{"id":"https://openalex.org/W2019535641","doi":"https://doi.org/10.1016/s0014-5793(98)00400-1","title":"Cross\u2010linking and mutational analysis of the oligomerization state of the cytokine macrophage migration inhibitory factor (MIF)","display_name":"Cross\u2010linking and mutational analysis of the oligomerization state of the cytokine macrophage migration inhibitory factor (MIF)","publication_year":1998,"publication_date":"1998-05-01","ids":{"openalex":"https://openalex.org/W2019535641","doi":"https://doi.org/10.1016/s0014-5793(98)00400-1","mag":"2019535641","pmid":"https://pubmed.ncbi.nlm.nih.gov/9613605"},"language":"en","primary_location":{"id":"doi:10.1016/s0014-5793(98)00400-1","doi":"https://doi.org/10.1016/s0014-5793(98)00400-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(98)00400-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2898%2900400-1","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2898%2900400-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033269665","display_name":"Ralf Mischke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ralf Mischke","raw_affiliation_strings":["Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Germany","Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063674598","display_name":"Robert Kleemann","orcid":"https://orcid.org/0000-0002-1350-0149","observed_orcids":["https://orcid.org/0000-0002-1350-0149"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert Kleemann","raw_affiliation_strings":["Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110133864","display_name":"Herwig Brunner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Herwig Brunner","raw_affiliation_strings":["Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080194585","display_name":"J\u00fcrgen Bernhagen","orcid":"https://orcid.org/0000-0003-2996-2652","observed_orcids":["https://orcid.org/0000-0003-2996-2652"]},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"J\u00fcrgen Bernhagen","raw_affiliation_strings":["Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Biochemistry, Chair for Interfacial Engineering, University of Stuttgart, Nobelstrasse 12, D-70569 Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080194585"],"corresponding_institution_ids":["https://openalex.org/I100066346"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":0.7179,"has_fulltext":true,"cited_by_count":67,"citation_normalized_percentile":{"value":0.69935002,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"427","issue":"1","first_page":"85","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13254","display_name":"Macrophage Migration Inhibitory Factor","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/macrophage-migration-inhibitory-factor","display_name":"macrophage migration inhibitory factor","score":1.0},{"id":"https://openalex.org/keywords/protein-cross-linking","display_name":"protein cross-linking","score":0.7120000123977661},{"id":"https://openalex.org/keywords/c-terminal-truncation-mutants","display_name":"C-terminal truncation mutants","score":0.6690000295639038},{"id":"https://openalex.org/keywords/dimerization","display_name":"dimerization","score":0.5820000171661377},{"id":"https://openalex.org/keywords/monomeric-state","display_name":"monomeric state","score":0.6399999856948853},{"id":"https://openalex.org/keywords/quaternary-structure","display_name":"quaternary structure","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C104177226","wikidata":"https://www.wikidata.org/wiki/Q15311903","display_name":"Macrophage migration inhibitory factor","level":3,"score":0.9606016874313354},{"id":"https://openalex.org/C2780642029","wikidata":"https://www.wikidata.org/wiki/Q726004","display_name":"Oligomer","level":2,"score":0.806665301322937},{"id":"https://openalex.org/C2776403692","wikidata":"https://www.wikidata.org/wiki/Q898416","display_name":"Trimer","level":3,"score":0.8043098449707031},{"id":"https://openalex.org/C2779546866","wikidata":"https://www.wikidata.org/wiki/Q531306","display_name":"Dimer","level":2,"score":0.7694700360298157},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6868889927864075},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.6458121538162231},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5707377195358276},{"id":"https://openalex.org/C193363816","wikidata":"https://www.wikidata.org/wiki/Q1617865","display_name":"Size-exclusion chromatography","level":3,"score":0.5686511397361755},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4394393563270569},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43869736790657043},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20028749108314514},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19309714436531067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.10963314771652222},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09857764840126038},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06889835000038147},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06618925929069519}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003432","descriptor_name":"Cross-Linking Reagents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008263","descriptor_name":"Macrophage Migration-Inhibitory Factors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019281","descriptor_name":"Dimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/s0014-5793(98)00400-1","doi":"https://doi.org/10.1016/s0014-5793(98)00400-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(98)00400-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2898%2900400-1","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:9613605","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9613605","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"},{"id":"pmh:oai:publica.fraunhofer.de:publica/192280","doi":null,"is_oa":false,"landing_page_url":"https://publica.fraunhofer.de/handle/publica/192280","pdf_url":null,"source":{"id":"https://openalex.org/S4306400318","display_name":"Fraunhofer-Publica (Fraunhofer-Gesellschaft)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4923324","host_organization_name":"Fraunhofer-Gesellschaft","host_organization_lineage":["https://openalex.org/I4923324"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.1016/s0014-5793(98)00400-1","doi":"https://doi.org/10.1016/s0014-5793(98)00400-1","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0014-5793(98)00400-1","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/S0014-5793%2898%2900400-1","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2019535641.pdf","grobid_xml":"https://content.openalex.org/works/W2019535641.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W109149868","https://openalex.org/W1513861898","https://openalex.org/W1541486667","https://openalex.org/W1577799117","https://openalex.org/W1607234954","https://openalex.org/W1974164942","https://openalex.org/W1974837412","https://openalex.org/W1979244891","https://openalex.org/W1986862345","https://openalex.org/W1990594190","https://openalex.org/W1993629820","https://openalex.org/W1997838054","https://openalex.org/W2011376754","https://openalex.org/W2014462918","https://openalex.org/W2015512183","https://openalex.org/W2015786952","https://openalex.org/W2019920544","https://openalex.org/W2023400093","https://openalex.org/W2024510500","https://openalex.org/W2026192283","https://openalex.org/W2026569411","https://openalex.org/W2028231353","https://openalex.org/W2035148202","https://openalex.org/W2038182929","https://openalex.org/W2040336985","https://openalex.org/W2045767889","https://openalex.org/W2051732509","https://openalex.org/W2053902929","https://openalex.org/W2057350048","https://openalex.org/W2059448081","https://openalex.org/W2062824264","https://openalex.org/W2063581768","https://openalex.org/W2065431218","https://openalex.org/W2070114315","https://openalex.org/W2075219502","https://openalex.org/W2090056328","https://openalex.org/W2097703618","https://openalex.org/W2108285949","https://openalex.org/W2108743612","https://openalex.org/W2126600660","https://openalex.org/W2141991660","https://openalex.org/W2146058212","https://openalex.org/W2164520041","https://openalex.org/W2504451905"],"related_works":["https://openalex.org/W1922434207","https://openalex.org/W2007590937","https://openalex.org/W2053713568","https://openalex.org/W2155500006","https://openalex.org/W2047829162","https://openalex.org/W7065197524","https://openalex.org/W2157079153","https://openalex.org/W7100418375","https://openalex.org/W2045767889","https://openalex.org/W2026192283"],"abstract_inverted_index":{"The":[0],"structure":[1],"of":[2,26,30,43,53,80,115,125,135,146,171,184],"the":[3,20,31,40,66,90,95,103,113,126,154,161,169],"cytokine":[4],"MIF":[5,44,57,73,116,137,179],"has":[6],"been":[7],"investigated":[8],"by":[9,61,68],"X-ray":[10],"crystallography,":[11],"NMR,":[12],"and":[13,22,55,58,64,70,83,92,107,133,156,187],"biochemical":[14],"methods":[15,63],"with":[16,89],"conflicting":[17],"results":[18,99],"regarding":[19],"structural":[21],"functional":[23],"oligomerization":[24,67,170],"state":[25],"this":[27,48],"protein.":[28],"Determination":[29],"oligomeric":[32],"state(s)":[33],"is":[34,117,166],"important":[35,167],"for":[36,120,168],"understanding":[37],"more":[38],"precisely":[39],"molecular":[41],"mechanism":[42],"action.":[45],"To":[46],"address":[47],"issue,":[49],"we":[50],"performed":[51],"cross-linking":[52],"human":[54,136],"mouse":[56],"selected":[59],"mutants":[60,105,131],"various":[62],"analyzed":[65],"SDS-PAGE":[69],"gel":[71],"filtration.":[72],"was":[74],"found":[75],"to":[76,149],"form":[77],"a":[78,140,150,182],"mixture":[79,183],"monomeric,":[81],"dimeric,":[82],"trimeric":[84,157],"states":[85],"at":[86],"physiological":[87,178],"concentrations,":[88],"monomer":[91],"dimer":[93],"representing":[94],"major":[96],"species.":[97],"Similar":[98],"were":[100,109],"obtained":[101],"when":[102],"carboxy-truncated":[104],"MIF(1-104)":[106],"MIF(1-109)":[108],"examined,":[110],"indicating":[111,159],"that":[112,160,177],"C-terminus":[114],"not":[118],"critical":[119],"trimer":[121],"stabilization.":[122],"Cross-linking":[123],"analysis":[124],"isosteric":[127],"Cys":[128],"-->":[129],"Ser":[130],"C56S":[132],"C80S":[134],"resulted":[138],"in":[139,153],"similar":[141],"oligomer":[142],"distribution,":[143],"whereas":[144],"substitution":[145],"Cys59":[147,165],"led":[148],"significant":[151],"reduction":[152],"dimeric":[155],"forms,":[158],"hydrophobic":[162],"region":[163],"around":[164],"MIF.":[172],"Together,":[173],"our":[174],"data":[175],"argue":[176],"solutions":[180],"contain":[181],"monomers,":[185],"dimers,":[186],"trimers.":[188]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
