{"id":"https://openalex.org/W2019688458","doi":"https://doi.org/10.1159/000345608","title":"Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer","display_name":"Downregulation of Fumarate Hydratase Is Related to Tumorigenesis in Sporadic Renal Cell Cancer","publication_year":2012,"publication_date":"2012-12-22","ids":{"openalex":"https://openalex.org/W2019688458","doi":"https://doi.org/10.1159/000345608","mag":"2019688458","pmid":"https://pubmed.ncbi.nlm.nih.gov/23295344"},"language":"en","primary_location":{"id":"doi:10.1159/000345608","doi":"https://doi.org/10.1159/000345608","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000345608","pdf_url":null,"source":{"id":"https://openalex.org/S2232815","display_name":"Urologia Internationalis","issn_l":"0042-1138","issn":["0042-1138","1423-0399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia Internationalis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044649134","display_name":"Yun\u2010Sok Ha","orcid":"https://orcid.org/0000-0003-3732-9814","observed_orcids":["https://orcid.org/0000-0003-3732-9814","https://orcid.org/0000-0001-8856-553X"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yun-Sok Ha","raw_affiliation_strings":["Department of Urology, College of Medicine, Chungbuk National University, Cheongju, South Korea","Department of Urology, College of Medicine, Chungbuk National University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University, Cheongju, South Korea","institution_ids":["https://openalex.org/I163753206"]},{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University and","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025803879","display_name":"Yoshitomo Chihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshitomo Chihara","raw_affiliation_strings":["Department of Urology, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066469657","display_name":"Hyung-Yoon Yoon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyung-Yoon Yoon","raw_affiliation_strings":["Department of Urology, College of Medicine, Chungbuk National University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University and","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051087755","display_name":"Yong\u2010June Kim","orcid":"https://orcid.org/0000-0001-7638-7174","observed_orcids":["https://orcid.org/0000-0001-7638-7174"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Yong-June Kim","raw_affiliation_strings":["Department of Urology, College of Medicine, Chungbuk National University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University and","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359396","display_name":"Tae-Hwan Kim","orcid":"https://orcid.org/0000-0001-6226-2733","observed_orcids":["https://orcid.org/0000-0001-6226-2733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tae-Hwan Kim","raw_affiliation_strings":["Department of Urology, College of Medicine, Kyungbuk National University, Daegu, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Kyungbuk National University, Daegu, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101798638","display_name":"Seung Hyo Woo","orcid":"https://orcid.org/0000-0002-7636-2679","observed_orcids":["https://orcid.org/0000-0002-7636-2679"]},"institutions":[{"id":"https://openalex.org/I4210125500","display_name":"Daejeon Eulji Medical Center, Eulji University","ror":"https://ror.org/0367gm239","country_code":"KR","type":"healthcare","lineage":["https://openalex.org/I21028721","https://openalex.org/I4210125500","https://openalex.org/I4210164890"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seung Hyo Woo","raw_affiliation_strings":["Department of Urology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Eulji University Hospital, Eulji University College of Medicine, Daejeon, South Korea","institution_ids":["https://openalex.org/I4210125500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039520888","display_name":"Seok Joong Yun","orcid":"https://orcid.org/0000-0001-7737-4746","observed_orcids":["https://orcid.org/0000-0001-7737-4746"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Seok-Joong Yun","raw_affiliation_strings":["Department of Urology, College of Medicine, Chungbuk National University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University and","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075421107","display_name":"Isaac Yi Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac Yi Kim","raw_affiliation_strings":["Section of Urologic Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, N.J., USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Urologic Oncology, The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, New Brunswick, N.J., USA","institution_ids":["https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110520443","display_name":"Yoshihiko Hirao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I64926303","display_name":"Nara Medical University","ror":"https://ror.org/045ysha14","country_code":"JP","type":"education","lineage":["https://openalex.org/I64926303"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshihiko Hirao","raw_affiliation_strings":["Department of Urology, Nara Medical University, Kashihara, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, Nara Medical University, Kashihara, Japan","institution_ids":["https://openalex.org/I64926303"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028262111","display_name":"Wun\u2010Jae Kim","orcid":"https://orcid.org/0000-0002-8060-8926","observed_orcids":["https://orcid.org/0000-0002-8060-8926"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Wun-Jae Kim","raw_affiliation_strings":["Department of Urology, College of Medicine, Chungbuk National University and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, College of Medicine, Chungbuk National University and","institution_ids":["https://openalex.org/I163753206"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1635,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.53224575,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"90","issue":"2","first_page":"233","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fumarate-hydratase","display_name":"fumarate hydratase","score":1.0},{"id":"https://openalex.org/keywords/sporadic-renal-cell-carcinoma","display_name":"sporadic renal cell carcinoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/gene-downregulation","display_name":"gene downregulation","score":0.7390000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.42500001192092896},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6740000247955322}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6003389358520508},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.5746637582778931},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5316436886787415},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5219385027885437},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.47062423825263977},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.41735705733299255},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4108807146549225},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3973175585269928},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2822844982147217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2040885090827942},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09731888771057129},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002292","descriptor_name":"Carcinoma, Renal Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005649","descriptor_name":"Fumarate Hydratase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007680","descriptor_name":"Kidney Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018095","descriptor_name":"Germ-Line Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000345608","doi":"https://doi.org/10.1159/000345608","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000345608","pdf_url":null,"source":{"id":"https://openalex.org/S2232815","display_name":"Urologia Internationalis","issn_l":"0042-1138","issn":["0042-1138","1423-0399"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia Internationalis","raw_type":"journal-article"},{"id":"pmid:23295344","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23295344","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Urologia internationalis","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W146893853","https://openalex.org/W181147267","https://openalex.org/W251025444","https://openalex.org/W1534920898","https://openalex.org/W1974567967","https://openalex.org/W2004056464","https://openalex.org/W2005828644","https://openalex.org/W2006621240","https://openalex.org/W2010160635","https://openalex.org/W2020830322","https://openalex.org/W2034680734","https://openalex.org/W2039545078","https://openalex.org/W2050069313","https://openalex.org/W2051927992","https://openalex.org/W2059747280","https://openalex.org/W2060290469","https://openalex.org/W2069698188","https://openalex.org/W2080774991","https://openalex.org/W2086965007","https://openalex.org/W2098029947","https://openalex.org/W2101628607","https://openalex.org/W2102010768","https://openalex.org/W2106787323","https://openalex.org/W2116143852","https://openalex.org/W2116711289","https://openalex.org/W2117173470","https://openalex.org/W2128563899","https://openalex.org/W2130219349","https://openalex.org/W2133051107","https://openalex.org/W2136749294","https://openalex.org/W2164284694","https://openalex.org/W2167021577"],"related_works":["https://openalex.org/W2003251107","https://openalex.org/W2042457414","https://openalex.org/W3040317521","https://openalex.org/W3196091643","https://openalex.org/W4398208022","https://openalex.org/W2282366831","https://openalex.org/W2973103117","https://openalex.org/W3080554367","https://openalex.org/W4392867177","https://openalex.org/W4286381468"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Although":[1],"germline":[2],"mutations":[3],"of":[4,13,36,48,54,78,133,145],"fumarate":[5],"hydratase":[6],"(FH)":[7],"are":[8],"a":[9,184],"useful":[10],"molecular":[11],"marker":[12],"hereditary":[14],"leiomyomatosis":[15],"and":[16,50,74,98,142,181],"renal":[17,167],"cell":[18],"cancer":[19],"(RCC)":[20],"syndrome,":[21],"their":[22],"clinical":[23,52,143],"significance":[24],"in":[25,32,65,75,109,113,160,178,191],"sporadic":[26,55,148,179],"RCC":[27,73,100,180,190],"has":[28],"not":[29],"been":[30],"studied":[31],"detail.":[33],"The":[34],"aim":[35],"the":[37,46,51,131,140,163,192],"present":[38],"study":[39],"was":[40,91,128],"to":[41,169],"investigate":[42],"possible":[43],"correlations":[44],"between":[45],"expression":[47,132,157],"FH":[49,60,103,125,134,155,171],"implications":[53],"RCC.":[56,149,170],"MATERIALS":[57],"AND":[58],"METHODS:":[59],"mRNA":[61,104,156],"levels":[62,105],"were":[63,106],"evaluated":[64],"140":[66],"tumor":[67,110],"specimens":[68,77],"from":[69,165],"patients":[70,146],"with":[71,139,147,162],"primary":[72],"62":[76],"corresponding":[79],"normal-appearing":[80,115],"kidney":[81,116],"tissue":[82],"using":[83],"real-time":[84],"quantitative":[85],"polymerase":[86],"chain":[87],"reaction.":[88],"Immunohistochemical":[89],"staining":[90,126],"performed":[92],"on":[93],"6":[94],"normal":[95,123,166],"surrounding":[96],"tissues":[97,111,117],"71":[99],"tissues.":[101],"RESULTS:":[102],"significantly":[107,159],"lower":[108],"than":[112],"matched":[114],"(p":[118],"=":[119],"0.031).":[120],"In":[121],"all":[122],"tissues,":[124],"intensity":[127],"strong.":[129],"However,":[130],"showed":[135,153],"no":[136],"significant":[137],"correlation":[138,161],"pathological":[141],"characteristics":[144],"CONCLUSIONS:":[150],"Our":[151],"results":[152],"that":[154],"decreased":[158],"transition":[164],"parenchyma":[168],"may":[172],"be":[173,183],"an":[174],"indicator":[175],"or":[176],"tumorigenesis":[177],"could":[182],"potential":[185],"target":[186],"for":[187],"therapies":[188],"against":[189],"future.":[193]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}