{"id":"https://openalex.org/W2019705343","doi":"https://doi.org/10.1210/me.2007-0039","title":"Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development","display_name":"Hes1 and Hes5 Control the Progenitor Pool, Intermediate Lobe Specification, and Posterior Lobe Formation in the Pituitary Development","publication_year":2007,"publication_date":"2007-04-10","ids":{"openalex":"https://openalex.org/W2019705343","doi":"https://doi.org/10.1210/me.2007-0039","mag":"2019705343","pmid":"https://pubmed.ncbi.nlm.nih.gov/17426285"},"language":"en","primary_location":{"id":"doi:10.1210/me.2007-0039","doi":"https://doi.org/10.1210/me.2007-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2007-0039","pdf_url":"https://academic.oup.com/mend/article-pdf/21/6/1458/8961906/mend1458.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mend/article-pdf/21/6/1458/8961906/mend1458.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Aya Kita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Aya Kita","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010243611","display_name":"Itaru Imayoshi","orcid":"https://orcid.org/0000-0001-9728-481X","observed_orcids":["https://orcid.org/0000-0001-9728-481X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Itaru Imayoshi","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038546233","display_name":"Masato Hojo","orcid":"https://orcid.org/0000-0001-7517-2622","observed_orcids":["https://orcid.org/0000-0001-7517-2622"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masato Hojo","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103161739","display_name":"Masashi Kitagawa","orcid":"https://orcid.org/0000-0002-6982-1558","observed_orcids":["https://orcid.org/0000-0002-6982-1558"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masashi Kitagawa","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012454190","display_name":"Hiroshi Kokubu","orcid":"https://orcid.org/0000-0003-2702-841X","observed_orcids":["https://orcid.org/0000-0003-2702-841X"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroshi Kokubu","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005902585","display_name":"Ryosuke Ohsawa","orcid":"https://orcid.org/0000-0003-4909-5787","observed_orcids":["https://orcid.org/0000-0003-4909-5787"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryosuke Ohsawa","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102793803","display_name":"Toshiyuki Ohtsuka","orcid":"https://orcid.org/0000-0001-6045-1012","observed_orcids":["https://orcid.org/0000-0001-6045-1012"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Toshiyuki Ohtsuka","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018917055","display_name":"Ryoichiro Kageyama","orcid":"https://orcid.org/0000-0002-5985-1120","observed_orcids":["https://orcid.org/0000-0002-5985-1120"]},"institutions":[{"id":"https://openalex.org/I22299242","display_name":"Kyoto University","ror":"https://ror.org/02kpeqv85","country_code":"JP","type":"education","lineage":["https://openalex.org/I22299242"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ryoichiro Kageyama","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]},{"raw_affiliation_string":"Kyoto University Graduate School of Medicine, and Institute for Virus Research (A.K., I.I., M.K., H.K., R.O., T.O., R.K.), Kyoto University, Kyoto 606-8507, Japan","institution_ids":["https://openalex.org/I22299242"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001222038","display_name":"Nobuo Hashimoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nobuo Hashimoto","raw_affiliation_strings":["Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery (A.K., M.H., M.K., N.H.), Kyoto 606-8507, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.0465,"has_fulltext":true,"cited_by_count":99,"citation_normalized_percentile":{"value":0.926661,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"21","issue":"6","first_page":"1458","last_page":"1466"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hes1","display_name":"Hes1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/hes5","display_name":"Hes5","score":1.0},{"id":"https://openalex.org/keywords/pituitary-development","display_name":"pituitary development","score":0.8820000290870667},{"id":"https://openalex.org/keywords/pituitary-hypoplasia","display_name":"pituitary hypoplasia","score":0.8040000200271606},{"id":"https://openalex.org/keywords/progenitor-cell-differentiation","display_name":"progenitor cell differentiation","score":0.7369999885559082},{"id":"https://openalex.org/keywords/anterior-pituitary","display_name":"anterior pituitary","score":0.7839999794960022},{"id":"https://openalex.org/keywords/neurohypophysis","display_name":"neurohypophysis","score":0.9710000157356262},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.824999988079071}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8637484312057495},{"id":"https://openalex.org/C2780283210","wikidata":"https://www.wikidata.org/wiki/Q18027301","display_name":"HES1","level":4,"score":0.8102120161056519},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.6662739515304565},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.6343247890472412},{"id":"https://openalex.org/C15729860","wikidata":"https://www.wikidata.org/wiki/Q2329919","display_name":"Progenitor","level":4,"score":0.4630909264087677},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43726539611816406},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37701818346977234},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3735414743423462},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3577800393104553},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.3480738401412964},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2541535496711731},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1573769748210907},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.098734050989151},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000072056","descriptor_name":"Transcription Factor HES-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008817","descriptor_name":"Mice, Mutant Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010904","descriptor_name":"Pituitary Gland, Posterior","qualifier_ui":"Q000002","qualifier_name":"abnormalities","is_major_topic":true},{"descriptor_ui":"D010904","descriptor_name":"Pituitary Gland, Posterior","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D010904","descriptor_name":"Pituitary Gland, Posterior","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012097","descriptor_name":"Repressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038081","descriptor_name":"Organogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1210/me.2007-0039","doi":"https://doi.org/10.1210/me.2007-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2007-0039","pdf_url":"https://academic.oup.com/mend/article-pdf/21/6/1458/8961906/mend1458.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:17426285","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17426285","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/135381","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2433/135381","pdf_url":null,"source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"}],"best_oa_location":{"id":"doi:10.1210/me.2007-0039","doi":"https://doi.org/10.1210/me.2007-0039","is_oa":true,"landing_page_url":"https://doi.org/10.1210/me.2007-0039","pdf_url":"https://academic.oup.com/mend/article-pdf/21/6/1458/8961906/mend1458.pdf","source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3060374186","display_name":"\u4e0b\u5782\u4f53\u524d\u99c6\u7d30\u80de\u306e\u5206\u5316\u904b\u547d\u6c7a\u5b9a\u6a5f\u69cb\u306b\u304a\u3051\u308bnotch-hes\u7d4c\u8def\u306e\u95a2\u4e0e\u306b\u95a2\u3059\u308b\u7814\u7a76","funder_award_id":"17659443","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019705343.pdf","grobid_xml":"https://content.openalex.org/works/W2019705343.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1561430338","https://openalex.org/W1568038787","https://openalex.org/W1721336579","https://openalex.org/W1768274470","https://openalex.org/W1890846155","https://openalex.org/W1965632185","https://openalex.org/W1978419854","https://openalex.org/W1981980962","https://openalex.org/W1983411205","https://openalex.org/W1989560209","https://openalex.org/W1994666066","https://openalex.org/W1996760907","https://openalex.org/W2005710834","https://openalex.org/W2006498329","https://openalex.org/W2018042402","https://openalex.org/W2040335200","https://openalex.org/W2048163917","https://openalex.org/W2048389644","https://openalex.org/W2053214100","https://openalex.org/W2056623845","https://openalex.org/W2062502773","https://openalex.org/W2063584052","https://openalex.org/W2067377975","https://openalex.org/W2076116049","https://openalex.org/W2081471404","https://openalex.org/W2081996545","https://openalex.org/W2088969512","https://openalex.org/W2115181518","https://openalex.org/W2118589362","https://openalex.org/W2138903858","https://openalex.org/W2148150892","https://openalex.org/W2151821298","https://openalex.org/W2161046164","https://openalex.org/W2166403834"],"related_works":["https://openalex.org/W1644428222","https://openalex.org/W2110220284","https://openalex.org/W1981980962","https://openalex.org/W2097794717","https://openalex.org/W2517927624","https://openalex.org/W1535331051","https://openalex.org/W2286896039","https://openalex.org/W2062383132","https://openalex.org/W2899560062","https://openalex.org/W2043489136"],"abstract_inverted_index":{"The":[0,37],"pituitary":[1,38,62,111,124],"gland":[2,125],"is":[3,29],"composed":[4],"of":[5,43,47,70,94,117,135,157,167,189],"two":[6],"distinct":[7],"entities:":[8],"the":[9,12,18,22,41,60,64,68,92,128,133,136,147,158,178,187,190],"adenohypophysis,":[10],"including":[11],"anterior":[13,137,174],"and":[14,17,35,45,54,97,107,131,141],"intermediate":[15,129,172],"lobes,":[16],"neurohypophysis,":[19],"known":[20,79],"as":[21,80],"posterior":[23,150],"lobe.":[24],"This":[25],"critical":[26],"endocrine":[27],"organ":[28],"essential":[30,185],"for":[31,59,105,186],"homeostasis,":[32],"metabolism,":[33],"reproduction,":[34],"growth.":[36],"development":[39,93],"requires":[40],"control":[42,163],"proliferation":[44],"differentiation":[46,116],"progenitor":[48,71,118,168],"cells.":[49,119],"Although":[50],"multiple":[51],"signaling":[52],"molecules":[53],"transcription":[55],"factors":[56],"are":[57,183],"required":[58],"proper":[61],"development,":[63],"mechanisms":[65],"that":[66,102],"regulate":[67],"fate":[69],"cells":[72,169],"remain":[73],"to":[74,154],"be":[75],"elucidated.":[76],"Hes":[77,161,181],"genes,":[78],"Notch":[81],"effectors,":[82],"play":[83],"a":[84],"crucial":[85],"role":[86],"in":[87],"specifying":[88],"cellular":[89],"fates":[90],"during":[91,177],"various":[95],"tissues":[96],"organs.":[98],"Here,":[99],"we":[100],"report":[101],"mice":[103,144],"deficient":[104],"Hes1":[106,140],"Hes5":[108,142],"display":[109],"severe":[110],"hypoplasia":[112],"caused":[113],"by":[114],"accelerated":[115],"In":[120],"addition,":[121],"this":[122],"hypoplastic":[123],"(adenohypophysis)":[126],"lacks":[127],"lobe":[130,138,175],"exhibits":[132],"features":[134],"only.":[139],"double-mutant":[143],"also":[145,171,184],"lack":[146],"neurohypophysis":[148],"(the":[149],"lobe),":[151],"probably":[152],"due":[153],"incomplete":[155],"evagination":[156],"diencephalon.":[159],"Thus,":[160],"genes":[162,182],"not":[164],"only":[165],"maintenance":[166],"but":[170],"vs.":[173],"specification":[176],"adenohypophysis":[179],"development.":[180],"formation":[188],"neurohypophysis.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
