{"id":"https://openalex.org/W2019577170","doi":"https://doi.org/10.1182/blood-2014-09-597716","title":"Cellular thrust and parry in the leukemic niche","display_name":"Cellular thrust and parry in the leukemic niche","publication_year":2014,"publication_date":"2014-10-30","ids":{"openalex":"https://openalex.org/W2019577170","doi":"https://doi.org/10.1182/blood-2014-09-597716","mag":"2019577170","pmid":"https://pubmed.ncbi.nlm.nih.gov/25359983"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2014-09-597716","doi":"https://doi.org/10.1182/blood-2014-09-597716","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-09-597716","pdf_url":"https://ashpublications.org/blood/article-pdf/124/18/2760/1380556/2760.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/124/18/2760/1380556/2760.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039839709","display_name":"Youmna Sami Kfoury","orcid":"https://orcid.org/0000-0003-2495-3378","observed_orcids":["https://orcid.org/0000-0003-2495-3378"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Youmna Kfoury","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSPITAL; HARVARD UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSPITAL; HARVARD UNIVERSITY","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083648953","display_name":"David T. Scadden","orcid":"https://orcid.org/0000-0001-9821-7133","observed_orcids":["https://orcid.org/0000-0001-9821-7133"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Scadden","raw_affiliation_strings":["MASSACHUSETTS GENERAL HOSPITAL; HARVARD UNIVERSITY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MASSACHUSETTS GENERAL HOSPITAL; HARVARD UNIVERSITY","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.4729,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68364344,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"124","issue":"18","first_page":"2760","last_page":"2761"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.013100000098347664,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.8930000066757202},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9620000123977661},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9629999995231628},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.6769999861717224}],"concepts":[{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6235758662223816},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.5492604970932007},{"id":"https://openalex.org/C2778975910","wikidata":"https://www.wikidata.org/wiki/Q1967077","display_name":"PARRY","level":2,"score":0.4967079758644104},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4617718458175659},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41731947660446167},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4112258553504944},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3924109637737274},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.345453679561615},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.337576687335968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1617269515991211},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07564693689346313},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2014-09-597716","doi":"https://doi.org/10.1182/blood-2014-09-597716","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-09-597716","pdf_url":"https://ashpublications.org/blood/article-pdf/124/18/2760/1380556/2760.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:25359983","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25359983","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2014-09-597716","doi":"https://doi.org/10.1182/blood-2014-09-597716","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2014-09-597716","pdf_url":"https://ashpublications.org/blood/article-pdf/124/18/2760/1380556/2760.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019577170.pdf","grobid_xml":"https://content.openalex.org/works/W2019577170.grobid-xml"},"referenced_works_count":8,"referenced_works":["https://openalex.org/W1967746635","https://openalex.org/W1971620413","https://openalex.org/W2018510875","https://openalex.org/W2033278321","https://openalex.org/W2044703599","https://openalex.org/W2045032252","https://openalex.org/W2056278417","https://openalex.org/W2132053539"],"related_works":["https://openalex.org/W1967746635","https://openalex.org/W2969834388","https://openalex.org/W3031972988","https://openalex.org/W2368572176","https://openalex.org/W2551494897","https://openalex.org/W4230329416","https://openalex.org/W2591772914","https://openalex.org/W2536957180","https://openalex.org/W3012351682","https://openalex.org/W2313742132"],"abstract_inverted_index":{"In":[0,37],"this":[1],"issue":[2],"of":[3],"Blood":[4],",":[5],"Krevvata":[6],"et":[7],"al":[8],"show":[9],"that":[10],"osteoblasts":[11,43],"duel":[12],"with":[13],"acute":[14],"leukemia":[15],"cells,":[16],"each":[17],"having":[18],"adverse":[19],"effects":[20],"on":[21],"the":[22],"other.[1][1]\n\n![Figure][2]":[23],"\n\n(A)":[24],"A":[25],"decrease":[26],"in":[27,30],"osteoblast":[28],"numbers":[29],"mostly":[31],"untreated":[32],"AML/MDS":[33],"patients":[34],"is":[35],"shown.":[36],"a":[38],"DTAosb":[39],"animal":[40],"model":[41],"where":[42],"were":[44]},"counts_by_year":[{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}