{"id":"https://openalex.org/W2019519183","doi":"https://doi.org/10.1158/1538-7445.am2014-5085","title":"Abstract 5085: Inducing multipolarity of acentrosomal mitotic spindles as a novel tumor-specific targeting strategy revealed by the antimitotic effect of mdivi-1","display_name":"Abstract 5085: Inducing multipolarity of acentrosomal mitotic spindles as a novel tumor-specific targeting strategy revealed by the antimitotic effect of mdivi-1","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2019519183","doi":"https://doi.org/10.1158/1538-7445.am2014-5085","mag":"2019519183"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2014-5085","doi":"https://doi.org/10.1158/1538-7445.am2014-5085","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5085","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115694775","display_name":"Jingnan Wang","orcid":"https://orcid.org/0009-0004-0111-2140","observed_orcids":["https://orcid.org/0009-0004-0111-2140"]},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingnan Wang","raw_affiliation_strings":["1Tsinghua University School of Medicine, Beijing, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Tsinghua University School of Medicine, Beijing, China;","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101906491","display_name":"Wei Qian","orcid":"https://orcid.org/0000-0002-9963-7751","observed_orcids":["https://orcid.org/0000-0002-9963-7751"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Qian","raw_affiliation_strings":["2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009589228","display_name":"Masahiro Shuda","orcid":"https://orcid.org/0000-0003-0595-2572","observed_orcids":["https://orcid.org/0000-0003-0595-2572"]},"institutions":[{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Masahiro Shuda","raw_affiliation_strings":["3Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3Molecular Virology Program, University of Pittsburgh Cancer Institute, Pittsburgh, PA;","institution_ids":["https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100462033","display_name":"Jianfeng Li","orcid":"https://orcid.org/0000-0003-2349-208X","observed_orcids":["https://orcid.org/0000-0003-2349-208X"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianfeng Li","raw_affiliation_strings":["4Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027422427","display_name":"Lucas Santana\u2010Santos","orcid":"https://orcid.org/0000-0002-0872-5431","observed_orcids":["https://orcid.org/0000-0002-0872-5431"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lucas Santana-Santos","raw_affiliation_strings":["5Biomedical Informatics, and Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"5Biomedical Informatics, and Computational and Systems Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027876809","display_name":"Robert William Sobol","orcid":"https://orcid.org/0000-0001-7385-3563","observed_orcids":["https://orcid.org/0000-0001-7385-3563"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert W. Sobol","raw_affiliation_strings":["2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055919829","display_name":"Bennett Van Houten","orcid":"https://orcid.org/0000-0002-4009-2478","observed_orcids":["https://orcid.org/0000-0002-4009-2478"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I4210128526","display_name":"UPMC Hillman Cancer Center","ror":"https://ror.org/03bw34a45","country_code":"US","type":"facility","lineage":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bennett Van Houten","raw_affiliation_strings":["2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Pharmacology & Chemical Biology, School of Medicine, University of Pittsburgh and Hillman Cancer Center, University of Pittsburgh Cancer Institute,, Pittsburgh, PA;","institution_ids":["https://openalex.org/I170201317","https://openalex.org/I4210128526"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"74","issue":"19_Supplement","first_page":"5085","last_page":"5085"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mdivi-1","display_name":"Mdivi-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/antimitotic-agents","display_name":"antimitotic agents","score":0.7210000157356262},{"id":"https://openalex.org/keywords/sv40-large-t-antigen","display_name":"SV40 large T antigen","score":0.824999988079071},{"id":"https://openalex.org/keywords/sv40-small-t-antigen","display_name":"SV40 small t antigen","score":0.9390000104904175},{"id":"https://openalex.org/keywords/malignant-transformation","display_name":"malignant transformation","score":0.5979999899864197},{"id":"https://openalex.org/keywords/genomic-instability","display_name":"genomic instability","score":0.7059999704360962},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5690000057220459},{"id":"https://openalex.org/keywords/mitochondrial-outer-membrane-permeabilization","display_name":"mitochondrial outer membrane permeabilization","score":0.9300000071525574},{"id":"https://openalex.org/keywords/bax-bak","display_name":"Bax/Bak","score":0.9150000214576721},{"id":"https://openalex.org/keywords/gamma-tubulin","display_name":"gamma-tubulin","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C10447061","wikidata":"https://www.wikidata.org/wiki/Q190769","display_name":"Centrosome","level":4,"score":0.814775288105011},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7634763717651367},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6200194358825684},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5793218612670898},{"id":"https://openalex.org/C47432576","wikidata":"https://www.wikidata.org/wiki/Q918594","display_name":"Spindle apparatus","level":4,"score":0.5193639397621155},{"id":"https://openalex.org/C3453395","wikidata":"https://www.wikidata.org/wiki/Q6935034","display_name":"Multipolar spindles","level":5,"score":0.49764493107795715},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.4873398244380951},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4441465735435486},{"id":"https://openalex.org/C85813293","wikidata":"https://www.wikidata.org/wiki/Q188909","display_name":"Cell division","level":3,"score":0.4365427494049072},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.42215263843536377},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4192464351654053},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.38927170634269714},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3308158814907074},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32039588689804077},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2218952775001526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16330140829086304}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2014-5085","doi":"https://doi.org/10.1158/1538-7445.am2014-5085","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2014-5085","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092955309","https://openalex.org/W4387954332","https://openalex.org/W3155811702","https://openalex.org/W1989139022","https://openalex.org/W4399797581","https://openalex.org/W2093940795","https://openalex.org/W2098697200","https://openalex.org/W2409609474","https://openalex.org/W4399430621","https://openalex.org/W2148944466"],"abstract_inverted_index":{"Abstract":[0],"Traditional":[1],"antimitotic":[2,19,81,116,282,340],"drugs":[3,28],"for":[4,114,356],"cancer":[5],"chemotherapy":[6],"often":[7],"have":[8],"undesired":[9],"toxicity":[10],"to":[11,23,162,164,176,231],"healthy":[12],"tissue,":[13],"limiting":[14],"clinical":[15],"application.":[16],"Developing":[17],"tumor-specific":[18,281,334],"strategies":[20],"is":[21,85,120],"necessary":[22],"improve":[24],"the":[25,30,109,115,165,201,217,220,262,305,339,348,353],"efficacy":[26],"of":[27,33,52,83,118,122,144,170,206,223,248,264,269,294,327,342,347,352],"in":[29,68,74,96,140,204,212,227,278],"selective":[31],"eradication":[32],"tumor":[34,70,110,141,213,228],"cells.":[35,79,104],"In":[36],"this":[37],"study,":[38],"we":[39],"discovered":[40],"mdivi-1":[41,84,93,119,235,243],"(mitochondrial":[42],"division":[43],"inhibitor-1),":[44],"which":[45,150],"was":[46,94,285,301],"originally":[47],"reported":[48],"as":[49,87,253,274,331],"an":[50],"inhibitor":[51],"mitochondrial":[53,186],"fission":[54],"protein":[55,57],"dynamin-related":[56],"1":[58],"(Drp1),":[59],"specifically":[60],"disrupts":[61],"M":[62,88],"phase":[63,89],"cell":[64,182],"cycle":[65],"progression":[66],"only":[67],"human":[69],"cells":[71,142,198,229,233],"and":[72,77,100,126,158,180,196,291],"not":[73,132,152,302],"non-transformed":[75,195],"fibroblasts":[76],"epithelial":[78],"The":[80,168],"effect":[82,117,341],"Drp1-independent,":[86],"abnormality":[90],"induced":[91],"by":[92,287,338],"observed":[95],"both":[97],"Drp1":[98,101],"wild-type":[99],"knockout":[102],"MEF":[103],"We":[105,258],"also":[106],"identified":[107],"that":[108,200,242,251,260],"transformation":[111],"process":[112],"required":[113],"downstream":[121],"SV40":[123],"large":[124],"T":[125],"small":[127],"t":[128],"antigens":[129],"-":[130],"but":[131],"hTERT-mediated":[133],"immortalization.":[134],"Mdivi-1":[135],"induces":[136],"multipolar":[137,225,265],"mitotic":[138,173,266,329],"spindles":[139,174,208,226,267,330],"regardless":[143],"centrosome":[145,155],"number.":[146],"Acentrosomal":[147],"spindle":[148,166,255],"poles,":[149],"do":[151],"contain":[153],"bona-fide":[154],"components":[156],"\u03b3-tubulin":[157],"centrin-2,":[159],"were":[160],"found":[161],"contribute":[163],"multipolarity.":[167],"formation":[169,222],"such":[171],"aberrant":[172],"leads":[175],"gross":[177],"genome":[178],"instability":[179],"apoptotic":[181],"death":[183],"through":[184],"Bax/Bak-mediated":[185],"outer":[187],"membrane":[188],"permeabilization":[189],"(MOMP).":[190],"Gene":[191],"expression":[192],"profiling":[193],"comparing":[194],"transformed":[197],"revealed":[199,337],"genes":[202],"involved":[203],"assembly":[205,263],"acentrosomal":[207,224,254,270,328],"are":[209],"highly":[210],"up-regulated":[211],"cells,":[214],"thus":[215],"providing":[216],"mechanism":[218],"underlying":[219],"preferential":[221],"compared":[230],"normal":[232],"after":[234],"treatment.":[236],"Taken":[237],"together,":[238],"our":[239],"studies":[240],"imply":[241],"represents":[244],"a":[245,275,280,332],"novel":[246,276,333],"class":[247],"quinazolinone":[249],"compounds":[250],"function":[252],"inducers":[256],"(ASI).":[257],"suggest":[259],"promoting":[261],"composed":[268],"poles":[271],"could":[272],"serve":[273],"strategy":[277,336],"achieving":[279],"effect.":[283],"(Work":[284],"supported":[286],"P30CA047904,":[288],"GM087798,":[289],"UPCI":[290],"PA":[292],"Dept":[293],"Health":[295],"CURE":[296],"program)":[297],"Note:":[298],"This":[299],"abstract":[300],"presented":[303],"at":[304],"meeting.":[306],"Citation":[307],"Format:":[308],"Jingnan":[309],"Wang,":[310],"Wei":[311],"Qian,":[312],"Masahiro":[313],"Shuda,":[314],"Jianfeng":[315],"Li,":[316],"Lucas":[317],"Santana-Santos,":[318],"Robert":[319],"W.":[320],"Sobol,":[321],"Bennett":[322],"Van":[323],"Houten.":[324],"Inducing":[325],"multipolarity":[326],"targeting":[335],"mdivi-1.":[343],"[abstract].":[344],"In:":[345],"Proceedings":[346],"105th":[349],"Annual":[350],"Meeting":[351],"American":[354],"Association":[355],"Cancer":[357,368],"Research;":[358],"2014":[359],"Apr":[360],"5-9;":[361],"San":[362],"Diego,":[363],"CA.":[364],"Philadelphia":[365],"(PA):":[366],"AACR;":[367],"Res":[369],"2014;74(19":[370],"Suppl):Abstract":[371],"nr":[372],"5085.":[373],"doi:10.1158/1538-7445.AM2014-5085":[374]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}