{"id":"https://openalex.org/W2019537332","doi":"https://doi.org/10.1089/ten.tec.2009.0396","title":"Insulin-like Growth Factor-I and Growth Differentiation Factor-5 Promote the Formation of Tissue-Engineered Human Nasal Septal Cartilage","display_name":"Insulin-like Growth Factor-I and Growth Differentiation Factor-5 Promote the Formation of Tissue-Engineered Human Nasal Septal Cartilage","publication_year":2010,"publication_date":"2010-02-23","ids":{"openalex":"https://openalex.org/W2019537332","doi":"https://doi.org/10.1089/ten.tec.2009.0396","mag":"2019537332","pmid":"https://pubmed.ncbi.nlm.nih.gov/20178406","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943402"},"language":"en","primary_location":{"id":"doi:10.1089/ten.tec.2009.0396","doi":"https://doi.org/10.1089/ten.tec.2009.0396","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2009.0396","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943402","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067792678","display_name":"Thomas H. Alexander","orcid":"https://orcid.org/0000-0002-0484-1574","observed_orcids":["https://orcid.org/0000-0002-0484-1574"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas H. Alexander","raw_affiliation_strings":["San Diego Veterans Administration Medical Center","University of California\u2013San Diego","Division of Otolaryngology\u2013Head and Neck Surgery, University of California\u2013San Diego, San Diego, California","San Diego Veterans Administration Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Veterans Administration Medical Center","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"San Diego Veterans Administration Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033988914","display_name":"August B. Sage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"August B. Sage","raw_affiliation_strings":["San Diego Veterans Administration Medical Center","San Diego Veterans Administration Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Veterans Administration Medical Center","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"San Diego Veterans Administration Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924251","display_name":"Albert C. Chen","orcid":"https://orcid.org/0000-0002-0953-3992","observed_orcids":["https://orcid.org/0000-0002-0953-3992"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Albert C. Chen","raw_affiliation_strings":["University of California\u2013San Diego","Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111791589","display_name":"Barbara L. Schumacher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Barbara L. Schumacher","raw_affiliation_strings":["San Diego Veterans Administration Medical Center","University of California\u2013San Diego","Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","San Diego Veterans Administration Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Veterans Administration Medical Center","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"San Diego Veterans Administration Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1322918889"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054217953","display_name":"Elliot Shelton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elliot Shelton","raw_affiliation_strings":["University of California\u2013San Diego","Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000662848","display_name":"Koichi Masuda","orcid":"https://orcid.org/0000-0002-5361-4415","observed_orcids":["https://orcid.org/0000-0002-5361-4415"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Koichi Masuda","raw_affiliation_strings":["University of California\u2013San Diego","Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026261610","display_name":"Robert L. Sah","orcid":"https://orcid.org/0000-0002-5493-9502","observed_orcids":["https://orcid.org/0000-0002-5493-9502"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert L. Sah","raw_affiliation_strings":["University of California\u2013San Diego","Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077816873","display_name":"Deborah J. Watson","orcid":"https://orcid.org/0000-0002-8044-8344","observed_orcids":["https://orcid.org/0000-0002-8044-8344"]},"institutions":[{"id":"https://openalex.org/I1322918889","display_name":"United States Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889"]},{"id":"https://openalex.org/I2799886695","display_name":"Veterans Health Administration","ror":"https://ror.org/05eq41471","country_code":"US","type":"government","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4210099595","display_name":"VA San Diego Healthcare System","ror":"https://ror.org/00znqwq11","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210099595","https://openalex.org/I4210138663"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Watson","raw_affiliation_strings":["San Diego Veterans Administration Medical Center","University of California\u2013San Diego","Division of Otolaryngology\u2013Head and Neck Surgery, University of California\u2013San Diego, San Diego, California","San Diego Veterans Administration Medical Center, San Diego, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Diego Veterans Administration Medical Center","institution_ids":["https://openalex.org/I2799886695","https://openalex.org/I4210099595"]},{"raw_affiliation_string":"University of California\u2013San Diego","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"Division of Otolaryngology\u2013Head and Neck Surgery, University of California\u2013San Diego, San Diego, California","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"San Diego Veterans Administration Medical Center, San Diego, California","institution_ids":["https://openalex.org/I1322918889"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067792678"],"corresponding_institution_ids":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I36258959","https://openalex.org/I4210099595"],"apc_list":null,"apc_paid":null,"fwci":3.3729,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.91311841,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"16","issue":"5","first_page":"1213","last_page":"1221"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7534000277519226,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11812","display_name":"Nasal Surgery and Airway Studies","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.8849999904632568},{"id":"https://openalex.org/keywords/gdf5","display_name":"GDF5","score":0.9980000257492065},{"id":"https://openalex.org/keywords/septal-cartilage","display_name":"septal cartilage","score":0.8999999761581421},{"id":"https://openalex.org/keywords/tissue-engineered-cartilage","display_name":"tissue-engineered cartilage","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chondrocytes","display_name":"chondrocytes","score":0.796999990940094},{"id":"https://openalex.org/keywords/growth-factor-combination","display_name":"growth factor combination","score":0.7289999723434448},{"id":"https://openalex.org/keywords/alginate-bead-culture","display_name":"alginate bead culture","score":0.6700000166893005},{"id":"https://openalex.org/keywords/transwell-culture","display_name":"transwell culture","score":0.6230000257492065},{"id":"https://openalex.org/keywords/glycosaminoglycan-accumulation","display_name":"glycosaminoglycan accumulation","score":0.8999999761581421},{"id":"https://openalex.org/keywords/type-ii-collagen","display_name":"type II collagen","score":0.9940000176429749},{"id":"https://openalex.org/keywords/tissue-mechanics","display_name":"tissue mechanics","score":0.7929999828338623},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.6660000085830688},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.6625683307647705},{"id":"https://openalex.org/C2780550940","wikidata":"https://www.wikidata.org/wiki/Q502730","display_name":"Cartilage","level":2,"score":0.5896635055541992},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.5799987316131592},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5292826294898987},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.49332109093666077},{"id":"https://openalex.org/C146539212","wikidata":"https://www.wikidata.org/wiki/Q5611740","display_name":"Growth differentiation factor","level":4,"score":0.4821571707725525},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.44321560859680176},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.4417009949684143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4282434582710266},{"id":"https://openalex.org/C118131993","wikidata":"https://www.wikidata.org/wiki/Q423671","display_name":"Transforming growth factor","level":2,"score":0.41134291887283325},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41034063696861267},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.35012948513031006},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3413967788219452},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.337465763092041},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31853732466697693},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2784178853034973},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.23047006130218506},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1793864667415619},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002356","descriptor_name":"Cartilage","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007334","descriptor_name":"Insulin-Like Growth Factor I","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009300","descriptor_name":"Nasal Septum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D023822","descriptor_name":"Tissue Engineering","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055428","descriptor_name":"Growth Differentiation Factor 5","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1089/ten.tec.2009.0396","doi":"https://doi.org/10.1089/ten.tec.2009.0396","is_oa":false,"landing_page_url":"https://doi.org/10.1089/ten.tec.2009.0396","pdf_url":null,"source":{"id":"https://openalex.org/S190192123","display_name":"Tissue Engineering Part C Methods","issn_l":"1937-3384","issn":["1937-3384","1937-3392"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Engineering Part C: Methods","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2943402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part C Methods","raw_type":"Text"},{"id":"pmid:20178406","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20178406","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue engineering. Part C, Methods","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.689.2150","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.689.2150","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943402/pdf/ten.tec.2009.0396.pdf","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2943402","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2943402","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Eng Part C Methods","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5520316217","display_name":null,"funder_award_id":"NIH-R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8787437337","display_name":"Bioengineering the Maturation, Size and Shape of Articular Cartilage Grafts","funder_award_id":"R01AR044058","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W151547172","https://openalex.org/W1593255198","https://openalex.org/W1967269017","https://openalex.org/W1968298531","https://openalex.org/W1985196036","https://openalex.org/W1989904395","https://openalex.org/W1991269311","https://openalex.org/W1992905836","https://openalex.org/W1996584907","https://openalex.org/W1998562433","https://openalex.org/W2015694728","https://openalex.org/W2018944021","https://openalex.org/W2030484761","https://openalex.org/W2032255522","https://openalex.org/W2035469813","https://openalex.org/W2037178326","https://openalex.org/W2038885341","https://openalex.org/W2042709934","https://openalex.org/W2050273631","https://openalex.org/W2051970854","https://openalex.org/W2055978912","https://openalex.org/W2056927577","https://openalex.org/W2063445189","https://openalex.org/W2076062177","https://openalex.org/W2076302120","https://openalex.org/W2083108251","https://openalex.org/W2084961243","https://openalex.org/W2089261882","https://openalex.org/W2090858352","https://openalex.org/W2091233593","https://openalex.org/W2108790008","https://openalex.org/W2130586735","https://openalex.org/W2135211678","https://openalex.org/W2140477641","https://openalex.org/W2156834162","https://openalex.org/W2175893124","https://openalex.org/W2402259549","https://openalex.org/W2406095913","https://openalex.org/W2409535317","https://openalex.org/W2414770837"],"related_works":["https://openalex.org/W2042709934","https://openalex.org/W2110215016","https://openalex.org/W2551125867","https://openalex.org/W2187215087","https://openalex.org/W2402259549","https://openalex.org/W2140477641","https://openalex.org/W1989904395","https://openalex.org/W2046219092","https://openalex.org/W1991269311","https://openalex.org/W1912459459"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Tissue":[1],"engineering":[2],"of":[3,15,23,41,46,60,69,105,117,124,156,169,242,269,318,326,333],"human":[4,31,79,92],"nasal":[5,80],"septal":[6,81],"chondrocytes":[7,82],"offers":[8],"the":[9,24,36,167,243,267,348],"potential":[10],"to":[11,50,56,273],"create":[12],"large":[13],"quantities":[14],"autologous":[16],"material":[17],"for":[18,102,162,183,210,235,255],"use":[19],"in":[20,72,88,99,107,186,213,217,277,281,330],"reconstructive":[21],"surgery":[22],"head":[25],"and":[26,38,63,115,145,158,198,201,208,229,239,262,271,293,303,314,322,335,339],"neck.":[27],"Culture":[28],"with":[29,90,110,189,194,220,225,285,301,310,320,344],"recombinant":[30],"growth":[32,61,120,126,135,140,256,349],"factors":[33,62],"may":[34],"improve":[35],"biochemical":[37],"biomechanical":[39,240,341],"properties":[40,241,342],"engineered":[42],"tissue.":[43],"The":[44],"objectives":[45],"this":[47],"study":[48],"were":[49,86,96,147,205,245],"(1)":[51],"perform":[52,65],"a":[53,278],"high-throughput":[54],"screen":[55],"assess":[57],"multiple":[58],"combinations":[59,258],"(2)":[64],"more":[66],"detailed":[67],"testing":[68,164],"candidates":[70],"identified":[71],"part":[73,77,170,249,265],"I.":[74,171],"METHODS:":[75],"In":[76,248,264],"I,":[78,250],"from":[83,173],"three":[84],"donors":[85,175],"expanded":[87],"monolayer":[89],"pooled":[91],"serum":[93],"(HS).":[94],"Cells":[95],"then":[97,206],"embedded":[98],"alginate":[100,181,236],"beads":[101],"2":[103,184],"weeks":[104,185,212],"culture":[106,182],"medium":[108,187,218,233,319],"supplemented":[109,188,219],"2%":[111,190,221,274,286,311],"or":[112,191,195,222,226],"10%":[113,192,223],"HS":[114,193,224,275,287],"1":[116],"90":[118],"different":[119],"factor":[121,141,257],"combinations.":[122],"Combinations":[123],"insulin-like":[125],"factor-I":[127],"(IGF-1),":[128],"bone":[129],"morphogenetic":[130],"protein":[131],"(BMP)-2,":[132],"BMP-7,":[133],"BMP-13,":[134],"differentiation":[136],"factor-5":[137],"(GDF-5),":[138],"transforming":[139],"\u03b2":[142],"(TGF\u03b2)-2,":[143],"insulin,":[144],"dexamethasone":[146],"evaluated.":[148],"Glycosaminoglycan":[149],"(GAG)":[150],"accumulation":[151,252,297,332],"was":[152,160,253,298,308],"measured.":[153,246],"A":[154],"combination":[155],"IGF-1":[157,197,228,261,270,302,321],"GDF-5":[159,230,272,323],"selected":[161],"further":[163],"based":[165],"on":[166],"results":[168,329],"Chondrocytes":[172,200],"four":[174],"underwent":[176],"expansion":[177],"followed":[178],"by":[179],"three-dimensional":[180],"without":[196,227,347],"GDF-5.":[199,263,304,315],"their":[202],"associated":[203],"matrix":[204],"recovered":[207],"cultured":[209],"4":[211],"12":[214],"mm":[215],"transwells":[216],"(the":[231],"same":[232],"used":[234],"culture).":[237],"Biochemical":[238],"neocartilage":[244,327],"RESULTS:":[247],"GAG":[251,292,334],"highest":[254],"including":[259],"both":[260],"II,":[266],"addition":[268],"resulted":[276],"12-fold":[279],"increase":[280],"construct":[282],"thickness":[283],"compared":[284,343],"alone":[288],"(p":[289],"<":[290],"0.0001).":[291],"type":[294,336],"II":[295,337],"collagen":[296,338],"significantly":[299],"higher":[300],"Confined":[305],"compression":[306],"modulus":[307],"greatest":[309],"HS,":[312],"IGF-1,":[313],"CONCLUSION:":[316],"Supplementation":[317],"during":[324],"creation":[325],"constructs":[328,345],"increased":[331],"improved":[340],"created":[346],"factors.":[350]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
