{"id":"https://openalex.org/W2019615565","doi":"https://doi.org/10.1016/s1388-1981(01)00188-3","title":"Cholesterol enrichment upregulates intercellular adhesion molecule-1 in human vascular endothelial cells","display_name":"Cholesterol enrichment upregulates intercellular adhesion molecule-1 in human vascular endothelial cells","publication_year":2001,"publication_date":"2001-12-01","ids":{"openalex":"https://openalex.org/W2019615565","doi":"https://doi.org/10.1016/s1388-1981(01)00188-3","mag":"2019615565","pmid":"https://pubmed.ncbi.nlm.nih.gov/11786300"},"language":"en","primary_location":{"id":"doi:10.1016/s1388-1981(01)00188-3","doi":"https://doi.org/10.1016/s1388-1981(01)00188-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(01)00188-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Y. Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Yuan","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084153205","display_name":"Lynne K. Verna","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L.K. Verna","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091188597","display_name":"Nanping Wang","orcid":"https://orcid.org/0000-0002-8528-8132","observed_orcids":["https://orcid.org/0000-0002-8528-8132"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N.P. Wang","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033486796","display_name":"Hailing Liao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H.L. Liao","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045338165","display_name":"Kuo-Sheng Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.S. Ma","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025279909","display_name":"Yinsheng Wang","orcid":"https://orcid.org/0000-0001-5565-283X","observed_orcids":["https://orcid.org/0000-0001-5565-283X"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Wang","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062607187","display_name":"Yi Zhu","orcid":"https://orcid.org/0000-0001-7725-9166","observed_orcids":["https://orcid.org/0000-0001-7725-9166"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y. Zhu","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112153651","display_name":"M B Stemerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M.B. Stemerman","raw_affiliation_strings":["Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California, Riverside, CA, 92521, USA","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112153651"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":{"value":3670,"currency":"USD","value_usd":3670},"apc_paid":null,"fwci":0.732,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.67707219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"1534","issue":"2-3","first_page":"139","last_page":"148"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.5684000253677368,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.02160000056028366,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholesterol","display_name":"cholesterol","score":0.9290000200271606},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9789999723434448},{"id":"https://openalex.org/keywords/vascular-endothelial-cells","display_name":"vascular endothelial cells","score":0.8119999766349792},{"id":"https://openalex.org/keywords/ap-1-transcription-factor","display_name":"AP-1 transcription factor","score":0.8040000200271606},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.921999990940094},{"id":"https://openalex.org/keywords/low-density-lipoprotein","display_name":"low-density lipoprotein","score":0.8009999990463257},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.984000027179718},{"id":"https://openalex.org/keywords/cholesterol-to-phospholipid-ratio","display_name":"cholesterol/phospholipid ratio","score":0.8069999814033508},{"id":"https://openalex.org/keywords/endothelial-activation","display_name":"endothelial activation","score":0.5429999828338623},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.786993145942688},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.7479575276374817},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.5223387479782104},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48645922541618347},{"id":"https://openalex.org/C88045685","wikidata":"https://www.wikidata.org/wiki/Q174576","display_name":"Activator (genetics)","level":3,"score":0.46586278080940247},{"id":"https://openalex.org/C2909375385","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Intercellular Adhesion Molecule-1","level":3,"score":0.42093685269355774},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.41840124130249023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40932849049568176},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3275758624076843},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.28594937920570374},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.17788895964622498},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14693903923034668}],"mesh":[{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014471","descriptor_name":"Umbilical Veins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018808","descriptor_name":"Transcription Factor AP-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s1388-1981(01)00188-3","doi":"https://doi.org/10.1016/s1388-1981(01)00188-3","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1388-1981(01)00188-3","pdf_url":null,"source":{"id":"https://openalex.org/S4210172276","display_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","issn_l":"1388-1981","issn":["1388-1981","1879-2618"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","raw_type":"journal-article"},{"id":"pmid:11786300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11786300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2168106930","display_name":"ENDOTHELIUM AND VASCULAR FUNCTION","funder_award_id":"P01HL043023","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1507147384","https://openalex.org/W1513897103","https://openalex.org/W1529651253","https://openalex.org/W1537855747","https://openalex.org/W1548820511","https://openalex.org/W1584944565","https://openalex.org/W1606142823","https://openalex.org/W1931341062","https://openalex.org/W1933491090","https://openalex.org/W1949173079","https://openalex.org/W1966714249","https://openalex.org/W1985777107","https://openalex.org/W1995122069","https://openalex.org/W1996358960","https://openalex.org/W2000693909","https://openalex.org/W2003389414","https://openalex.org/W2016018685","https://openalex.org/W2016087073","https://openalex.org/W2020405150","https://openalex.org/W2025480704","https://openalex.org/W2054728789","https://openalex.org/W2056034929","https://openalex.org/W2063673474","https://openalex.org/W2065031942","https://openalex.org/W2067034969","https://openalex.org/W2069370313","https://openalex.org/W2070366694","https://openalex.org/W2074011532","https://openalex.org/W2078789063","https://openalex.org/W2084870400","https://openalex.org/W2088905535","https://openalex.org/W2100107297","https://openalex.org/W2113387942","https://openalex.org/W2114253742","https://openalex.org/W2114704077","https://openalex.org/W2118571557","https://openalex.org/W2119870811","https://openalex.org/W2137570167","https://openalex.org/W2139319526","https://openalex.org/W2148464328","https://openalex.org/W2154851868","https://openalex.org/W2160678120","https://openalex.org/W2168526937","https://openalex.org/W2246457688","https://openalex.org/W2284820033","https://openalex.org/W2410507304","https://openalex.org/W2472201763","https://openalex.org/W4239624232"],"related_works":["https://openalex.org/W4402585852","https://openalex.org/W2043461339","https://openalex.org/W1983861227","https://openalex.org/W2006385789","https://openalex.org/W2089951882","https://openalex.org/W147921404","https://openalex.org/W2165472969","https://openalex.org/W2025480704","https://openalex.org/W1983086379","https://openalex.org/W2084870400"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}