{"id":"https://openalex.org/W201972559","doi":"https://doi.org/10.1016/0022-510x(86)90001-8","title":"Cholinesterases in cerebrospinal fluid","display_name":"Cholinesterases in cerebrospinal fluid","publication_year":1986,"publication_date":"1986-02-01","ids":{"openalex":"https://openalex.org/W201972559","doi":"https://doi.org/10.1016/0022-510x(86)90001-8","mag":"201972559","pmid":"https://pubmed.ncbi.nlm.nih.gov/3711929"},"language":"en","primary_location":{"id":"doi:10.1016/0022-510x(86)90001-8","doi":"https://doi.org/10.1016/0022-510x(86)90001-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-510x(86)90001-8","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111557057","display_name":"F. Jacob Huff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"F.Jacob Huff","raw_affiliation_strings":["Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","Department of Neurology, Harvard Medical School at the Massachusetts General Hospital, Boston U.S.A","Department of Psychology, Massachusetts Institute of Technology, Cambridge U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Neurology, Harvard Medical School at the Massachusetts General Hospital, Boston U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychology, Massachusetts Institute of Technology, Cambridge U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105729839","display_name":"Jean-Claude E. Maire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Claude Maire","raw_affiliation_strings":["Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge, MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge, MA U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111694111","display_name":"John H. Growdon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John H. Growdon","raw_affiliation_strings":["Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","Department of Neurology, Harvard Medical School at the Massachusetts General Hospital, Boston U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Neurology, Harvard Medical School at the Massachusetts General Hospital, Boston U.S.A","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019100335","display_name":"Suzanne Corkin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne Corkin","raw_affiliation_strings":["Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","Department of Psychology, Massachusetts Institute of Technology, Cambridge U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Research Center, Massachusetts Institute of Technology, Cambridge U.S.A","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Department of Psychology, Massachusetts Institute of Technology, Cambridge U.S.A","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109899809","display_name":"Richard Jay Wurtman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Wurtman","raw_affiliation_strings":["Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge, MA U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroendocrine Regulation, Massachusetts Institute of Technology, Cambridge, MA U.S.A","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5111557057"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I63966007"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":7.1732,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.97516152,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"72","issue":"2-3","first_page":"121","last_page":"129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/butyrylcholinesterase","display_name":"butyrylcholinesterase","score":1.0},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9649999737739563},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.9890000224113464},{"id":"https://openalex.org/keywords/dementia-severity","display_name":"dementia severity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.9269999861717224},{"id":"https://openalex.org/keywords/language-disorders","display_name":"language disorders","score":0.8339999914169312},{"id":"https://openalex.org/keywords/contrast-sensitivity","display_name":"contrast sensitivity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C2779101902","wikidata":"https://www.wikidata.org/wiki/Q22679015","display_name":"Butyrylcholinesterase","level":5,"score":0.9509010314941406},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.9056247472763062},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8462798595428467},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.6795169115066528},{"id":"https://openalex.org/C31896038","wikidata":"https://www.wikidata.org/wiki/Q415635","display_name":"Cholinesterase","level":2,"score":0.601642906665802},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5460869669914246},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.538445234298706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5132129192352295},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.4774635136127472},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4294637441635132},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41966187953948975},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35479670763015747},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3459394574165344},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32374143600463867},{"id":"https://openalex.org/C2779059548","wikidata":"https://www.wikidata.org/wiki/Q383701","display_name":"Ach\u00e9","level":4,"score":0.24502697587013245},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2134106457233429},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.15644049644470215},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13417240977287292}],"mesh":[{"descriptor_ui":"D000110","descriptor_name":"Acetylcholinesterase","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D002091","descriptor_name":"Butyrylcholinesterase","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D002802","descriptor_name":"Cholinesterases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-510x(86)90001-8","doi":"https://doi.org/10.1016/0022-510x(86)90001-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-510x(86)90001-8","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},{"id":"pmid:3711929","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3711929","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the neurological sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2094033601","display_name":null,"funder_award_id":"MH 28783","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G4225780372","display_name":null,"funder_award_id":"AG000232","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G5430082279","display_name":null,"funder_award_id":"MH32724","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W595210553","https://openalex.org/W1971048984","https://openalex.org/W1971907312","https://openalex.org/W1980424405","https://openalex.org/W1980845432","https://openalex.org/W1984287695","https://openalex.org/W1986367861","https://openalex.org/W1990451873","https://openalex.org/W1992282617","https://openalex.org/W1998654733","https://openalex.org/W2004713321","https://openalex.org/W2011293597","https://openalex.org/W2017177022","https://openalex.org/W2017728335","https://openalex.org/W2024570412","https://openalex.org/W2025281971","https://openalex.org/W2029408077","https://openalex.org/W2045325653","https://openalex.org/W2053293311","https://openalex.org/W2065347688","https://openalex.org/W2066718452","https://openalex.org/W2066864238","https://openalex.org/W2072898228","https://openalex.org/W2080451697","https://openalex.org/W2083346300","https://openalex.org/W2083563317","https://openalex.org/W2085798930","https://openalex.org/W2088273166","https://openalex.org/W2089630704","https://openalex.org/W2103914883","https://openalex.org/W2104227586","https://openalex.org/W2104606868","https://openalex.org/W2124540184","https://openalex.org/W2133361146","https://openalex.org/W2137589527","https://openalex.org/W2143314326","https://openalex.org/W2156220037","https://openalex.org/W2159529587","https://openalex.org/W2160161086","https://openalex.org/W2227277894","https://openalex.org/W2413923572","https://openalex.org/W4239429569","https://openalex.org/W7005345365"],"related_works":["https://openalex.org/W2040825345","https://openalex.org/W2970561911","https://openalex.org/W2081861377","https://openalex.org/W2419370790","https://openalex.org/W2053378713","https://openalex.org/W2055541697","https://openalex.org/W2074567403","https://openalex.org/W2093531351","https://openalex.org/W1987298986","https://openalex.org/W1981568250"],"abstract_inverted_index":null,"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
