{"id":"https://openalex.org/W2019730880","doi":"https://doi.org/10.1371/journal.ppat.1004509","title":"Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability","display_name":"Shed GP of Ebola Virus Triggers Immune Activation and Increased Vascular Permeability","publication_year":2014,"publication_date":"2014-11-20","ids":{"openalex":"https://openalex.org/W2019730880","doi":"https://doi.org/10.1371/journal.ppat.1004509","mag":"2019730880","pmid":"https://pubmed.ncbi.nlm.nih.gov/25412102","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4239094"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1004509","doi":"https://doi.org/10.1371/journal.ppat.1004509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004509","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004509&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004509&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007601713","display_name":"Beatriz Escudero-P\u00e9rez","orcid":"https://orcid.org/0000-0003-3655-0525","observed_orcids":["https://orcid.org/0000-0003-3655-0525"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Beatriz Escudero-P\u00e9rez","raw_affiliation_strings":["Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022567237","display_name":"Valentina A. Volchkova","orcid":"https://orcid.org/0000-0003-4028-782X","observed_orcids":["https://orcid.org/0000-0003-4028-782X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Valentina A. Volchkova","raw_affiliation_strings":["Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048456874","display_name":"Olga Dolnik","orcid":"https://orcid.org/0000-0001-7739-4798","observed_orcids":["https://orcid.org/0000-0001-7739-4798"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olga Dolnik","raw_affiliation_strings":["Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071483398","display_name":"Philip Lawrence","orcid":"https://orcid.org/0000-0002-7637-045X","observed_orcids":["https://orcid.org/0000-0002-7637-045X"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Philip Lawrence","raw_affiliation_strings":["Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028710784","display_name":"Viktor E. Volchkov","orcid":"https://orcid.org/0000-0001-7896-8706","observed_orcids":["https://orcid.org/0000-0001-7896-8706"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I113428412","display_name":"\u00c9cole Normale Sup\u00e9rieure de Lyon","ror":"https://ror.org/04zmssz18","country_code":"FR","type":"education","lineage":["https://openalex.org/I113428412","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210161906","display_name":"Centre International de Recherche en Infectiologie","ror":"https://ror.org/059sz6q14","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210100596","https://openalex.org/I4210161906","https://openalex.org/I4405259976"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Viktor E. Volchkov","raw_affiliation_strings":["Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Basis of Viral Pathogenicity, CIRI, INSERM U1111, CNRS UMR5308, Universit\u00e9 de Lyon, Universit\u00e9 Claude Bernard Lyon 1, Ecole Normale Sup\u00e9rieure de Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028710784"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I113428412","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210161906"],"apc_list":{"value":3043,"currency":"USD","value_usd":3043},"apc_paid":{"value":3043,"currency":"USD","value_usd":3043},"fwci":15.3709,"has_fulltext":true,"cited_by_count":181,"citation_normalized_percentile":{"value":0.99422261,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"10","issue":"11","first_page":"e1004509","last_page":"e1004509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ebola-virus","display_name":"Ebola virus","score":0.9919999837875366},{"id":"https://openalex.org/keywords/soluble-glycoprotein","display_name":"soluble glycoprotein","score":0.6899999976158142},{"id":"https://openalex.org/keywords/secreted-glycoprotein","display_name":"secreted glycoprotein","score":0.7870000004768372},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.9089999794960022},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9869999885559082},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.6980000138282776},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.7039999961853027},{"id":"https://openalex.org/keywords/mannose-binding-lectin","display_name":"mannose-binding lectin","score":0.9350000023841858},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6579999923706055},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.9980000257492065},{"id":"https://openalex.org/keywords/costimulatory-molecules","display_name":"costimulatory molecules","score":0.8100000023841858},{"id":"https://openalex.org/keywords/host-inflammatory-response","display_name":"host inflammatory response","score":0.4880000054836273},{"id":"https://openalex.org/keywords/viral-pathogenicity","display_name":"viral pathogenicity","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6161351799964905},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5717196464538574},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.5396217703819275},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4922129213809967},{"id":"https://openalex.org/C2776205754","wikidata":"https://www.wikidata.org/wiki/Q6750945","display_name":"Mannose receptor","level":4,"score":0.48950183391571045},{"id":"https://openalex.org/C2777469322","wikidata":"https://www.wikidata.org/wiki/Q8064876","display_name":"Ebola virus","level":3,"score":0.48507753014564514},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4815680980682373},{"id":"https://openalex.org/C2778297628","wikidata":"https://www.wikidata.org/wiki/Q5009843","display_name":"CD80","level":5,"score":0.4743712544441223},{"id":"https://openalex.org/C108625454","wikidata":"https://www.wikidata.org/wiki/Q187126","display_name":"Glycoprotein","level":2,"score":0.43624603748321533},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.3834252953529358},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.35695570707321167},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3178595304489136},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.2185787856578827},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.1812668740749359},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.17723622918128967},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.13042044639587402},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09725210070610046},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019142","descriptor_name":"Hemorrhagic Fever, Ebola","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D029043","descriptor_name":"Ebolavirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.ppat.1004509","doi":"https://doi.org/10.1371/journal.ppat.1004509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004509","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004509&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},{"id":"pmid:25412102","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25412102","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4239094","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4239094/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.1785","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.1785","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3e/3a/ppat.1004509.PMC4239094.pdf","raw_type":"text"},{"id":"pmh:oai:HAL:hal-01911315v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-01911315","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, 2014, 10 (11), pp.e1004509. &#x27E8;10.1371/journal.ppat.1004509&#x27E9;","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:ffe2e0b441fa45c6bc54f04f94c742bd","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ffe2e0b441fa45c6bc54f04f94c742bd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 10, Iss 11, p e1004509 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1247726","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Shed_GP_of_Ebola_Virus_Triggers_Immune_Activation_and_Increased_Vascular_Permeability_/1247726","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1004509","doi":"https://doi.org/10.1371/journal.ppat.1004509","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1004509","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004509&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4425882893","display_name":null,"funder_award_id":"ANR-07-MIME-006-01","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"},{"id":"https://openalex.org/G633704252","display_name":"ANTIcipating the Global Onset of Novel Epidemics","funder_award_id":"278976","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8474129329","display_name":"Bases mol\u00e9culaires de la r\u00e9sistance \u00e0 l\u00bfinfection par le virus Ebola.","funder_award_id":"ANR-07-MIME-0006","funder_id":"https://openalex.org/F4320320883","funder_display_name":"Agence Nationale de la Recherche"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320883","display_name":"Agence Nationale de la Recherche","ror":"https://ror.org/00rbzpz17"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019730880.pdf","grobid_xml":"https://content.openalex.org/works/W2019730880.grobid-xml"},"referenced_works_count":83,"referenced_works":["https://openalex.org/W408225","https://openalex.org/W1496474841","https://openalex.org/W1504643362","https://openalex.org/W1863223069","https://openalex.org/W1902994327","https://openalex.org/W1918252214","https://openalex.org/W1934712179","https://openalex.org/W1966471922","https://openalex.org/W1966742128","https://openalex.org/W1970839833","https://openalex.org/W1971189758","https://openalex.org/W1974773759","https://openalex.org/W1978996068","https://openalex.org/W1982922581","https://openalex.org/W1984322059","https://openalex.org/W1985976782","https://openalex.org/W1986908601","https://openalex.org/W1991100819","https://openalex.org/W1993048073","https://openalex.org/W2001327611","https://openalex.org/W2011846108","https://openalex.org/W2012748795","https://openalex.org/W2012875512","https://openalex.org/W2014418657","https://openalex.org/W2019168201","https://openalex.org/W2019771217","https://openalex.org/W2021285446","https://openalex.org/W2024686947","https://openalex.org/W2030622694","https://openalex.org/W2031628932","https://openalex.org/W2031852128","https://openalex.org/W2038501005","https://openalex.org/W2047683488","https://openalex.org/W2053240442","https://openalex.org/W2054965116","https://openalex.org/W2058824570","https://openalex.org/W2067510101","https://openalex.org/W2068558236","https://openalex.org/W2069019468","https://openalex.org/W2069678563","https://openalex.org/W2075823058","https://openalex.org/W2076113735","https://openalex.org/W2077896985","https://openalex.org/W2082882388","https://openalex.org/W2087662167","https://openalex.org/W2090686248","https://openalex.org/W2094480265","https://openalex.org/W2098059264","https://openalex.org/W2099471944","https://openalex.org/W2102286438","https://openalex.org/W2107446952","https://openalex.org/W2109176931","https://openalex.org/W2114563488","https://openalex.org/W2114637517","https://openalex.org/W2115102869","https://openalex.org/W2117792885","https://openalex.org/W2120982869","https://openalex.org/W2128364938","https://openalex.org/W2128963410","https://openalex.org/W2129860769","https://openalex.org/W2133003848","https://openalex.org/W2134224958","https://openalex.org/W2135722581","https://openalex.org/W2136813430","https://openalex.org/W2138838687","https://openalex.org/W2139266436","https://openalex.org/W2142216001","https://openalex.org/W2142957009","https://openalex.org/W2148172043","https://openalex.org/W2150615472","https://openalex.org/W2152939400","https://openalex.org/W2155970168","https://openalex.org/W2159660583","https://openalex.org/W2159723028","https://openalex.org/W2160796054","https://openalex.org/W2161862450","https://openalex.org/W2166968703","https://openalex.org/W2168112834","https://openalex.org/W2397447190","https://openalex.org/W2400738601","https://openalex.org/W2404848110","https://openalex.org/W2415865018","https://openalex.org/W2464879818"],"related_works":["https://openalex.org/W7096828662","https://openalex.org/W2027228134","https://openalex.org/W7143649816","https://openalex.org/W4392421219","https://openalex.org/W2886878531","https://openalex.org/W4307500043","https://openalex.org/W7100029378","https://openalex.org/W4313383718","https://openalex.org/W2133003848","https://openalex.org/W2159723028"],"abstract_inverted_index":{"During":[0],"Ebola":[1],"virus":[2,283],"(EBOV)":[3],"infection":[4,277],"a":[5,18,65,189],"significant":[6],"amount":[7],"of":[8,48,85,99,112,161,171,184,201,209,252,268],"surface":[9,110,200],"glycoprotein":[10,33],"GP":[11,29,40,62,104,143,158,178,211,237],"is":[12,145,155,180],"shed":[13,61,103,122,142,168,177,210,225,236],"from":[14,37,239],"infected":[15,53],"cells":[16,79,101,162,241],"in":[17,45,109],"soluble":[19],"form":[20],"due":[21],"to":[22,121,192,212,276,281],"cleavage":[23],"by":[24,102],"cellular":[25,149],"metalloprotease":[26],"TACE.":[27],"Shed":[28],"and":[30,51,75,80,87,95,118,154,219,230,246,254,257,271,278],"non-structural":[31],"secreted":[32,124],"sGP,":[34],"both":[35,217],"expressed":[36],"the":[38,46,83,107,199,207,222,249,266,269],"same":[39],"gene,":[41],"have":[42],"been":[43],"detected":[44],"blood":[47],"human":[49],"patients":[50],"experimentally":[52],"animals.":[54],"In":[55,71,136,234],"this":[56,137],"study":[57],"we":[58,139,205],"demonstrate":[59,175],"that":[60,141,176],"could":[63,133,242,263],"play":[64],"particular":[66],"role":[67],"during":[68],"EBOV":[69],"infection.":[70],"effect":[72,258],"it":[73,132],"binds":[74],"activates":[76,126],"non-infected":[77,244],"dendritic":[78],"macrophages":[81,130,247],"inducing":[82],"secretion":[84],"pro-":[86,253],"anti-inflammatory":[88,255],"cytokines":[89,256],"(TNF\u03b1,":[90],"IL1\u03b2,":[91],"IL6,":[92],"IL8,":[93],"IL12p40,":[94],"IL1-RA,":[96],"IL10).":[97],"Activation":[98],"these":[100],"correlates":[105],"with":[106,163,194],"increase":[108],"expression":[111],"co-stimulatory":[113],"molecules":[114],"CD40,":[115],"CD80,":[116],"CD83":[117],"CD86.":[119],"Contrary":[120],"GP,":[123,226],"sGP":[125],"neither":[127],"DC":[128],"nor":[129],"while":[131],"bind":[134],"DCs.":[135],"study,":[138],"show":[140],"activity":[144,179],"likely":[146],"mediated":[147],"through":[148],"toll-like":[150],"receptor":[151],"4":[152],"(TLR4)":[153],"dependent":[156],"on":[157,198],"glycosylation.":[159],"Treatment":[160],"anti-TLR4":[164],"antibody":[165],"completely":[166],"abolishes":[167],"GP-induced":[169],"activation":[170],"cells.":[172],"We":[173],"also":[174],"negated":[181],"upon":[182],"addition":[183],"mannose-binding":[185],"sera":[186],"lectin":[187],"MBL,":[188],"molecule":[190],"known":[191],"interact":[193],"sugar":[195],"arrays":[196],"present":[197],"different":[202],"microorganisms.":[203],"Furthermore,":[204],"highlight":[206],"ability":[208],"affect":[213],"endothelial":[214],"cell":[215],"function":[216],"directly":[218],"indirectly,":[220],"demonstrating":[221],"interplay":[223],"between":[224],"systemic":[227],"cytokine":[228],"release":[229,251],"increased":[231],"vascular":[232,259],"permeability.":[233,260],"conclusion,":[235],"released":[238],"virus-infected":[240],"activate":[243],"DCs":[245],"causing":[248],"massive":[250],"These":[261],"activities":[262],"be":[264],"at":[265],"heart":[267],"excessive":[270],"dysregulated":[272],"inflammatory":[273],"host":[274],"reactions":[275],"thus":[279],"contribute":[280],"high":[282],"pathogenicity.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":13},{"year":2015,"cited_by_count":22},{"year":2014,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
