{"id":"https://openalex.org/W2019713198","doi":"https://doi.org/10.3389/fnsys.2011.00027","title":"Widespread Increases in Malondialdehyde Immunoreactivity in Dopamine-Rich and Dopamine-Poor Regions of Rat Brain Following Multiple, High Doses of Methamphetamine","display_name":"Widespread Increases in Malondialdehyde Immunoreactivity in Dopamine-Rich and Dopamine-Poor Regions of Rat Brain Following Multiple, High Doses of Methamphetamine","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W2019713198","doi":"https://doi.org/10.3389/fnsys.2011.00027","mag":"2019713198","pmid":"https://pubmed.ncbi.nlm.nih.gov/21602916","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3093137"},"language":"en","primary_location":{"id":"doi:10.3389/fnsys.2011.00027","doi":"https://doi.org/10.3389/fnsys.2011.00027","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnsys.2011.00027","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnsys.2011.00027/pdf","source":{"id":"https://openalex.org/S97434221","display_name":"Frontiers in Systems Neuroscience","issn_l":"1662-5137","issn":["1662-5137"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fnsys.2011.00027/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046249896","display_name":"Kristen Ashley Horner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kristen A. Horner","raw_affiliation_strings":["Division of Basic Medical Sciences, Mercer University School of Medicine Macon, GA, USA","Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St., Macon, 31207, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Basic Medical Sciences, Mercer University School of Medicine Macon, GA, USA","institution_ids":["https://openalex.org/I150149174"]},{"raw_affiliation_string":"Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St., Macon, 31207, GA, United States","institution_ids":["https://openalex.org/I150149174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079157291","display_name":"Yamiece E. Gilbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yamiece E. Gilbert","raw_affiliation_strings":["Mercer University School of Medicine, Department of Community Medicine, 1550 College St., Macon, 31207, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercer University School of Medicine, Department of Community Medicine, 1550 College St., Macon, 31207, GA, United States","institution_ids":["https://openalex.org/I150149174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070144458","display_name":"Susan D. Cline","orcid":"https://orcid.org/0000-0003-3664-082X","observed_orcids":["https://orcid.org/0000-0003-3664-082X"]},"institutions":[{"id":"https://openalex.org/I150149174","display_name":"Mercer University","ror":"https://ror.org/04bk7v425","country_code":"US","type":"education","lineage":["https://openalex.org/I150149174"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan D. Cline","raw_affiliation_strings":["Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St., Macon, 31207, GA, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mercer University School of Medicine, Division of Basic Medical Sciences, 1550 College St., Macon, 31207, GA, United States","institution_ids":["https://openalex.org/I150149174"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046249896"],"corresponding_institution_ids":["https://openalex.org/I150149174"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.7688,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.71830178,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":null,"first_page":"27","last_page":"27"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.8471999764442444,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.07180000096559525,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10445","display_name":"Antioxidant Activity and Oxidative Stress","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/methamphetamine","display_name":"methamphetamine","score":0.9829999804496765},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9750000238418579},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6439999938011169},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.6119999885559082},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7710000276565552},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9160000085830688},{"id":"https://openalex.org/keywords/caudate-putamen","display_name":"caudate-putamen","score":0.8809999823570251},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.8429999947547913},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9990000128746033},{"id":"https://openalex.org/keywords/frontal-cortex","display_name":"frontal cortex","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine-metabolism","display_name":"dopamine metabolism","score":0.41600000858306885},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.6759999990463257}],"concepts":[{"id":"https://openalex.org/C2780376393","wikidata":"https://www.wikidata.org/wiki/Q191924","display_name":"Methamphetamine","level":2,"score":0.8544437289237976},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.8111814856529236},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.773521900177002},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5001797676086426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4360666275024414},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3839491605758667},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33083444833755493},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3048322796821594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2860819697380066},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.1192483901977539}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fnsys.2011.00027","doi":"https://doi.org/10.3389/fnsys.2011.00027","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnsys.2011.00027","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnsys.2011.00027/pdf","source":{"id":"https://openalex.org/S97434221","display_name":"Frontiers in Systems Neuroscience","issn_l":"1662-5137","issn":["1662-5137"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3093137","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3093137","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Syst Neurosci","raw_type":"Text"},{"id":"pmid:21602916","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21602916","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in systems neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:221563c0887d4b74879d36febc7c77be","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/221563c0887d4b74879d36febc7c77be","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Systems Neuroscience, Vol 5 (2011)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnsys.2011.00027","doi":"https://doi.org/10.3389/fnsys.2011.00027","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnsys.2011.00027","pdf_url":"https://www.frontiersin.org/articles/10.3389/fnsys.2011.00027/pdf","source":{"id":"https://openalex.org/S97434221","display_name":"Frontiers in Systems Neuroscience","issn_l":"1662-5137","issn":["1662-5137"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Systems Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019713198.pdf","grobid_xml":"https://content.openalex.org/works/W2019713198.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1559160425","https://openalex.org/W1683600212","https://openalex.org/W1734433368","https://openalex.org/W1910685430","https://openalex.org/W1953980706","https://openalex.org/W1966526057","https://openalex.org/W1969249644","https://openalex.org/W1981143827","https://openalex.org/W1982409916","https://openalex.org/W1984915051","https://openalex.org/W1988720067","https://openalex.org/W2006874780","https://openalex.org/W2007271767","https://openalex.org/W2016487797","https://openalex.org/W2019067627","https://openalex.org/W2029511179","https://openalex.org/W2037762470","https://openalex.org/W2040690369","https://openalex.org/W2046302119","https://openalex.org/W2050279789","https://openalex.org/W2057679038","https://openalex.org/W2064611362","https://openalex.org/W2071154425","https://openalex.org/W2071230039","https://openalex.org/W2075813302","https://openalex.org/W2076922712","https://openalex.org/W2080519272","https://openalex.org/W2082660819","https://openalex.org/W2083351059","https://openalex.org/W2084240094","https://openalex.org/W2087134765","https://openalex.org/W2089486469","https://openalex.org/W2092883259","https://openalex.org/W2096254928","https://openalex.org/W2103717990","https://openalex.org/W2117792476","https://openalex.org/W2118389697","https://openalex.org/W2122742102","https://openalex.org/W2125289626","https://openalex.org/W2125823313","https://openalex.org/W2127695246","https://openalex.org/W2131058184","https://openalex.org/W2131891666","https://openalex.org/W2133129015","https://openalex.org/W2134194270","https://openalex.org/W2136565900","https://openalex.org/W2136776364","https://openalex.org/W2139949932","https://openalex.org/W2146904216","https://openalex.org/W2152696387","https://openalex.org/W2154345916","https://openalex.org/W2164853857","https://openalex.org/W2170298556","https://openalex.org/W2207054346","https://openalex.org/W2767056753","https://openalex.org/W2949582036","https://openalex.org/W3192068312"],"related_works":["https://openalex.org/W7096285684","https://openalex.org/W1910685430","https://openalex.org/W2749711364","https://openalex.org/W2093270446","https://openalex.org/W2131891666","https://openalex.org/W2039355119","https://openalex.org/W2088704249","https://openalex.org/W4246946387","https://openalex.org/W2355570118","https://openalex.org/W2061641420"],"abstract_inverted_index":{"Treatment":[0],"with":[1,66,212],"multiple":[2,67,270],"high":[3,68,236],"doses":[4,69,237],"of":[5,27,33,50,61,70,78,94,102,105,112,119,160,164,168,173,182,206,238],"methamphetamine":[6],"(METH)":[7],"can":[8,273],"induce":[9,156,274],"oxidative":[10,62],"damage,":[11],"including":[12],"dopamine":[13],"(DA)-mediated":[14],"reactive":[15],"oxygen":[16],"species":[17],"(ROS)":[18],"formation,":[19],"which":[20,141],"may":[21,89,155,281],"contribute":[22,90],"to":[23,91,178,286],"the":[24,36,76,92,100,113,117,138,148,161,174,180,187,196,246,259,287],"neurotoxic":[25,204],"damage":[26,63,158,279],"monoamine":[28],"neurons":[29],"and":[30,40,64,80,190,200,226,250,263,276],"long-term":[31],"depletion":[32],"DA":[34,95,106,145,165,169,289],"in":[35,75,127,137,186,232,245,258],"caudate":[37],"putamen":[38],"(CPu)":[39],"substantia":[41],"nigra":[42],"pars":[43],"compacta":[44],"(SNpc).":[45],"Malondialdehyde":[46],"(MDA),":[47],"a":[48,59,203],"product":[49],"lipid":[51],"peroxidation":[52],"by":[53,184],"ROS,":[54],"is":[55,132],"commonly":[56],"used":[57],"as":[58,97,193,195],"marker":[60],"treatment":[65,272],"METH":[71,129,154,207,213,239,253,271],"increases":[72],"MDA":[73,87,98,135,185,242],"reactivity":[74,136],"CPu":[77],"humans":[79],"experimental":[81],"animals.":[82],"Recent":[83],"data":[84,151,267],"indicate":[85,268],"that":[86,126,153,269,280],"itself":[88],"destruction":[93],"neurons,":[96],"causes":[99],"accumulation":[101],"toxic":[103],"intermediates":[104],"metabolism":[107],"via":[108],"its":[109],"chemical":[110],"modification":[111,181],"enzymes":[114],"necessary":[115],"for":[116,219,230],"breakdown":[118],"DA.":[120],"However,":[121],"it":[122],"has":[123],"been":[124],"shown":[125],"human":[128],"abusers":[130],"there":[131],"also":[133,255],"increased":[134,241,256],"frontal":[139],"cortex,":[140,249],"receives":[142],"relatively":[143],"fewer":[144],"afferents":[146],"than":[147],"CPu.":[149],"These":[150],"suggest":[152],"neuronal":[157,278],"regardless":[159],"regional":[162],"density":[163],"or":[166],"origin":[167],"input.":[170],"The":[171],"goal":[172],"current":[175],"study":[176],"was":[177],"examine":[179],"proteins":[183],"DA-rich":[188],"nigrostriatal":[189,288],"mesoaccumbal":[191],"systems,":[192],"well":[194],"less":[197],"DA-dense":[198],"cortex":[199],"hippocampus":[201],"following":[202],"regimen":[205],"treatment.":[208],"Animals":[209],"were":[210],"treated":[211],"(10":[214],"mg/kg)":[215],"every":[216],"2":[217],"h":[218],"6":[220],"h,":[221],"sacrificed":[222],"1":[223],"week":[224],"later,":[225],"examined":[227],"using":[228],"immunocytochemistry":[229],"changes":[231],"MDA-adducted":[233],"proteins.":[234],"Multiple,":[235],"significantly":[240],"immunoreactivity":[243],"(MDA-ir)":[244],"CPu,":[247],"SNpc,":[248],"hippocampus.":[251],"Multiple":[252],"administration":[254],"MDA-ir":[257],"ventral":[260],"tegmental":[261],"area":[262],"nucleus":[264],"accumbens.":[265],"Our":[266],"persistent":[275],"widespread":[277],"not":[282],"necessarily":[283],"be":[284],"limited":[285],"system.":[290]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}