{"id":"https://openalex.org/W2019533738","doi":"https://doi.org/10.1038/emboj.2010.218","title":"Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo","display_name":"Cooperative functions of Chk1 and Chk2 reduce tumour susceptibility in vivo","publication_year":2010,"publication_date":"2010-09-10","ids":{"openalex":"https://openalex.org/W2019533738","doi":"https://doi.org/10.1038/emboj.2010.218","mag":"2019533738","pmid":"https://pubmed.ncbi.nlm.nih.gov/20834228","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2964167"},"language":"en","primary_location":{"id":"doi:10.1038/emboj.2010.218","doi":"https://doi.org/10.1038/emboj.2010.218","is_oa":false,"landing_page_url":"https://doi.org/10.1038/emboj.2010.218","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2964167","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021965894","display_name":"Hiroyuki Niida","orcid":"https://orcid.org/0000-0001-7508-055X","observed_orcids":["https://orcid.org/0000-0001-7508-055X"]},"institutions":[{"id":"https://openalex.org/I3123035732","display_name":"Hamamatsu University School of Medicine","ror":"https://ror.org/00ndx3g44","country_code":"JP","type":"education","lineage":["https://openalex.org/I3123035732"]},{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroyuki Niida","raw_affiliation_strings":["Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan","Department of Biochemistry, Hamamatsu University School of Medicine, Handayama, Higashi\u2010ku Hamamatsu Shizuoka Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Japan","institution_ids":["https://openalex.org/I33858575"]},{"raw_affiliation_string":"Department of Biochemistry, Hamamatsu University School of Medicine, Handayama, Higashi\u2010ku Hamamatsu Shizuoka Japan","institution_ids":["https://openalex.org/I3123035732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033983919","display_name":"Kazuhiro Murata","orcid":"https://orcid.org/0000-0003-0760-976X","observed_orcids":["https://orcid.org/0000-0003-0760-976X"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazuhiro Murata","raw_affiliation_strings":["Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011309423","display_name":"Midori Shimada","orcid":"https://orcid.org/0000-0002-2718-8600","observed_orcids":["https://orcid.org/0000-0002-2718-8600"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Midori Shimada","raw_affiliation_strings":["Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053534566","display_name":"Kumiko Ogawa","orcid":"https://orcid.org/0000-0002-4454-3838","observed_orcids":["https://orcid.org/0000-0002-4454-3838"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Ogawa","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111568403","display_name":"Kumiko Ohta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kumiko Ohta","raw_affiliation_strings":["Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021819151","display_name":"Kyoko Suzuki","orcid":"https://orcid.org/0000-0002-8380-1561","observed_orcids":["https://orcid.org/0000-0002-8380-1561"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko Suzuki","raw_affiliation_strings":["Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074210193","display_name":"Hidetsugu Fujigaki","orcid":"https://orcid.org/0000-0001-9655-1074","observed_orcids":["https://orcid.org/0000-0001-9655-1074"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hidetsugu Fujigaki","raw_affiliation_strings":["Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026222425","display_name":"Aik Kia Khaw","orcid":"https://orcid.org/0000-0002-4523-7269","observed_orcids":["https://orcid.org/0000-0002-4523-7269"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Aik Kia Khaw","raw_affiliation_strings":["Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036539394","display_name":"Birendranath Banerjee","orcid":"https://orcid.org/0000-0001-8819-8231","observed_orcids":["https://orcid.org/0000-0001-8819-8231"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Birendranath Banerjee","raw_affiliation_strings":["Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008546813","display_name":"Manoor Prakash Hande","orcid":"https://orcid.org/0000-0002-4511-6256","observed_orcids":["https://orcid.org/0000-0002-4511-6256"]},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"M Prakash Hande","raw_affiliation_strings":["Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore Singapore Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060520465","display_name":"Tomomi Miyamoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomomi Miyamoto","raw_affiliation_strings":["Department of Comparative and Experimental Medicine and Center for Animal Science, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative and Experimental Medicine and Center for Animal Science, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043659392","display_name":"Ichiro Miyoshi","orcid":"https://orcid.org/0000-0001-6578-3390","observed_orcids":["https://orcid.org/0000-0001-6578-3390"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ichiro Miyoshi","raw_affiliation_strings":["Department of Comparative and Experimental Medicine and Center for Animal Science, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Comparative and Experimental Medicine and Center for Animal Science, Graduate School of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101507859","display_name":"Tomoyuki Shirai","orcid":"https://orcid.org/0000-0001-6269-5387","observed_orcids":["https://orcid.org/0000-0001-6269-5387"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomoyuki Shirai","raw_affiliation_strings":["Department of Experimental Pathology and Tumor Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Pathology and Tumor Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005230969","display_name":"Noboru Motoyama","orcid":"https://orcid.org/0009-0005-4992-2289","observed_orcids":["https://orcid.org/0009-0005-4992-2289"]},"institutions":[{"id":"https://openalex.org/I4210160102","display_name":"National Center for Geriatrics and Gerontology","ror":"https://ror.org/05h0rw812","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210160102"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Noboru Motoyama","raw_affiliation_strings":["Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cognitive Brain Science, National Center for Geriatrics and Gerontology Obu Aichi Japan","institution_ids":["https://openalex.org/I4210160102"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078976663","display_name":"Mireille Delhase","orcid":"https://orcid.org/0000-0003-2312-1051","observed_orcids":["https://orcid.org/0000-0003-2312-1051"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mireille Delhase","raw_affiliation_strings":["Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036354240","display_name":"Ettore Appella","orcid":"https://orcid.org/0000-0003-0569-9722","observed_orcids":["https://orcid.org/0000-0003-0569-9722"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ettore Appella","raw_affiliation_strings":["Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA,","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034145502","display_name":"Makoto Nakanishi","orcid":"https://orcid.org/0000-0002-6707-3584","observed_orcids":["https://orcid.org/0000-0002-6707-3584"]},"institutions":[{"id":"https://openalex.org/I33858575","display_name":"Nagoya City University","ror":"https://ror.org/04wn7wc95","country_code":"JP","type":"education","lineage":["https://openalex.org/I33858575"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Makoto Nakanishi","raw_affiliation_strings":["Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology, Nagoya City University, Kawasumi, Mizuho-cho Mizuho-ku Nagoya Japan","institution_ids":["https://openalex.org/I33858575"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034145502"],"corresponding_institution_ids":["https://openalex.org/I33858575"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":2.548,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.89967494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"29","issue":"20","first_page":"3558","last_page":"3570"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.8848000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.10949999839067459,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chk1","display_name":"Chk1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/chk2","display_name":"Chk2","score":1.0},{"id":"https://openalex.org/keywords/checkpoint-kinase","display_name":"checkpoint kinase","score":0.7279999852180481},{"id":"https://openalex.org/keywords/cancer-susceptibility","display_name":"cancer susceptibility","score":0.9459999799728394},{"id":"https://openalex.org/keywords/g2-m-checkpoint","display_name":"G2/M checkpoint","score":0.8180000185966492},{"id":"https://openalex.org/keywords/g1-s-checkpoint","display_name":"G1/S checkpoint","score":0.9359999895095825},{"id":"https://openalex.org/keywords/intra-s-phase-checkpoint","display_name":"S-phase checkpoint","score":0.9779999852180481},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.8560000061988831},{"id":"https://openalex.org/keywords/p53-phosphorylation","display_name":"p53 phosphorylation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.6460000276565552},{"id":"https://openalex.org/keywords/rb","display_name":"Rb","score":0.7940000295639038},{"id":"https://openalex.org/keywords/oncogene-induced-senescence","display_name":"oncogene-induced senescence","score":0.9959999918937683},{"id":"https://openalex.org/keywords/spontaneous-dna-damage","display_name":"spontaneous DNA damage","score":0.9539999961853027},{"id":"https://openalex.org/keywords/mouse-embryonic-fibroblasts","display_name":"mouse embryonic fibroblasts","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9225051403045654},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6480225324630737},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.32800501585006714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3229973316192627},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3108324706554413}],"mesh":[{"descriptor_ui":"D000071877","descriptor_name":"Checkpoint Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004260","descriptor_name":"DNA Repair","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011494","descriptor_name":"Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016922","descriptor_name":"Cellular Senescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053208","descriptor_name":"Kaplan-Meier Estimate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064447","descriptor_name":"Checkpoint Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/emboj.2010.218","doi":"https://doi.org/10.1038/emboj.2010.218","is_oa":false,"landing_page_url":"https://doi.org/10.1038/emboj.2010.218","pdf_url":null,"source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2198473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2964167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:20834228","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20834228","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2964167","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2964167/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2198473","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2964167","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320322616","display_name":"Mitsubishi Foundation","ror":"https://ror.org/02y2f3e22"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W1531836615","https://openalex.org/W1537708951","https://openalex.org/W1903850103","https://openalex.org/W1937607074","https://openalex.org/W1964763247","https://openalex.org/W1966249371","https://openalex.org/W1970891016","https://openalex.org/W1988876917","https://openalex.org/W2001353514","https://openalex.org/W2002802048","https://openalex.org/W2008280357","https://openalex.org/W2010378709","https://openalex.org/W2015061258","https://openalex.org/W2017235640","https://openalex.org/W2018116689","https://openalex.org/W2028044172","https://openalex.org/W2028943929","https://openalex.org/W2029304297","https://openalex.org/W2034317592","https://openalex.org/W2039382131","https://openalex.org/W2041156660","https://openalex.org/W2042732211","https://openalex.org/W2044366106","https://openalex.org/W2050981751","https://openalex.org/W2054576158","https://openalex.org/W2058005740","https://openalex.org/W2059971436","https://openalex.org/W2062284662","https://openalex.org/W2073685453","https://openalex.org/W2076786521","https://openalex.org/W2078066154","https://openalex.org/W2078842115","https://openalex.org/W2082559623","https://openalex.org/W2087404852","https://openalex.org/W2088332201","https://openalex.org/W2088512897","https://openalex.org/W2097627379","https://openalex.org/W2100674208","https://openalex.org/W2104979060","https://openalex.org/W2105592350","https://openalex.org/W2111131079","https://openalex.org/W2114205900","https://openalex.org/W2114647652","https://openalex.org/W2116964110","https://openalex.org/W2118266991","https://openalex.org/W2120921507","https://openalex.org/W2121371748","https://openalex.org/W2145292441","https://openalex.org/W2146364516","https://openalex.org/W2146741358","https://openalex.org/W2148964728","https://openalex.org/W2149795092","https://openalex.org/W2149938795","https://openalex.org/W2154141161","https://openalex.org/W2158689768","https://openalex.org/W2166548889","https://openalex.org/W2169965735","https://openalex.org/W2186961771","https://openalex.org/W2194159459","https://openalex.org/W2324248025","https://openalex.org/W2329294870"],"related_works":["https://openalex.org/W4249720026","https://openalex.org/W2002802048","https://openalex.org/W2314683555","https://openalex.org/W1992125584","https://openalex.org/W1966249371","https://openalex.org/W1986979664","https://openalex.org/W2083225541","https://openalex.org/W2009517339","https://openalex.org/W2070622422","https://openalex.org/W2029304297"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}