{"id":"https://openalex.org/W2019721100","doi":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","title":"Hepatitis B virus surface (S) transactivator with DNA-binding properties","display_name":"Hepatitis B virus surface (S) transactivator with DNA-binding properties","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2019721100","doi":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","mag":"2019721100","pmid":"https://pubmed.ncbi.nlm.nih.gov/10745225"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","doi":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106766375","display_name":"Saxena Alka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Saxena Alka","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010033769","display_name":"Hemlata Durgapal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Durgapal Hemlata","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021573430","display_name":"Vaishali Chaudhuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chaudhuri Vaishali","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076248093","display_name":"Shahid Jameel","orcid":"https://orcid.org/0000-0001-5424-9774","observed_orcids":["https://orcid.org/0000-0001-5424-9774"]},"institutions":[{"id":"https://openalex.org/I4210142124","display_name":"International Centre for Genetic Engineering and Biotechnology","ror":"https://ror.org/03j4rrt43","country_code":"IN","type":"facility","lineage":["https://openalex.org/I4210142124","https://openalex.org/I91080651"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jameel Shahid","raw_affiliation_strings":["Virology Group, International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Virology Group, International Center for Genetic Engineering and Biotechnology (ICGEB), New Delhi, India","institution_ids":["https://openalex.org/I4210142124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036856339","display_name":"Panda Subrat Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63739035","display_name":"All India Institute of Medical Sciences","ror":"https://ror.org/02dwcqs71","country_code":"IN","type":"education","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210148677","https://openalex.org/I63739035"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Panda Subrat Kumar","raw_affiliation_strings":["Department of Pathology, All India Institute of Medical Sciences, New Delhi, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, All India Institute of Medical Sciences, New Delhi, India","institution_ids":["https://openalex.org/I63739035"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5036856339"],"corresponding_institution_ids":["https://openalex.org/I63739035"],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":1.2774,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.78985439,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"61","issue":"1","first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatitis-b-virus","display_name":"hepatitis B virus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dna-binding","display_name":"DNA binding","score":0.5649999976158142},{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.6919999718666077},{"id":"https://openalex.org/keywords/proto-oncogenes","display_name":"proto-oncogenes","score":0.6880000233650208},{"id":"https://openalex.org/keywords/c-jun-promoter","display_name":"c-jun promoter","score":0.7300000190734863},{"id":"https://openalex.org/keywords/c-fos-promoter","display_name":"c-fos promoter","score":1.0},{"id":"https://openalex.org/keywords/ap-1","display_name":"AP-1","score":0.7559999823570251},{"id":"https://openalex.org/keywords/tfiid","display_name":"TFIID","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-hepatitis-b","display_name":"chronic hepatitis B","score":0.7839999794960022}],"concepts":[{"id":"https://openalex.org/C1292079","wikidata":"https://www.wikidata.org/wiki/Q3817769","display_name":"Transactivation","level":4,"score":0.7392237186431885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.674358606338501},{"id":"https://openalex.org/C199491388","wikidata":"https://www.wikidata.org/wiki/Q1869477","display_name":"Long terminal repeat","level":4,"score":0.6588051319122314},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.6024430990219116},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.595055103302002},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5668253898620605},{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.5609015226364136},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5558322072029114},{"id":"https://openalex.org/C2777441520","wikidata":"https://www.wikidata.org/wiki/Q1444330","display_name":"Rous sarcoma virus","level":3,"score":0.5453164577484131},{"id":"https://openalex.org/C73616013","wikidata":"https://www.wikidata.org/wiki/Q5731703","display_name":"Hepatitis B virus PRE beta","level":5,"score":0.5120654702186584},{"id":"https://openalex.org/C183978625","wikidata":"https://www.wikidata.org/wiki/Q903596","display_name":"Electrophoretic mobility shift assay","level":4,"score":0.4435255825519562},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4284519851207733},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.42183977365493774},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3548726737499237},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.32263708114624023},{"id":"https://openalex.org/C194575299","wikidata":"https://www.wikidata.org/wiki/Q2843746","display_name":"Hepatitis B virus DNA polymerase","level":4,"score":0.18794262409210205},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12671741843223572}],"mesh":[{"descriptor_ui":"D000090063","descriptor_name":"Proto-Oncogene Mas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001358","descriptor_name":"Avian Sarcoma Viruses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006515","descriptor_name":"Hepatitis B virus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011993","descriptor_name":"Recombinant Fusion Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015367","descriptor_name":"Human T-lymphotropic virus 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015367","descriptor_name":"Human T-lymphotropic virus 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015368","descriptor_name":"Human T-lymphotropic virus 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016325","descriptor_name":"HIV Long Terminal Repeat","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016758","descriptor_name":"Genes, jun","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020079","descriptor_name":"Terminal Repeat Sequences","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054334","descriptor_name":"Viral Regulatory and Accessory Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","doi":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9071(200005)61:1<1::aid-jmv1>3.0.co;2-a","pdf_url":null,"source":{"id":"https://openalex.org/S49828768","display_name":"Journal of Medical Virology","issn_l":"0146-6615","issn":["0146-6615","1096-9071"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medical Virology","raw_type":"journal-article"},{"id":"pmid:10745225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10745225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medical virology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W155964910","https://openalex.org/W437178797","https://openalex.org/W1799117517","https://openalex.org/W1874132424","https://openalex.org/W1916829140","https://openalex.org/W1939804351","https://openalex.org/W1966448677","https://openalex.org/W1980865611","https://openalex.org/W1983796564","https://openalex.org/W1984148853","https://openalex.org/W1984736192","https://openalex.org/W1986871443","https://openalex.org/W1991961027","https://openalex.org/W1992566200","https://openalex.org/W2005071171","https://openalex.org/W2008666823","https://openalex.org/W2010356985","https://openalex.org/W2010435021","https://openalex.org/W2027559511","https://openalex.org/W2034116029","https://openalex.org/W2051551171","https://openalex.org/W2060484288","https://openalex.org/W2065716796","https://openalex.org/W2070443263","https://openalex.org/W2075468561","https://openalex.org/W2075570601","https://openalex.org/W2075793367","https://openalex.org/W2076684492","https://openalex.org/W2081472291","https://openalex.org/W2093019351","https://openalex.org/W2094872845","https://openalex.org/W2111918191","https://openalex.org/W2144206181","https://openalex.org/W2148578115","https://openalex.org/W2156477890","https://openalex.org/W2165409475","https://openalex.org/W2167105480","https://openalex.org/W2419420942","https://openalex.org/W4246892132"],"related_works":["https://openalex.org/W2030642077","https://openalex.org/W168169400","https://openalex.org/W1986871443","https://openalex.org/W2413015347","https://openalex.org/W2284098364","https://openalex.org/W185353069","https://openalex.org/W2406372906","https://openalex.org/W2027559511","https://openalex.org/W2419420942","https://openalex.org/W1675652804"],"abstract_inverted_index":{"Chronic":[0],"infection":[1],"with":[2,41,217],"hepatitis":[3],"B":[4],"virus":[5,128,135,140],"(HBV)":[6],"in":[7,28,38,46,79],"humans":[8],"is":[9,70,199,212],"strongly":[10],"linked":[11],"to":[12,35,97,155,164],"the":[13,47,54,58,67,74,102,144,174],"development":[14],"of":[15,20,57,66,73,182,202],"hepatocellular":[16],"carcinoma":[17],"(HCC).":[18],"Activation":[19],"growth-regulatory":[21],"genes":[22],"may":[23],"play":[24],"a":[25,71,85,200],"crucial":[26],"role":[27],"carcinogenesis.":[29],"Proto-oncogene":[30],"expression":[31],"has":[32],"been":[33],"shown":[34],"be":[36],"higher":[37],"HCC":[39],"tissue":[40],"integrated":[42],"HBV":[43,59,165],"DNA":[44],"than":[45],"normal":[48],"liver.":[49],"Earlier,":[50],"we":[51],"showed":[52],"that":[53,123,161,197,209],"3'":[55],"end":[56],"major":[60],"surface":[61],"gene":[62],"(S)":[63],"(426-855":[64],"nucleotides":[65],"S":[68,89,104],"region)":[69],"transactivator":[72,201],"X":[75,166],"promoter-enhancer":[76],"regulatory":[77,118],"element":[78],"co-transfection":[80],"experiments.":[81],"This":[82],"region":[83],"expresses":[84],"truncated":[86,103],"carboxy":[87],"terminal":[88,130],"protein":[90,105],"extending":[91],"from":[92],"amino":[93],"acid":[94],"residues":[95],"102":[96],"226.":[98],"In":[99],"this":[100,183,210],"study,":[101],"(trc-S)":[106],"was":[107,185],"examined":[108],"for":[109,173],"its":[110,157],"enhancing":[111],"activity":[112,211],"on":[113],"several":[114,203],"viral":[115,206],"and":[116,143,146,168,176,191,205,208],"cellular":[117,204],"elements.":[119],"The":[120,180],"results":[121],"indicate":[122],"trc-S":[124,162,198],"activates":[125],"rous":[126],"sarcoma":[127],"long":[129],"repeat":[131],"(LTR),":[132],"human":[133,138],"T-lymphotropic":[134],"2":[136],"LTR,":[137,142],"immunodeficiency":[139],"1":[141],"c-jun":[145],"c-fos":[147],"promoters.":[148],"Electrophoretic":[149],"mobility":[150],"shift":[151],"assays":[152],"carried":[153],"out":[154],"investigate":[156],"DNA-binding":[158],"properties":[159],"established":[160],"binds":[163],"promoter":[167],"oligonucleotides":[169],"representing":[170],"binding":[171],"sites":[172],"AP1":[175],"TFIID":[177],"transcription":[178],"factors.":[179],"specificity":[181],"interaction":[184,216],"confirmed":[186],"by":[187,214],"using":[188],"competition":[189],"experiments":[190,195],"supershift":[192],"assays.":[193],"These":[194],"suggest":[196],"promoters":[207],"mediated":[213],"direct":[215],"DNA.":[218]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
