{"id":"https://openalex.org/W2019541709","doi":"https://doi.org/10.1002/jlcr.2580311007","title":"Synthesis of S\u2010[3\u2010(4(5)\u2010imidazolyl)propyl],N\u2010[2(4\u2010{125I}\u2010iodophenyl)ethyl]isothiourea sulfate (125I\u2010iodophenpropit), a new probe for histamine H3 receptor binding sites.","display_name":"Synthesis of S\u2010[3\u2010(4(5)\u2010imidazolyl)propyl],N\u2010[2(4\u2010{125I}\u2010iodophenyl)ethyl]isothiourea sulfate (125I\u2010iodophenpropit), a new probe for histamine H3 receptor binding sites.","publication_year":1992,"publication_date":"1992-10-01","ids":{"openalex":"https://openalex.org/W2019541709","doi":"https://doi.org/10.1002/jlcr.2580311007","mag":"2019541709"},"language":"en","primary_location":{"id":"doi:10.1002/jlcr.2580311007","doi":"https://doi.org/10.1002/jlcr.2580311007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580311007","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086324869","display_name":"Wiro M. P. B. Menge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wiro M. P. B. Menge","raw_affiliation_strings":["Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108807334","display_name":"Henk Van der Goot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Henk Van Der Goot","raw_affiliation_strings":["Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110031242","display_name":"Hendrik Timmerman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hendrik Timmerman","raw_affiliation_strings":["Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacochemistry, Free University, De Boelelaan 1083, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035010632","display_name":"Jos L. H. Eersels","orcid":"https://orcid.org/0000-0001-7521-583X","observed_orcids":["https://orcid.org/0000-0001-7521-583X"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jos. L. H. Eersels","raw_affiliation_strings":["Radio-Nuclide-Centre, Free University, De Boelelaan 1085c, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radio-Nuclide-Centre, Free University, De Boelelaan 1085c, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110038802","display_name":"Jacobus D. M. Herscheid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Jacobu S. D. M. Herscheid","raw_affiliation_strings":["Radio-Nuclide-Centre, Free University, De Boelelaan 1085c, 1081 HV Amsterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radio-Nuclide-Centre, Free University, De Boelelaan 1085c, 1081 HV Amsterdam, The Netherlands","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":2.2825,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.86753661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"10","first_page":"781","last_page":"786"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.8817999958992004,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.1120000034570694,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/histamine-h3-receptor","display_name":"histamine H3 receptor","score":0.781000018119812},{"id":"https://openalex.org/keywords/radioligand-synthesis","display_name":"radioligand synthesis","score":0.9020000100135803},{"id":"https://openalex.org/keywords/iodine-125-labeling","display_name":"iodine-125 labeling","score":0.9440000057220459},{"id":"https://openalex.org/keywords/histamine-h3-receptor-antagonists","display_name":"histamine H3 receptor antagonists","score":0.7419999837875366},{"id":"https://openalex.org/keywords/radiopharmaceuticals","display_name":"radiopharmaceuticals","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9618873596191406},{"id":"https://openalex.org/C2778343803","wikidata":"https://www.wikidata.org/wiki/Q172290","display_name":"Sulfate","level":2,"score":0.5680679082870483},{"id":"https://openalex.org/C111771559","wikidata":"https://www.wikidata.org/wiki/Q66295","display_name":"Derivative (finance)","level":2,"score":0.5268049240112305},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.5228574275970459},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.4797821640968323},{"id":"https://openalex.org/C178907741","wikidata":"https://www.wikidata.org/wiki/Q745930","display_name":"Nucleophile","level":3,"score":0.43795332312583923},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4050412178039551},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3346635699272156},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.19635549187660217},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1952352523803711},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C106159729","wikidata":"https://www.wikidata.org/wiki/Q2294553","display_name":"Financial economics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/jlcr.2580311007","doi":"https://doi.org/10.1002/jlcr.2580311007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jlcr.2580311007","pdf_url":null,"source":{"id":"https://openalex.org/S90602895","display_name":"Journal of Labelled Compounds and Radiopharmaceuticals","issn_l":"0362-4803","issn":["0362-4803","1099-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Labelled Compounds and Radiopharmaceuticals","raw_type":"journal-article"},{"id":"pmh:oai:vubissmart:VUBISSMART:2000:113087","doi":null,"is_oa":false,"landing_page_url":"https://biblio.vub.ac.be/vubir/synthesis-of-125iiodophenpropit-a-new-probe-for-histamine-h3-receptor-binding-sites(e9bccdb4-0055-4894-871b-1cad6f17347b).html","pdf_url":null,"source":{"id":"https://openalex.org/S4306402573","display_name":"VUBIR (Vrije Universiteit Brussel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13469542","host_organization_name":"Vrije Universiteit Brussel","host_organization_lineage":["https://openalex.org/I13469542"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1969572953","https://openalex.org/W1969674755","https://openalex.org/W2000211620","https://openalex.org/W2029431513","https://openalex.org/W2039031830","https://openalex.org/W2045358799","https://openalex.org/W2049705361","https://openalex.org/W2052755701","https://openalex.org/W2066290513","https://openalex.org/W2077687762","https://openalex.org/W2079077313","https://openalex.org/W2163641477","https://openalex.org/W2332958451","https://openalex.org/W4233203697","https://openalex.org/W4235461115","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7025118926","https://openalex.org/W1981011005","https://openalex.org/W2058045382","https://openalex.org/W2086265997","https://openalex.org/W2063033946","https://openalex.org/W2031009715","https://openalex.org/W2003205396","https://openalex.org/W2063798275","https://openalex.org/W2600005903","https://openalex.org/W2027343229"],"abstract_inverted_index":{"Abstract":[0],"The":[1,20,37],"synthesis":[2],"of":[3,58],"the":[4,31],"first":[5],"high":[6],"specific":[7,56],"activity":[8,57],"{125I}":[9],"labelled":[10],"selective":[11],"H3":[12],"antagonist,":[13],"Iodophenpropit\u2010":[14],"i.e.,":[15],"S\u2010[3\u2010(4(5)\u2010imidazolyl)propyl],N\u2010[2\u2010(4\u2010{125I}\u2010iodophenyl)ethyl]isothiourea":[16],"sulfate":[17],"is":[18],"reported.":[19],"radiolabelled":[21],"compound":[22],"was":[23,39],"prepared":[24],"by":[25],"Cu(I)assisted":[26],"nucleophilic":[27],"non\u2010isotopic":[28],"exchange":[29],"from":[30],"corresponding":[32],"bromo":[33],"derivative":[34],"(VUF":[35],"4598).":[36],"125I\u2010Iodophenpropit":[38],"purified":[40],"using":[41],"reverse":[42],"phase":[43],"HPLC":[44],"and":[45,50,54],"obtained":[46],"in":[47],"a":[48,55],"chemical":[49],"radiochemical":[51],"purity":[52],">98%":[53],"1900":[59],"Ci/mmol.":[60]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}