{"id":"https://openalex.org/W2019699562","doi":"https://doi.org/10.1172/jci118416","title":"Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.","display_name":"Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs.","publication_year":1996,"publication_date":"1996-01-15","ids":{"openalex":"https://openalex.org/W2019699562","doi":"https://doi.org/10.1172/jci118416","mag":"2019699562","pmid":"https://pubmed.ncbi.nlm.nih.gov/8567948","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/507018"},"language":"en","primary_location":{"id":"doi:10.1172/jci118416","doi":"https://doi.org/10.1172/jci118416","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118416","pdf_url":"http://www.jci.org/articles/view/118416/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/118416/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081370276","display_name":"Barbara M. Johnston","orcid":"https://orcid.org/0000-0001-5889-8501","observed_orcids":["https://orcid.org/0000-0001-5889-8501"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"B M Johnston","raw_affiliation_strings":["Department of Pediatrics, University of Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030623189","display_name":"Carina E. Mallard","orcid":"https://orcid.org/0000-0001-8953-919X","observed_orcids":["https://orcid.org/0000-0001-8953-919X"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"E C Mallard","raw_affiliation_strings":["Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103437134","display_name":"Chris E. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"C E Williams","raw_affiliation_strings":["Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058979039","display_name":"Peter David Gluckman","orcid":"https://orcid.org/0000-0002-5711-1655","observed_orcids":["https://orcid.org/0000-0002-5711-1655"]},"institutions":[{"id":"https://openalex.org/I154130895","display_name":"University of Auckland","ror":"https://ror.org/03b94tp07","country_code":"NZ","type":"education","lineage":["https://openalex.org/I154130895"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"P D Gluckman","raw_affiliation_strings":["Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Center for Developmental Medicine & Biology, Department of Pediatrics, University of Auckland, Private Bag 92019, Auckland, New Zealand","institution_ids":["https://openalex.org/I154130895"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I154130895"],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":21.9459,"has_fulltext":true,"cited_by_count":180,"citation_normalized_percentile":{"value":0.99729333,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"97","issue":"2","first_page":"300","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11184","display_name":"Neonatal and fetal brain pathology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypoxic-ischemic-brain-injury","display_name":"hypoxic-ischemic brain injury","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.8659999966621399},{"id":"https://openalex.org/keywords/cerebral-ischemia","display_name":"cerebral ischemia","score":0.7459999918937683},{"id":"https://openalex.org/keywords/fetal-sheep","display_name":"fetal sheep","score":0.6420000195503235},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.5759999752044678},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.5950000286102295},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.7070000171661377},{"id":"https://openalex.org/keywords/cytotoxic-edema","display_name":"cytotoxic edema","score":0.9850000143051147},{"id":"https://openalex.org/keywords/carotid-occlusion","display_name":"carotid artery occlusion","score":0.7649999856948853},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.47600001096725464},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.7070000171661377}],"concepts":[{"id":"https://openalex.org/C51296783","wikidata":"https://www.wikidata.org/wiki/Q1645498","display_name":"Microgram","level":3,"score":0.8731391429901123},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7122048139572144},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.5928226709365845},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.5024065971374512},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.46251073479652405},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.4495023787021637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44820430874824524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4458857774734497},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.43350154161453247},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.4140878915786743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21873733401298523},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.0},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005311","descriptor_name":"Fetal Hypoxia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D007511","descriptor_name":"Ischemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1172/jci118416","doi":"https://doi.org/10.1172/jci118416","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118416","pdf_url":"http://www.jci.org/articles/view/118416/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:507018","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/507018","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:8567948","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8567948","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1172/jci118416","doi":"https://doi.org/10.1172/jci118416","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci118416","pdf_url":"http://www.jci.org/articles/view/118416/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334749","display_name":"Health Research Council of New Zealand","ror":"https://ror.org/00zbf3d93"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019699562.pdf","grobid_xml":"https://content.openalex.org/works/W2019699562.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1483718240","https://openalex.org/W1492445976","https://openalex.org/W1532583795","https://openalex.org/W1838892598","https://openalex.org/W1964471002","https://openalex.org/W1965293509","https://openalex.org/W1966374564","https://openalex.org/W1967758963","https://openalex.org/W1971147541","https://openalex.org/W1971744347","https://openalex.org/W1973212439","https://openalex.org/W1974953454","https://openalex.org/W1981239364","https://openalex.org/W1981774487","https://openalex.org/W1986472833","https://openalex.org/W1986819079","https://openalex.org/W1990126994","https://openalex.org/W1993005324","https://openalex.org/W1994048302","https://openalex.org/W1997089281","https://openalex.org/W1998423663","https://openalex.org/W1999801514","https://openalex.org/W2002965897","https://openalex.org/W2004973419","https://openalex.org/W2005448070","https://openalex.org/W2006571637","https://openalex.org/W2008283809","https://openalex.org/W2010219735","https://openalex.org/W2012302642","https://openalex.org/W2013774985","https://openalex.org/W2014174769","https://openalex.org/W2020005796","https://openalex.org/W2023246700","https://openalex.org/W2026053667","https://openalex.org/W2026491786","https://openalex.org/W2027152719","https://openalex.org/W2028534955","https://openalex.org/W2028855493","https://openalex.org/W2029426042","https://openalex.org/W2030997373","https://openalex.org/W2033243512","https://openalex.org/W2038792569","https://openalex.org/W2038813809","https://openalex.org/W2047780911","https://openalex.org/W2053615617","https://openalex.org/W2053765138","https://openalex.org/W2055869269","https://openalex.org/W2068995265","https://openalex.org/W2069398669","https://openalex.org/W2072286244","https://openalex.org/W2074429640","https://openalex.org/W2075931967","https://openalex.org/W2081096579","https://openalex.org/W2089146248","https://openalex.org/W2095111472","https://openalex.org/W2098170512","https://openalex.org/W2106339836","https://openalex.org/W2107100596","https://openalex.org/W2121498370","https://openalex.org/W2123793880","https://openalex.org/W2139488193","https://openalex.org/W2414189003","https://openalex.org/W2418238559"],"related_works":["https://openalex.org/W1986472833","https://openalex.org/W2053765138","https://openalex.org/W2068304779","https://openalex.org/W1174340403","https://openalex.org/W79328412","https://openalex.org/W2349022952","https://openalex.org/W2367080983","https://openalex.org/W2366662067","https://openalex.org/W2017229877","https://openalex.org/W2000261039"],"abstract_inverted_index":{"This":[0,205],"study":[1],"was":[2,51,63,71,91,133,162],"designed":[3],"to":[4,25],"determine":[5],"the":[6,118,127,147,156,185,201],"potential":[7],"of":[8,31,149,159],"IGF-1":[9,207],"as":[10],"a":[11,54],"neuronal":[12,69,98,176],"rescue":[13,177],"agent":[14],"after":[15,178,200],"cerebral":[16,27,56,179],"ischemia.":[17],"Unanesthetized":[18],"late":[19],"gestation":[20],"fetal":[21],"sheep":[22],"were":[23,101,123],"subjected":[24],"30-min":[26],"ischemia":[28],"by":[29],"inflation":[30],"carotid":[32],"artery":[33],"occluder":[34],"cuffs.":[35],"2":[36,198],"h":[37,199],"later":[38],"either":[39],"0.1":[40,74,115],"microgram":[41,44,75,81,96,116,138,143],"rhIGF-1,":[42,45,48,85],"1":[43,59,80,95,137,142],"10":[46,89],"micrograms":[47,90],"or":[49],"vehicle":[50],"infused":[52],"into":[53],"lateral":[55],"ventricle":[57],"over":[58],"h.":[60],"Histologic":[61],"outcome":[62],"assessed":[64],"5":[65],"d":[66],"later.":[67],"Overall":[68],"loss":[70,99],"reduced":[72,152,163],"with":[73,88,114,136,141],"(P":[76,82],"<":[77,83],"0.05)":[78],"and":[79,111,121,126,151,164,194,213],"0.002)":[84],"but":[86,184],"treatment":[87],"not":[92,124],"effective.":[93],"With":[94],"rhIGF-1":[97,117,144,173,191],"scores":[100],"significantly":[102],"lower":[103],"in":[104,130,166,182],"brain":[105],"regions":[106,132],"examined":[107],"including":[108],"cortex,":[109],"hippocampus,":[110],"striatum,":[112],"whereas":[113],"parietal":[119],"cortex":[120],"thalamus":[122],"improved":[125],"improvement":[128],"seen":[129],"other":[131,210],"less":[134],"than":[135],"rhIGF-1.":[139],"Treatment":[140],"also":[145],"delayed":[146,165],"onset":[148],"seizures":[150],"their":[153],"incidence.":[154],"Moreover,":[155],"secondary":[157],"phase":[158],"cytotoxic":[160],"edema":[161],"onset.":[167],"We":[168],"conclude":[169],"that":[170],"low":[171],"dose":[172,188],"therapy":[174],"promotes":[175],"hypoxic-ischemic":[180],"injury":[181],"utero,":[183],"effect":[186],"is":[187,192],"dependent.":[189],"Importantly,":[190],"effective":[193],"nontoxic":[195],"when":[196],"administered":[197],"hypoxic":[202],"ischemic":[203],"insult.":[204],"distinguishes":[206],"from":[208],"most":[209],"neuroprotective":[211],"therapies":[212],"suggests":[214],"clinical":[215],"application":[216],"may":[217],"be":[218],"possible.":[219]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}