{"id":"https://openalex.org/W2019617490","doi":"https://doi.org/10.1007/s10522-013-9474-z","title":"The systems biology of mitochondrial fission and fusion and implications for disease and aging","display_name":"The systems biology of mitochondrial fission and fusion and implications for disease and aging","publication_year":2013,"publication_date":"2013-10-11","ids":{"openalex":"https://openalex.org/W2019617490","doi":"https://doi.org/10.1007/s10522-013-9474-z","mag":"2019617490","pmid":"https://pubmed.ncbi.nlm.nih.gov/24122214"},"language":"en","primary_location":{"id":"doi:10.1007/s10522-013-9474-z","doi":"https://doi.org/10.1007/s10522-013-9474-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10522-013-9474-z","pdf_url":null,"source":{"id":"https://openalex.org/S85312528","display_name":"Biogerontology","issn_l":"1389-5729","issn":["1389-5729","1573-6768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019312126","display_name":"Anuradha Chauhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Anuradha Chauhan","raw_affiliation_strings":["Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067743298","display_name":"Julio Vera","orcid":"https://orcid.org/0000-0002-3076-5122","observed_orcids":["https://orcid.org/0000-0002-3076-5122"]},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julio Vera","raw_affiliation_strings":["Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022724143","display_name":"Olaf Wolkenhauer","orcid":"https://orcid.org/0000-0001-6105-2937","observed_orcids":["https://orcid.org/0000-0001-6105-2937"]},"institutions":[{"id":"https://openalex.org/I4665924","display_name":"University of Rostock","ror":"https://ror.org/03zdwsf69","country_code":"DE","type":"education","lineage":["https://openalex.org/I4665924"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Olaf Wolkenhauer","raw_affiliation_strings":["Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology and Bioinformatics, University of Rostock, 18051, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]},{"raw_affiliation_string":"Department of Systems Biology & Bioinformatics, University of Rostock, Rostock, Germany","institution_ids":["https://openalex.org/I4665924"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5019312126"],"corresponding_institution_ids":["https://openalex.org/I4665924"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.2381,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.18311061,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"15","issue":"1","first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitochondrial-fission","display_name":"mitochondrial fission","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mitochondrial-fusion","display_name":"mitochondrial fusion","score":1.0},{"id":"https://openalex.org/keywords/mitochondrial-dynamics","display_name":"mitochondrial dynamics","score":0.953000009059906},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.4490000009536743},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.9309999942779541},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.9679999947547913},{"id":"https://openalex.org/keywords/atp-production","display_name":"ATP production","score":0.5199999809265137},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mtdna-mutations","display_name":"mitochondrial DNA mutations","score":0.8209999799728394},{"id":"https://openalex.org/keywords/systems-biology","display_name":"systems biology","score":0.4909999966621399}],"concepts":[{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.8245444297790527},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.7937130928039551},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7534282207489014},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6504629254341125},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6390447616577148},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49395400285720825},{"id":"https://openalex.org/C12294094","wikidata":"https://www.wikidata.org/wiki/Q929080","display_name":"Fission","level":3,"score":0.4852761924266815},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.47562268376350403},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39469483494758606},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3097858428955078},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.07657459378242493},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07096552848815918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.06233870983123779},{"id":"https://openalex.org/C152568617","wikidata":"https://www.wikidata.org/wiki/Q2348","display_name":"Neutron","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000222","descriptor_name":"Adaptation, Physiological","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D004272","descriptor_name":"DNA, Mitochondrial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060833","descriptor_name":"Cellular Microenvironment","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D063154","descriptor_name":"Mitochondrial Dynamics","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s10522-013-9474-z","doi":"https://doi.org/10.1007/s10522-013-9474-z","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s10522-013-9474-z","pdf_url":null,"source":{"id":"https://openalex.org/S85312528","display_name":"Biogerontology","issn_l":"1389-5729","issn":["1389-5729","1573-6768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"journal-article"},{"id":"pmid:24122214","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24122214","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biogerontology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W181330873","https://openalex.org/W1778352924","https://openalex.org/W1967644266","https://openalex.org/W1977603766","https://openalex.org/W1981118363","https://openalex.org/W1982439221","https://openalex.org/W1983594275","https://openalex.org/W1983777461","https://openalex.org/W1985072454","https://openalex.org/W1987522464","https://openalex.org/W1988501212","https://openalex.org/W1989026904","https://openalex.org/W1990268001","https://openalex.org/W1992712867","https://openalex.org/W1997890801","https://openalex.org/W2002453549","https://openalex.org/W2006148668","https://openalex.org/W2007706445","https://openalex.org/W2012442838","https://openalex.org/W2014512134","https://openalex.org/W2016725835","https://openalex.org/W2021244362","https://openalex.org/W2023283007","https://openalex.org/W2023542615","https://openalex.org/W2023726011","https://openalex.org/W2024354091","https://openalex.org/W2025970537","https://openalex.org/W2027396595","https://openalex.org/W2029204107","https://openalex.org/W2030145039","https://openalex.org/W2030945597","https://openalex.org/W2032234589","https://openalex.org/W2033832481","https://openalex.org/W2043758926","https://openalex.org/W2044494908","https://openalex.org/W2044897807","https://openalex.org/W2048339025","https://openalex.org/W2048418127","https://openalex.org/W2053127901","https://openalex.org/W2053555724","https://openalex.org/W2054059225","https://openalex.org/W2056253513","https://openalex.org/W2057495460","https://openalex.org/W2058028795","https://openalex.org/W2058102407","https://openalex.org/W2058221907","https://openalex.org/W2059320820","https://openalex.org/W2060102400","https://openalex.org/W2061425021","https://openalex.org/W2061796067","https://openalex.org/W2062630699","https://openalex.org/W2065018825","https://openalex.org/W2068337326","https://openalex.org/W2069076431","https://openalex.org/W2069114279","https://openalex.org/W2069730374","https://openalex.org/W2074333893","https://openalex.org/W2075353339","https://openalex.org/W2077206871","https://openalex.org/W2079764908","https://openalex.org/W2084034472","https://openalex.org/W2084876450","https://openalex.org/W2085525271","https://openalex.org/W2087623771","https://openalex.org/W2090168827","https://openalex.org/W2094273895","https://openalex.org/W2101300328","https://openalex.org/W2102141778","https://openalex.org/W2102626915","https://openalex.org/W2104048407","https://openalex.org/W2104954806","https://openalex.org/W2113053834","https://openalex.org/W2121077787","https://openalex.org/W2123880844","https://openalex.org/W2123973944","https://openalex.org/W2124140045","https://openalex.org/W2124872060","https://openalex.org/W2124980889","https://openalex.org/W2125116813","https://openalex.org/W2131050167","https://openalex.org/W2131415852","https://openalex.org/W2134390575","https://openalex.org/W2135604642","https://openalex.org/W2135645000","https://openalex.org/W2137844183","https://openalex.org/W2138760860","https://openalex.org/W2139636031","https://openalex.org/W2150114634","https://openalex.org/W2153029275","https://openalex.org/W2160803964","https://openalex.org/W2164653071","https://openalex.org/W2166131107","https://openalex.org/W2166750626","https://openalex.org/W2169202177","https://openalex.org/W2171741694","https://openalex.org/W2991126964","https://openalex.org/W4206511281","https://openalex.org/W4299157219"],"related_works":["https://openalex.org/W3003394141","https://openalex.org/W2062407677","https://openalex.org/W3013760465","https://openalex.org/W2087255642","https://openalex.org/W3020298166","https://openalex.org/W2057495460","https://openalex.org/W3164775823","https://openalex.org/W2007706445","https://openalex.org/W2609512343","https://openalex.org/W2397010381"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}