{"id":"https://openalex.org/W2019678244","doi":"https://doi.org/10.1128/aac.15.5.642","title":"Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections","display_name":"Growth Inhibition by Acycloguanosine of Herpesviruses Isolated from Human Infections","publication_year":1979,"publication_date":"1979-05-01","ids":{"openalex":"https://openalex.org/W2019678244","doi":"https://doi.org/10.1128/aac.15.5.642","mag":"2019678244","pmid":"https://pubmed.ncbi.nlm.nih.gov/230783","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/352730"},"language":"en","primary_location":{"id":"doi:10.1128/aac.15.5.642","doi":"https://doi.org/10.1128/aac.15.5.642","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.15.5.642","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352730","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082691948","display_name":"Clyde S. Crumpacker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clyde S. Crumpacker","raw_affiliation_strings":["Division of Infectious Disease Department of Medicine and Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Infectious Disease Department of Medicine and Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111692212","display_name":"Lowell E. Schnipper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lowell E. Schnipper","raw_affiliation_strings":["Division of Oncology, Department of Medicine and Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine and Thorndike Laboratory of Harvard Medical School, Beth Israel Hospital, Boston, Massachusetts 02215","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105459932","display_name":"John A. Zaia","orcid":"https://orcid.org/0000-0003-4209-4888","observed_orcids":["https://orcid.org/0000-0003-4209-4888"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John A. Zaia","raw_affiliation_strings":["Division of Clinical Microbiology, Sidney Farber Cancer Institute, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Microbiology, Sidney Farber Cancer Institute, Boston, Massachusetts 02215","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051264386","display_name":"Myron J. Levin","orcid":"https://orcid.org/0000-0002-7468-106X","observed_orcids":["https://orcid.org/0000-0002-7468-106X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Myron J. Levin","raw_affiliation_strings":["Division of Clinical Microbiology, Sidney Farber Cancer Institute, Boston, Massachusetts 02215"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Microbiology, Sidney Farber Cancer Institute, Boston, Massachusetts 02215","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":37.9055,"has_fulltext":false,"cited_by_count":276,"citation_normalized_percentile":{"value":0.99906598,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"15","issue":"5","first_page":"642","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10981","display_name":"Cytomegalovirus and herpesvirus research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acycloguanosine","display_name":"acycloguanosine","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.824999988079071},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9449999928474426},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-2","display_name":"herpes simplex virus type 2","score":1.0},{"id":"https://openalex.org/keywords/varicella-zoster-virus","display_name":"varicella-zoster virus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cytomegalovirus","display_name":"cytomegalovirus","score":1.0},{"id":"https://openalex.org/keywords/dental-plaque-inhibition","display_name":"plaque inhibition","score":0.7239999771118164},{"id":"https://openalex.org/keywords/clinical-isolates","display_name":"clinical isolates","score":0.7620000243186951},{"id":"https://openalex.org/keywords/thymidine-incorporation","display_name":"thymidine incorporation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.628000020980835},{"id":"https://openalex.org/keywords/guanosine-analogs","display_name":"guanosine analogs","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7728649973869324},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7644728422164917},{"id":"https://openalex.org/C2776409557","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Herpesviridae","level":4,"score":0.6719083786010742},{"id":"https://openalex.org/C2776159415","wikidata":"https://www.wikidata.org/wiki/Q6868","display_name":"Varicella zoster virus","level":3,"score":0.6697986125946045},{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.6592815518379211},{"id":"https://openalex.org/C2777732132","wikidata":"https://www.wikidata.org/wiki/Q6946","display_name":"Cytomegalovirus","level":5,"score":0.6563578248023987},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.6243606209754944},{"id":"https://openalex.org/C2779820661","wikidata":"https://www.wikidata.org/wiki/Q6929","display_name":"Human cytomegalovirus","level":3,"score":0.6028416156768799},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5780723094940186},{"id":"https://openalex.org/C2781399669","wikidata":"https://www.wikidata.org/wiki/Q1509095","display_name":"Simplexvirus","level":5,"score":0.5096843242645264},{"id":"https://openalex.org/C2777108182","wikidata":"https://www.wikidata.org/wiki/Q422464","display_name":"Thymidine","level":3,"score":0.4931201636791229},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.39079412817955017},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.23719316720962524},{"id":"https://openalex.org/C2780727368","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral disease","level":3,"score":0.2240450084209442},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06316578388214111}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006147","descriptor_name":"Guanine","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006564","descriptor_name":"Herpesviridae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D006566","descriptor_name":"Herpesviridae Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/aac.15.5.642","doi":"https://doi.org/10.1128/aac.15.5.642","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.15.5.642","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:352730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},{"id":"pmid:230783","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/230783","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:352730","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/352730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337376","display_name":"NIH Clinical Center","ror":"https://ror.org/04vfsmv21"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1546705333","https://openalex.org/W1875514548","https://openalex.org/W1983903823","https://openalex.org/W1987219872","https://openalex.org/W1990971508","https://openalex.org/W1993169474","https://openalex.org/W2018690866","https://openalex.org/W2019511032","https://openalex.org/W2029509365","https://openalex.org/W2041703498","https://openalex.org/W2042497728","https://openalex.org/W2042693397","https://openalex.org/W2045360603","https://openalex.org/W2052150472","https://openalex.org/W2059712988","https://openalex.org/W2081586257","https://openalex.org/W2084583336","https://openalex.org/W2090634114","https://openalex.org/W2110232411","https://openalex.org/W2130350204","https://openalex.org/W2142455356","https://openalex.org/W2333553600","https://openalex.org/W2336194566","https://openalex.org/W2337332253","https://openalex.org/W4245076937","https://openalex.org/W4254603395"],"related_works":["https://openalex.org/W2037227675","https://openalex.org/W2081570115","https://openalex.org/W1997670438","https://openalex.org/W2412737692","https://openalex.org/W2171298763","https://openalex.org/W1973967304","https://openalex.org/W2408836570","https://openalex.org/W7096528253","https://openalex.org/W2012219054","https://openalex.org/W7151261148"],"abstract_inverted_index":{"Inhibition":[0],"by":[1,7,31,121,124],"acycloguanosine":[2],"(ACG)":[3],"of":[4,27,40,51,62,87,102,132,137,146,172],"plaque":[5],"formation":[6],"harpes":[8],"simplex":[9],"virus":[10,64,142],"types":[11],"1":[12],"and":[13,16,20,58,79,82,116,140,143],"2":[14],"(HSV-1":[15],"HSV-2),":[17],"varicella-zoster":[18,63,141],"virus,":[19],"cytomegalovirus":[21,75,88,167],"was":[22,53,66,93],"studied.":[23],"Seventeen":[24],"clinical":[25,135],"isolates":[26,50,61,76,86,136],"HSV-1":[28],"were":[29,77],"inhibited":[30,118,159],"ACG":[32,98,133,162],"at":[33,95,99,155,168],"a":[34,100],"mean":[35,46],"50%":[36],"inhibitory":[37],"dose":[38],"(ID(50))":[39,92],"0.15":[41],"+/-":[42,55,68],"0.09":[43],"muM.":[44,70,97,174],"The":[45,71],"ID(50)":[47],"for":[48,59,73,83],"10":[49],"HSV-2":[52],"1.62":[54],"0.76":[56],"muM,":[57,81],"four":[60,84],"it":[65],"3.75":[67],"1.30":[69],"ID(50)'s":[72],"two":[74],"100":[78,173],"160":[80],"additional":[85],"no":[89,106],"end":[90],"point":[91],"reached":[94],"200":[96,103],"concentration":[101],"muM":[104],"had":[105,163],"effect":[107,165],"on":[108,166],"deoxyribonucleic":[109],"acid":[110],"synthesis":[111],"in":[112,153,170],"human":[113,151],"fibroblast":[114],"cells":[115,123,152],"only":[117],"thymidine":[119],"incorporation":[120],"Vero":[122],"one-third.":[125],"These":[126],"studies":[127],"demonstrated":[128],"the":[129,144],"antiviral":[130],"activity":[131],"against":[134],"HSV-1,":[138],"HSV-2,":[139],"lack":[145],"toxicity":[147],"to":[148],"monkey":[149],"or":[150],"culture":[154],"concentrations":[156,169],"which":[157],"markedly":[158],"these":[160],"viruses.":[161],"little":[164],"excess":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
