{"id":"https://openalex.org/W2019717013","doi":"https://doi.org/10.1007/s13238-013-0018-8","title":"DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells","display_name":"DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells","publication_year":2014,"publication_date":"2014-02-01","ids":{"openalex":"https://openalex.org/W2019717013","doi":"https://doi.org/10.1007/s13238-013-0018-8","mag":"2019717013","pmid":"https://pubmed.ncbi.nlm.nih.gov/24515614","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3956975"},"language":"en","primary_location":{"id":"doi:10.1007/s13238-013-0018-8","doi":"https://doi.org/10.1007/s13238-013-0018-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-0018-8","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/2/124/47216157/13238_2013_article_18.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein &amp; Cell","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/proteincell/article-pdf/5/2/124/47216157/13238_2013_article_18.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035230648","display_name":"Yinghao Zhang","orcid":"https://orcid.org/0000-0001-5230-6376","observed_orcids":["https://orcid.org/0000-0001-5230-6376","https://orcid.org/0000-0001-9850-0895"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4391767814","display_name":"State Key Laboratory of Brain and Cognitive Science","ror":"https://ror.org/048wy7h78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinghao Zhang","raw_affiliation_strings":["Medical Research Division, Regional Academic Health Center, Edinburg, TX, 78541, USA","Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, Edinburg, TX, 78541, USA","institution_ids":[]},{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111736073","display_name":"Fang-Mei Chang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fang-Mei Chang","raw_affiliation_strings":["Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101959846","display_name":"Jianjun Huang","orcid":"https://orcid.org/0000-0001-9031-3059","observed_orcids":["https://orcid.org/0000-0001-9031-3059"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Huang","raw_affiliation_strings":["Department of Clinical Biochemistry, Xiangya Medical College, Central South University, 410013, Changsha, China","Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Biochemistry, Xiangya Medical College, Central South University, 410013, Changsha, China","institution_ids":["https://openalex.org/I139660479"]},{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042776973","display_name":"Jacob J. Junco","orcid":"https://orcid.org/0000-0002-2435-7739","observed_orcids":["https://orcid.org/0000-0002-2435-7739"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob J. Junco","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029143160","display_name":"Shivani Kaushal Maffi","orcid":"https://orcid.org/0000-0002-1802-3740","observed_orcids":["https://orcid.org/0000-0002-1802-3740"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shivani K. Maffi","raw_affiliation_strings":["Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055714044","display_name":"Hannah I. Pridgen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah I. Pridgen","raw_affiliation_strings":["Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052350642","display_name":"Gabriel Catano","orcid":"https://orcid.org/0000-0001-6047-2286","observed_orcids":["https://orcid.org/0000-0001-6047-2286"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gabriel Catano","raw_affiliation_strings":["Department of Medicine, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043349619","display_name":"Hong Dang","orcid":"https://orcid.org/0000-0002-7305-4208","observed_orcids":["https://orcid.org/0000-0002-7305-4208"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Dang","raw_affiliation_strings":["Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center, School of Medicine, University of North Carolina at Chapel Hill, 27599, Chapel Hill, NC, USA","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101843019","display_name":"Xiang Dong Ding","orcid":"https://orcid.org/0000-0003-1097-176X","observed_orcids":["https://orcid.org/0000-0003-1097-176X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Ding","raw_affiliation_strings":["Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067365392","display_name":"Fuquan Yang","orcid":"https://orcid.org/0000-0002-2841-5342","observed_orcids":["https://orcid.org/0000-0002-2841-5342"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuquan Yang","raw_affiliation_strings":["Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Proteomics, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065828916","display_name":"Dae Joon Kim","orcid":"https://orcid.org/0000-0002-7977-9955","observed_orcids":["https://orcid.org/0000-0002-7977-9955","https://orcid.org/0009-0005-4940-035X"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dae Joon Kim","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]},{"raw_affiliation_string":"The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076209858","display_name":"Thomas J. Slaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas J. Slaga","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100664208","display_name":"Rongqiao He","orcid":"https://orcid.org/0000-0003-4261-9939","observed_orcids":["https://orcid.org/0000-0003-4261-9939"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4391767814","display_name":"State Key Laboratory of Brain and Cognitive Science","ror":"https://ror.org/048wy7h78","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongqiao He","raw_affiliation_strings":["State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540","https://openalex.org/I4391767814"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003236713","display_name":"Sung\u2010Jen Wei","orcid":"https://orcid.org/0000-0001-6880-6850","observed_orcids":["https://orcid.org/0000-0001-6880-6850","https://orcid.org/0000-0002-9810-9041"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sung-Jen Wei","raw_affiliation_strings":["Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]},{"raw_affiliation_string":"Medical Research Division, Regional Academic Health Center, 78541, Edinburg, TX, USA","institution_ids":[]},{"raw_affiliation_string":"The Cancer Therapy and Research Center, The University of Texas Health Science Center at San Antonio, 78229, San Antonio, TX, USA","institution_ids":["https://openalex.org/I165951966"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5003236713"],"corresponding_institution_ids":["https://openalex.org/I165951966"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.2517,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.51208541,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":"2","first_page":"124","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.10090000182390213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dss1","display_name":"DSS1","score":0.9879999756813049},{"id":"https://openalex.org/keywords/protein-modification","display_name":"protein modification","score":0.6190000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8579999804496765},{"id":"https://openalex.org/keywords/oxidized-proteins","display_name":"oxidized proteins","score":0.7850000262260437},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ubiquitination","display_name":"ubiquitination","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ubiquitin-proteasome-system","display_name":"ubiquitin-proteasome system","score":0.9860000014305115},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.6890000104904175},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.7749999761581421},{"id":"https://openalex.org/keywords/protein-adducts","display_name":"protein adducts","score":0.675000011920929}],"concepts":[{"id":"https://openalex.org/C27740335","wikidata":"https://www.wikidata.org/wiki/Q14878333","display_name":"Proteasome","level":2,"score":0.7319241166114807},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6875896453857422},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6412141919136047},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.5618259906768799},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5121610164642334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5050485730171204},{"id":"https://openalex.org/C2911199164","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitins","level":5,"score":0.48861032724380493},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.46935683488845825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4445871412754059},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.372035413980484},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.22349190711975098},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12902158498764038}],"mesh":[{"descriptor_ui":"D005609","descriptor_name":"Free Radicals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025801","descriptor_name":"Ubiquitin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D046188","descriptor_name":"Protein Modification, Translational","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D046988","descriptor_name":"Proteasome Endopeptidase Complex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054875","descriptor_name":"Ubiquitination","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":8,"locations":[{"id":"doi:10.1007/s13238-013-0018-8","doi":"https://doi.org/10.1007/s13238-013-0018-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-0018-8","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/2/124/47216157/13238_2013_article_18.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein &amp; Cell","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2940380","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3956975","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3956975","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3956975","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein Cell","raw_type":"Text"},{"id":"pmid:24515614","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24515614","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein & cell","raw_type":"Journal Article"},{"id":"pmh:cdr.lib.unc.edu:sx61dv204","doi":null,"is_oa":true,"landing_page_url":"https://doi.org/10.17615/d7mk-1z94","pdf_url":"https://doi.org/10.17615/d7mk-1z94","source":{"id":"https://openalex.org/S4306401075","display_name":"Carolina Digital Repository (University of North Carolina at Chapel Hill)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114027177","host_organization_name":"University of North Carolina at Chapel Hill","host_organization_lineage":["https://openalex.org/I114027177"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Protein Cell, 5(2)","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.811.8241","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.811.8241","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/be/22/13238_2013_Article_18.PMC3956975.pdf","raw_type":"text"},{"id":"doi:10.17615/d7mk-1z94","doi":"https://doi.org/10.17615/d7mk-1z94","is_oa":true,"landing_page_url":"https://doi.org/10.17615/d7mk-1z94","pdf_url":null,"source":{"id":"https://openalex.org/S7407051488","display_name":"UNC Libraries","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:3145891398","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/71234X/201402/49073158.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306557839","display_name":"\u86cb\u767d\u8d28\u4e0e\u7ec6\u80de\uff1a\u82f1\u6587\u7248","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u86cb\u767d\u8d28\u4e0e\u7ec6\u80de\uff1a\u82f1\u6587\u7248","raw_type":null}],"best_oa_location":{"id":"doi:10.1007/s13238-013-0018-8","doi":"https://doi.org/10.1007/s13238-013-0018-8","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-0018-8","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/2/124/47216157/13238_2013_article_18.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein &amp; Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4043000042438507,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1221135887","display_name":"Mays Cancer Center at UT Health SA","funder_award_id":"P30CA054174","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1703005167","display_name":null,"funder_award_id":"2010CB912303","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G2746383473","display_name":null,"funder_award_id":"GJHZ201302","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G3358101468","display_name":null,"funder_award_id":"2012CB911004","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G3874765150","display_name":null,"funder_award_id":"P30 CA054174","funder_id":"https://openalex.org/F4320332686","funder_display_name":"University of Texas Health Science Center at San Antonio"}],"funders":[{"id":"https://openalex.org/F4320311096","display_name":"Virginia Commonwealth University","ror":"https://ror.org/02nkdxk79"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320332686","display_name":"University of Texas Health Science Center at San Antonio","ror":"https://ror.org/02f6dcw23"},{"id":"https://openalex.org/F4320332688","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019717013.pdf","grobid_xml":"https://content.openalex.org/works/W2019717013.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1485416082","https://openalex.org/W1503901149","https://openalex.org/W1534171724","https://openalex.org/W1597643123","https://openalex.org/W1659912652","https://openalex.org/W1936380547","https://openalex.org/W1949298472","https://openalex.org/W1961774825","https://openalex.org/W1968229731","https://openalex.org/W1968704764","https://openalex.org/W1969505359","https://openalex.org/W1980064429","https://openalex.org/W1980745735","https://openalex.org/W1981465641","https://openalex.org/W1985031521","https://openalex.org/W1985591678","https://openalex.org/W1987206830","https://openalex.org/W1988746802","https://openalex.org/W2000292506","https://openalex.org/W2004283265","https://openalex.org/W2007157911","https://openalex.org/W2008128102","https://openalex.org/W2011272179","https://openalex.org/W2012296420","https://openalex.org/W2013429682","https://openalex.org/W2015881243","https://openalex.org/W2019496322","https://openalex.org/W2020120461","https://openalex.org/W2021919397","https://openalex.org/W2025106485","https://openalex.org/W2032996948","https://openalex.org/W2033839927","https://openalex.org/W2038878016","https://openalex.org/W2041973951","https://openalex.org/W2044695362","https://openalex.org/W2045144602","https://openalex.org/W2047937380","https://openalex.org/W2047983287","https://openalex.org/W2048897966","https://openalex.org/W2048966030","https://openalex.org/W2049569756","https://openalex.org/W2053450572","https://openalex.org/W2056867819","https://openalex.org/W2058302603","https://openalex.org/W2064380972","https://openalex.org/W2069309708","https://openalex.org/W2075862048","https://openalex.org/W2076834744","https://openalex.org/W2084034209","https://openalex.org/W2093525687","https://openalex.org/W2103573935","https://openalex.org/W2111250240","https://openalex.org/W2115414474","https://openalex.org/W2120772351","https://openalex.org/W2123781000","https://openalex.org/W2124098523","https://openalex.org/W2132270233","https://openalex.org/W2138057005","https://openalex.org/W2141819645","https://openalex.org/W2143500687","https://openalex.org/W2147993424","https://openalex.org/W2150418491","https://openalex.org/W2162695817","https://openalex.org/W2166987747","https://openalex.org/W2170773702","https://openalex.org/W2171108478","https://openalex.org/W2172114663","https://openalex.org/W2177092266","https://openalex.org/W2469305017","https://openalex.org/W2912221368"],"related_works":["https://openalex.org/W7098718031","https://openalex.org/W2126178199","https://openalex.org/W7097366805","https://openalex.org/W2022433801","https://openalex.org/W2557706130","https://openalex.org/W2053450572","https://openalex.org/W2089033608","https://openalex.org/W2079070625","https://openalex.org/W1778688476","https://openalex.org/W2075428562"],"abstract_inverted_index":{"Timely":[0],"removal":[1],"of":[2,30],"oxidatively":[3],"damaged":[4],"proteins":[5,20,41,63,75,91,136],"is":[6,21,60,104],"critical":[7],"for":[8,17],"cells":[9],"exposed":[10],"to":[11,62,101,106,140,147],"oxidative":[12,66],"stresses;":[13],"however,":[14],"cellular":[15],"mechanism":[16],"clearing":[18],"oxidized":[19,40,74],"not":[22],"clear.":[23],"Our":[24],"study":[25],"reveals":[26],"a":[27,36,129,137],"novel":[28,119],"type":[29],"protein":[31,120],"modification":[32,121],"that":[33],"may":[34,133],"play":[35],"role":[37],"in":[38,50,68,71,124],"targeting":[39,82],"and":[42,70],"remove":[43],"them.":[44,149],"In":[45],"this":[46,118],"process,":[47],"DSS1":[48,77,99,126],"(deleted":[49],"split":[51],"hand/split":[52],"foot":[53],"1),":[54],"an":[55,108,113],"evolutionally":[56],"conserved":[57],"small":[58],"protein,":[59],"conjugated":[61],"induced":[64],"by":[65,112],"stresses":[67],"vitro":[69],"vivo,":[72],"implying":[73],"are":[76,92],"clients.":[78],"A":[79],"subsequent":[80,142],"ubiquitination":[81],"DSS1-protein":[83],"adducts":[84],"has":[85],"been":[86],"observed,":[87],"suggesting":[88],"the":[89,95],"client":[90],"degraded":[93],"through":[94],"ubiquitin-proteasome":[96],"pathway.":[97],"The":[98],"attachment":[100,132],"its":[102],"clients":[103],"evidenced":[105],"be":[107],"enzymatic":[109],"process":[110],"modulated":[111],"unidentified":[114],"ATPase.":[115],"We":[116],"name":[117],"as":[122,128],"DSSylation,":[123],"which":[125],"plays":[127],"modifier,":[130],"whose":[131],"render":[134],"target":[135],"signature":[138],"leading":[139],"their":[141],"ubiquitination,":[143],"thereby":[144],"recruits":[145],"proteasome":[146],"degrade":[148]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
