{"id":"https://openalex.org/W2019655378","doi":"https://doi.org/10.1186/1471-2407-10-331","title":"EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis","display_name":"EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis","publication_year":2010,"publication_date":"2010-06-25","ids":{"openalex":"https://openalex.org/W2019655378","doi":"https://doi.org/10.1186/1471-2407-10-331","mag":"2019655378","pmid":"https://pubmed.ncbi.nlm.nih.gov/20579375","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2912862"},"language":"en","primary_location":{"id":"doi:10.1186/1471-2407-10-331","doi":"https://doi.org/10.1186/1471-2407-10-331","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-331","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-331","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050945412","display_name":"Ranju Ralhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Ranju Ralhan","raw_affiliation_strings":["Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G1X5, Canada. rralhan@mtsinai.on.ca","Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON M5G1X5, Canada. rralhan@mtsinai.on.ca","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101816296","display_name":"Jun Cao","orcid":"https://orcid.org/0000-0002-1406-2881","observed_orcids":["https://orcid.org/0000-0002-1406-2881"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jun Cao","raw_affiliation_strings":["Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063224515","display_name":"Terence Lim","orcid":"https://orcid.org/0009-0006-6651-4807","observed_orcids":["https://orcid.org/0009-0006-6651-4807"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Terence Lim","raw_affiliation_strings":["Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106628285","display_name":"Christina MacMillan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christina MacMillan","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056695807","display_name":"Jeremy L. Freeman","orcid":"https://orcid.org/0000-0002-4184-3683","observed_orcids":["https://orcid.org/0000-0002-4184-3683"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jeremy L Freeman","raw_affiliation_strings":["Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001439539","display_name":"Paul G. Walfish","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Paul G Walfish","raw_affiliation_strings":["Alex and Simona Shnaider Research Laboratory in Molecular Oncology, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada","Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","Department of Otolaryngology, Head and Neck Surgery, University of Toronto, 190 Elizabeth Street, Fraser Elliot Building, Toronto, Ontario, M5G 2N2, Canada","Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Alex and Simona Shnaider Research Laboratory in Molecular Oncology, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Department of Medicine, Endocrine Division, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Department of Otolaryngology, Head & Neck Surgery Program, Joseph and Mildred Sonshine Family Centre for Head and Neck Diseases, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]},{"raw_affiliation_string":"Department of Otolaryngology, Head and Neck Surgery, University of Toronto, 190 Elizabeth Street, Fraser Elliot Building, Toronto, Ontario, M5G 2N2, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, 600 University Avenue, Toronto, ON, M5G 1X5, Canada","institution_ids":["https://openalex.org/I1291836623"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001439539","https://openalex.org/A5050945412"],"corresponding_institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":4.4658,"has_fulltext":true,"cited_by_count":88,"citation_normalized_percentile":{"value":0.94911008,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"10","issue":"1","first_page":"331","last_page":"331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epcam","display_name":"EpCAM","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nuclear-localization","display_name":"nuclear localization","score":0.8029999732971191},{"id":"https://openalex.org/keywords/thyroid-cancer","display_name":"thyroid cancer","score":0.871999979019165},{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9229999780654907},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.984000027179718},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.9049999713897705},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9089999794960022},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9559999704360962},{"id":"https://openalex.org/keywords/proteolytic-cleavage","display_name":"proteolytic cleavage","score":0.7799999713897705},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.6000000238418579}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.67103111743927},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5992788076400757},{"id":"https://openalex.org/C2779761222","wikidata":"https://www.wikidata.org/wiki/Q826522","display_name":"Thyroid cancer","level":3,"score":0.5659009218215942},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4901374280452728},{"id":"https://openalex.org/C2780140570","wikidata":"https://www.wikidata.org/wiki/Q3545481","display_name":"Surgical oncology","level":2,"score":0.47801482677459717},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.454860657453537},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43698030710220337},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42362847924232483},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.37341606616973877}],"mesh":[{"descriptor_ui":"D000071858","descriptor_name":"Epithelial Cell Adhesion Molecule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000231","descriptor_name":"Adenocarcinoma, Papillary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000231","descriptor_name":"Adenocarcinoma, Papillary","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013964","descriptor_name":"Thyroid Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015815","descriptor_name":"Cell Adhesion Molecules","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1186/1471-2407-10-331","doi":"https://doi.org/10.1186/1471-2407-10-331","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-331","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-331","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},{"id":"pmid:20579375","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20579375","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC cancer","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2912862","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2912862/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"Text"},{"id":"pmh:oai:utoronto.scholaris.ca:1807/83904","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/83904","pdf_url":"https://utoronto.scholaris.ca/bitstreams/c600aafd-6ac0-4e1a-8fb5-5b37ef7bd7f8/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.353.8712","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.353.8712","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/82/70/BMC_Cancer_2010_Jun_25_10_331.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:09e8e35c282648ad890491eb8624595d","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/09e8e35c282648ad890491eb8624595d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BMC Cancer, Vol 10, Iss 1, p 331 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1471-2407-10-331","doi":"https://doi.org/10.1186/1471-2407-10-331","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1471-2407-10-331","pdf_url":"https://bmccancer.biomedcentral.com/counter/pdf/10.1186/1471-2407-10-331","source":{"id":"https://openalex.org/S192926780","display_name":"BMC Cancer","issn_l":"1471-2407","issn":["1471-2407"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019655378.pdf","grobid_xml":"https://content.openalex.org/works/W2019655378.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1495683248","https://openalex.org/W1580488470","https://openalex.org/W1836452880","https://openalex.org/W1964115821","https://openalex.org/W1964743637","https://openalex.org/W1967137553","https://openalex.org/W1975234773","https://openalex.org/W1986978780","https://openalex.org/W1990767426","https://openalex.org/W1990998243","https://openalex.org/W1993632446","https://openalex.org/W1997716402","https://openalex.org/W1999310339","https://openalex.org/W2006039609","https://openalex.org/W2012919091","https://openalex.org/W2023427658","https://openalex.org/W2029231546","https://openalex.org/W2029634531","https://openalex.org/W2032307016","https://openalex.org/W2035106853","https://openalex.org/W2035925771","https://openalex.org/W2040605299","https://openalex.org/W2043103956","https://openalex.org/W2051055358","https://openalex.org/W2078825790","https://openalex.org/W2094900895","https://openalex.org/W2105471629","https://openalex.org/W2107852079","https://openalex.org/W2108668400","https://openalex.org/W2111708038","https://openalex.org/W2114061652","https://openalex.org/W2133847945","https://openalex.org/W2141774586","https://openalex.org/W2151289162","https://openalex.org/W2152037292","https://openalex.org/W2155589271","https://openalex.org/W2157452165","https://openalex.org/W2158741313","https://openalex.org/W2164246089","https://openalex.org/W2166025078","https://openalex.org/W2166351608","https://openalex.org/W2170175754","https://openalex.org/W2589037780"],"related_works":["https://openalex.org/W2087911404","https://openalex.org/W1974217139","https://openalex.org/W7095414710","https://openalex.org/W1970958617","https://openalex.org/W2152191855","https://openalex.org/W7099262134","https://openalex.org/W2016024198","https://openalex.org/W7116793373","https://openalex.org/W2087951346","https://openalex.org/W1474150218"],"abstract_inverted_index":{"BACKGROUND:":[0],"Proteolytic":[1],"cleavage":[2],"of":[3,8,30,36,71,89,97,123,144,178,187,198],"the":[4,101],"extracellular":[5],"domain":[6,21],"(EpEx)":[7],"Epithelial":[9],"cell":[10],"adhesion":[11],"molecule":[12],"(EpCAM)":[13],"and":[14,47,66,83,91,94,111,125,184,214,221],"nuclear":[15,93,114,121,139,166,183,192,202],"signaling":[16],"by":[17],"its":[18],"intracellular":[19],"oncogenic":[20],"Ep-ICD":[22,37,46,124,140,167,188,193,203],"has":[23],"recently":[24],"been":[25],"implicated":[26],"in":[27,38,189],"increased":[28,92,182],"proliferation":[29],"cancer":[31,59],"cells.":[32],"The":[33,80,116],"clinical":[34],"significance":[35],"human":[39],"tumors":[40],"remains":[41],"an":[42],"enigma.":[43],"METHODS:":[44],"EpEx,":[45],"beta-catenin":[48],"immunohistochemistry":[49],"using":[50],"specific":[51],"antibodies":[52],"was":[53],"conducted":[54],"on":[55],"58":[56],"archived":[57],"thyroid":[58,85,105],"(TC)":[60],"tissue":[61],"blocks":[62],"from":[63],"34":[64],"patients":[65,73,137,161],"correlated":[67,194],"with":[68,195],"survival":[69,133],"analysis":[70,129],"these":[72],"for":[74,135,160,211,224],"up":[75],"to":[76,157],"17":[77],"years.":[78],"RESULTS:":[79],"anaplastic":[81],"(ATC)":[82],"aggressive":[84,190,212,225],"cancers":[86,106],"showed":[87,108,119],"loss":[88,143,177],"EpEx":[90,110,146,180],"cytoplasmic":[95,185],"accumulation":[96,186],"Ep-ICD.":[98,115],"In":[99],"contrast,":[100],"low":[102],"grade":[103],"papillary":[104],"(PTC)":[107],"membranous":[109,145,171],"no":[112],"detectable":[113],"ATC":[117],"also":[118],"concomitant":[120],"expression":[122,141],"beta-catenin.":[126],"Kaplan-Meier":[127],"Survival":[128],"revealed":[130],"reduced":[131],"overall":[132],"(OS)":[134],"TC":[136,199,213],"showing":[138],"or":[142,168],"(p":[147],"<":[148],"0.0004),":[149],"median":[150],"OS":[151,197],"=":[152],"5":[153],"months":[154,159],"as":[155,207],"compared":[156],"198":[158],"who":[162],"did":[163],"not":[164],"show":[165],"demonstrated":[169],"only":[170],"EpE.":[172],"CONCLUSION:":[173],"We":[174],"report":[175],"reciprocal":[176],"membrane":[179],"but":[181],"TC;":[191],"poor":[196],"patients.":[200],"Thus":[201],"localization":[204],"may":[205,215],"serve":[206],"a":[208,217],"useful":[209],"biomarker":[210],"represent":[216],"novel":[218],"diagnostic,":[219],"prognostic":[220],"therapeutic":[222],"target":[223],"TC.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
