{"id":"https://openalex.org/W2019531508","doi":"https://doi.org/10.1016/j.actatropica.2005.10.004","title":"Drug resistance\u2013virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission","display_name":"Drug resistance\u2013virulence relationship in Plasmodium falciparum causing severe malaria in an area of seasonal and unstable transmission","publication_year":2005,"publication_date":"2005-12-06","ids":{"openalex":"https://openalex.org/W2019531508","doi":"https://doi.org/10.1016/j.actatropica.2005.10.004","mag":"2019531508","pmid":"https://pubmed.ncbi.nlm.nih.gov/16336938"},"language":"en","primary_location":{"id":"doi:10.1016/j.actatropica.2005.10.004","doi":"https://doi.org/10.1016/j.actatropica.2005.10.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actatropica.2005.10.004","pdf_url":null,"source":{"id":"https://openalex.org/S190456265","display_name":"Acta Tropica","issn_l":"0001-706X","issn":["0001-706X","1873-6254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Tropica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004824725","display_name":"Hayder Ahmed Giha","orcid":"https://orcid.org/0000-0001-6343-1949","observed_orcids":["https://orcid.org/0000-0001-6343-1949"]},"institutions":[{"id":"https://openalex.org/I150406212","display_name":"University of Khartoum","ror":"https://ror.org/02jbayz55","country_code":"SD","type":"education","lineage":["https://openalex.org/I150406212"]}],"countries":["SD"],"is_corresponding":true,"raw_author_name":"Hayder A. Giha","raw_affiliation_strings":["Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan. gehaha2002@yahoo.com","Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan. gehaha2002@yahoo.com","institution_ids":["https://openalex.org/I150406212"]},{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111739473","display_name":"Mustafa Idris Elbashir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150406212","display_name":"University of Khartoum","ror":"https://ror.org/02jbayz55","country_code":"SD","type":"education","lineage":["https://openalex.org/I150406212"]}],"countries":["SD"],"is_corresponding":false,"raw_author_name":"Mustafa I. Elbashir","raw_affiliation_strings":["Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010906594","display_name":"Ishraga Eltayeb M. A-Elbasit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150406212","display_name":"University of Khartoum","ror":"https://ror.org/02jbayz55","country_code":"SD","type":"education","lineage":["https://openalex.org/I150406212"]}],"countries":["SD"],"is_corresponding":false,"raw_author_name":"Ishraga E. A-Elbasit","raw_affiliation_strings":["Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012153185","display_name":"Thoraya Mohamed Elhassan A-Elgadir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150406212","display_name":"University of Khartoum","ror":"https://ror.org/02jbayz55","country_code":"SD","type":"education","lineage":["https://openalex.org/I150406212"]}],"countries":["SD"],"is_corresponding":false,"raw_author_name":"Thoraya M.E. A-Elgadir","raw_affiliation_strings":["Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073325091","display_name":"Gehad E. ElGhazali","orcid":"https://orcid.org/0000-0001-9514-3765","observed_orcids":["https://orcid.org/0000-0001-9514-3765"]},"institutions":[{"id":"https://openalex.org/I150406212","display_name":"University of Khartoum","ror":"https://ror.org/02jbayz55","country_code":"SD","type":"education","lineage":["https://openalex.org/I150406212"]}],"countries":["SD"],"is_corresponding":false,"raw_author_name":"Gehad E. ElGhazali","raw_affiliation_strings":["Department of Microbiology and Immunology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan","Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]},{"raw_affiliation_string":"Malaria Research Centre (MalRC), Department of Biochemistry, Faculty of Medicine, University of Khartoum, P.O. Box 102, Khartoum, Sudan","institution_ids":["https://openalex.org/I150406212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041779453","display_name":"Margaret J. Mackinnon","orcid":"https://orcid.org/0000-0003-1279-9625","observed_orcids":["https://orcid.org/0000-0003-1279-9625"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Margaret J. Mackinnon","raw_affiliation_strings":["Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113539400","display_name":"Hamza Ali Babiker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Hamza A. Babiker","raw_affiliation_strings":["Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Animal and Population Biology, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5004824725"],"corresponding_institution_ids":["https://openalex.org/I150406212"],"apc_list":{"value":3160,"currency":"USD","value_usd":3160},"apc_paid":null,"fwci":3.687,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91997387,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"97","issue":"2","first_page":"181","last_page":"187"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9929999709129333},{"id":"https://openalex.org/keywords/severe-malaria","display_name":"severe malaria","score":0.9229999780654907},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.9570000171661377},{"id":"https://openalex.org/keywords/virulence","display_name":"virulence","score":0.8709999918937683},{"id":"https://openalex.org/keywords/chloroquine-resistance","display_name":"chloroquine resistance","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pfcrt","display_name":"pfcrt","score":0.859000027179718},{"id":"https://openalex.org/keywords/pfmdr1","display_name":"pfmdr1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/parasite-fitness","display_name":"parasite fitness","score":0.8519999980926514},{"id":"https://openalex.org/keywords/malaria-seasonality","display_name":"seasonal malaria transmission","score":0.7850000262260437},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.8844472169876099},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.8601787090301514},{"id":"https://openalex.org/C99389464","wikidata":"https://www.wikidata.org/wiki/Q3319949","display_name":"Gametocyte","level":4,"score":0.8216613531112671},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.6976587772369385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6662915349006653},{"id":"https://openalex.org/C2777425658","wikidata":"https://www.wikidata.org/wiki/Q422438","display_name":"Chloroquine","level":3,"score":0.6425531506538391},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.5829975008964539},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.5195025205612183},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5164520740509033},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.4780757427215576},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.42179277539253235},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41482013463974},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.20990842580795288},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14196845889091492},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1238778829574585},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11780363321304321},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D012621","descriptor_name":"Seasons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014774","descriptor_name":"Virulence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D016778","descriptor_name":"Malaria, Falciparum","qualifier_ui":"Q000469","qualifier_name":"parasitology","is_major_topic":true},{"descriptor_ui":"D018528","descriptor_name":"ATP-Binding Cassette Transporters","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.actatropica.2005.10.004","doi":"https://doi.org/10.1016/j.actatropica.2005.10.004","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.actatropica.2005.10.004","pdf_url":null,"source":{"id":"https://openalex.org/S190456265","display_name":"Acta Tropica","issn_l":"0001-706X","issn":["0001-706X","1873-6254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Tropica","raw_type":"journal-article"},{"id":"pmid:16336938","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16336938","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta tropica","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W66070344","https://openalex.org/W1636385668","https://openalex.org/W1835840082","https://openalex.org/W1838568970","https://openalex.org/W1922732464","https://openalex.org/W1967607927","https://openalex.org/W1972177048","https://openalex.org/W1974313358","https://openalex.org/W1982912829","https://openalex.org/W1987063801","https://openalex.org/W1990720025","https://openalex.org/W1991141156","https://openalex.org/W1991190622","https://openalex.org/W1991638152","https://openalex.org/W1992733039","https://openalex.org/W2003597358","https://openalex.org/W2008672550","https://openalex.org/W2009258477","https://openalex.org/W2016924391","https://openalex.org/W2024885080","https://openalex.org/W2035027338","https://openalex.org/W2039353100","https://openalex.org/W2041172948","https://openalex.org/W2061658473","https://openalex.org/W2065794755","https://openalex.org/W2071271960","https://openalex.org/W2072158612","https://openalex.org/W2074654911","https://openalex.org/W2078099795","https://openalex.org/W2087662292","https://openalex.org/W2090036211","https://openalex.org/W2091586468","https://openalex.org/W2105468816","https://openalex.org/W2108981715","https://openalex.org/W2129965217","https://openalex.org/W2132831164","https://openalex.org/W2132923209","https://openalex.org/W2139362855","https://openalex.org/W2157141899","https://openalex.org/W2158788393","https://openalex.org/W2169823386","https://openalex.org/W2333050857","https://openalex.org/W2403484530","https://openalex.org/W4211010162","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W7213336818","https://openalex.org/W2053806668","https://openalex.org/W1983736456","https://openalex.org/W1503046840","https://openalex.org/W2116350812","https://openalex.org/W66911986","https://openalex.org/W2122768388","https://openalex.org/W1971406241","https://openalex.org/W2049549858","https://openalex.org/W2486662874"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}