{"id":"https://openalex.org/W2019532708","doi":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","title":"Samarangenin B from Limonium sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis","display_name":"Samarangenin B from Limonium sinense Suppresses Herpes Simplex Virus Type 1 Replication in Vero Cells by Regulation of Viral Macromolecular Synthesis","publication_year":2002,"publication_date":"2002-09-01","ids":{"openalex":"https://openalex.org/W2019532708","doi":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","mag":"2019532708","pmid":"https://pubmed.ncbi.nlm.nih.gov/12183238","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/127446"},"language":"en","primary_location":{"id":"doi:10.1128/aac.46.9.2854-2864.2002","doi":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC127446","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111758402","display_name":"Yuh-Chi Kuo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yuh-Chi Kuo","raw_affiliation_strings":["Institute of Life Science, Fu-Jen University","National Research Institute of Chinese Medicine","National Research Institute of Chinese Medicine,Taipei, Taiwan, Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Life Science, Fu-Jen University","institution_ids":[]},{"raw_affiliation_string":"National Research Institute of Chinese Medicine","institution_ids":["https://openalex.org/I4210094085"]},{"raw_affiliation_string":"National Research Institute of Chinese Medicine,Taipei, Taiwan, Republic of China","institution_ids":["https://openalex.org/I4210094085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110476952","display_name":"Lie-Chwen Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Lie-Chwen Lin","raw_affiliation_strings":["National Research Institute of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Institute of Chinese Medicine","institution_ids":["https://openalex.org/I4210094085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111637854","display_name":"Wei\u2010Jern Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wei-Jern Tsai","raw_affiliation_strings":["National Research Institute of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Institute of Chinese Medicine","institution_ids":["https://openalex.org/I4210094085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111526491","display_name":"Cheng\u2010Jen Chou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Cheng-Jen Chou","raw_affiliation_strings":["National Research Institute of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Institute of Chinese Medicine","institution_ids":["https://openalex.org/I4210094085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082877210","display_name":"Szu\u2010Hao Kung","orcid":"https://orcid.org/0000-0002-0674-951X","observed_orcids":["https://orcid.org/0000-0002-0674-951X"]},"institutions":[{"id":"https://openalex.org/I4387156312","display_name":"National Yang Ming University","ror":"https://ror.org/009h5ks85","country_code":"TW","type":"education","lineage":["https://openalex.org/I148366613","https://openalex.org/I4387156312"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Szu-Hao Kung","raw_affiliation_strings":["Department of Medical Technology and Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei, Taiwan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Technology and Institute of Biotechnology in Medicine, National Yang-Ming University, Taipei, Taiwan","institution_ids":["https://openalex.org/I4387156312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004193217","display_name":"Yen-Hui Ho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094085","display_name":"National Research Institute of Chinese Medicine","ror":"https://ror.org/00nnyvd56","country_code":"TW","type":"facility","lineage":["https://openalex.org/I4210094085"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yen-Hui Ho","raw_affiliation_strings":["National Research Institute of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Research Institute of Chinese Medicine","institution_ids":["https://openalex.org/I4210094085"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3231,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.79749589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"46","issue":"9","first_page":"2854","last_page":"2864"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12087","display_name":"Natural Compound Pharmacology Studies","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limonium-sinense","display_name":"Limonium sinense","score":1.0},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9869999885559082},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.9639999866485596},{"id":"https://openalex.org/keywords/viral-replication-inhibition","display_name":"viral replication inhibition","score":0.6259999871253967},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.6019999980926514},{"id":"https://openalex.org/keywords/icp0","display_name":"ICP0","score":0.6679999828338623},{"id":"https://openalex.org/keywords/icp4","display_name":"ICP4","score":0.9990000128746033},{"id":"https://openalex.org/keywords/viral-dna-polymerase","display_name":"viral DNA polymerase","score":0.5830000042915344},{"id":"https://openalex.org/keywords/viral-gene-expression","display_name":"viral gene expression","score":0.6320000290870667},{"id":"https://openalex.org/keywords/oct-1","display_name":"Oct-1","score":0.6179999709129333},{"id":"https://openalex.org/keywords/glycoprotein-b","display_name":"glycoprotein B","score":0.7940000295639038},{"id":"https://openalex.org/keywords/vero-cells","display_name":"Vero cells","score":0.652999997138977}],"concepts":[{"id":"https://openalex.org/C89138240","wikidata":"https://www.wikidata.org/wiki/Q3066564","display_name":"Vero cell","level":3,"score":0.9270237684249878},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7683548927307129},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.7510232925415039},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6061073541641235},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.5883854627609253},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5353152751922607},{"id":"https://openalex.org/C73573662","wikidata":"https://www.wikidata.org/wiki/Q130996","display_name":"DNA replication","level":3,"score":0.512661874294281},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4646690785884857},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4129871726036072},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3784644901752472},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09429553151130676}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D001578","descriptor_name":"Benzopyrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002522","descriptor_name":"Chlorocebus aethiops","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D004259","descriptor_name":"DNA-Directed DNA Polymerase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010948","descriptor_name":"Viral Plaque Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014709","descriptor_name":"Vero Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D024202","descriptor_name":"Electrophoretic Mobility Shift Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029606","descriptor_name":"Plumbaginaceae","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aac.46.9.2854-2864.2002","doi":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aac.46.9.2854-2864.2002","pdf_url":null,"source":{"id":"https://openalex.org/S47215897","display_name":"Antimicrobial Agents and Chemotherapy","issn_l":"0066-4804","issn":["0066-4804","1070-6283","1098-6596"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial Agents and Chemotherapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:108402","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC127446","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:12183238","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12183238","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrobial agents and chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:127446","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC127446/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Antimicrob Agents Chemother","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:108402","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC127446","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W1496112205","https://openalex.org/W1496779362","https://openalex.org/W1845768949","https://openalex.org/W1970070211","https://openalex.org/W1972938146","https://openalex.org/W1978618775","https://openalex.org/W1979038645","https://openalex.org/W1981058681","https://openalex.org/W1982861035","https://openalex.org/W1985517915","https://openalex.org/W1991093313","https://openalex.org/W1998604091","https://openalex.org/W2011137726","https://openalex.org/W2023523980","https://openalex.org/W2025399383","https://openalex.org/W2026939347","https://openalex.org/W2027210619","https://openalex.org/W2030879320","https://openalex.org/W2045360603","https://openalex.org/W2047000767","https://openalex.org/W2050382883","https://openalex.org/W2050717506","https://openalex.org/W2050760235","https://openalex.org/W2056862882","https://openalex.org/W2076875645","https://openalex.org/W2077128329","https://openalex.org/W2088742449","https://openalex.org/W2092714643","https://openalex.org/W2104796719","https://openalex.org/W2107975420","https://openalex.org/W2116139599","https://openalex.org/W2118584295","https://openalex.org/W2119232680","https://openalex.org/W2120863353","https://openalex.org/W2146481809","https://openalex.org/W2167414261","https://openalex.org/W2240221961","https://openalex.org/W2262433442","https://openalex.org/W2335618751","https://openalex.org/W2422338657","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2007865382","https://openalex.org/W1979038645","https://openalex.org/W2058720485","https://openalex.org/W4392166220","https://openalex.org/W315081143","https://openalex.org/W2271027009","https://openalex.org/W3115314316","https://openalex.org/W1995705002","https://openalex.org/W6957942563","https://openalex.org/W2160310902"],"abstract_inverted_index":{"Inhibitory":[0],"effects":[1],"of":[2,52,64,85,113,144,170,183,191,194,213],"ethanolic":[3],"extracts":[4],"from":[5,30,139],"10":[6],"Chinese":[7],"herbs":[8],"on":[9,55],"herpes":[10],"simplex":[11],"virus":[12,65],"type":[13],"1":[14],"(HSV-1)":[15],"replication":[16,57,78,143],"were":[17,133],"investigated.":[18],"By":[19],"a":[20,83],"bioassay-guided":[21],"fractionation":[22],"procedure,":[23],"samarangenin":[24],"B":[25,34,54,115,157,179,196,246],"(Sam":[26],"B)":[27],"was":[28,58,93,150],"isolated":[29],"Limonium":[31],"sinense;":[32],"Sam":[33,53,136,153,156,178,195,245],"significantly":[35],"suppressed":[36],"HSV-1":[37,56,77,145,207,231,252],"multiplication":[38,92],"in":[39,75,130,147,166,203,238],"Vero":[40,131,148,167,239],"cells":[41,132,149],"without":[42],"apparent":[43],"cytotoxicity.":[44],"Time-of-addition":[45],"experiments":[46],"suggested":[47],"that":[48,111,142,177,244],"the":[49,62,73,76,181,214],"inhibitory":[50],"action":[51,193],"not":[59],"due":[60],"to":[61,70,90,198],"blocking":[63,220],"adsorption.":[66],"In":[67],"an":[68,171,184,248],"attempt":[69],"further":[71],"localize":[72],"point":[74],"cycle":[79],"where":[80],"arrest":[81],"occurred,":[82],"set":[84],"key":[86],"regulatory":[87],"events":[88],"leading":[89],"viral":[91,96],"examined,":[94],"including":[95,211],"immediate-early":[97],"(alpha),":[98],"early":[99],"(beta),":[100],"and":[101,106,120,126,162,216,228,234],"late":[102],"(gamma)":[103],"gene":[104,164,209],"expression":[105,125,129,165,212,237],"DNA":[107,146,159,225,232],"replication.":[108,253],"Results":[109,169],"indicated":[110],"levels":[112],"glycoprotein":[114],"(gB),":[116],"gC,":[117],"gD,":[118],"gG,":[119],"infected-cell":[121],"protein":[122,236],"5":[123],"(ICP5)":[124],"gB":[127],"mRNA":[128],"impeded":[134],"by":[135,152,205,219,229],"B.":[137,154],"Data":[138],"PCR":[140],"showed":[141],"arrested":[151],"Furthermore,":[155],"decreased":[158],"polymerase,":[160],"ICP0,":[161],"ICP4":[163,217],"cells.":[168,240],"electrophoretic":[172],"mobility":[173],"shift":[174],"assay":[175],"demonstrated":[176],"interrupted":[180],"formation":[182],"alpha-trans-induction":[185],"factor/C1/Oct-1/GARAT":[186],"multiprotein":[187],"complex.":[188],"The":[189],"mechanisms":[190],"antiviral":[192,249],"seem":[197],"be":[199],"mediated,":[200],"at":[201],"least":[202],"part,":[204],"inhibiting":[206],"alpha":[208],"expression,":[210],"ICP0":[215],"genes,":[218],"beta":[221],"transcripts":[222],"such":[223],"as":[224],"polymerase":[226],"mRNA,":[227],"arresting":[230],"synthesis":[233],"structural":[235],"These":[241],"results":[242],"show":[243],"is":[247],"agent":[250],"against":[251]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
