{"id":"https://openalex.org/W2019613864","doi":"https://doi.org/10.1016/j.jconrel.2015.02.003","title":"Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics","display_name":"Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics","publication_year":2015,"publication_date":"2015-02-03","ids":{"openalex":"https://openalex.org/W2019613864","doi":"https://doi.org/10.1016/j.jconrel.2015.02.003","mag":"2019613864","pmid":"https://pubmed.ncbi.nlm.nih.gov/25660205"},"language":"en","primary_location":{"id":"doi:10.1016/j.jconrel.2015.02.003","doi":"https://doi.org/10.1016/j.jconrel.2015.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.02.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0168365915000930/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://www.sciencedirect.com/science/article/pii/S0168365915000930/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067722783","display_name":"Cornelia Lorenzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Cornelia Lorenzer","raw_affiliation_strings":["University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011031148","display_name":"Mehrdad Dirin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Mehrdad Dirin","raw_affiliation_strings":["University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020548715","display_name":"Anna-Maria Winkler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna-Maria Winkler","raw_affiliation_strings":["University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032962394","display_name":"Volker Baumann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Volker Baumann","raw_affiliation_strings":["University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081278197","display_name":"Johannes Winkler","orcid":"https://orcid.org/0000-0002-7278-1999","observed_orcids":["https://orcid.org/0000-0002-7278-1999"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Johannes Winkler","raw_affiliation_strings":["University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria. Electronic address: johannes.winkler@univie.ac.at","University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria. Electronic address: johannes.winkler@univie.ac.at","institution_ids":["https://openalex.org/I129774422"]},{"raw_affiliation_string":"University of Vienna, Department of Pharmaceutical Chemistry, Althanstra\u00dfe 14, 1090 Vienna, Austria","institution_ids":["https://openalex.org/I129774422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081278197"],"corresponding_institution_ids":["https://openalex.org/I129774422"],"apc_list":{"value":4440,"currency":"USD","value_usd":4440},"apc_paid":{"value":4440,"currency":"USD","value_usd":4440},"fwci":3.8796,"has_fulltext":true,"cited_by_count":292,"citation_normalized_percentile":{"value":0.96559006,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"203","issue":null,"first_page":"1","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sirna-therapeutics","display_name":"siRNA therapeutics","score":0.9860000014305115},{"id":"https://openalex.org/keywords/targeted-delivery","display_name":"targeted delivery","score":0.5789999961853027},{"id":"https://openalex.org/keywords/gene-silencing","display_name":"gene silencing","score":0.8700000047683716},{"id":"https://openalex.org/keywords/liposomes","display_name":"liposomes","score":0.5600000023841858},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.6919999718666077},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.8709999918937683},{"id":"https://openalex.org/keywords/transcytosis","display_name":"transcytosis","score":0.8550000190734863},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.621999979019165},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.7639999985694885},{"id":"https://openalex.org/keywords/oligonucleotide-therapeutics","display_name":"oligonucleotide therapeutics","score":0.7120000123977661},{"id":"https://openalex.org/keywords/liver-targeted-drug-delivery","display_name":"liver-targeted drug delivery","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C185350488","wikidata":"https://www.wikidata.org/wiki/Q615386","display_name":"Transcytosis","level":4,"score":0.6896423101425171},{"id":"https://openalex.org/C10679952","wikidata":"https://www.wikidata.org/wiki/Q5308937","display_name":"Druggability","level":3,"score":0.6163706183433533},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.5879287719726562},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5065628290176392},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.4617275297641754},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42955344915390015},{"id":"https://openalex.org/C13245373","wikidata":"https://www.wikidata.org/wiki/Q3715494","display_name":"Drug carrier","level":3,"score":0.42698296904563904},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42347198724746704},{"id":"https://openalex.org/C129312508","wikidata":"https://www.wikidata.org/wiki/Q133686","display_name":"Oligonucleotide","level":3,"score":0.4132697284221649},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37520915269851685},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3351668119430542},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.3305990695953369},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2898630201816559},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2777280807495117},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.27518966794013977},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.22066324949264526},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.18356826901435852},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12017735838890076},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.11542624235153198},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10457631945610046},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.09847009181976318},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09523296356201172}],"mesh":[{"descriptor_ui":"D000067492","descriptor_name":"RNAi Therapeutics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004727","descriptor_name":"Endothelium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.jconrel.2015.02.003","doi":"https://doi.org/10.1016/j.jconrel.2015.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.02.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0168365915000930/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},{"id":"pmid:25660205","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25660205","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of controlled release : official journal of the Controlled Release Society","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/j.jconrel.2015.02.003","doi":"https://doi.org/10.1016/j.jconrel.2015.02.003","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jconrel.2015.02.003","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0168365915000930/pdf","source":{"id":"https://openalex.org/S161954266","display_name":"Journal of Controlled Release","issn_l":"0168-3659","issn":["0168-3659","1873-4995"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Controlled Release","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3207356259","display_name":null,"funder_award_id":"2007\u20132013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8534927873","display_name":null,"funder_award_id":"115363","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8619952457","display_name":"Tumor-targeting of therapeutic oligonucleotides with DARPins","funder_award_id":"I 519","funder_id":"https://openalex.org/F4320321181","funder_display_name":"Austrian Science Fund"},{"id":"https://openalex.org/G8670248735","display_name":"Collaboration on the Optimisation of  Macromolecular Pharmaceutical Access to Cellular Targets","funder_award_id":"115363","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019613864.pdf","grobid_xml":"https://content.openalex.org/works/W2019613864.grobid-xml"},"referenced_works_count":188,"referenced_works":["https://openalex.org/W56901349","https://openalex.org/W98712137","https://openalex.org/W142058135","https://openalex.org/W190672668","https://openalex.org/W1462966185","https://openalex.org/W1575330800","https://openalex.org/W1597636635","https://openalex.org/W1643374506","https://openalex.org/W1647075334","https://openalex.org/W1652469027","https://openalex.org/W1675450733","https://openalex.org/W1729734762","https://openalex.org/W1839513988","https://openalex.org/W1939069213","https://openalex.org/W1964146045","https://openalex.org/W1966187612","https://openalex.org/W1967765481","https://openalex.org/W1968682237","https://openalex.org/W1971601502","https://openalex.org/W1972545546","https://openalex.org/W1972841312","https://openalex.org/W1975052907","https://openalex.org/W1975875150","https://openalex.org/W1976484755","https://openalex.org/W1979322667","https://openalex.org/W1979935130","https://openalex.org/W1980161576","https://openalex.org/W1982076909","https://openalex.org/W1982902233","https://openalex.org/W1983856140","https://openalex.org/W1983964788","https://openalex.org/W1985388948","https://openalex.org/W1987196669","https://openalex.org/W1989611595","https://openalex.org/W1993721193","https://openalex.org/W1993796296","https://openalex.org/W1995956587","https://openalex.org/W1996637041","https://openalex.org/W1999607053","https://openalex.org/W2000213276","https://openalex.org/W2002050544","https://openalex.org/W2004246909","https://openalex.org/W2005381620","https://openalex.org/W2008028087","https://openalex.org/W2008161734","https://openalex.org/W2009383197","https://openalex.org/W2009629825","https://openalex.org/W2017003565","https://openalex.org/W2017885336","https://openalex.org/W2020763460","https://openalex.org/W2023843484","https://openalex.org/W2024102779","https://openalex.org/W2025113219","https://openalex.org/W2025379011","https://openalex.org/W2025663809","https://openalex.org/W2027886431","https://openalex.org/W2028068115","https://openalex.org/W2028973041","https://openalex.org/W2029772834","https://openalex.org/W2031493003","https://openalex.org/W2033711847","https://openalex.org/W2035543573","https://openalex.org/W2036928635","https://openalex.org/W2037042911","https://openalex.org/W2038246612","https://openalex.org/W2040101610","https://openalex.org/W2040564031","https://openalex.org/W2041649971","https://openalex.org/W2041665769","https://openalex.org/W2042217072","https://openalex.org/W2042863693","https://openalex.org/W2043082218","https://openalex.org/W2044935159","https://openalex.org/W2045461387","https://openalex.org/W2045840002","https://openalex.org/W2047165821","https://openalex.org/W2048369172","https://openalex.org/W2048809853","https://openalex.org/W2049233124","https://openalex.org/W2049776758","https://openalex.org/W2052144389","https://openalex.org/W2054292501","https://openalex.org/W2054593632","https://openalex.org/W2055313665","https://openalex.org/W2055750804","https://openalex.org/W2057016701","https://openalex.org/W2057080391","https://openalex.org/W2059262359","https://openalex.org/W2060056553","https://openalex.org/W2060119915","https://openalex.org/W2060221489","https://openalex.org/W2060956312","https://openalex.org/W2062237973","https://openalex.org/W2065176007","https://openalex.org/W2066074720","https://openalex.org/W2066234893","https://openalex.org/W2067617639","https://openalex.org/W2068942685","https://openalex.org/W2069880685","https://openalex.org/W2070003597","https://openalex.org/W2070070981","https://openalex.org/W2070693578","https://openalex.org/W2073073594","https://openalex.org/W2073262653","https://openalex.org/W2074929394","https://openalex.org/W2075668934","https://openalex.org/W2076700114","https://openalex.org/W2078643924","https://openalex.org/W2078890343","https://openalex.org/W2079840724","https://openalex.org/W2079867104","https://openalex.org/W2080718344","https://openalex.org/W2082421311","https://openalex.org/W2083249633","https://openalex.org/W2083292951","https://openalex.org/W2083524314","https://openalex.org/W2088390557","https://openalex.org/W2089586599","https://openalex.org/W2090160156","https://openalex.org/W2090163359","https://openalex.org/W2091546373","https://openalex.org/W2091944526","https://openalex.org/W2091993321","https://openalex.org/W2094503153","https://openalex.org/W2094641772","https://openalex.org/W2095244900","https://openalex.org/W2095317094","https://openalex.org/W2096917691","https://openalex.org/W2099753372","https://openalex.org/W2100276489","https://openalex.org/W2100615745","https://openalex.org/W2102110918","https://openalex.org/W2105339389","https://openalex.org/W2105410188","https://openalex.org/W2106543868","https://openalex.org/W2109699895","https://openalex.org/W2110634891","https://openalex.org/W2111497685","https://openalex.org/W2114317477","https://openalex.org/W2115373796","https://openalex.org/W2116424844","https://openalex.org/W2117224856","https://openalex.org/W2117738176","https://openalex.org/W2118372997","https://openalex.org/W2122771422","https://openalex.org/W2124018243","https://openalex.org/W2124304994","https://openalex.org/W2124365637","https://openalex.org/W2125460615","https://openalex.org/W2126044151","https://openalex.org/W2127409621","https://openalex.org/W2128545033","https://openalex.org/W2130886644","https://openalex.org/W2133380348","https://openalex.org/W2135192000","https://openalex.org/W2135500767","https://openalex.org/W2136021162","https://openalex.org/W2141089307","https://openalex.org/W2141518860","https://openalex.org/W2142675285","https://openalex.org/W2145860075","https://openalex.org/W2145871683","https://openalex.org/W2148041292","https://openalex.org/W2150244588","https://openalex.org/W2151849193","https://openalex.org/W2156764325","https://openalex.org/W2157085976","https://openalex.org/W2157916750","https://openalex.org/W2157963288","https://openalex.org/W2159147379","https://openalex.org/W2162403028","https://openalex.org/W2162676548","https://openalex.org/W2168339179","https://openalex.org/W2169678660","https://openalex.org/W2170248971","https://openalex.org/W2170325534","https://openalex.org/W2235217437","https://openalex.org/W2312836697","https://openalex.org/W2315015256","https://openalex.org/W2316132657","https://openalex.org/W2321507256","https://openalex.org/W2334426515","https://openalex.org/W2334475149","https://openalex.org/W2334882569","https://openalex.org/W2411706862","https://openalex.org/W2478392002","https://openalex.org/W4243799445","https://openalex.org/W4251025034"],"related_works":["https://openalex.org/W7223208089","https://openalex.org/W187149330","https://openalex.org/W4311367297","https://openalex.org/W2795125879","https://openalex.org/W2883109277","https://openalex.org/W2120820989","https://openalex.org/W2068942685","https://openalex.org/W4297918257","https://openalex.org/W2738523285","https://openalex.org/W2122935177"],"abstract_inverted_index":{"Therapeutic":[0],"gene":[1],"silencing":[2],"promises":[3],"significant":[4],"progress":[5],"in":[6,55,59,62,87,101,144,189],"pharmacotherapy,":[7],"including":[8,147],"considerable":[9],"expansion":[10],"of":[11,30,50,94,123,134,165,173,177,201,227],"the":[12,17,27,72,153,161,178,190,197,222],"druggable":[13],"target":[14],"space":[15],"and":[16,33,42,48,67,81,104,152,210,216,221,225,229],"possibility":[18],"for":[19,92,98],"treating":[20],"orphan":[21],"diseases.":[22,96,175],"Technological":[23],"hurdles":[24],"have":[25,53,106],"complicated":[26],"efficient":[28,56,170],"use":[29],"therapeutic":[31],"oligonucleotides,":[32],"siRNA":[34,202],"agents":[35],"suffer":[36],"particularly":[37],"from":[38],"insufficient":[39],"pharmacokinetic":[40],"properties":[41],"poor":[43],"cellular":[44,150],"uptake.":[45],"Intense":[46],"development":[47],"evolution":[49],"delivery":[51,69],"systems":[52,70],"resulted":[54],"uptake":[57],"predominantly":[58],"liver":[60],"tissue,":[61],"which":[63,157],"practically":[64],"all":[65],"nanoparticulate":[66],"liposomal":[68],"show":[71],"highest":[73],"accumulation.":[74],"The":[75,155,219],"most":[76],"efficacious":[77],"strategies":[78],"include":[79],"liposomes":[80],"bioconjugations":[82],"with":[83],"N-acetylgalactosamine.":[84],"Both":[85],"are":[86,235],"early":[88],"clinical":[89,199],"evaluation":[90],"stages":[91],"treatment":[93],"liver-associated":[95],"Approaches":[97],"achieving":[99],"knockdown":[100],"other":[102,145],"tissues":[103],"tumors":[105,116],"been":[107],"proven":[108],"to":[109,115,168,186],"be":[110,118],"more":[111],"complicated.":[112],"Selective":[113],"targeting":[114,136],"may":[117],"enabled":[119],"through":[120,181],"careful":[121],"modulation":[122],"physical":[124],"properties,":[125],"such":[126],"as":[127,206,208],"particle":[128],"size,":[129],"or":[130,232],"by":[131,160],"taking":[132],"advantage":[133],"specific":[135],"ligands.":[137,218],"Significant":[138],"barriers":[139],"stand":[140],"between":[141],"sufficient":[142],"accumulation":[143,188],"organs,":[146],"endothelial":[148],"barriers,":[149],"membranes,":[151],"endosome.":[154],"brain,":[156],"is":[158,164,184,204],"shielded":[159],"blood-brain":[162,179],"barrier,":[163],"particular":[166],"interest":[167],"facilitate":[169],"oligonucleotide":[171],"therapy":[172],"neurological":[174],"Transcytosis":[176],"barrier":[180],"receptor-specific":[182],"docking":[183],"investigated":[185],"increase":[187],"central":[191],"nervous":[192],"system.":[193],"In":[194],"this":[195],"review,":[196],"current":[198],"status":[200],"therapeutics":[203],"summarized,":[205],"well":[207],"innovative":[209],"promising":[211],"preclinical":[212],"concepts":[213],"employing":[214],"tissue-":[215],"tumor-targeted":[217],"requirements":[220],"respective":[223],"advantages":[224],"drawbacks":[226],"bioconjugates":[228],"ligand-decorated":[230],"lipid":[231],"polymeric":[233],"particles":[234],"discussed.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":26},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":35},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":34},{"year":2016,"cited_by_count":37},{"year":2015,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
