-0001-6103-2629","observed_orcids":["https://orcid.org/0000-0001-6103-2629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kenneth S. Koblan","raw_affiliation_strings":["Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of \u2020Medicinal Chemistry, \u2021Molecular Pain Research, \u00a7Movement Disorders, and \u2225Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486, United States","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5042273890"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.6625,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.6201847,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2","issue":"7","first_page":"352","last_page":"362"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9258000254631042,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.013299999758601189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13047","display_name":"Pharmacological Receptor Mechanisms and Effects","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.9779999852180481},{"id":"https://openalex.org/keywords/receptor-subtype-selectivity","display_name":"receptor subtype selectivity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9020000100135803},{"id":"https://openalex.org/keywords/receptor-occupancy","display_name":"receptor occupancy","score":0.621999979019165},{"id":"https://openalex.org/keywords/motor-coordination","display_name":"motor coordination","score":0.8309999704360962},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.9480000138282776},{"id":"https://openalex.org/keywords/spinal-nerve-ligation","display_name":"spinal nerve ligation","score":0.9480000138282776},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.8870000243186951},{"id":"https://openalex.org/keywords/analgesics","display_name":"analgesics","score":0.39800000190734863}],"concepts":[{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7581068277359009},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.7254796028137207},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.6925191283226013},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6410112380981445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6020585894584656},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.59462571144104},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.5099092721939087},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.4233972728252411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36164039373397827},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3019111156463623},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1573910415172577},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072237","descriptor_name":"ERG1 Potassium Channel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002375","descriptor_name":"Catalepsy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D002375","descriptor_name":"Catalepsy","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007202","descriptor_name":"Indicators and Reagents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007536","descriptor_name":"Isomerism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008253","descriptor_name":"Macaca mulatta","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D010069","descriptor_name":"Oxadiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013127","descriptor_name":"Spinal Nerves","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D018691","descriptor_name":"Excitatory Amino Acid Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051638","descriptor_name":"Ether-A-Go-Go Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/cn200013d","doi":"https://doi.org/10.1021/cn200013d","is_oa":false,"landing_page_url":"https://doi.org/10.1021/cn200013d","pdf_url":null,"source":{"id":"https://openalex.org/S180465690","display_name":"ACS Chemical Neuroscience","issn_l":"1948-7193","issn":["1948-7193"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chemical Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2404196","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3369735","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3369735","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3369735","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Chem Neurosci","raw_type":"Text"},{"id":"pmid:22816022","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22816022","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS chemical neuroscience","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2404196","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3369735","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W242690426","https://openalex.org/W1772604871","https://openalex.org/W1963641716","https://openalex.org/W1964127562","https://openalex.org/W1965866432","https://openalex.org/W1969384722","https://openalex.org/W1970696774","https://openalex.org/W1978171643","https://openalex.org/W1980739999","https://openalex.org/W1980940635","https://openalex.org/W1983675510","https://openalex.org/W1987716191","https://openalex.org/W1992428237","https://openalex.org/W2006299239","https://openalex.org/W2019196831","https://openalex.org/W2021710224","https://openalex.org/W2024298612","https://openalex.org/W2028155820","https://openalex.org/W2028569155","https://openalex.org/W2033963948","https://openalex.org/W2042982295","https://openalex.org/W2053473574","https://openalex.org/W2056477716","https://openalex.org/W2058365209","https://openalex.org/W2062241212","https://openalex.org/W2062928716","https://openalex.org/W2065169750","https://openalex.org/W2065204560","https://openalex.org/W2067501599","https://openalex.org/W2069359718","https://openalex.org/W2072166333","https://openalex.org/W2072686777","https://openalex.org/W2073222688","https://openalex.org/W2078046592","https://openalex.org/W2080519186","https://openalex.org/W2085912953","https://openalex.org/W2092356280","https://openalex.org/W2094651630","https://openalex.org/W2100193366","https://openalex.org/W2112893277","https://openalex.org/W2112923968","https://openalex.org/W2129233012","https://openalex.org/W2131051482","https://openalex.org/W2140899588","https://openalex.org/W2153963727","https://openalex.org/W2154142567","https://openalex.org/W2174684682","https://openalex.org/W2175040484","https://openalex.org/W2253970803","https://openalex.org/W2949574343","https://openalex.org/W2949889185","https://openalex.org/W4250195749","https://openalex.org/W4406059073"],"related_works":["https://openalex.org/W2729540152","https://openalex.org/W2062241212","https://openalex.org/W1963641716","https://openalex.org/W2131051482","https://openalex.org/W2008188786","https://openalex.org/W2131765996","https://openalex.org/W2914410285","https://openalex.org/W2080519186","https://openalex.org/W2047576957","https://openalex.org/W1980265858"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,17,23,32,79,87],"3-substituted":[3],"aminocyclopentanes":[4],"has":[5],"been":[6],"identified":[7],"as":[8],"highly":[9],"potent":[10],"and":[11,21,82],"selective":[12],"NR2B":[13,39],"receptor":[14,40],"antagonists.":[15],"Incorporation":[16],"a":[18,74,91],"1,2,4-oxadiazole":[19],"linker":[20],"substitution":[22],"the":[24,30,48,60],"pendant":[25],"phenyl":[26],"ring":[27],"led":[28],"to":[29],"discovery":[31],"orally":[33],"bioavailable":[34],"analogues":[35],"that":[36],"showed":[37,52],"efficient":[38],"occupancy":[41],"in":[42,59,73,83,90],"rats.":[43],"Unlike":[44],"nonselective":[45],"NMDA":[46],"antagonists,":[47],"NR2B-selective":[49],"antagonist":[50],"22":[51,67],"no":[53],"adverse":[54],"affects":[55],"on":[56],"motor":[57],"coordination":[58],"rotarod":[61],"assay":[62],"at":[63],"high":[64],"dose.":[65],"Compound":[66],"was":[68],"efficacious":[69],"following":[70],"oral":[71],"administration":[72],"spinal":[75],"nerve":[76],"ligation":[77],"model":[78,86],"neuropathic":[80],"pain":[81],"an":[84],"acute":[85],"Parkinson's":[88],"disease":[89],"dose":[92],"dependent":[93],"manner.":[94]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
