{"id":"https://openalex.org/W2019645370","doi":"https://doi.org/10.1016/j.jalz.2009.04.925","title":"P3\u2010254: Exebryl\u20101: A novel small molecule currently in human clinical trials as a disease\u2010modifying drug for the treatment of Alzheimer's disease","display_name":"P3\u2010254: Exebryl\u20101: A novel small molecule currently in human clinical trials as a disease\u2010modifying drug for the treatment of Alzheimer's disease","publication_year":2009,"publication_date":"2009-06-25","ids":{"openalex":"https://openalex.org/W2019645370","doi":"https://doi.org/10.1016/j.jalz.2009.04.925","mag":"2019645370"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2009.04.925","doi":"https://doi.org/10.1016/j.jalz.2009.04.925","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.925","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019375169","display_name":"Alan D. Snow","orcid":"https://orcid.org/0000-0002-7333-3100","observed_orcids":["https://orcid.org/0000-0002-7333-3100"]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan D. Snow","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074811293","display_name":"Joel A. Cummings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel Cummings","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085592378","display_name":"Thomas P. Lake","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Lake","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074267150","display_name":"Qubai Hu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qubai Hu","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086980931","display_name":"Luke Esposito","orcid":"https://orcid.org/0000-0002-3565-9126","observed_orcids":["https://orcid.org/0000-0002-3565-9126"]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luke Esposito","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109074941","display_name":"Judy A. Cam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Judy Cam","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102978148","display_name":"Michael Hudson","orcid":"https://orcid.org/0000-0003-0972-9415","observed_orcids":["https://orcid.org/0000-0003-0972-9415"]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Hudson","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Elizabeth Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth Smith","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075235800","display_name":"Steve Runnels","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134826","display_name":"ProteoTech (United States)","ror":"https://ror.org/03fz0tx04","country_code":"US","type":"company","lineage":["https://openalex.org/I4210134826"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve Runnels","raw_affiliation_strings":["ProteoTech Inc., Kirkland, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ProteoTech Inc., Kirkland, WA, USA","institution_ids":["https://openalex.org/I4210134826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019375169"],"corresponding_institution_ids":["https://openalex.org/I4210134826"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.1033,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.77982874,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"5","issue":"4S_Part_14","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9769999980926514}],"concepts":[{"id":"https://openalex.org/C44752575","wikidata":"https://www.wikidata.org/wiki/Q1417562","display_name":"Morris water navigation task","level":3,"score":0.7591642141342163},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.7183635234832764},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.6356053352355957},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5827004313468933},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5255961418151855},{"id":"https://openalex.org/C31705614","wikidata":"https://www.wikidata.org/wiki/Q423510","display_name":"Amyloid precursor protein","level":4,"score":0.5133363604545593},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4689214825630188},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4411761462688446},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.4225607216358185},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4182541072368622},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41684672236442566},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40844130516052246},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3897159695625305},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38277167081832886},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3507609963417053},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.312994122505188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2493494153022766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22023466229438782},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08480235934257507},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2009.04.925","doi":"https://doi.org/10.1016/j.jalz.2009.04.925","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2009.04.925","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1976312485","https://openalex.org/W2750286013","https://openalex.org/W2034653510","https://openalex.org/W2235843597","https://openalex.org/W2036377394","https://openalex.org/W2534071036","https://openalex.org/W2041061142","https://openalex.org/W4389127885","https://openalex.org/W2899087182","https://openalex.org/W2341713216"],"abstract_inverted_index":{"Exebryl-1":[0,35,63,70,82,92,109,145,151,195,208,238,252,268],"is":[1,269],"a":[2,94,126,172,189,216,245,273],"unique":[3],"small":[4,276],"molecule":[5,277],"compound":[6],"designed":[7],"and":[8,30,45,53,78,100,135,155,161,220,260,283],"developed":[9],"with":[10,61],"over":[11],"9-years":[12],"of":[13,40,69,81,115,158,218,281],"pre-clinical":[14],"research":[15],"at":[16,112,205,256],"ProteoTech":[17],"Inc":[18],"(Kirkland,":[19],"WA).":[20],"Using":[21],"2":[22],"different":[23],"APP":[24,121,164],"transgenic":[25,103,122,165],"mouse":[26,104,166],"models":[27],"(i.e.":[28],"Swedish":[29],"London":[31],"mutation,":[32],"Tg2576":[33],"mice),":[34],"was":[36,59,89,110],"analyzed":[37],"for":[38,278],"reduction":[39,96],"brain":[41,57,105,129],"beta-amyloid":[42],"protein":[43,85,242],"(A\u00df)":[44],"memory":[46,143],"improvement":[47],"by":[48,213,224],"Morris":[49,131],"water":[50,132],"maze":[51,133],"testing":[52,134],"probe":[54,136],"trials.":[55],"Blood":[56],"penetration":[58],"examined":[60],"radiolabeled":[62],"in":[64,74,87,97,102,119,141,163,175,193,244,263],"Sprague":[65],"Dawley":[66],"rats.":[67],"Effects":[68],"on":[71,83],"secretase":[72],"modulation":[73],"APP-overexpressing":[75],"cell":[76],"lines,":[77],"the":[79,116,197,227,279],"effects":[80],"tau":[84,241],"aggregation":[86,243],"vitro,":[88],"also":[90,148,209,235],"examined.":[91],"caused":[93],"marked":[95,139,173],"A\u00df":[98,128,159,177,184,211,228],"formation":[99],"accumulation":[101],"following":[106,144],"oral":[107,191],"administration.":[108],"effective":[111,183,255],"all":[113],"stages":[114],"disease,":[117],"even":[118],"older":[120],"animals":[123],"that":[124,150,237,251],"posessed":[125],"high":[127],"load.":[130],"trials":[137],"demonstrated":[138,149],"improvements":[140],"hippocampus-dependent":[142],"treatment.":[146],"Data":[147],"effectively":[152,239],"reduced":[153,210],"soluble":[154],"insoluble":[156],"forms":[157],"40":[160],"42":[162],"brain,":[167],"as":[168,170,215],"well":[169],"causing":[171],"increase":[174],"CSF":[176],"(believed":[178],"to":[179,182,226,271],"be":[180,254],"due":[181],"clearance":[185],"from":[186],"brain).":[187],"Following":[188],"single":[190],"dose":[192],"rats,":[194],"penetrates":[196],"blood-brain-barrier":[198],"within":[199,230],"30":[200],"minutes,":[201],"reaching":[202],"peak":[203],"levels":[204],"4":[206],"hours.":[207],"generation,":[212],"serving":[214],"modulator":[217],"beta-":[219],"alpha-secretase,":[221],"most":[222],"likely":[223],"binding":[225],"region":[229],"APP.":[231],"In":[232],"vitro":[233],"evidence":[234],"suggested":[236],"reduces":[240],"dose-dependent":[246],"manner.":[247],"These":[248],"studies":[249],"suggest":[250],"may":[253],"lowering":[257],"A\u00df,":[258],"plaque":[259],"tangle":[261],"load":[262],"Alzheimer's":[264],"disease":[265],"(AD)":[266],"patients.":[267],"believed":[270],"represent":[272],"new":[274],"disease-modifying":[275],"treatment":[280],"AD":[282],"related":[284],"disorders.":[285]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
